尿毒症患者血清钙、镁及某些微量元素含量的观察

本文测定了22例尿毒症患者和25名健康人(对照组)的血清钙、镁、锌、铜、硒和铬的含量。与对照组比较尿毒症患者血清钙、锌和硒水平明显降低(p<0.01～0.05);血清镁含量及Cu/Zn比值升高(p<0.01);血清铜和铬值改变无统计学意义。并讨论了尿毒症患者上述各种元素含量变化异常的原因、机制及其临床意义。     

新生儿窒息血清微量元素观察

目的探讨新生儿窒息血清微量元素水平变化情况,分析不同窒息程度新生儿血清微量元素的差异。方法选取2011年4月至2012年7月本院的53例窒息新生儿为观察组,同期的53例健康新生儿为对照组,将2组新生儿的血清锌、铁、硒、镁、钙及铜水平进行检测及比较,并将观察组中重度窒息者及轻度窒息者的上述指标进行比较。结果观察组的血清锌、铁、硒、镁及钙水平均明显低于对照组,而血清铜水平则明显高于对照组,而观察组中重度窒息者的血清锌、铁、硒、镁及钙水平低于轻度窒息者,血清铜则高于轻度窒息者,差异有统计学意义(P<0.05)。结论窒息新生儿血清微量元素水平呈现异常状态,且重度窒息新生儿表现更为明显。     

锌硒宝辅助治疗小儿肾病综合征35例

目的 :对锌硒宝进行药物评价。方法 :小儿肾病综合征 5 0例 ,治疗组 3 5例采用激素加锌硒宝治疗 ;对照组 15例只用激素治疗。结果 :1治疗组肾病近期临床缓解率明显高于对照组 ( P<0 .0 5 ) ,呼吸道感染发生率明显低于对照组 ( P<0 .0 5 ) ;2治疗组血清 Ig G、Ig A含量显著高于对照组 ( P <0 .0 5 ) ,两组血清 Ig M含量差异不显著 ( P >0 .0 5 )。结论 :锌硒宝具有免疫调节作用 ,能促进肾病恢复 ,减少呼吸道感染发生率     

微量元素钙镁锌铁铜与妊娠期高血压疾病的关系

目的探讨孕妇妊娠期高血压疾病时母、脐血中微量元素钙、镁、锌、铁、铜含量与病情程度的关系以及母、脐血间有无差异。方法用日立7600型自动生化分析仪及罗氏自动生化分析仪测定正常晚期妊娠孕妇血清28例、新生儿脐血清31例及妊娠期高血压疾病患者血清及脐血清各62例的钙、镁、锌、铁、铜血清含量并进行对照研究。结果①妊娠期高血压疾病患者血清及新生儿脐血清锌、钙、镁含量显著均低于正常对照组(P<0.01)、血清铁、铜含量显著均高于正常对照组(P<0.01);且重度患者血清及新生儿脐血清锌、钙、镁含量显著均低于轻度(P<0.01)、血清铁、铜含量显著均高于轻度(P<0.01)。②从正常孕妇与妊娠期高血压疾病患者血清与脐血血清锌、铜、铁、钙、镁含量的比较中可以看出,孕妇血清锌、铁、钙、镁含量均显著低于脐血清锌、铁、钙、镁含量(P<0.05),孕妇血清铜含量显著高于脐血清铜含量(P<0.01)。结论①血清微量元素锌、钙、镁的减少,铁、铜的升高可能与妊娠期高血压疾病的发生、发展有一定的关系。②无论孕妇机体在正常状态下还是在病理状态下,都首先保证胎儿对锌、铜、铁、钙、镁的需要。     

硒酸脂多糖治疗白内障的临床观察

观察８２例（１５９只眼）早、中期老年性白内障和糖尿病性白内障患者，经口服硒酸脂多糖治疗３个月后的视力与７３例（１４１只眼）对照组患者的视力相比较，结果显示有非常显著的差异。硒对老年性实质型白内障和糖尿病性白内障有明显的治疗效果。     

硒酸脂多糖治疗白内障的临床观察

观察８２例（１５９只眼）早，中期老年性白内障和糖尿病性白内障患者，经口服硒酸脂多糖治疗３个月后的视力与７３例（１４１只眼）对照组患者的视力相比较，结果显示有非常显著的差异，硒对老年性实质型白内障和糖尿病性白内障有明显的治疗效果。     

