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目的探讨胰十二指肠切除扩大淋巴结清扫术治疗胰头癌的临床意义。方法选取2010年1月至2018年12月因胰头癌在本院行胰腺十二指肠切除术的55例患者,根据术中淋巴结清扫范围分为标准组(n=22)与扩大组(n=33)。标准组行胰腺十二指肠切除手术及标准淋巴结清扫,扩大组行扩大淋巴结清扫。比较两组手术时间、出血量、住院时间、术后并发症及术后生存时间。结果两组术后并发症发生率比较差异无统计学意义。两组术中出血量、术后平均住院时间比较差异无统计学意义。两组手术时间、淋巴结清扫个数比较差异具有统计学意义(P<0.05);但两组患者1、3、5年生存率比较差异无统计学意义。结论扩大淋巴结清扫并不增加手术并发症发生率和死亡率,但不能明显提高患者的生存期。 相似文献
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胰十二指肠切除术和保留十二指肠的胰头切除术治疗慢性胰腺炎的临床疗效比较 总被引:1,自引:0,他引:1
目的针对病变主要集中于胰头的慢性胰腺炎,比较两种胰头切除手术——胰十二指肠切除术(包括传统术式和保留幽门的术式)和保留十二指肠的胰头切除术(包括不切开主胰管和切开主胰管的术式)的临床疗效。方法采用回顾性临床对照研究,将2001年1月至2007年5月我院收治并行各类胰头切除手术的41例慢性胰腺炎患者按手术方式分为胰十二指肠切除术组(n=19)和保留十二指肠的胰头切除术组(n=22),比较两种术式的疼痛缓解率、手术并发症发生率和住院时间长短等临床指标。结果胰十二指肠切除术组和保留十二指肠的胰头切除术组的疼痛总缓解率、疼痛完全缓解率分别为94%、84%和95%、81%(P>0.05);而两组的并发症发生率分别为21%和0%(P<0.01),术后平均住院时间分别为14d和8.5d(P<0.01)。结论针对胰头病变为主的慢性胰腺炎及其导致的并发症,保留十二指肠的胰头切除术与胰十二指肠切除术均具有良好的疼痛缓解率,但前者的手术创伤小、并发症少和住院时间更短,因此,保留十二指肠的胰头切除术可能更具有优势。 相似文献
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目的比较不同年代胰头癌外科治疗情况,总结治疗经验.方法回顾性分析1958~2003年在我院外科接受治疗的346例胰头癌患者的临床资料.结果1958~1976、1977~1987、1988~1998及1999~2003年胰头癌切除率分别为26.6%(21/79)、26.7%(16/60)、20.2%(22/109)及22.4%(20/98),总切除率为22.8%(79/346),未能切除病例多采用胆囊十二指肠吻合术解除胆道梗阻.1958~1976、1977~1987、1988~1998及1999~2003年胰十二指肠切除术后并发症发生率分别为42.3%(9/21)、37.5%(6/16)、27.3%(6/22)及10.0%(2/20).1958~1976年手术死亡率为19.0%(4/21),原因为胰瘘(2例)、肝肾功能衰竭(1例)和胆道感染(1例);1977~1987年手术死亡率为12.5%(2/16),原因为胰瘘及多器官功能衰竭(各1例);1988~1998年手术死亡率为4.5%(1/22),原因为多器官功能衰竭(1例);1999~2003年20例胰十二指肠切除术无围手术期死亡病例.1958~1976年胰头癌胰十二指肠切除术后1、3及5年存活率分别为55.5%、23.1%及11.0%,1977~1987年分别为56.3%、25.0%及12.5%,1988~1998年分别为59.1%、27.2%及13.6%.结论由于围手术期治疗和监护技术的进步,手术技术操作的成熟,胰头癌手术死亡率和并发症发生率均有显著下降,但手术切除率和生存率没有显著变化. 相似文献
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目的: 研究无接触分离技术(no-touch isolation technique,NTIT)在胰头癌根治性切除术中的应用,探讨以NTIT技术为重点的胰十二指肠切除术对肿瘤转移及预后的影响?方法:对2004年2月~2009年9月施行胰十二指肠切除术的57例胰头癌患者进行对照研究?其中NTIT组32例,常规手术组25例?测定手术病例肿瘤切除前?后门静脉血细胞角蛋白20(CK20) mRNA表达情况?分析两组生存期?肝转移率和死亡率?结果:两组患者术后并发症发生率无明显差异?切除肿瘤病灶前,门静脉血内CK20 mRNA 的阳性表达率常规手术组和NTIT组分别为16.00%?18.75%,无统计学差异?肿瘤切除后,常规手术组CK20 mRNA的阳性率显著高于NTIT组(52.00% vs. 25.00%,P=0.036)?术后随访,NTIT组?常规手术组术后1?3?5年生存率分别为76.6%?50.0%?40.0%和75.0%?33.3%?8.8%?NTIT组5年生存率高于常规手术组(P=0.018)?术后死亡原因分析显示NTIT组肝转移率显著低于常规手术组(P=0.024)?结论: 胰头癌根治性切除术中采用NTIT技术能有效减少癌细胞播散,减少术后肝转移发生率,改善预后? 相似文献
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目的提高胰头及壶腹部癌手术切除率,减少并发症及提高术后生存率。方法总结39例胰头十二指肠切除术的治疗经验。结果对39例胰头及壶腹部癌患者根据肿瘤不同分期行不同范围扩大切除及淋巴结清扫术,并行改良Child重建术。切除范围注重区域性整块切除,包括周围淋巴结清扫。消化道重建采用胰肠、胆肠端侧吻合。手术时间4.0~6.5h(平均4.6h),术中平均失血500ml,手术并发症发生率为23.1%。术后1、3、5年生存率分别为69.2%、46.2%、23.1%。结论胰头十二指肠切除术应由专业组人员完成。不同范围的清扫可降低肿瘤局部复发率。胰肠、胆肠端侧吻合操作不复杂,术后并发症发生率较低。 相似文献
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目的探讨预防胰十二指肠切除术(pancreaticoduodenectomy,PD)术后胰漏的合理胰腺残端处理方式.方法回顾性分析该院10年间行PD治疗的壶腹周围癌肿患者的临床资料.观察围手术期的情况和术后胰漏及由此引发的腹腔感染的发生率.结果两组病人间围手术期情况的差异无统计学意义,胰管空肠端侧吻合组与胰腺空肠端端吻合组术后胰漏发生率分别为3.9%和12.6%(P=0.044).腹腔感染发生率分别为1.3%和9.7%(P=0.026),相关死亡率为0和5.8%.结论胰管空肠端侧吻合重建确实可靠,能够有效地降低PD后胰漏的发生. 相似文献
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本文报告了用胰头、十二指肠切除术治疗壶腹周围及胰头部肿瘤36例,手术死亡率2.8%,手术并发症胰瘘发生率19.4%,胆瘘11%,出血5.5%。随访结果,乏特氏壶腹癌5年生存率46.1%;10年生存率33.3%;胰头癌5年生存率14.3%。对术后并发症及其处理进行了讨论。 相似文献
