寻常型银屑病患者血清及皮肤组织中PLA2活性研究

应用快速简便微量滴定法测定寻常型银屑病患者和正常人血清中及皮肤组织中磷脂酶A2 (PLA2 )活性 ,结果发现 ,寻常型银屑病患者血清及皮肤组织中PLA2 活性均高于正常对照组 ,进行期和皮损面积 >30 %组的患者血清中PLA2 活性明显高于静止期和皮损面积 <30 %的患者 ,但患者血中PLA2 水平与病程无关。提示血清中PLA2 活性可能与银屑病的病情活动性有关 ,PLA2 在银屑病的发病机制中起着一定的作用。     

寻常型银屑病患者血清及皮肤组织中PLA2活性研究

应用快速简便微量滴定法测定寻常型银屑病患者和正常人血清中及皮肤组织中磷脂酶A2(PLA2)活性,结果发现,寻常型银屑病患者血清及皮肤组织中PLA2活性均高于正常对照组,进行期和皮损面积＞30%组的患者血清中PLA2活性明显高于静止期和皮损面积＜30%的患者,但患者血中PLA2水平与病程无关.提示血清中PLA2活性可能与银屑病的病情活动性有关,PLA2在银屑病的发病机制中起着一定的作用.     

寻常型银屑病患者血浆及皮肤组织中内皮素的含量

采用放射免疫分析法检测４６例寻常型银屑病患者血浆内皮素水平和其中２５例患者的皮损与非皮损组织内皮素的含量，结果显示：（１）寻常型银屑病患者血浆内皮素水平显著高于正常人（Ｐ〈０．０１），进行期患者显著高于静止期患者（Ｐ〈０．０１），皮损大于３０％患者高于皮损小于３０％患者（Ｐ〈０．０１）。（２）寻常型银屑病患者皮损组织内皮素含量较非皮损组织显著增高（Ｐ〈０．０１），提示内皮素和寻常型银屑病发病有一定     

儿童玫瑰糠疹和寻常型银屑病皮肤镜特征分析

目的 探讨儿童玫瑰糠疹、寻常型银屑病的皮肤镜下特征,为二者临床诊断提供依据。方法 回顾性分析2021年1月至2023年8月安徽省儿童医院皮肤科收治的玫瑰糠疹和寻常型银屑病患儿各32例的皮肤镜图像。观察皮肤镜下皮损的背景颜色,鳞屑颜色和分布,血管形态和排列模式情况,统计分析组间差异。结果 皮肤镜下玫瑰糠疹组背景颜色呈淡黄色24例（75.0%）,鳞屑分布呈外周型26例（81.2%）,血管形态为点状血管28例（87.5%）,血管排列模式呈局灶性31例（96.9%）;寻常型银屑病组背景颜色呈亮红色25例（78.1%）,鳞屑分布呈弥漫性23例（71.9%）,血管形态呈（点状+肾小球状+环状+发夹状）血管混合31例（96.9%）,血管排列模式呈弥漫均一性30例（93.8%）,两组差异均有统计学意义（P<0.05）。结论 儿童玫瑰糠疹与寻常型银屑病在皮肤镜下具有不同特征,可用于临床辅助诊断。     

2型糖尿病患者血浆TXA2和PGI2失衡及PLA2活性变化

目的：探讨2型糖尿病（DM）患者血栓素A2（TXA2）和前列环素（PGI2）失衡及PLA2活性变化。方法：以放免法测定血栓素B2和6－酮－前列腺素含量,以改良Zieve法测定血浆PLA2活性,同时观察空腹血糖（FBG）、空腹胰岛素（FINS）、甘油三酯（TG）等的变化。结果：①2型DM患者存在TXA2和PGI2合成异常,且Ⅱ组（有微血管病变组）较I组（无微血管病变组）更为严重;②2型DM患者组血浆PLA2显著低于正常对照组,但I组与Ⅱ组之间无显著差异;③2型DM患者组TXB2与FBG、TG显著正相关,6－K－PGF1a与FINS显著负相关,TXB2与6－K－PGF1a均与血浆PLA2无显著相关性。结论：①TXA2和PGI2失衡在2型糖尿病及微血管病变的发生发展中起重要作用;②血浆分泌型PLA2活性变化与2型糖尿病密切相关,但在糖尿病患者TXA2和PGI2失衡及微血管病变中可能不起直接作用;③糖脂代谢紊乱以及高胰岛素血症在TXA2和PGI2失衡及DM微血管病变中起重要作用。     

