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1.
Background Patients with sentinel lymph node (SLN) metastases need delayed completion axillary lymph node dissection (ALND) if intraoperative
assessment of SLN is not employed. This study was designed to compare morbidity in patients undergoing complete ALND in the
first (and only) operation versus those undergoing the two-step procedure (SLN biopsy followed by delayed completion ALND).
Methods Secondary analysis of the Axillary Lymphatic Mapping Against Nodal Axillary Clearance (ALMANAC) randomized trial compared
83 patients with SLN metastases who proceeded to delayed completion ALND (two-step ALND) with 96 node-positive patients who
underwent ALND as the only axillary procedure (one-step ALND). Outcome variables were assessed at baseline and at 3, 6, and
12 months after surgery.
Results The 83 SLN-positive patients undergoing completion ALND were younger (p = 0.038) compared with the one-step ALND group. There was no difference in lymphedema, sensory loss, intercostobrachial (ICB)
nerve division rates, impairment of shoulder movement, infection rate, or time to resumption of normal day-to-day activities
after surgery between the two groups. Median axillary operative time for completion ALND in the two-step group was significantly
higher than one-step ALND (33 min vs. 25 min, p = 0.004). The median hospital stay for the second surgery in the two-step group was similar to one-step ALND (6 days). The
total median hospital stay (first and second surgery) was significantly higher for the two-stage procedure (10 vs. 6 days,
p < 0.001).
Conclusion A two-stage axillary node dissection procedure in patients with SLN metastases has similar arm morbidity to one-stage ALND.
The second surgery is associated with increased axillary operative time and total hospital stay. 相似文献
2.
Badgwell BD Povoski SP Abdessalam SF Young DC Farrar WB Walker MJ Yee LD Zervos EE Carson WE Burak WE 《Annals of surgical oncology》2003,10(4):376-380
Background: Sentinel lymph node biopsy (SLNB) is gaining acceptance as an alternative to axillary lymph node dissection. The purpose of this study was to determine the frequency and pattern of disease recurrence after SLNB.Methods: Two-hundred twenty-two consecutive patients undergoing SLNB from April 6, 1998, to October 27, 1999, and who were 24 months out from their procedure were identified from a prospectively maintained database. Retrospective chart review and data analysis were performed to identify variables predictive of recurrence.Results: The median patient follow-up was 32 months (range, 24–43 months). A total of 159 patients (72%) were sentinel lymph node (SLN) negative and had no further axillary treatment. Five of these patients (3.1%) developed a recurrence (one local and four distant), with no isolated regional (axillary) recurrences. Sixty-three patients (28%) were SLN positive and underwent a subsequent axillary lymph node dissection. Six of these patients (9.5%) developed a recurrence (three local, one regional, and two distant). Pathologic tumor size (P < .001), lymphovascular invasion (P = .018), and a positive SLN (P = .048) were all statistically significantly associated with disease recurrence.Conclusions:With a minimum follow-up of 24 months, patients with a negative SLN and no subsequent axillary treatment demonstrate a low frequency of disease recurrence. This supports the use of SLNB as the sole axillary staging procedure in SLN-negative patients. 相似文献
3.
Cox C White L Allred N Meyers M Dickson D Dupont E Cantor A Ly Q Dessureault S King J Nicosia S Vrcel V Diaz N 《Annals of surgical oncology》2006,13(5):708-711
Background Sentinel lymph node (SLN) biopsy combined with microstaging-associated immunohistochemical staining for cytokeratin more accurately
assigns patients to their corresponding diagnostic stage. The purpose of this study was to compare the survival outcomes of
node-negative patients who received an SLN biopsy with historical control data of node-negative patients who received routine
complete axillary lymph node dissection (CALND) in the pre-SLN biopsy era.
Methods Under institutional review board approval, 2458 node-negative invasive breast cancer patients between the ages of 25 and 94
years (mean, 60 years) were treated at our institution from January 1986 to May 2004. Of these 2458 patients, 604 (25%) were
evaluated with CALND, whereas 1854 (75%) were evaluated with SLN biopsy. All were treated according to the current stage-specific
guidelines. Kaplan-Meier graphs of overall survival and disease-free survival were constructed for each group of patients,
and the two groups were compared by using the log-rank test.