健康者脑梗塞与急性心肌梗塞患者间血清微量元素测值对比及临床意义

本文报告36例脑梗塞、38例急性心肌梗塞（AMI）患者和40例健康对照组8种微量常见元素测值，并分别进行对比．结果：脑梗塞与AMI患者血清硒（Se），铬（Cr）、钙（Ca）、镁（Mg）和锌（Zn）含量较对照组降低，镉（Cd）升高，均有显著或非常显著差异（P＜0．01）；三组间锶（Sr）均无差异（P＞0．05）．AMI患者的铜（Cn）和铜／锌（Cn／Zn）比值较脑梗塞患者非常显著增高（P＜0．01），血清Se则降低，但差异不显著（P＞0．05）．分析了各元素在心脑梗塞中的作用和测值差异的原因，指出微量常量元素检测和调整人体元素的平衡对防治心脑血管病有重要意义．     

健康者脑梗塞与急性心肌梗塞患者间血清微量元素测值对比及临 …

本文报告３６例脑梗塞，３８例急性心肌梗塞（ＡＭＩ）患者和４０例健康对照组８种微量元素测值，并分别进行了对比。结果：脑梗塞与ＡＭＩ患者血清硒（Ｓｅ），铬（Ｃｒ），钙（Ｃａ），镁（Ｍｇ）和锌（Ｚｎ）含量较对照组降低，镉（Ｃｄ）升高，均有显著或非常显著差异（Ｐ〈０．０１），三组间锶（Ｓｒ）均无差异（Ｐ〉０．０５）。ＡＭＩ患者铜（Ｃｎ）和铜／锌（Ｃｕ／Ｚｎ）比值较脑梗塞患者非常显著增高（Ｐ〈０．０１），血     

脑血管疾病与血清中微量元素含量的关系

<正> 我们应用日本AA-835型原子吸收分光光度计采用火焰原子吸收法对97例脑血管疾病患者(男67例,女30例,平均年龄55.9岁,其中出血性12例,缺血性85例)和50例健康人(男23例,女27例,平均年龄55.4岁)进行了血清铜、锌、锂、硒等四种微量元素的含量比较。在获得较好的分析准确度与精密度数据后观察其结果,发现脑血管疾病患者的血清铜、锌、锂、硒均显著低于健康人(P<0.001),而铜锌比值脑血管疾病患者与健康人无显著性差异(P>0.05)。表明,血清中铜、锌、     

厌食症儿童血矿物质元素测定及相关性分析

目的探讨厌食症与矿物质元素钙、镁、铜、铁、锌、铅含量异常的相互关系。方法对符合诊断标准的220例厌食症患儿的血清矿物质元素检测结果与正常儿童检测结果进行1：1配对对照。结果厌食症组患儿血清铁和血清锌水平低于正常对照组,血铅含量高于正常对照组,差异有显著性意义（P〈0.01）,血清镁、铜、钙水平与对照组比较差异无显著性。结论锌、铁缺乏及铅水平升高与厌食症的发病有一定的关系,在厌食症治疗中,应注意检测血锌、铁及血铅含量。     

Transport of trace elements in lenses of normal and hereditary cataract UPL rats

The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of normal and hereditary cataract UPL rats to investigate the transport mechanisms of trace elements during cataract development. Be, Na, Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Tc, Ru and Rh accumulate in normal and UPL cataract rat lenses. The rates of uptake of trace elements differ among species and also differ between normal and UPL rat lenses. The uptakes of V and Sr are greater in normal rat lenses, while the uptakes of Mn and Co are greater in UPL rat lenses. High concentrations of Zn are transported into normal rat lenses in comparison with other elements. However, the uptake of Se was highest in the lenses of UPL cataract rats. In addition, the difference in Se uptake between the normal and UPL rat lenses was greatest among the tested trace elements. The present study suggests that the transport characteristics of trace elements are different in the lenses of normal and UPL cataract rats. The different transport characteristics of trace elements in the lenses of normal and UPL cataract rats, especially the higher accumulation of Se in UPL rat lenses, may be implicated in cataract development.     

