低体重和肥胖儿童身体成分特点及脂肪肌肉含量与骨密度相关性研究

目的 探讨低体重和肥胖儿童身体成分特点及其脂肪肌肉含量与骨密度的相关性.方法 选择2015年6月至2016年6月于眉山市妇幼保健院儿保门诊体检的5~7岁儿童为研究对象,按体质量指数(BMI)分为低体重组、肥胖组和对照组,测量身体成分各项指标,包括体脂比、全身脂肪含量、肌肉含量及局部和全身骨密度,并对结果进行分析.结果 同性别儿童低体重组的体脂比、全身脂肪含量、肌肉含量及局部和全身骨密度均分别明显低于对照组,二者之间差异均具有统计学意义(t=3.076~3.326,均P<0.05);同性别儿童对照组的体脂比、全身脂肪含量、肌肉含量及局部和全身骨密度均分别明显低于肥胖组,二者之间差异均具有统计学意义(t=2.998~3.427,均P<0.05).经Logistic回归分析:低体重组儿童的肌肉含量与不同部位骨密度均呈正相关性(r=0.779~0.889,均P<0.05);肥胖组男性儿童的肌肉含量与下肢骨密度、体脂比和全身脂肪含量与躯干骨密度均呈正相关性(r=0.779~0.882,均P<0.05),肥胖组女性儿童肌肉含量与上肢骨密度,以及体脂比、全身脂肪含量和肌肉含量与下肢骨密度均呈正相关性(r=0.781~0.901,均P<0.05);对照组儿童的肌肉含量与不同部位骨密度均呈正相关性(r=0.779~0.912,均P<0.05),对照组女性儿童的体脂比、全身脂肪含量和肌肉含量均与下肢骨密度和全身骨密度均呈正相关性(r=0.805~0.912,均P<0.05).结论 与正常儿童相比,低体重和肥胖儿童身体成分构成,各指标与骨密度的相关关系明显不同于正常儿童.在对儿保门诊儿童管理中,体重、体脂比、全身脂肪含量、肌肉含量的变化均是需要关注的重要指标,从而促进其骨骼健康发育.     

Effects of a high fat diet on bone of growing rats. Correlations between visceral fat,adiponectin and bone mass density

In this study, we investigated some bone parameters (bone mineral content, bone mineral density, skeleton area) in growing rats fed with a high fat diet. Correlations between bone and body composition parameters are reported. Two groups of Wistar male rats (35 days old, body mass 80 ± 6 g) were used. Water and food were given " ad libitum " during 10 weeks. Sixteen rats (L) were given a lipid enriched diet and were compared to 16 rats (S) fed with a standard diet. Body composition and bone parameters were assessed using DXA. Results indicated that L rats had lower body mass, lean body mass; fat mass was not different between the two groups. Bone mineral content, bone mineral density, skeleton area of L rats were lower compared with S rats. Significant correlations were noted between body composition, adiponectin and bone parameters. High fat diet intake during the growing period has deleterious effects on bone parameters in rats. This study confirms in growing rats that a high fat diet is pathogenic, including bone metabolism.     

Bone loss at the proximal femur and reduced lean mass following liver transplantation: a longitudinal study.