Results Overall survival and disease-free survival for the CALND and SLN biopsy groups did not differ significantly (P = .98). The average number of lymph nodes extracted in the pre-SLN biopsy group was 18, whereas the average number of SLNs
extracted in the post-SLN biopsy group was 3.
Conclusions The survival rate among node-negative breast cancer patients who received an SLN biopsy alone has proven to have no significant
difference (P = .98) from the survival rate among node-negative patients who received a CALND. SLN biopsy alone should replace CALND as
the primary tool for axillary staging of breast cancer in node-negative patients. 相似文献
4.
Taback B Nguyen P Hansen N Edwards GK Conway K Giuliano AE 《Annals of surgical oncology》2006,13(8):1099-1104
Background Lymphatic mapping (LM) with sentinel lymph node (SLN) biopsy has revolutionized the surgical staging of primary breast cancer,
but its utility and feasibility have not been established in patients with ipsilateral breast tumor recurrence (IBTR) after
breast-conserving surgery (BCS) and radiation.
Methods We reviewed our breast cancer database to identify all patients who underwent preoperative lymphoscintigraphy for IBTR and
whose primary tumor had been managed by BCS, SLN biopsy and/or axillary node dissection, and adjuvant breast irradiation.
Results Preoperative lymphoscintigraphy identified migration to the regional nodal drainage basins in 11 (73%) of 15 patients, as
follows: 5 ipsilateral axillary, 1 supraclavicular, 2 internal mammary, 2 interpectoral, and 3 contralateral axillary. Two
patients demonstrated drainage to two nodal basins. In four patients, no drainage was observed. Intraoperative LM with radioisotope
plus blue dye identified at least 1 SLN in 11 of 14 patients, and histopathologic evaluation revealed metastasis in 3 patients
(2 contralateral axillary and 1 ipsilateral axillary). During preoperative lymphoscintigraphy, the radiocolloid migration
time tended to be longer and the drainage pathways more variable than those associated with primary tumors.
Conclusions LM/SLN biopsy can be successfully performed in patients with IBTR after prior BCS, axillary surgical staging, and adjuvant
radiation. This approach illustrates variations in the lymphatic drainage of recurrent breast tumors and may permit the identification
of regional metastasis not noted with conventional imaging techniques. 相似文献
5.
Zurrida S Galimberti V Orvieto E Robertson C Ballardini B Cremonesi M De Cicco C Luini A 《Annals of surgical oncology》2000,7(1):28-31
Background: Sentinel node (SN) biopsy may predict axillary status in breast cancer. We retrospectively analyzed more than 500 SN cases, to suggest more precise indications for the technique.Methods99mTc-labeled colloid was injected close to the tumor; lymphoscintigraphy was then performed to reveal the SN. The next day, during surgery, the SN was removed by using a gamma probe. Complete axillary dissection followed, except in later cases recruited to a randomized trial. The SN was examined intraoperatively by conventional frozen section, in later cases by sampling the entire node and using immunocytochemistry.Results: In the first series, the SN was identified in 98.7% of cases; in 6.7%, the SN was negative but other axillary nodes were positive; in 32.1%, the SN was negative by intraoperative frozen section but metastatic by definitive histology, prompting introduction of the exhaustive method. In the randomized trial, the SN was identified in all cases so far, the false-negative rate is approximately 6.5%, and in 15 cases, internal mammary chain nodes were biopsied.Conclusions: SN biopsy can reliably assess axillary status in selected patients. The problems are the SN detection rate, false negatives, and the intraoperative examination, which can miss 30% of SN metastases. Our exhaustive method overcomes the latter problem, but it is time consuming.Presented at the 52nd Annual Meeting of Society of Surgical Oncology, Orlando, Florida, March 4–7, 1999. 相似文献
6.
Background Sentinel node biopsy (SNB) for breast cancer has a false-negative rate of approximately 5%. Initial reports of follow-up show
lower axillary recurrence rates than expected. We performed axillary ultrasonography to determine whether occult recurrences
could be detected.
Methods In a community hospital setting, 289 patients who had SNB for breast cancer in a single surgeon’s practice underwent axillary
examination by the surgeon followed by axillary ultrasonography by a dedicated breast radiologist. Ultrasonography was performed
one time from 4 to 79 months (median, 25 months) after surgery. Five patients with suspicious nodes had ultrasound-guided
fine-needle aspiration, and one had a core biopsy.