肝硬变患者血清微量元素测定的临床意义

目的：探讨肝硬变患血清中微量元素含量的变化。方法：应用原子吸收分光光度法测定了102例肝硬变患血清中硒（Se^2 ),锌（Zn^2 ),铁（Fe^2 ),镁（Mg^2 )含量，并与62名正常健康人作对照，结果：肝硬变患血清中Se^2 ,Zn^2 ,Fe^2 ,Mg^2 含量减少（P＜0．01），而铜的水平则显升高（P＜0．01），Cu^2 /Zn^2 比值也显升高（P＜0．01），结论：检测肝硬变患血清中微量元素的变化有重要的临床意义。     

Analysis of essential elements in Pragya-peya--a herbal drink and its constituents by neutron activation

Ayurvedic herbal formulations are a good source of several nutrient elements essential for metabolic processes. Pragya-peya, a herbal drink and its 12 herbal constituents have been analyzed for 7 minor (Al, Ca, Cl, Mg, Na, K, P) and 15 trace (Ba, Br, Co, Cr, Cs, Fe, Hg, La, Mn, Rb, Sc, Se, Th, V, Zn) elements by instrumental neutron activation analysis (INAA). The method involves thermal neutron irradiation in a reactor followed by counting at several intervals. Also Cd, Cu, Ni and Pb contents were determined by atomic absorption spectrometry (AAS). Elemental data were validated by simultaneously analysing reference materials (RMs) such as mixed Polish herbs (INCT-MPH-2) and peach leaves (SRM-1547). Sample homogeneity was tested by analysing samples from three different batches collected at different intervals. Pragya-peya has been found to be especially rich in several nutrient elements such as Ca, K, V, Fe, Mn, Se and Zn whereas no single constituent is enriched in all the nutrient elements. Concentrations of elements are discussed vis-a-vis their medicinal/therapeutic uses. Several elements such as Na, K, P, Ca, Fe, Co, and Zn seem to be well correlated in 12 constituent herbs.     

甘露消渴胶囊中11种元素的含量分析

目的探讨中成药中元素的分布是否存在某种规律性。方法以微波消解法制备供试品,采用电感耦合等离子体-质谱（ICP—MS）法测定中成药甘露消渴胶囊中Cr,Mn,Cu,Zn,Se,Ni,V,Fe,Ca,Mg,K等11种元素的含量。结果甘露消渴胶囊中的Cr,Mn,Se,Ni,V,Fe,Ca,Mg,K相对含量较高,Cu／Zn比值较低。结论该测定结果为研究此类中成药中元素含量与治疗糖尿病之间的关系提供了参考数据。     

天津市胃癌发病因素的探讨——Ⅲ.血中维生素A、E及某些元素的变化与胃癌的关系

本研究为1∶1配对的病例对照研究,通过对97例胃癌病人和对照的血清维生素 A、E 和某些元素的分析,采用条件 Logistic 回归模型分析,发现病人血清维生素 A、E 和 Se、Zn、Ca 及 Zn/Cd 比值降低,Cu、Cd 和 Cu/Zn 比值增高是胃癌发生的危险因素,并都有明显的剂量反应关系。     

重组人生长激素治疗前后矮身材儿童血清钙及锌的变化

目的探讨生长激素缺乏症(Growth hormone deficiency,GHD)患者、非生长激素缺乏性矮身材(Non-GH deficient short stature,NGHDSS)患者及GHD患者应用生长激素治疗前后的钙、锌变化。方法20例GHD患者在治疗前及治疗3月后分别测钙、锌水平并观察他们的身高变化,并与20例NGHDSS患者和20例正常儿童进行对照。钙、锌采用生化仪测定。结果GHD患者治疗前血清钙水平与正常对照组无显著性差异(P=0．54),治疗3个月后血清钙水平较治疗前稍减低,但元显著性差异(P=0．892)。NGHDSS患者血清钙水平与GHD组无显著性差异(P=0．892),与正常对照组无显著性差异(P=0．64)。GHD患者治疗前血清锌水平与正常对照组无显著性差异(P=0．42),治疗3个月后血清锌水平较治疗前增加,有显著性差异(P=0．042,P＜0．05)。NGHDSS患者血清锌水平与GHD组无显著性差异(P=0．75),与正常对照组无显著性差异(P=0．48)。结论①GHD及NGHDSS患者血清钙水平正常,GHD患者短期治疗后略有降低,提示GHD患者治疗早期应适当补充钙制剂;②GHD及NGHDSS患者血清锌水平正常,GHD患者治疗后血锌水平上升,提示锌缺乏不是引起儿童严重矮身材的主要原因,生长激素治疗可促进锌的吸收。     

