Prevalence of coronary heart disease risk factors in an urban black population: the Minnesota Heart Survey, 1985

A cross-sectional study of a sample of Minnesota black urban residents was conducted in 1985 to develop cardiovascular risk profiles. Participants were evaluated during a home interview (N = 1,254, 78% participation) and a survey center visit (N = 1,052, 65% participation). Black men had significantly higher mean systolic and diastolic blood pressure than Black women (129.7/80.9 vs 124.8/77.3, respectively). Age-specific values for systolic and diastolic blood pressure were greater in men than women for all age categories. Men were more likely to have uncontrolled hypertension or to be unaware of their hypertension than women in all age categories. Women had significantly higher mean total and high-density lipoprotein cholesterol values than men (202.1 and 56.1 mg/dl vs 193.2 and 48.7 mg/dl, respectively). Age-specific values for total and high-density lipoprotein cholesterol values were greater in women than men for all age categories except the 35-44 age group. Men were significantly more likely to be current cigarette smokers (43.3% vs 33.2%) and to have higher cigarette consumption per day (17 vs 14) than women. The major risk factors for cardiovascular disease (with the exception of smoking) were lower in the Minnesota study in 1985 than in the National Health and Nutrition Examination Survey in 1976-1980. These lower levels may also be a component in the decline of cardiovascular disease mortality rates among Blacks.     

Differences in modifiable cardiovascular disease risk factors in Australian schoolchildren: the results of a nationwide survey

Two thousand four hundred schoolchildren ages 9, 12, and 15 years were randomly selected to participate in the Health and Fitness Survey of Australian Schoolchildren in 1985. Data on blood lipids, aerobic fitness, blood pressure, and obesity were obtained through physical measurement. Information on socioeconomic status and ethnic origin was collected via questionnaire. Serum total cholesterol and low and high-density lipoprotein cholesterol were lowest in the oldest age group. Girls had significantly higher serum lipid levels, the difference being greatest at 15 years. However, comparison of the total cholesterol/high-density lipoprotein cholesterol ratio showed a trend in the direction of decreasing risk with increasing age for girls, with the reverse being found in boys. Fifteen-year-old girls were also the fattest and least fit of all the children, but had significantly lower systolic and diastolic blood pressures than their male peers. Children of Asian ethnic origin had significantly lower systolic and diastolic blood pressures and a significantly higher mean high-density lipoprotein cholesterol and were less likely to be overweight compared with other ethnic groups. Children from Mediterranean/Middle-East countries were significantly fatter and had a higher mean diastolic blood pressure than the other ethnic groups. These differences were detectable at age 9 years. Children from lower socioeconomic backgrounds were fatter and had a significantly lower mean high-density lipoprotein cholesterol and higher mean serum triglyceride levels. As with ethnic origin, these differences were detectable at age 9 years. The results demonstrate that age, sex, ethnic origin, and socioeconomic status can be used as variables to describe mean differences in the levels of cardiovascular risk factors in the national population of children. As some elevations in risk factors appear to be present in the youngest age group and these levels correlate with fatty streak and fibrous plaque formation in young adulthood, preventive programs should aim at intervention prior to puberty.     

Changes in cardiovascular risk factors and health behaviours from 1992 to 1997 in the Republic of Karelia, Russia

BACKGROUND: In Russia rapid changes have taken place both in total and chronic disease mortality during recent years. Little reliable information is available on the trends in conventional risk factors in Russia. METHODS: Chronic disease risk factors and health behaviours were studied in the Republic of Karelia, Russia in 1992 and 1997, in population surveys connected with the National FINRISK Study in Finland. Independent random population samples (n = 1000) of people aged between 25 and 64 years were drawn in both survey years. Surveys included a self-administered questionnaire, physical measurements and laboratory analyses. RESULTS: The levels of systolic blood pressure, total serum cholesterol, and high-density lipoprotein cholesterol decreased among both genders from 1992 to 1997, but the difference between the survey years was statistically significant only among women. Both self-reported alcohol consumption and serum gamma-glutamyl transferase levels increased significantly in both men and women. There was a significant shift in the type of fat used on bread and in cooking, from butter use to use of margarine and vegetable oil, among both genders. CONCLUSIONS: As a whole the risk factor levels in the Republic of Karelia are high. However, some slight improvement in risk profile was seen. Positive changes in dietary habits, such as change in the quality of fat and associated reduction in serum cholesterol levels may have contributed to the decline in cardiovascular disease mortality seen in Russia since 1995. However, since smoking and elevated blood pressure levels as well as alcohol consumption are still highly prevalent, there is a great need for effective interventions.     