Results No patient had suspicious nodes on clinical examination. Only six patients had ultrasound findings that warranted intervention.
Five patients had benign cytological characteristics, and one had a benign core biopsy result. No evidence of axillary recurrence
was found in any patient.
Conclusions Axillary ultrasonography did not detect occult metastases in any patient and is not recommended for routine follow-up after
SNB. The lack of ultrasound evidence of metastasis suggests that the recurrence rate is likely to remain low. 相似文献
7.
Background In this study we performed subdermal injection of 99mTc-labeled albumin combined with subareolar (SA) injection of blue dye, and we compared this technique with two techniques
previously used in terms of the success of sentinel lymph node (SLN) identification, false-negative (FN) rate, and the overall
accuracy and sensitivity of the three procedures. In all patients we performed a complete axillary lymph node dissection.
Methods From January 1999 to September 2004, a total of 195 patients with localized breast cancer were treated. Patients were subdivided
into three groups. In patients in group 1 (n = 115; January 1999 to December 2001), lymphoscintigraphy together with injection
of vital dye was performed; in group 2 (n = 40; January to October 2002), SA injection of blue dye alone was performed; and
in group 3 (n = 40; November 2002 to September 2004), SA injection of blue dye and subdermal injection of radioisotope was
performed.
Results The success rate of identifying an SLN by a combination of the two techniques was 95% in group 1 and 100% in group 3. The
FN rate was 9% in group 1 and 0% in groups 2 and 3. The overall accuracy of lymphatic mapping was 97% in group 1 and 100%
in groups 2 and 3. Sensitivity was 91% in group 1 and 100% in groups 2 and 3.
Conclusions This study of SA injection for SLN biopsy using dual tracers demonstrates a high SLN identification rate and an absent FN
rate. We propose that injection into the SA plexus is the optimal way to perform lymphatic mapping of the breast. This technique
seems to be feasible even in patients with multicentric cancers. 相似文献
8.
Fink AM Lass H Hartleb H Jurecka W Salzer H Steiner A 《Annals of surgical oncology》2008,15(3):848-853
Background One-half of breast cancer patients with positive sentinel lymph node (SN) have no further metastases in the axillary lymph
node basin. The aim of the present study was to identify patients with positive SN who are unlikely to have further metastases
in the axillary lymph node basin, using a new classification of SN, namely the S-classification.
Methods Specimens of positive SN were subjected to a pathological review according to the previously published S-classification. S-stages
of positive SN were correlated with the status of further metastases in the axillary lymph node basin after axillary lymph
node dissection (ALND).
Results Of 117 patients who underwent sentinel lymph node biopsy, 36 (30.8%) had a positive SN and were subjected to level I and II
ALND. The occurrence of positive nonsentinel nodes was significantly related to the S-stage of SN. No patient with stage SI
had additional metastases in the nonsentinel lymph nodes, while 14.3% of patients with SII stage disease and 60.9 % of patients
with SIII disease had other non-SN that were metastatic.
Conclusion S-stages of positive SN are highly predictive for axillary nonsentinel node status. Especially patients with SI sentinel node
metastases appear to be at low risk for further nonsentinel node metastases. 相似文献
9.
Subareolar Injection May Be More Accurate Than Other Techniques for Sentinel Lymph Node Biopsy in Breast Cancer 总被引:2,自引:1,他引:1
D'Eredita' G Ferrarese F Cecere V Massa ST de Carne F Fabiano G 《Annals of surgical oncology》2003,10(8):942-947
Background: The aims of this study were to compare peritumoral injection of 99mTc-labeled albumin and subdermal injection of blue dye with subareolar (SA) injection of blue dye alone in terms of success of the sentinel lymph node identification rate, false negative (FN) rate, overall accuracy, and sensitivity of the two procedures.Methods: From January 1999 to October 2002, 155 patients with localized breast cancer were treated. Patients were subdivided into two groups. In patients in group 1 (n = 115; January 1999 to December 2001), lymphoscintigraphy together with injection of vital dye was performed. In patients in group 2 (n = 40; January 2002 to October 2002), SA injection of blue dye alone was performed.Results: In patients in group 1, the overall successful identification rate was 94.8%. The success rate of identifying a sentinel lymph node by a combination of the two techniques was 95%. With blue dye alone, the successful identification rate was 94.6% in patients in group 1 (subdermal) and 97.5% in group 2 (SA). The FN rate was 9% in group 1 and 0% in group 2. The overall accuracy of lymphatic mapping was 97% in group 1 and 100% in group 2. Sensitivity was 91% in group 1 and 100% in group 2.Conclusions: This study of dye-only injection into the SA plexus demonstrates a high sentinel node identification rate, absent FN rate, and rapid learning curve. On the basis of these findings, we propose that injections into the SA lymphatic plexus are the optimal way to perform dye-only lymphatic mapping of the breast. 相似文献
10.