Metal analysis in citrus sinensis fruit peel and psidium guajava leaf

The determination of metal traces is very important because they are involved in biological cycles and indicate high toxicity. The objective of the present study is to measure the levels of heavy metals and mineral ions in medicinally important plant species, Citrus sinensis and Psidium guajava. This study investigates the accumulation of Copper (Cu), Zinc (Zn), Cadmium (Cd), Aluminum (Al), Mercury (Hg), Arsenic (As), Selenium (Se) and inorganic minerals like Calcium (Ca) and Magnesium (Mg) in C. sinensis (sweet orange) fruit peel and P. guajava (guava) leaf, to measure the levels of heavy metal contamination. Dried powdered samples of the plants were digested using wet digestion method and elemental determination was done by atomic absorption spectrophotometer. Results are expressed as mean ± standard deviation and analysed by student's 't' test. Values are considered significant at P < 0.05. The results were compared with suitable safety standards and the levels of Cu, Zn, Cd, Mg and Ca in C. sinensis fruit peel and P. guajava leaves were within the acceptable limits for human consumption. The order of concentration of elements in both the samples showed the following trend: Mg > Ca > Al > Zn > Cu > Cd > Hg = As = Se. The content of Hg, As and Se in C. sinensis fruit peel and P. guajava leaves was significantly low and below detection limit. The content of toxic metals in tested plant samples was found to be low when compared with the limits prescribed by various authorities (World Health Organization, WHO; International Centre for Materials Research, ICMR; American Public Health Association, APHA). The content of Hg, As and Se in C. sinensis fruit peel and P. guajava leaves was not detectable and met the appropriate safety standards. In conclusion, the tested plant parts taken in the present study were found to be safe.     

Comparative uptake behavior of trace elements in adult and suckling rat lens

The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of adult and suckling rats to investigate the transport mechanisms of trace elements during developmental maturation. Be, Sc, V, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Ru and Rh accumulate in adult and suckling rat lenses. The rates of uptake of trace elements differ among each species and also differ between adult and suckling rat lenses. The uptakes of Fe and Sr are greater in adult rat lenses, while the uptakes of Se and Rb are greater in suckling rat lenses. High concentrations of Zn are transported into the lenses of both adult and suckling rats in comparison with other elements, and the content of Zn in suckling rat lens is higher than in adult lens. The present study suggests that different mechanisms depending on the stage of development act to transport trace elements into lenses.     

Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation

To assess the co-effect of Se and Zn on Cd accumulation in the liver and kidney and on their histology, male rats were exposed either to Cd, Cd+Zn, Cd+Se, or Cd+Zn+Se in their drinking water, during 35 days. Exposure to Cd resulted in its accumulation in the liver and kidney. In the Cd-Zn and Cd-Zn-Se groups, Cd contents in the two organs were significantly (p < 0.01) higher than those in the Cd group. Se did not induce any significant difference in hepatic and renal concentrations of Cd in comparison to Cd-treated group. Light microscopic examination indicated severe histological changes in the two organs under Cd influence. Se or Zn partially alleviated the damage observed in the liver. The same effect was remarked in the kidney with Se, but no differences in the renal histological structure have been observed between the Zn-Cd and the control groups. With Se and Zn simultaneous treatment during Cd exposure, the observed morphological changes had practically disappeared from the liver, but were only reduced in the kidney. CONCLUSION: Se and Zn can have a cooperative effect in the protection against Cd-induced structural damage in the liver but not in the kidney.     

Concentration and reference interval of trace elements in human hair from students living in Palermo, Sicily (Italy)

Trace element contents in specimens of hair collected from 137 children aged 11-13 years old, living in Palermo (Sicily, Italy) were determined by ICP-MS. This work reports analytical data for the following 19 elements: Al, As, Ba, Cd, Co, Cr, Cu, Li, Mn, Mo, Ni, Pb, Rb, Sb, Se, Sr, U, V and Zn. The most abundant chemical elements were zinc and copper (Zn > Cu), with concentrations exceeding 10 μg/g (Zn = 189.2 μg/g; Cu = 22.9 μg/g). Other elements with concentrations greater than 1 μg/g were, in order of abundance, Al>Sr>Ba>Pb. The remaining elements were all below 1 μg/g. The average elemental concentrations in hair were statistically compared by Kolmogorov-Smirnov's test taking children's gender into account. Al, Ba, Cr, Li, Rb, Sb, Sr, V and Zn were statistically different according to gender, with significance p < 0.001. This study thus confirms the need for hair analysis to differentiate female data from those of males. IUPAC coverage intervals and coverage uncertainties for trace elements in the analysed hair samples are also reported.