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目的:分析手术治疗胰头癌的疗效并进一步探讨胰头癌手术指征及术式选择.方法:回顾性分析2000~2004年间我科手术治疗的97例胰头癌患者的临床资料.结果:97例患者中行单纯胰十二指肠切除术(Pancreatoduodenectomy,PD)41例,联合门静脉/肠系膜上静脉(PV/SMV)切除的胰十二指肠切除术13例,其余43例均行姑息性胆肠内引流术.行姑息性切除患者均于1年内死亡,单纯胰十二指肠切除组1年及3年生存率分别为58.5%和26.8%,联合血管切除组1年及3年生存率分别为53.8%和23.1%.结论:根治性切除是目前所有治疗措施中能够达到治愈的唯一手段,在严格把握手术适应症的前提下开展联合血管切除的的根治术可提高根治性切除率及术后生存率. 相似文献
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Effect of multiple-phase regional intra-arterial infusion chemotherapy on patients with resectable pancreatic head adenocarcinoma 总被引:4,自引:0,他引:4
JIN Chen YAO Lie LONG Jiang FU De-liang YU Xian-jun XU Jin YANG Feng NI Quan-xing 《中华医学杂志(英文版)》2009,122(3):284-290
Background Regional intra-arterial infusion chemotherapy (RIAC) has been more valuable to improve prognosis and quality of life of patients with inoperable pancreatic adenocarcinomas, and adjuvant RIAC plays an important role in prolonging survival and reducing risk of liver metastasis after radical resection of pancreatic cancer, but the effect of preoperative or multiple-phase RIAC (preoperative combined with postoperative RIAC) for resectable pancreatic cancers has not been investigated. In this prospective study, the effect of multiple-phase RIAC for patients with resectable pancreatic head adenocarcinoma was evaluated, and its safety and validity comparing with postoperative RIAC were also assessed. Methods Patients with resectable pancreatic head cancer were randomly assigned to two groups. Patients in group A (n=-50) were treated with new therapeutic mode of extended pancreaticoduodenectomy combined with multiple-phase RIAC, and those in group B (n=-50) were treated with extended pancreaticoduodenectomy combined with postoperative RIAC in the same period. The feasibility, compliance and efficiency of the new therapeutic mode were evaluated by tumor size, serum tumor markers, clinical benefit response (CBR), surgical complications, mortality and toxicity of RIAC. The disease-free survival time, median survival time, incidence of liver metastasis, survival rate at 1, 2, 3 and 5 years were also observed. Life curves were generated by the Kaplan-Meier method. Results The pain relief rate and CBR in group A was 80% and 84% respectively. Serum tumor markers decreased obviously and tumors size decreased in 26% of patients after preoperative RIAC in group A. No more surgical complications, mortality or severe systemic side effects were observed in group A compared with group B. The incidence of liver metastasis in group A was 34% which was lower than 50% in group B. The disease-free survival time and median survival time in group A were 15.5 months and 18 months respectively. The 1-, 2-, 3- and 5-year survival rates were 54.87%, 34.94%, 24.51% and 12.25% respectively. There was no significant difference of survival time or survival rates between two groups. Conclusions Multiple-phase RIAC is effective in combined therapy of resectable pancreatic head carcinomas by enhancing inhibition of tumor growth and reduction of liver metastasis, without negative effect on patients' safety or surgical procedure. 相似文献