Development of a tool for assessment of local government health policy

OBJECTIVE: A tool was developed for assessment of health status in communities to help formulate health policy of local governments and allow estimates of magnitude of changes in mortality with modification of selected risk variables. MATERIALS AND METHODS: A total of 25,201 men and 51,776 women aged 40-69 years who underwent health checkups in Ibaraki-ken, Japan, in 1993 were followed through 2002. Risk ratios for all cause, cardiovascular disease, cerebrovascular disease, ischemic heart disease, all cancer, and lung cancer deaths were calculated according to smoking, heavy alcohol consumption, obesity, hypertension, hypercholesterolemia, low high-density lipoprotein cholesterol, and diabetes using a Cox proportional hazards model. Regression coefficients for body mass index, systolic blood pressure, serum total cholesterol, serum high-density lipoprotein cholesterol, and plasma glucose were also calculated by the model with quadratic terms. On the basis of the results, we developed a tool using Microsoft EXCEL, allowing estimation of the magnitude of changes in death rates according to variation in mean and standard deviation values for risk factors by impact fraction. RESULTS: The developed tool facilitates estimation of magnitude of changes in death rates with alteration in exposure rates and means/standard deviations of risk variables with intervention. The best magnitude of decline for all cause mortality with a 50% reduction of exposure to smoking was 10% in men. The magnitudes of decline in cardiovascular disease mortality with a 50% reduction in hypertension were 12% in men and 11% in women. Furthermore, the magnitude of decline in cardiovascular disease mortality if a 10% lowering of mean systolic blood pressure were achieved would be 22% in men and 18% in women. CONCLUSIONS: Our developed tool may be useful to assess health status in communities with cooperation between municipal and prefectural governments.     

Cardiovascular risk factors among black schoolchildren: comparisons among four Know Your Body studies

Baseline cardiovascular risk factor variables were obtained from 1,041 black District of Columbia children in Grades 4-6 as part of a Know Your Body evaluation project. Screening included height, weight, triceps skinfold measurements, systolic and diastolic blood pressures, step-test for fitness, serum cholesterol, high-density lipoprotein cholesterol and thiocyanate. Results were compared with those in three other Know Your Body studies, Bronx, New York, Westchester, New York, and Los Angeles, and indicated that District of Columbia black children are more likely to have high cholesterol levels and to fail the fitness test than black children in the other studies. In the District of Columbia, obese children had significantly higher total serum cholesterol, systolic, diastolic, and high-density lipoprotein levels, and were less fit than other District of Columbia children; almost three-fourths of all of the children had one or more risk factors. Socioeconomic status was negatively correlated with diastolic blood pressure, skinfold thickness, and cholesterol levels and was positively correlated with high-density lipoprotein cholesterol. Rates of obesity and diastolic blood pressure were consistent with Bronx and Westchester comparisons suggesting that socioeconomic status interacts with ethnicity to determine risk factor levels. The existence of children with multiple risk factors in all of the Know Your Body studies supports the need for early intervention.     