The longevity of recipients of liver transplant may be compromised by spinal osteoporosis and vertebral fractures. However, femoral neck fractures are associated with a higher morbidity and mortality than spine fractures. As there is little information on bone loss at this clinically important site of fracture, the aim of this study was to determine whether accelerated bone loss occurs at the proximal femur following transplantation. Bone mineral density and body composition were measured at the femoral neck, lumbar spine and total body, using dual x-ray absorptiometry in 22 men and 19 women, age 46 +/- 1.4 y (mean +/- SEM) before and at a mean of 19 mo after surgery (range 3-44). Results were expressed in absolute terms (g/cm2) and as a z score. Before transplantation, z scores for bone mineral density were reduced at the femoral neck (-0.47 +/- 0.21 SD), trochanter (-0.56 +/- 0.19 SD), Ward's triangle (-0.35 +/- 0.14 SD), lumbar spine (-0.76 +/- 0.13 SD), and total body (-0.78 +/- 0.15 SD) (all P < 0.01 to < 0.001). Following transplantation, bone mineral density decreased by 8.0 +/- 1.7% at the femoral neck (P < or = 0.01) and by 2.0 +/- 1.2% at the lumbar spine (P < or = 0.05). Total weight increased by 12.2 +/- 2.3%, lean mass decreased by 5.7 +/- 1.4%, while fat mass increased from 24.1 +/- 2.0% to 35.1 +/- 1.8% (all P < or = 0.001). Patients with end-stage liver disease have reduced bone mineral density. Liver transplantation is associated with a rapid decrease in bone mineral density at the proximal femur, further increasing fracture risk and a reduction in lean (muscle) mass, which may also predispose to falls. Prophylactic therapy to prevent further bone loss should be considered in patients after liver transplantation.     

The Utility of Body Composition Assessment in Nutrition and Clinical Practice: An Overview of Current Methodology

Body composition is a key component for maintaining good general health and longevity. It can be influenced by a variety of factors, including genetics, environment, and lifestyle choices. The assessment of body composition is an essential tool for nutrition specialists to effectively evaluate nutritional status and monitor progression during dietary interventions. As humans age, there is a natural increase in fat mass coupled with a gradual decline in lean mass, specifically in bone and muscle mass. Individuals with a high body fat percentage are at a greater risk of cardiovascular diseases, type 2 diabetes, several types of cancer, and early mortality. Significant decreases in bone mineral density signify osteopenia and osteoporosis, while reductions in skeletal muscle mass increase the risk of developing sarcopenia. Moreover, undernutrition exacerbates the effects of many medical conditions and is important to address. Though weight tracking and calculation of BMI are used commonly by clinicians and dietitians, these measures do not provide insight on the relative contributions of fat mass and fat-free mass or the changes in these compartments that may reflect disease risk. Therefore, it is important that healthcare professionals have a critical understanding of body composition assessment and the strengths and limitations of the methods available.     

Fat mass measured by DXA varies with scan velocity

OBJECTIVE: To study the influence of scan velocities of DXA on the measured size of fat mass, lean body mass, bone mineral content and density, and total body weight. RESEARCH METHODS AND PROCEDURES: The subjects were 71 healthy white adults, 38 women and 33 men. The mean age was 41.7 +/- 13.5 years and body mass index was 28.6 +/- 5.6 kg/m(2). The subjects were scanned consecutively in slow, medium, and fast scan mode by a Lunar DPX-IQ DXA scanner. RESULTS: Throughout the body mass index and sagittal height ranges, scanned lean body mass significantly decreased with higher scan velocity and lean body mass was 2.7% lower in fast than in medium mode (p < 0.0001). In contrast, fat mass, percentage of body fat, and bone mineral contents were higher with increasing scan velocity. Areas not analyzed by the scanner, so called blue spots, increased with scan velocity and sagittal height, and their presence significantly enhanced the error. Body weight estimated by DXA in slow mode was -0.8% lower than scale weight in the women (p < 0.001) and -0.2% in men (not significant), and the difference was greater with increasing scan velocity. DISCUSSION: Scan velocity significantly influences the measured fat mass size, lean body mass, bone mineral content, and body weight. To obtain the most accurate results, slow mode is preferable and fast scans should be avoided. Future studies should report and take scan velocity into consideration.     