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目的 比较分析局部晚期食管癌行新辅助化疗联合手术治疗(CS组)与单纯手术治疗(S组)5年生存率、手术切除率、术后并发症及病死率,评价新辅助化疗在局部晚期食管痛治疗中的价值.方法 收集自2003年8月至2009年3月局部晚期食管癌(cT3-4N1M0)患者117例,其中新辅助化疗联合手术治疗42例,单纯手术治疗75例.评估新辅助化疗疗效,将两种治疗方式的手术切除率、术后并发症及病死率进行比较,并回顾性分析两组患者5年生存率.结果 新辅助化疗后完全缓解率达11.9%,部分缓解率达47.6%,总有效率为59.5%.CS组手术切除率为100%,S组为89.5%,两组间差异有统计学意义(P=0.029).CS组术后病死率为0,S组为1.3%,两组间差异无统计学意义(P=0.452).两组患者术后吻合口瘘、肺部感染、声音嘶哑、乳糜胸等并发症发生率差异均无统计学意义.CS组术后第1、2、5年生存率分别为83.2%、57.4%、31.7%,S组为81.3%、49.4%、26.4%,CS组总生存率稍高于S组,但差异无统计学意义(P=0.266).进一步分层分析,化疗有效患者(CR+PR)第1、2、5年生存率分别为83.6%、71.1%、51.8%,相对于S组差异有统计学意义(P=0.010).结论 新辅助化疗可提高局部晚期食管癌患者的手术切除率及化疗有效患者的远期生存率,并且不增加术后病死率及并发症发生率. 相似文献
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Radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph, and soft-tissue dissection in pancreatic head cancer 总被引:2,自引:0,他引:2
Background Recent studies have revealed that the reason for the low surgical resection rate of pancreatic carcinoma partly lies in its biological behavior, which is characterized by neural infiltration. This study aimed to investigate the clinical significance of radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph, and soft-tissue dissection for carcinoma of the pancreatic head.
Methods Forty-six patients with pancreatic head cancer were treated in our hospital from 1995 to 2005. The patients were divided into two groups: radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph and soft-tissue dissection (group A, n=25) and routine Whipple's operation (group B, n=-21). There were no significant differences between the two groups in relation to age, gender and preoperative risk factors, and perioperative conditions, patholoclical data and survival rates were studied.
Results There were no significant differences in tumor size, surgical procedure time, postoperative complications, and time of hospitalization. However, the number and positive rate of resected lymph nodes in group A were significantly higher than those in group B (P〈0.05). The 1- and 3-year survival rate in group A were 80% and 53%, respectively, which was higher than those in group B (P〈0.05). There were significant differences in the survival rates between patients with and without nerve infiltration in group A (P〈0.05).
Conclusions Radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph and soft-tissue dissection, can effectively remove the lymph and nerve tissues that were infiltrated by tumor. Meanwhile, this method can reduce the local recurrence rate so as to improve the long-term survival of patients. 相似文献
Methods Forty-six patients with pancreatic head cancer were treated in our hospital from 1995 to 2005. The patients were divided into two groups: radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph and soft-tissue dissection (group A, n=25) and routine Whipple's operation (group B, n=-21). There were no significant differences between the two groups in relation to age, gender and preoperative risk factors, and perioperative conditions, patholoclical data and survival rates were studied.