Cardiovascular risk factor changes in Finland, 1972-1997

BACKGROUND: The cardiovascular risk factor levels of the population have been assessed in Finland since 1972. In the beginning the surveys were done to evaluate the North Karelia Project, which was a community-based preventive programme. A national cardiovascular disease (CVD) prevention strategy was developed and implemented during the late 1970s. Subsequently, a national cardiovascular risk factors monitoring system was developed to assess the effectiveness of the national strategy. METHODS: Cross-sectional population samples were studied in 1972 and 1977 in North Karelia and Kuopio provinces in eastern Finland. An area in southwestern Finland was included in 1982, followed by the Helsinki metropolitan area in 1992 and Oulu province in northern Finland in 1997. A total of 19 761 men and 20 761 women aged 30-59 participated in the six surveys (1972, 1977, 1982, 1987, 1992, 1997). RESULTS: The serum cholesterol levels of both genders have continuously declined. Systolic blood pressure levels have declined since 1972, but no further decline in diastolic blood pressure was found in 1997. Smoking prevalence among men continued to decline mainly due to an increase in the percentage of never-smokers. For the first time the increase in smoking prevalence among women levelled off and started to decline, mainly because the number of female quitters had increased. CONCLUSIONS: These data suggest that the cardiovascular health programme in Finland has succeeded in decreasing the general risk factor level of the population.     

Migration and self-rated health: a comparison between Finns living in Sweden and Finns living in Finland

AIMS: There is a lack of studies comparing health among immigrant groups with health among the population in their country of origin. This study compared the prevalence of self-rated poor health between Finns living in Sweden and Finns living in Finland. METHODS: Data were obtained from the Swedish Annual Level of Living Survey between 1996 and 2003 and the Finnish national survey "Health 2000'. Odds ratios (OR) of self-rated poor health were estimated adjusting for age, marital status, education, employment and smoking. The participants were 21,991 Swedes and 836 Finns living in Sweden, and 5,096 Finns living in Finland. RESULTS: For Finnish women living in Sweden the odds of self-rated poor health was significantly higher (OR=1.25, 95% CI=1.02-1.54) than for Finnish women living in Finland. An opposite pattern appeared among men; Finnish men living in Finland tended to have higher odds of self-rated poor health than Finnish men living in Sweden, although not to a statistically significant extent. In addition, Finns in Finland and in Sweden rated their health poorer than Swedes. CONCLUSIONS: Migration may have a different effect on Finnish men's and women's self-rated health. Further studies are needed to investigate the complex pathways between country of residence and self-rated health among immigrants.     

Association of Suboptimal Health Status and Cardiovascular Risk Factors in Urban Chinese Workers

Suboptimal health status (SHS) has become a new public health challenge in urban China. Despite indications that SHS may be associated with progression or development of chronic diseases such as cardiovascular and metabolic diseases, there are few reports on SHS investigations. To explore the relationship between SHS and traditional cardiovascular risk factors, a cross-sectional study was conducted in a sample of 4,881 workers employed in 21 companies in urban Beijing. Blood pressure, glucose, lipid levels (total cholesterol, high-density lipoprotein [HDL] cholesterol, low-density lipoprotein [LDL] cholesterol and triglycerides), cortisol, and body mass index were measured. SHS score was derived from data collection in the SHS questionnaire (SHSQ-25). Univariate analysis and linear two-level model were used to analyze the association of SHS with the cardiovascular risk factors. Serum cortisol level was much higher among the SHS high-score group than that among the low SHS score group (204.31 versus 161.33 ng/ml, P < 0.001). In a linear two-level model, we found correlation between SHS and systolic blood pressure, diastolic blood pressure, plasma glucose, total cholesterol, and HDL cholesterol among men, and correlation between SHS and systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, and HDL cholesterol among women after controlling for age, education background, occupation, smoking, and physical activity. SHS is associated with cardiovascular risk factors and contributes to the development of cardiovascular disease. SHS should be recognized in the health care system, especially in primary care.     

The interaction of cigarette smoking, oral contraceptive use, and cardiovascular risk factor variables in children: the Bogalusa Heart Study.

Two separate surveys were conducted in a total biracial population of children ages 8-17 years to determine the effects of cigarette smoking and oral contraceptive use on blood pressure and serum lipids and lipoproteins. Information regarding smoking habits and oral contraceptive use was obtained from detailed questionnaires. For White boys and White and Black girls, a small but statistically significant decrease in diastolic blood pressure levels for cigarette smokers when compared to non-smokers was noted. A significant increase among cigarette smokers in beta-lipoprotein cholesterol, pre-beta-lipoprotein cholesterol, and triglycerides as well as a decrease in alpha-lipoprotein cholesterol was noted, especially for White girls. This change in lipoprotein levels for cigarette smokers was noted in both surveys. Oral contraceptive users had higher total cholesterol and beta-lipoprotein cholesterol and lower alpha-lipoprotein cholesterol than nonusers. After adjusting for oral-contraceptive use, particularly among White girls, cigarette smokers still demonstrated high pre-beta-lipoprotein cholesterol and lower alpha-lipoprotein cholesterol levels than non-smokers. These results suggest that the lipid and lipoprotein response to cigarette smoking and oral contraceptive use is to increase cardiovascular risk.     