中老年妇女骨密度与体成份、下肢肌力及抗骨折能力的相关性分析

目的:探讨骨密度与体成分、下肢肌力、抗骨折能力、之间的相互关系。方法:选定40~89岁进行健康查体的妇女626名,测定身高、体重、计算体重指数,采用骨密度仪测量股骨颈骨密度,神经关节功能测试仪测定下肢肌力、抗骨折能力、全身的脂肪含量,进行各观察指标间的相关性分析。结果:股骨颈骨密度与身高、体重、体重指数和全身脂肪含量、下肢肌力均成显著正相关;与股骨颈抗骨折能力呈正相关;股骨颈抗骨折能力与骨密度、下肢肌力成正相关,与体重及体重指数、全身脂肪含量呈负相关。结论:重体重、脂肪含量高的人有较高的骨密度,但其抗骨折能力并不一定强。中年以后体重增加而下肢肌力及骨密度下降是造成机体抗骨折能力下降的重要因素。抗骨折能力做为诊断骨质疏松的一个新的指标在临床诊断及治疗中不可忽视。     

Effect of timing of meal intake after squat exercise training on bone formation in the rat hindlimb

We hypothesized that bone acquisition was affected by the timing of meal intake after resistance exercise training. This was based on the following previous results: 1) Nutrient intake right after exercise resulted in an increase in muscle mass and a decrease in abdominal fat mass as well as muscle protein synthesis when compared to the intake of a meal later after the exercise; and 2) body composition has been proposed to be a good predictor of bone mass. To substantiate our hypothesis, 20 male rats were assigned to either a group fed a meal right after squat exercise (R) or a group fed a meal 4 h after the exercise (L). The 10-wk training program consisted of approximately 70% of one repetition maximum for each animal, 15 repetitions per set, 10 sets per day, 3 d per week. As a result, hindlimb muscle mass in the R group was greater (p < 0.05) than that in the L group and abdominal fat mass was less (p < 0.01) in the R group as compared to the L group, regardless of there being no significant difference in body weight between the groups. Bone volume in the tibia (p < 0.01) and femur (p < 0.05) were both significantly greater in the R group than in the L group. Bone mineral content index (BMCI) and bone mineral density index (BMDI) in the tibia of the R group were significantly (p < 0.05) greater than the corresponding values of the L group. The greater BMCI and BMDI in the tibia were positively and significantly (p < 0.05) related with hindlimb muscle mass, but not with abdominal fat mass. There was no significant difference in BMCI and BMDI in the femur between the groups. These results suggest that the R regimen may contribute to increased bone acquisition in the tibia as compared to the L regimen, and this effect is partly due to the enlargement of muscle mass in the R group as compared to the L group.     

Body composition changes in cachectic patients receiving home parenteral nutrition

BACKGROUND: The purpose of this study was to evaluate the initial body compositional changes experienced by malnourished patients requiring home parenteral nutrition (HPN) for repletion. METHODS: Eight patients were prospectively studied for 3 months. Body composition was determined by dual-energy X-ray absorptiometry (DXA), and a comprehensive nutrition assessment was performed including body weight, visceral proteins, triceps skinfold (TSF), midupper arm circumference (MUAC), midupper arm muscle circumference (MUAMC), body mass index (BMI), delayed hypersensitivity skin tests (DHST), and diet history. RESULTS: Body composition measured by DXA showed an increase in (mean +/- SD) total fat from 5770 +/- 2805 to 10581 +/- 1980 g (p < .001) and bone mineral content from 2155 +/- 429 to 2190 +/- 443 g (p = .047). Lean soft tissue remained unchanged. Body weight and BMI increased from 47.7 +/- 6.6 to 53.6 +/- 8.2 kg (p = .006) and from 16.6 +/- 1.5 to 18.6 +/- 1.5 kg/m2 (p = .005), respectively. TSF increased from 6.3 +/- 3.1 to 10.4 +/- 4.0 mm (p < .001), and MUAMC remained stable. There was a significant improvement in transferrin from 191 +/- 82 to 326 +/- 128 mg/dL (p = .043), and a trend toward improvement in albumin and DHST. Body weight was highly correlated with DXA weight at baseline (r = .997; 95% confidence interval [CI], 0.98 to 1.00; p < .001) and at 3 months (r = .988; 95% CI, 0.93 to 1.00; p <.001). TSF correlated with total fat as measured by DXA at baseline (r = .839; 95% CI, 0.33 to 0.97; p = .009) but not at 3 months (r = .693; 95% CI, -0.02 to 0.94; p = .057). MUAMC correlated with lean soft tissue measured by DXA both at baseline (r = .739; 95% CI 0.07 to 0.95; p = .036) and at 3 months (r = .870; 95% CI, 0.43 to 0.98; p = .005). Physical activity, on a subjective scale of 1 (low activity) to 3 (high activity), improved over the 3-month period from 1.3 +/- 0.5 to 2.2 +/- 0.8 (p = .031). CONCLUSIONS: Initial weight gain experienced by malnourished HPN patients is primarily fat. Bone mineral content increases, but lean soft tissue does not change. Overall nutritional status is improved as exhibited by significant improvements in body weight and serum transferrin and a trend toward improvement in albumin and delayed hypersensitivity skin tests.     