Results There were no significant differences in tumor size, surgical procedure time, postoperative complications, and time of hospitalization. However, the number and positive rate of resected lymph nodes in group A were significantly higher than those in group B (P〈0.05). The 1- and 3-year survival rate in group A were 80% and 53%, respectively, which was higher than those in group B (P〈0.05). There were significant differences in the survival rates between patients with and without nerve infiltration in group A (P〈0.05).
Conclusions Radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph and soft-tissue dissection, can effectively remove the lymph and nerve tissues that were infiltrated by tumor. Meanwhile, this method can reduce the local recurrence rate so as to improve the long-term survival of patients. 相似文献
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小肝癌的临床治疗 总被引:2,自引:0,他引:2
目的探讨小肝癌(≤5cm)优化的个体治疗方案。方法回顾性分析了2000年1月-2004年12月在我院接受治疗的849例小肝癌患者的临床资料,分为手术切除组(n=406)和微创治疗组(n=443),比较两组患者的生存率、复发率和治疗后并发症。结果手术切除组患者术后3年生存率为72.1%,其中262例肿瘤≤3cm患者的3年生存率为73.3%,144例肿瘤3—5cm患者的3年生存率为70.5%,两组相比差异无显著性(P=0.46);术后1、2和3年复发率分别为13.5%、29.9%和39.8%。微创治疗组患者治疗后3年生存率为73.8%,其中136例肿瘤≤3cm患者的3年生存率为74.7%,307例肿瘤3-5cm的患者3年生存率为72.2%,两组相比差异无显著性(P=0.45);治疗后1、2和3年复发率分别为12.6%、28.7%和40.4%。微创治疗组中肿瘤≤3cm患者治疗后3年生存率明显高于手术切除组中肿瘤≤3cm的患者(P〈0.05)。手术切除组患者治疗后并发症发生率明显高于微创治疗组患者(30.8%vs6.1%,P〈0.01)。结论微创治疗与传统手术切除治疗小肝癌患者的疗效相当,包含微创治疗的综合治疗手段将有助于提高小肝癌患者的生存率和生活质量。 相似文献
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目的探讨局部切除术在早期直肠癌治疗中的临床应用价值。方法回顾性分析117例早期直肠癌患者的临床资料,其中局部切除75例,根治术42例,比较两种术式的术后并发症和预后(5年生存率)情况。结果局部切除组术后并发症发生率5.3%,5年生存率85.3%;根治组术后并发症发生率16.7%,5年生存率90.5%。两种术式的5年生存率比较差异无统计学意义(P〉0.05),术后并发症发生率局部切除组明显低于根治组(P〈0.05)。结论局部切除术治疗早期直肠癌,方法简单可靠,并发症少,能提高患者术后生存质量。严格选择合适病例是治疗的关键。 相似文献
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Radical resection of gastric carcinoma with pancreas and spleen preservation a nd functional cleaning of lymph nodes 总被引:3,自引:0,他引:3
Objective To study the clinical value of radical resection of gastric carcinoma with pancreas and spleen preservation (PSP) and functional cleaning of lymph nodes (LNs) of the spleen hillus and along the splenic artery. Methods Pancreas and spleen involvement was retrospectively reviewed among 439 cases of resectable carcinoma of the gastric cardia,gastric corpus and total stomach. During gastric surgery, 2 ml of methylene blue was injected into the subserosal space of the gastric cardia or corpus to observe the spread of lymphatic flow in 54 cases of gastric carcinoma. The metastatic rate of LNs in splenic hillus and along the trunk of the splenic artery (No10, No11), postoperative complications and survival rates were investigated in 63 gastric carcinoma patients that had received gastrectomy with pancreas and spleen preservation (PSP). These were compared with the pancreas preservation (PP) group and pancreas and spleen combined resection (PSR) group. Results Among these 439 cases, only 25 cases were observed with direct invasion to the pancreas (5. 