Fertility and perinatal health among Finnish immigrants in Sweden

Several studies have reported poorer infant outcome among immigrants, but contrary evidence also exists. Between 1940 and 1999 more than a half million Finns emigrated to Sweden, which made Finns the largest minority group in Sweden. Our aim was to investigate fertility trends, parturients' background and pregnancy outcomes among Finns in Sweden, and to compare the findings with those obtained among Swedes in Sweden and Finns in Finland. The data came from the Finnish and Swedish Medical Birth Registers for the years 1987-1998. All deliveries by women born in Finland and having given birth in Sweden (N=33874) were compared with a 10% sample of all deliveries by Swedish parturients in Sweden (N=108549) and of all Finnish deliveries (n=75133). Among Finns in Sweden, the number of live births per 1000 women aged 15-49 years declined significantly in the late 1990s. The change in the total fertility rate was less dramatic: the rate for Finns in Sweden followed the total Swedish rate although it remained from 5% to 10% higher up to the mid-1990s. Finns who had given birth in Sweden were older, had a higher parity and a higher prevalence of previous miscarriages, and smoked more often than did Swedes in Sweden or Finns in Finland. The crude infant outcomes of Finns having given birth in Sweden were equal to those among Swedes in Sweden (except for the incidence of small for gestational age), but poorer than in Finland. Biological factors explained the differences between Finns in Sweden and Finland in being small for gestational age, and biological factors and smoking explained the difference in prematurity. The difference in low birth weight remained statistically significant (3.9% versus 3.6% among singletons). In conclusion, fertility trends followed the pattern prevailing in the resident country. The relatively good outcome of children whose mothers were born in Finland but who had given birth in Sweden can partly be explained by the healthy migrant effect.     

Interdependence of associations of physical activity, smoking, and alcohol and coffee consumption with serum high-density lipoprotein and non-high-density lipoprotein cholesterol--a population study in eastern Finland

The interdependence of the associations of physical activity, smoking, and consumption of alcohol and coffee with serum high-density lipoprotein and non-high-density lipoprotein cholesterol concentrations was studied in 9,347 persons ages 25-64 years from east and southwest Finland. In covariance analyses with corrections for age, body mass index, saturated fat index, and fasting time, the mean adjusted serum high-density lipoprotein to non-high-density lipoprotein cholesterol ratio was high among physically active male non-smokers but not among smokers (P = 0.024 for two-way interaction). The cholesterol ratio was lower among both men (P = 0.010 for two-way interaction) and women (P = 0.030 for two-way interaction) reporting no or very little use of alcohol, and this association was stronger among smokers and women with high coffee consumption (P less than 0.001 for two-way interaction). Our data suggest that the elevating effect of regular physical exercise on serum high-density lipoprotein cholesterol may be absent in smokers, whereas that of alcohol is greater in smokers than nonsmokers. High coffee consumption associates with decreased serum high-density lipoprotein cholesterol levels in smokers but increased levels in non-smokers.     

Fifteen-year trends in coronary risk factors in Finland, with special reference to North Karelia

The North Karelia Project, a major demonstration programme for coronary heart disease (CHD) prevention, was begun in an eastern province of Finland in 1972. A number of national CHD prevention activities have been undertaken, quite a few of them since 1977. This paper reports the 15-year changes in CHD risk factors (serum cholesterol, blood pressure, and smoking) in North Karelia and in the original reference area of the project, and more recent changes in a third area in southwestern Finland. The results are based on well-standardized, comparable surveys of cross-sectional populations, aged 30 to 59 years. The results indicate that risk factors reduced markedly in North Karelia from 1972-1977, to a lesser extent from 1977-1982, and only a little from 1982-1987. There was also a decline in the reference area during the first ten years (1972-1982) but the changes did not exceed those in North Karelia and during the second phase, from 1982-1987, risk factor changes were minor. Risk factor levels in the third area in southwestern Finland changed little from 1982-1987. Present serum cholesterol and blood pressure levels in North Karelia are still higher than in southwestern Finland, but smoking is less common among North Karelian men. These findings are discussed in the light of the recent information on Finnish dietary changes and CHD mortality; their bearing on the need for new cardiovascular disease prevention activities in Finland is also discussed.     