Body composition, age and femoral bone mass of young adult women.

Maximum bone mineral density of the femur was measured by dual-photon densitometry in 282 healthy white women, aged 20 to 40 years. Femoral sites included the neck, Wards triangle, and the trochanter. Quetelet Index was used as a measure of weight adjusted for height, and body composition was measured using four-point bioelectrical impedance and anthropometry. Maximum bone mass is believed to be an important measure if the level established which remain characteristic or predict bone mineral density during the aging process. Body weight was correlated with each measure of femoral bone density, including the femoral neck (r = .42), Wards triangle (r = .34), and the trochanter (r = .44). Weight was more highly correlated with bone mass than with other measures of body composition, including fat-free mass, percent body fat, humeral muscle area, and humeral fat area. We observed that age was negatively associated with bone mass at all three femoral sites, even in subjects within the age range of 20 to 40 years, and the relationship was significant after controlling for Quetelet Index. There was no evidence of a nonlinear relationship that would indicate when maximal femoral bone mass reaches its peak within this age range.     

Impact of weight-cycling history on bone density in obese women

OBJECTIVE: The purpose of this study was to examine the effect of weight cycling (as defined by the frequency and magnitude of intentional weight loss) on bone mineral density and bone mineral content in obese sedentary women. RESEARCH METHODS AND PROCEDURES: Bone mineral content and density measured by DXA, submaximal physical fitness assessment, nutrient intake, oral contraceptive use, and weight-cycling history were assessed in 195 healthy, overweight sedentary women (age, 21 to 45 years; body mass index, 27 to 40 kg/m(2)) before beginning a behavioral weight-loss intervention. RESULTS: After controlling for body weight, multivitamin use, oral contraceptive/estrogen use, and calcium and magnesium intake, women who had a history of weight cycling did not have significantly lower total-body bone mineral content or density or total femur bone mineral density. In addition, 99% of subjects were above or within one SD of age and gender normative data for total femur bone mineral density. DISCUSSION: It does not seem that a history of weight cycling has an adverse affect on total femur and total-body bone mineral density in overweight sedentary premenopausal women.     

Skeletal and body-composition effects of anorexia nervosa

Eleven female patients (aged 18-46 y) with anorexia nervosa were measured by use of dual-photon absorptiometry for 1) bone mineral content (BMC, in g) and bone mineral density (BMD, in g/cm2) of the total skeleton and its regions, 2) BMD of the lumbar spine and the proximal femur, and 3) total body soft-tissue composition. The patients weighed 44.4 kg, approximately 15 kg less than normal peers (n = 22). The fat mass (3.35 kg) and content of soft tissue (7.8%) were four and three times lower (p less than 0.001) respectively, than those in normal women (15.1 kg and 26%, respectively). The total skeleton mineral (1921 g) was approximately 25% less than that of young normal women. The BMC as a fraction of the lean tissue mass was approximately 4.9% in the patients and 5.9% in normal women. Total body and femoral BMD averaged only 10% and 13% lower than those of normal women, respectively; however, spinal BMD was particularly reduced (approximately 25%, p less than 0.001).     