7%), and 10 cases with direct invasion to the spleen (2. 3%). After pathological examination of the pancreatic body and tail, we found 22 cases with pancreas and spleen combined resection, 4 cases (18. 2%, 4/22) with direct invasion of the capsule and 2 with invasion to the superficial parenchyma (9. 1%, 2/22), without metastasis to the lymph nodes within the pancreas and spleen. The metastatic rate of No10,No11 lymph nodes were 17. 5% (11/63) and 19. 1% (12/63) in the PSP group, 20. 8% (45/216) and 25%(54/216) in the PP group, and 20% (6/30) and 23. 3% (7/30) in the PSR group. There were no statistically significant differences (P>0. 05). Injection of methylene blue into the subserosal space of the stomach did not diffuse into the spleen or pancreatic parenchyma. Postoperative complications, diabetes and mortality in PSP (0%,0%,0%) were lower than in PP (4. 2%, 0. 9%, 0. 9%) or PSR (40%,10%,3. 3%). The 5-year survival rate (5-YSR) and 10-YSR in PSP (57. 5%, 52. 0%) were higher than in PSR (37. 5%,30. 0%). Those patients with stage Ⅱ and Ⅲa treated by PSP, improved markedly. Conclusions The surgical procedure of pancreas and spleen preservation for gastric cancer is a safe and organ function protected method. Postoperative complications were lower and survival rates were higher , the radicality was not reduced. These results indicate that PSP is preferred in patients with gastric carcinoma of stage Ⅱ or Ⅲa. 相似文献
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目的 探讨以腹膜后神经、淋巴结及软组织廓清为重点的胰头癌胰十二指肠根治性切除术的临床意义.方法 将浙江省人民医院1995年2月至2000年2月施行胰十二指肠切除术的21例胰头癌患者(常规组)和2000年2月至2005年2月施行以腹膜后神经、淋巴结及软组织廓清为重点的胰十二指肠根治性切除术的25例胰头癌患者(后腹膜廓清组)进行比较研究.两组患者在年龄、性别、术前危险因素方面差异无统计学意义,对两组的围手术期情况、病理资料、生存率进行对照分析.结果 两组患者的肿瘤大小方面差异无统计学意义,术中情况、术后并发症、住院时间差异亦无统计学意义,而后腹膜廓清组的淋巴结清扫数目及转移率和神经浸润转移率显著高于常规组(P<0.05),后腹膜廓清组的1、3年生存率分别为80%、52%,高于常规组.后腹膜廓清组中神经浸润阳性与阴性的生存率差异有统计学意义.结论 在胰头癌根治术中后腹膜神经、淋巴结及软组织廓清的应用,可以有效地清除癌组织浸润的神经、淋巴组织,减少术后局部复发的发生率,使远期生存率得到提高. 相似文献
18.
目的比较分化型甲状腺癌(DTC)手术切除后单纯T4抑制治疗与131I治疗联合T4抑制治疗的生存率与复发率,证明DTC术后131I治疗的必要性。方法232例DTC病例分为A组:手术切除后T4抑制治疗(n=108),B组:手术切除后联合131I治疗联合T4抑制治疗(n=124)。根据寿命法分别统计两组无死亡生存率、无复发生存率、无进展生存率和无疾病生存率。各组和各生存率间采用F检验作两两比较。结果A组病例在手术后1、5、10年的复发率分别为4.63%、8.33%和12.04%,B组为0.81%、4.03%和7.26%。A组半数病例复发时间为2年,而B组为4年。两组在无复发生存率、无进展生存率和无疾病生存率比较上,B组明显优于A组。结论DTC患者手术切除后即行131I治疗是预防和治疗、复发或转移的最佳治疗方法。 相似文献
19.
AG490提高极限肝切除术后大鼠存活率的机制 总被引:7,自引:0,他引:7
目的研究特异性炎症介质阻断剂AG490提高极限肝切除术后大鼠生存率的机制.方法将38只90%肝切除的雄性SD大鼠随机分为对照组(n=10)和AG490组(n=28),后者术中至术后36 h内每12 h向腹腔内注射AG490 1 mg·kg-1,观察术后生存率,检测各项肝功能及血糖指标.结果对照组与AG490组大鼠的术后存活率分别为0%和25%;AG490组大鼠的术后转氨酶和血糖水平明显优于对照组(P<0.05),并且在48 h后胆红素水平明显下降(P<0.05);两组大鼠的血清蛋白水平均缓慢下降但差异无显著性(P>0.05).结论AG490可显著提高极限肝切除术后大鼠的生存率,该作用主要受益于其对剩余肝功能的保护,而非促进肝脏再生. 相似文献
20.
射频消融与手术切除治疗老年性小肝细胞癌的疗效比较 总被引:1,自引:0,他引:1
目的:评价射频消融(RFA)与手术切除治疗老年性原发性小肝细胞癌的临床疗效,为临床选择合适的治疗方法提供有益参考.方法:2004年1月-2010年12月本文作者收治127例老年性小肝细胞癌患者,按所接受的治疗方法分为RFA组76例与手术组51例,回顾性分析2组患者术后的住院时间、并发症发生率、生存率及复发率等临床资料,... 相似文献