我国体检人群不良生活方式与代谢指标异常的相关分析

目的了解我国体检人群不良生活方式和代谢指标异常之间的关系。方法收集全国65家体检机构2009年169251人次的体检数据,分析吸烟、运动、饮酒与空腹血糖和血脂异常之间的关系。结果体检人群的吸烟率、运动率、过量饮酒率分别为37．2％、42．8％、25．9％。吸烟、缺少运动、过量饮酒对体检人群空腹血糖和血脂的水平有明显影响,可增加或降低相应指标的异常率。比如男性体检人群吸烟组血糖正常检出率仅为85．1％,而不吸烟组血糖正常检出率为88．0％,两组差异有统计学意义。结论吸烟、缺少运动、过量饮酒等不良生活方式对我国体检人群空腹血糖和血脂水平有明显影响。戒烟、限酒、增加体力活动有利于体检人群控制空腹血糖和血脂水平,降低心血管疾病的发病风险。     

Lifetime overweight status in relation to serial changes in body composition and risk factors for cardiovascular disease: The Fels Longitudinal Study

OBJECTIVE: The aims were to determine if 1) individuals who became and maintained overweight during their entire lifetime differ from those who were never-overweight in terms of annual changes in adiposity and concurrent changes in cardiovascular disease (CVD) risk factors; 2) the changes and their relationships to each other varied between these groups or by sex within the groups; and 3) alcohol usage, smoking habits, and level of physical activity differed between groups. RESEARCH METHODS AND PROCEDURES: Data from 16,315 examinations of 414 individuals were utilized to assess lifetime overweight (body mass index [BMI] > 25 kg/m2) status. A regressive analytic approach was used to determine the average annual changes for each individual over an adult serial interval ranging from 4 to 20 years. RESULTS: Men and women who have become and maintained overweight have higher blood pressure and a poorer lipid/lipoprotein risk profile than those who have never been overweight. There is an accelerated deterioration in the atherogenic profile of overweight men and women as indicated by annual changes in CVD risk factors about double that of their never-overweight counterparts. In women, increased risk is derived from increasing systolic and diastolic blood pressure, whereas in men the increased risk comes not only from increasing diastolic blood pressure but also cholesterol, triglycerides, and low-density lipoprotein cholesterol levels and, to a lesser extent, decreasing high-density lipoprotein cholesterol. DISCUSSION: The reduced physical activity observed in the overweight adults may be related to their accumulation of adipose tissue at a rate about double their never-overweight counterparts, and this may be driving the higher rate of increase of CVD risk factors in the overweight groups.     

Associations of body mass index and percentage body fat by bioelectrical impedance analysis with cardiovascular risk factors in Japanese male office workers

To determine whether body mass index (BMI, kg/m2) or percentage body fat (%BF) by bioelectrical impedance analysis (BIA) better reflects the cardiovascular risk profile, we examined the associations among BMI, %BF by BIA, and cardiovascular risk factors (systolic blood pressure (SBP), diastolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL-C/HDL-C ratio, and triglycerides (TG)) in 1,217 Japanese male office workers aged 25 to 59 years. From stepwise regression analyses of cardiovascular risk factors on age, BMI, alcohol intake, and cigarette smoking, significant correlates were, in the order of relative importance: age, BMI, and alcohol intake for SBP and DBP (the cumulative percentage of variation; 14.9% and 21.3%, respectively); age, BMI, and alcohol intake (negative) for LDL-C (11.0%); BMI (negative), alcohol, and cigarette smoking (negative) for HDL-C (19.9%); BMI, alcohol intake (negative), age, and cigarette smoking for LDL-C/HDL-C ratio (23.1%); and BMI, age, cigarette smoking, and alcohol intake for Log TG (21.7%). From stepwise regression analyses using %BF by BIA as an independent factor, %BF by BIA was also significantly associated with each cardiovascular risk factor, but the decrease in explained variance for each cardiovascular risk factor was 0.2-4.5%, compared with the model using BMI as an independent factor. These results suggest that BMI may better reflect blood pressure or serum lipid profile than %BF by BIA.     