Effects of body mass index on bone mineral density in men

INTRODUCTION: A strong positive association between body mass index and bone mineral density is well defined in postmenopausal osteoporosis, but not in men. AIMS: The primary goal of the current research was to investigate this association in case of men. METHODS: According to WHO criteria (T-score below -1.0 at all measure site) seventy-two (mean age 55.7 +/- 0.99, range 38-78 yr normal density) healthy male with normal density were recruited. Exclusion criteria were the absence of any risk factors or signs of metabolic disease. Bone mineral measurements at the lumbar spine (L2-4) and femoral neck were performed by the dual-energy X-ray absorptiometry (DEXA, Lunar DPX-L, USA), bone mineral content of the non-dominant radius was measured with single photon absorptiometry (SPA, NK-364, Hungary). Participants were divided into three groups according to body mass index normal weight (18.5-24.9 kg/m2), moderate overweight (25-29.9 kg/m2) and obese subjects (> 30 kg/m2). RESULTS: Femur neck density was significantly lower in the normal weight than in the overweight counterparts (0.969 +/- 0.03 vs 1.062 +/- 0.02 p = 0.01). There was a strong positive association between BMI and femur neck BMD (r = 0.412 p < 0.001). Body mass was an independent predictor of femur neck bone mineral density (regression coefficients 0.382, p = 0.001). There was not correlation at the lumbar spine and the radius sites. CONCLUSION: Bone density at femur neck sites is lower in the normal weight men than in obese subjects, therefore the risk factors for proximal femur osteoporosis are higher in these cases. Prevention strategy is needed for men in the lowest quintile of body mass to prevent further decrease in BMD and reduce the risk of hip fracture.     

Calcium Intake, Vitamin D and Bone Health Status of Post-menopausal Chinese Women in Kuala Lumpur

Bone health status was investigated in 178 free-living Chinese post-menopausal women in Kuala Lumpur. Body mass index (BMI), body composition (using whole body DXA), calcium intake and serum 25-OH vitamin D status were measured along with biochemical markers of bone turnover, that is, pro-collagen Type 1 N-terminal peptide (P1NP), osteocalcin (OC) and C-telopeptide β cross link of Type 1 collagen (CTX- β). Bone mineral density (BMD) was measured using DXA (Hologic, USA) at the lumbar spine, femoral neck and total hip. Results showed that osteopenia was present in 50% of the subjects at the spine and 57.9% at the femoral neck. Osteoporosis was diagnosed in 10% of the subjects at both the femoral neck and spine. A total of 29.3% of the subjects had high levels of CTX- β. Mean serum level of 25-OH vitamin D was 60.4+15.6 nmol/L and 50.6% of the subjects had hypovitaminosis D (defined as < 50 nmol/l). Mean total calcium intake of the subjects was 497 + 233 mg, of which only 14% met the RNI for calcium with the additional intake of calcium supplements. Body fat was also significantly correlated (r=0.181, p< 0.05) with BMD at the spine but not BMD at the femoral neck. Lean body mass was positively correlated with BMD at the spine (r=0.289, p< 0.001) and femoral neck (r=0.295, p< 0.001). CTX-β was negatively correlated with BMD at the spine (r= -0.235, p< 0.001), whereas P1NP (r=-0.215, p< 0.001) and osteocalcin (r=-0.265, p< 0.001) were both negatively correlated with BMD at the femoral neck. Generally, the study found that women with osteopenia had higher levels of bone turnover markers, less lean body mass and lower calcium intake than women with normal BMD. In conclusion, this study demonstrated that the majority of free living Chinese post-menopausal women in Kuala Lumpur have low calcium intake, low 25-OH vitamin D status and low bone mass and elevated biochemical markers of bone turnover.     