寻常型银屑病患者血清S100A12水平的测定及临床意义

目的了解寻常型银屑病患者血清中S100A12水平及其临床意义。方法 ELISA法检测50例寻常型银屑病患者和50例健康对照组血清S100A12水平,并计算患者银屑病面积和严重程度指数(psoriasis area and severity index,PASI)。使用Pearson分析法分析S100A12水平与PASI相关性。结果寻常型银屑病组血清S100A12水平为(154.4±114.9)ng/mL;对照组血清S100A12水平为(72.6±62.8)ng/mL。寻常型银屑病组S100A12水平高于对照组,差异有统计学意义(P0.05)。Pearson分析结果显示寻常型银屑病组S100A12水平与PASI评分之间呈正相关性(r=0.436,P0.05)。结论银屑病患者血清S100A12水平明显高于健康人,与疾病严重程度相关,可作为判断银屑病严重程度的指标。     

寻常型银屑病伴糖尿病2例

1 病例介绍 例1,女性,66岁。全身皮肤反复出现鳞屑性红斑30年,以冬春季为重,夏秋季减轻,曾用中、西药治疗,病情反复。近6个月来皮肤瘙痒加重,皮疹增多,并出现烦渴、多尿、多食、消瘦,于1994年2月19日入院。体检:心肺肝脾无异常发现。皮肤科检查,皮肤弹性尚可,头部、胸背部、四肢可见多形暗红色鳞屑性斑块,大部分融合成片,Auspitz征阳性。实验室检查:血常规正常,空腹血糖(FBS)为10.89mmol/L,餐后2h血糖(PBS)18.66mmol/L,尿糖(?),糖化血红蛋白(GHb)41。opmol HMF/g·Hb(正常值16.9～21.4,化学法),胰岛素释放试验为:0′:13.84,30′:14.88,60′:22.55,120′:35.48,180′:26.79mIU/L,诊断为寻常型银屑病并非胰岛素依较型糖尿病。给予雷公藤6片/d,美吡达15mg/d,均分3次口服及外用乐肤液、尿素软膏苛,皮损于入院20d后消退,尿糖转阴,住院3Zd,出院时FBS 6.39mmol/L,PBSl0.17mmol/L,门诊继续治疗。     

寻常型银屑病三大基本中医证型皮损的皮肤镜特征观察

目的 观察寻常型银屑病中医各证型皮损的皮肤镜表现特征,为更客观准确的判断银屑病中医证型提供依据.方法 收集2019年1月—2019年12月期间于北京中医医院皮肤科确诊的且经中医辨证分别属血热证、血燥证及血瘀证的寻常型银屑病患者50例.使用皮肤镜观察记录各中医证型皮损的背景颜色、鳞屑特征、血管特征,并进行统计分析.结果 ...     

寻常型银屑病并发白癜风2例

银屑病、白癜风均为临床常见病，但二病发生在同一患者身上则较少见，现将门诊见到的2例报告如下。     

寻常型银屑病患者生活质量调查

目的：对寻常型银屑病患者的生活质量进行调查研究。方法：对266例寻常型银屑病患者进行皮肤病生活质量指数（dermatology life quality index,DLQI）问卷调查;同时对患者病情进行评分,根据银屑病皮损面积及严重程度指数（psoriasis area and severity index,PASI）分值情况判断病情严重程度,并针对不同严重程度患者的生活质量进行比较。结果：寻常型银屑病患者DLQI分值从大到小排序为：治疗（2.00±0.87）,心理（1.76±0.93）,穿衣（1.59±0.90）,生理（1.52±0.81）,社交娱乐（1.59±0.90）,家庭（1.43±0.76）,饮食（1.31±0.87）,工作学习（1.30±0.75）,日常活动（1.29±0.79）,性生活（0.93±0.91）,运动（0.91±0.89）。且不同严重程度患者的DLQI分值相比较差异有统计学意义（P〈0.05）。结论：寻常型银屑病患者在治疗和心理方面受影响较大,并且病情越严重可能会对患者的生活质量影响越大。     

趋化因子CCL27在寻常型银屑病患者血清的表达以及与PASI的相关性

目的 观察寻常型银屑病患者血清CCL27表达水平与PASI的相关性.方法 采用ELISA方法,比较试验组(寻常型银屑病患者)与对照组(健康人)血清中CCL27表达水平;并比较试验组血清CCL27水平与PASI评分的相关性.结果 寻常型银屑病组血清CCL27表达水平明显高于健康组,P＜0.01,CCL27在寻常型银屑病组血清的表达水平与PASI呈明显正相关(r=1.000,P＜0.01).结论 患者血清CCL27水平与寻常型银屑病病情发生发展密切相关.     

