碘仿根管充填剂治疗磨牙折裂100颗

目的探讨碘仿根管充填剂治疗磨牙折裂的疗效。方法临床选择磨牙折裂患牙100颗,先按全冠要求备牙,环绕牙冠轴面制备槽沟,采用碘仿根管充填剂封闭牙折裂间隙,再用结扎丝捆扎的方法,最后全冠修复。结果100颗折裂磨牙经治疗后76颗患牙得以保留,全冠修复后功能良好,有效率76％。结论碘仿根管充填剂封闭裂隙可以作为牙折裂保留患牙的一种治疗方法。     

牙隐裂及牙折裂患者的临床诊治体会

目的 探讨牙隐裂及牙折裂的临床诊断和综合治疗方法.方法 按临床症状把175颗隐裂牙分为单纯性牙隐裂、隐裂合并牙髓炎或根尖周炎、牙折裂三种类型,分别采用调颌、直接充填、冠修复、根管治疗后冠修复、行冠延长术和分根术后冠修复等方法 综合治疗.结果 在1-5年的随访观察中,2颗单纯性牙隐裂中采用调颌和直接充填法,3颗直接全冠修复,170颗有症状的牙隐裂经根管治疗后全冠修复保存率96%,其中2颗牙失败.结论 牙隐裂与牙折裂越早治疗,治愈率越高.尽可能有效地保存折裂牙,对于维持牙列完整具有重要的临床意义.     

可摘局部义齿修复后余留牙全冠修复45例的临床体会

目的探讨可摘局部义齿修复后患者口内余留患牙进行全冠修复的方法。方法将患牙按制作全冠要求进行牙体制备,用自凝塑料复制出患牙的完整牙体形态,以此塑料冠为熔模,为余留牙制作全冠。结果45例患者53颗患牙,经此方法修复后,均取得了满意的效果。结论采用此方法为余留患牙制作全冠,很好的解决了与原义齿的匹配问题,是一种可行的修复方法。     

隐裂牙150例治疗体会

目的 探讨隐裂牙的治疗体会.方法 2007年1月～2009年9月年收治隐裂牙患者150例,分别进行封闭裂隙、直接充填、根管治疗全冠修复、盖髓后永久充填治疗.结果 180颗患牙治疗后随访(15.56±2.8)个月,复查170颗患牙,有效150颗、失败20颗;牙釉质裂有效96.43%,高于其他两组(P<0.05), 94个牙根管治疗后全冠修复的患牙有效率为97.88%,也明显高于其他各组(P<0.05).结论 早发现、早诊断、早治疗对隐裂牙的保存有积极的意义,需作全冠修复可取得良好的疗效.     

80例隐裂牙伴发牙髓炎治疗的临床体会

目的 探讨一次性完成根管治疗术治疗隐裂致牙髓炎后及时全冠保护的临床疗效.方法 对80例89颗有牙髓炎症状的隐裂牙作一次性完成根管治疗术治疗,追踪随访2年,通过临床及X线检查评价其疗效.结果:80例89颗有77颗牙成功,占86.5%.结论 隐裂牙伴发牙髓炎患牙一次性完成根管治疗术治疗后及时全冠保护,成功率较高,大大降低了患牙折裂的可能.     

14例活髓牙纵折的临床分析

[目的]对活髓牙的纵折进行分析,探讨治疗方法和预防措施.[方法]收集临床14例纵折患牙,进行完善的根管治疗后,全冠修复,保存患牙.[结果]14例患牙经过及时完善的根管治疗和全冠修复,2年的随诊观察,均取得满意的疗效.[结论]活髓牙折裂只要早期固定,及时进行根管治疗,全冠修复,疗效良好.     

隐裂牙的临床诊断及治疗体会

目的:探讨隐裂牙的临床诊断及治疗方法。方法:根据隐裂牙的临床症状不同,对49颗患牙分别采用直接全冠修复和一次性根管治疗后全冠修复。结果:治疗后1~2年随访观察,直接全冠修复的患牙中7颗无明显症状,咬合功能良好,成功率63.6%;其余38颗患牙中36颗得以保存,成功率94.7%。结论:隐裂牙早期发现、治疗并及时全冠修复,对于保存隐裂牙有重要的临床意义。     

隐裂牙的全冠修复效果评析

目的 研究全冠修复隐裂牙的临床效果.方法 选择在口腔门诊首次就诊的无牙髓炎症状、有牙髓炎症状或根尖炎症状的隐裂牙85颗,先对隐裂牙进行铸造全冠或金属烤瓷全冠牙体预备,临时全冠修复后,进行完善根管治疗,再行铸造全冠或金属烤瓷冠进行永久性修复.结果 经过两年的临床追踪效果良好,85颗经全冠修复的患牙,临床检查无异常表现,X线片显示牙周及根尖周组织均正常.结论 全冠修复牙隐裂可防止牙体折裂,保存患牙、保持牙列的完整性,具有美观、舒适、咀嚼效能高等优点.     

牙隐裂全冠修复的疗效观察

目的 研究牙隐裂的早期诊断,全冠修复及预后效果.方法 已确诊96颗隐裂牙根据全冠修复后再行根管治疗,治疗后及时用铸造或金属烤瓷全冠对患牙进行永久性修复.结果 经过2年的追踪观察,96颗全冠修复牙中有7颗失败,其余经全冠修复的患牙临床检查无异常,X线片显示牙周及根尖组织均正常.临床效果良好,结论 隐裂早期诊断和择机进行全冠修复治疗是保存活牙髓、防止牙体折裂,保持牙列的完整性,维护牙体功能的有效方法.提高患者的咀嚼效率和生活质量.     

磨牙半牙切除术后修复疗效观察

目的：评价下颌磨牙半牙切除术后固定修复的疗效。方法：对20颗牙根严重受累的下颌磨牙行半牙切除术,术后12周对20颗患牙分别采用单端固定桥、双端固定桥或单冠修复,观察术后3个月、6个月、1年时的修复效果并进行评价。结果：20颗患牙3个月后复查,17颗满意,3颗基本满意,满意率85%;6个月后复查,15颗满意,3颗基本满意,2颗不满意,满意率75%;12个月后复查,13颗满意,4颗基本满意,3颗不满意,满意率65%。结论：下颌磨牙半牙切除术后固定修复是保留患牙的良好方法,建议采用双端固定桥、联冠单端固定桥修复,谨慎采用单冠修复,若作为活动义齿基牙,建议只作根面覆盖义齿修复。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.