The effect of bulimia upon diet, body fat, bone density, and blood components

A study was conducted to determine baseline data for dietary intake, percent body fat, bone mineral density, and blood components in women with bulimia. Eight bulimic and 10 control subjects completed the study. Each subject was assessed for a 3-day diet, frequency of purge, menstrual history, percent body fat, bone mineral density, by dual photon absorptiometry, and blood components. Mean age, height, and weight of subjects were similar. Percent body fat was similar for both groups. Vomiting was the predominant method of purge. Folacin intake was found to be significantly (p less than .05) lower in bulimic subjects. Control subjects consumed greater quantities of vitamin/mineral supplements than the bulimic subjects. Bone mineral density (gm/cm2) was found to be lower in bulimic subjects. Mean hemoglobin (gm/L [gm/dL]) levels were found to be significantly (p less than .01) higher in control subject. The data indicate that the method and duration of purge behavior could influence bone mineral density and blood components.     

Fan beam dual energy X-ray absorptiometry body composition measurements in piglets

OBJECTIVES: A piglet model was used to validate and cross validate the fan-beam (FB) dual energy X-ray absorptiometry (DXA) software vKH6 and to determine the predictive values of physiologic parameters (weight, length, age and gender) on body composition. METHODS: Nineteen piglets (Group A: 600 to 21100 g) were used to validate the FB-DXA measurements of body composition based on chemical analysis of the carcass. An additional 22 piglets (Group B: 640 g to 17660 g) had FB-DXA measurements, and these values were compared to the predicted values generated from regression equations computed from group A piglets. Body composition for bone mass, lean mass and fat mass was based on ash weight, nitrogen and fat measured from three aliquots of homogenate from each carcass. Data from all piglets (n = 41) were used to determine the variations in body composition. Data analysis used regression, t test and analysis of variance. RESULTS: Duplicate DXA (total weight TW, bone mineral content BMC, bone area BA, bone mineral density BMD, lean mass LM and fat mass FM) measurements were highly correlated (r = 0.98 to 1.00, p < 0.001 for all comparisons) and were not significantly different. No significant differences were found in the residuals from predicted versus measured DXA values between the larger and the smaller (<1.6 kg) piglets from Group A. For Group B piglets, the DXA measured TW of 5666 +/- 5692 g (mean +/- SD), LM (5063 +/- 5048 g), FM (465 +/- 510 g), BMC (138 +/- 139 g), BA (486 +/- 365 cm(2)) and BMD (0.235 +/- 0.071 g/cm(2)) were highly significantly correlated with (r = 0.94 to 1.00, p < 0.001 for all comparisons) and were not significantly different from the predicted values. Data from all piglets (n = 41) showed that weight is the dominant predictor of whole body and regional body composition. Length, age or gender contributed to <2% of the variability of body composition. CONCLUSION: Body composition measurements using the FB DXA software vKH6 is highly reproducible. The software vKH6 is validated for use in a wide range of body weights and body composition, and cross-validated using a separate group of animals. Body weight is the dominant predictor of body composition in immature piglets.     

Sub-regional tissue morphometry in male athletes and controls using dual X-Ray absorptiometry (DXA)

Athletes have traditionally been evaluated for body composition by percent fat, percent muscle, and somatotype. Since the late 1980s, dual X-ray absorptiometry (DXA) has offered total and regional body composition of bone mineral content (BMC), lean tissue and fat, but studies involving athletes are rare (11) and have not included regional tissue distribution. In the present study, DXA was used to compare a total of 121 male subjects belonging to 9 different athletic groups and controls. ANOVA showed total tissue percent BMC, lean tissue, and fat were significantly different between the various athletic groups (p <.001). Regional differences in tissue distribution between different athletic groups affect BMC and lean tissue (p <.001), but not fat (p >.05). However, athletes of the leanest groups had different fat distribution to that of nonexercising controls (p <.01). It appears that fat distribution is nonspecific in its response to exercise, while lean and BMC distributions show highly specific adaptations to specific sports.     