阿维A对寻常性银屑病患者血清IL-18的影响

目的研究IL-18在寻常性银屑病发病中的作用及阿维A对其的诃节作用,进一步探讨阿维A治疗银屑病的机制。方法应用双抗体夹心酶联免疫吸附法（ELISA）检测30例寻常性银屑病患者经阿维A治疗前后外周血IL-18的水平变化。结果寻常性银屑病患者经阿维A治疗前的血清中IL—18的水平显著高于治疗后及正常人对照组;治疗后血清中IL—18水平较治疗前显著下降（P〈0．05）。结论IL—18在寻常性银屑病致病中起重要作用;阿维A治疗银屑病的机制可能是通过抑制IL-18的分泌而达到治疗作用。     

益赛普对寻常型银屑病血小板活性的影响

目的 评价益赛普治疗寻常型斑块状银屑病的疗效,分析益赛普治疗前后患者血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）的变化,探讨MPV和银屑病面积与严重性指数（PASI）评分的相关性。方法 寻常性银屑病患者采用益赛普治疗24周,治疗前、中、后均予血常规检查和评估PASI,比较其变化。采用Pearson法分析MPV与PASI的相关性。结果 经益赛普治疗后,治疗前后的PLT、MPV、PDW比较,差异有统计学意义（P?<0.05）。MPV与PASI呈正相关（r?=0.147,P?=0.030）。结论 益赛普治疗寻常型银屑病有效,MPV可作为临床上评估银屑病皮损严重程度及治疗效果的参考指标。     

阿维A对寻常型银屑病患者血清TNF—α及IL-8的影响

目的确定肿瘤坏死-α（TNF-α）及白介素-8（IL-8）在寻常型银屑病发病中的作用及阿维A对其的调节作用。方法应用双抗体夹心酶联免疫吸附法（ELISA）检测30例寻常型银屑病患者经阿维A治疗前后外周血清中TNF-α及IL-8的水平。结果寻常型银屑病患者血清中TNF-α、IL-8的水平较正常人对照组显著增高（P〈0．01）。治疗后血清中TNF-α、IL-8较治疗前显著下降（P〈0．01）。结论阿维A可通过调节血清中TNF-α、IL-8水平而起到治疗作用。     

Heart rate and arrhythmia in patients with psoriasis vulgaris

BACKGROUND: Psoriasis is a chronic inflammatory disease involving 1-3% of the human population worldwide. Many systemic diseases including cardiovascular disturbances have been described in psoriatic patients. However, there is a scarcity of data on heart rate, heart rate variability, arrhythmia and conduction abnormalities in this group of patients. METHODS: The study comprised 32 patients with chronic psoriasis vulgaris and negative personal history of heart problems. Severity of the disease was evaluated by Psoriasis Area and Severity Index (PASI). Twenty-four-h continuous electrocardiographic monitoring (24-h Holter ECG) was performed in all patients. RESULTS: Heart rate was significantly higher both during the day and at night in patients with psoriasis vulgaris than in the control group (p < 0.0001). There was a positive correlation between the increased heat rate, both during the day and at night, in psoriatic patients and severity of the disease expressed as PASI. Single supraventricular beats were significantly more frequently observed in psoriatic patients vs. the control group (p < 0.0001). CONCLUSIONS: An active inflammatory process observed in psoriasis seems to exert its influence on increased heart rate and supraventricular beats development. However, to confirm the above findings, further studies on larger groups of psoriatic patients, presenting different types of the disease are mandatory.     

Electrocardiographic P-wave characteristics in patients with psoriasis vulgaris

Abstract

Introduction. Seasonal variations in hemoglobin-A1c have been reported in diabetic patients, but the underlying mechanisms have not been elucidated.

Aims. To study if insulin sensitivity, insulin secretion, and fasting plasma glucose showed seasonal variations in a Swedish population-based cohort of elderly men.

Methods. Altogether 1117 men were investigated with a euglycemic insulin clamp and measurements of fasting plasma glucose and insulin secretion after an oral glucose tolerance test. Values were analyzed in linear regression models with an indicator variable for winter/summer season and outdoor temperature as predictors.

Results. During winter, insulin sensitivity (M/I, unit = 100 × mg × min^-1 × kg^-1/(mU × L^-1)) was 11.0% lower (4.84 versus 5.44, P = 0.0003), incremental area under the insulin curve was 16.4% higher (1167 versus 1003 mU/L, P = 0.007). Fasting plasma glucose was, however, not statistically significantly different (5.80 versus 5.71 mmol/L, P = 0.28) compared to the summer season. There was an association between outdoor temperature and M/I (0.57 units increase (95% CI 0.29–0.82, P < 0.0001) per 10°C increase of outdoor temperature) independent of winter/summer season. Adjustment for life-style factors, type 2 diabetes, and medication did not alter these results.

Conclusions. Insulin sensitivity showed seasonal variations with lower values during the winter and higher during the summer season. Inverse compensatory variations of insulin secretion resulted in only minor variations of fasting plasma glucose. Insulin sensitivity was associated with outdoor temperature. These phenomena should be further investigated in diabetic patients.