Relationship between baseline risk factors and coronary heart disease and total mortality in the multiple risk factor intervention trial

The relationship between selected baseline risk factors and subsequent coronary heart disease (CHD) death and total mortality among participants in the Multiple Risk Factor Intervention Trial (MRFIT) was studied in order to determine (a) whether the three risk factors used to identify high-risk men for the trial were associated with CHD death; (b) whether other risk factors measured at baseline, especially lipoprotein cholesterol levels, were associated with CHD and total mortality; and (c) whether there were any differences between special intervention (SI) and usual care (UC) participants in the relationship of the specific levels of risk factors to CHD or total mortality. The three main risk factors (blood cholesterol, cigarette smoking, and diastolic blood pressure) and age were significantly associated with CHD mortality; age, diastolic blood pressure, and cigarette smoking were associated with total mortality. The risk score based on the multiple logistic equation developed from the Framingham Study was also strongly associated with CHD mortality. When the joint associations of selected baseline risk factors with CHD and total mortality were considered, age, diastolic blood pressure, cigarette smoking, and low- and high-density lipoprotein cholesterol were significantly associated with CHD mortality; age, cigarette smoking, and low-density lipoprotein cholesterol were positively associated with total mortality. Systolic blood pressure significantly improved the prediction of CHD mortality for SI and UC men when it was added to a regression model that included age, diastolic blood pressure, cigarettes smoked per day, body mass index, and lipoprotein levels, but improved the prediction of total mortality only for SI men. In similar analyses, serum thiocyanate improved the prediction of both CHD and total mortality for UC men. Among SI men the improved prediction gained by considering serum thiocyanate was less pronounced and not significant for CHD death. This latter finding may be due in part to the changes made in smoking behavior by SI participants during the course of the study. The estimated regression coefficients for CHD and total mortality endpoints were not significantly different between the SI and UC groups.     

Relation of dehydroepiandrosterone and dehydroepiandrosterone sulfate with cardiovascular disease risk factors in women: longitudinal results from the Massachusetts Women's Health Study

Low circulating levels of the adrenal steroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are thought to be associated with increased risk of cardiovascular disease (CVD) in men. In women, either a positive or null association with CVD has been found. The nature of the relation between DHEAS and CVD risk factors in women is unclear and is based on cross-sectional data. We present results from a longitudinal investigation of serum DHEA and DHEAS and cardiovascular disease risk factors in 236 women, initially 50-60 years old, from a population-based prospective (1986-1995) study of the menopausal transition. We used generalized estimating equations to model the relation of serum DHEA and DHEAS to systolic and diastolic blood pressure and serum levels of total cholesterol, high density lipoprotein cholesterol, and apolipoproteins A and B, adjusting for other factors related to CVD. Both DHEA and DHEAS were positively related to diastolic and systolic blood pressure, and DHEAS was negatively related to apolipoprotein A. DHEA and DHEAS were also positively related to smoking, alcohol use, estrone, and estradiol levels, and inversely related to age. Our results suggest that higher levels of DHEA and DHEAS in middle-aged women may indicate increased CVD risk.     

Cardiovascular diseases in Chinese, Malays, and Indians in Singapore. II. Differences in risk factor levels.