生活习惯对围绝经期妇女人体组成成分的影响

目的:探讨不同生活习惯对围绝经期妇女人体组成成分的影响,为制定群体保健措施提供依据。方法:选取45～55岁围绝经期妇女132例作为研究对象,采用生物电阻抗法测定人体组成学指标,并随机问卷调查,对其生活习惯予以分型,其资料进行方差分析。结果:运动规律型、饮食饮水重视型以及性生活和谐型分别与相应的其他两型比较、饮食饮水一般型与非重视型比较,体质量、脂肪(%)、肥胖度、体质指数、腰臀比明显降低(P<0.01,P<0.05),肌肉(%)、骨总量(%)、水分总量(%)显著提高(均P<0.01);运动一般型与非运动型比较,骨总量(%)增高(P<0.05)。结论:中强度规律运动、重视饮食饮水调节及夫妻性生活和谐能减轻体质量、减少体脂及腹部脂肪堆积,增强肌肉、骨量、提高水分;低强度一般运动仅能提高骨量,对减肥无效果。     

Effect of alcohol intake on bone mineral density in elderly women: The EPIDOS Study. Epidémiologie de l'Ostéoporose

To study potential associations between alcohol consumption and bone mineral density in women aged 75 years or older, the authors analyzed 7,598 ambulatory women (mean age, 79.9 years; standard deviation, 3.8 years) recruited at five centers in France between 1992 and 1994. The current alcohol intake was assessed using a self-questionnaire. Bone mineral density was measured by dual-photon X-ray absorptiometry of the proximal femur and total body and adjusted for age, weight, and height (Z score). Compared with nonusers, women who drank 11-29 g of alcohol per day (g/day) had higher bone mineral density values at the trochanteric site (p = 0.0017). Neither 1-10 g/day nor >30 g/day users had increased bone mineral density levels. These results were unrelated to estrogen replacement therapy use, dietary calcium intake, current smoking status, usual physical activity, educational attainment, household monthly income, and general health status. Alcohol intake was not associated with bone mineral density at the femoral neck. Total body bone mineral density was lower in subjects with alcohol intakes >30 g/day (p = 0.047). Our data suggest that moderate drinking (e.g., 1-3 glasses of wine per day) is associated with an increase in trochanteric bone mineral density in elderly ambulatory women. However, higher intakes may have detrimental effects on bone mass.     

绝经后女性血清脂联素与骨转换生化指标的关系

目的探讨绝经后女性血清脂联素(Adiponectin)与骨转换生化指标的关系。方法用酶联免疫吸附试验测定287名40～80岁健康绝经后女性血清脂联素以及血清骨特异性碱性磷酸酶(Bone alkaline phosphatase,BAP)和Ⅰ型胶原交联氨基末端肽(cross-linked N-telopeptide of type I collagen,NTx);用双能X线骨密度扫描仪(dual energy X-ray absorptiometry,DEXA)测定总体、腰椎正位、总髋部骨、左前臂骨密度(bone mineral density,BMD)以及体脂、瘦体质量;分析它们之间的关系。结果BAP与总体骨密度、腰椎BMD、髋部总体BMD、前臂BMD均呈负相关(r=-0.210、-0.236、-0.223、-0.226,P0.05),校正年龄和体质指数后,相关性都依然存在(r=-0.168、-0.187、-0.169、-0.175,P0.05)。NTx与总体BMD、腰椎BMD、髋部总体BMD、前臂BMD均呈负相关(r=-0.238、-0.232、-0.239、-0.221,P0.05),校正年龄和体质指数后,相关性都依然存在(r=-0.201、-0.189、-0.193、-0.185,P0.05)。脂联素与BAP、NTx均呈正相关(r=0.202、0.215,P0.05),校正年龄和体脂后,相关性都依然存在(r=0.169、0.183,P0.05)。脂联素与BAP以二次方程模型拟合程度最好,其最大决定系数(R2)为0.055;脂联素与NTx以二次方程模型拟合程度最好,其最大决定系数(R2)为0.089。绝经后骨质疏松(postmenopausal osteoporosis,PMO)女性血清脂联素水平较年龄相匹配的正常对照组增高(P0.05)。结论血清脂联素水平与骨转换生化指标呈正相关,提示脂联素可能为新型骨转换预测因子。