STUDY OBJECTIVE--The aim of the study was to examine cardiovascular risk factors to see how these might explain differences in cardiovascular disease mortality among Chinese, Malays, and Indians in the Republic of Singapore. DESIGN--The study was a population based cross sectional survey. Stratified systematic sampling of census districts, reticulated units, and houses was used. The proportions of Malay and Indian households were increased to improve statistical efficiency, since about 75% of the population is Chinese. SETTING--Subjects were recruited from all parts of the Republic of Singapore. SUBJECTS--2143 subjects aged 18 to 69 years were recruited (representing 60.3% of persons approached). There were no differences in response rate between the sexes and ethnic groups. MEASUREMENTS AND MAIN RESULTS--Data on cardiovascular risk factors were collected by questionnaire. Measurements were made of blood pressure, serum cholesterol, low and high density lipoprotein cholesterol, fasting triglycerides and plasma glucose. In males the age adjusted cigarette smoking rate was higher in Malays (53.3%) than in Chinese (37.4%) or Indians (44.5%). In both sexes, Malays had higher age adjusted mean systolic blood pressure: males 124.6 mm Hg v 121.2 mm Hg (Chinese) and 121.2 mm Hg (Indians); females 122.8 mm Hg v 117.3 mm Hg (Chinese) and 118.4 mm Hg (Indians). Serum cholesterol, low density lipoprotein cholesterol and triglyceride showed no ethnic differences. Mean high density lipoprotein cholesterol in males (age adjusted) was lower in Indians (0.69 mmol/litre) than in Chinese (0.87 mmol/litre) and Malays (0.82 mmol/litre); in females the mean value of 0.95 mmol/litre in Indians was lower than in Chinese (1.05 mmol/litre) and Malays (1.03 mmol/litre). Rank prevalence of diabetes for males was Indians (highest), Malays and then Chinese; for females it was Malays, Indians, Chinese. CONCLUSIONS--The higher mortality from ischaemic heart disease found in Indians in Singapore cannot be explained by the major risk factors of cigarette smoking, blood pressure and serum cholesterol; lower high density lipoprotein cholesterol and higher rates of diabetes may be part of the explanation. The higher systolic blood pressures in Malays may explain their higher hypertensive disease mortality.     

老年男性保健人群六年累计缺血陛心血管病发病率及其危险因素的前瞻陛研究

目的 研究老年保健人群6年累计缺血性心血管病(ICVD)的发病率及其相关危险因素.方法 基线人群为2003年5月某医院数据库记录在案的、出生于1938年1月1日前(即年龄＞65岁)的所有老年保健对象,剔除基线时已患有ICVD者.收集的危险因素有:基线时年龄、性别、体重指数、收缩压、血总胆固醇浓度、血甘油三酯浓度、血高密度脂蛋白胆固醇(HDL-C)浓度、血肌酐浓度、血载脂蛋白A1浓度、糖尿病、吸烟,以人年作为观察时间,计算基线危险因素不同分期水平下的人年发病率及累计发病率,进行单因素分析.使用Cox比例风险回归模型进行多因素分析.结果 基线人群为2271名男性老年人,6年内ICVD累计发病率为23.56%,人年发病率达到了45.41‰.单因素分析表明,与ICVD事件正相关的变量是:收缩压、体重指数、血总胆固醇水平、血甘油三酯水平、血载脂蛋白A1水平、糖尿病、吸烟;与ICVD事件负相关的变量是:血HDL-C浓度、血肌酐浓度;多元Cox比例风险模型的分析结果显示:收缩压、糖尿病、血总胆固醇、体重指数是最主要的危险因素,血HDL-C是主要的保护因素.结论 老年保健人群ICVD发病率较高.控制血压、血糖,提高血HDL-C水平可能是降低未来ICVD事件最为有效的措施.     

Cardiovascular risk factors,change in risk factors over 7 years,and the risk of clinical diabetes mellitus type 2. The Tromsø study

In a large longitudinal study, we examined the relationships between cardiovascular risk factors (blood lipids, blood pressure, smoking, and physical activity), and change in these risk factors over a 7-year period, and the risk of clinical diabetes mellitus type 2. There were 73 verified new cases of clinical diabetes mellitus type 2 (diagnosed between 1987 and 1995) and 9,982 controls who consistently denied diabetes in three health surveys in 1979/1980, 1986/1987, and 1994/1995. Baseline body mass index, serum triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure, and physical activity in leisure, as well as change in these risk factors, were significant predictors for clinical diabetes mellitus type 2. Thus, both the level of risk factors at baseline and change in risk factor level are of importance for the risk of clinical diabetes mellitus type 2.