Axillary lymph node status is a prognostic marker in breast cancer management, and axillary surgery plays an important role in staging and local control. This study aims to assess whether a combination of sentinel lymph node biopsy (SLNB) using patent blue dye and axillary node sampling (ANS) offers equivalent identification rate to dual tracer technique. Furthermore, we aim to investigate whether there are any potential benefits to this combined technique. Retrospective study of 230 clinically node-negative patients undergoing breast-conserving surgery for single T1–T3 tumours between 2006 and 2011. Axillae were staged using a combined blue dye SLNB/ANS technique. SLNs were localized in 226/230 (identification rate 98.3 %). Three of one hundred ninety-two patients with a negative SLN were found to have positive ANS nodes and 1/4 failed SLNB patients had positive ANS nodes. Thirty-four of two hundred twenty-six patients had SLN metastases and 11/34 (32.4 %) also had a positive non-sentinel lymph node on ANS. Twenty-one of twenty-four (87.5 %) node-positive T1 tumours had single node involvement. Nine of thirty-eight node-positive patients progressed to completion axillary clearance (cALND), and the rest were treated with axillary radiotherapy. Axillary recurrence was nil at median 5 year follow-up. Complementing SLNB with axillary node sampling (ANS) decreases the unavoidable false-negative rate associated with SLNB. Appropriate operator experience and technique can result in an SLN localization rate of 98 %, rivalling a dual tracer technique. The additional insight offered by ANS into the status of non-sentinel nodes has potential applications in an era of less frequent cALND. 相似文献
11.
van Rijk MC Nieweg OE Rutgers EJ Oldenburg HS Olmos RV Hoefnagel CA Kroon BB 《Annals of surgical oncology》2006,13(4):475-479
Background Neoadjuvant chemotherapy in breast cancer patients is a valuable method to determine the efficacy of chemotherapy and potentially
downsize the primary tumor, which facilitates breast-conserving therapy. In 18 studies published about sentinel node biopsy
after neoadjuvant chemotherapy, the sentinel node was identified in on average 89%, and the false-negative rate was on average
10%. Because of these mediocre results, no author dares to omit axillary clearance just yet. In our institute, sentinel lymph
node biopsy is performed before neoadjuvant chemotherapy. The aim of this study was to evaluate our experience with this approach.
Methods Sentinel node biopsy was performed before neoadjuvant chemotherapy in 25 T2N0 patients by using lymphoscintigraphy, a gamma
ray detection probe, and patent blue dye. Axillary lymph node dissection was performed after chemotherapy if the sentinel
node contained metastases.
Results Ten patients had a tumor-positive axillary sentinel node, and one patient had an involved lateral intramammary node. Four
patients had additional involved nodes in the completion lymph node dissection specimen. The other 14 patients (56%) had a
tumor-negative sentinel node and did not undergo axillary lymph node dissection. No recurrences have been observed after a
median follow-up of 18 months.
Conclusions Fourteen (56%) of the 25 patients were spared axillary lymph node dissection when the sentinel node was found to be disease
free. Performing sentinel node biopsy before neoadjuvant chemotherapy seems successful and reliable in patients with T2N0
breast cancer. 相似文献
12.
We report a case of axillary recurrence after sentinel node biopsy without axillary lymph node dissection in a patient with
breast cancer. A hot and dye-stained node was identified at the primary operation and then at the time of axillary recurrence.
Sentinel node biopsy is a promising alternative to axillary lymph node dissection in patients with breast cancer because of
the low associated incidence of axillary recurrence. 相似文献
13.
临床腋淋巴结阴性乳腺癌前哨淋巴结研究 总被引:21,自引:2,他引:21
目的:探讨前哨淋巴结活检术(sentinel lymph node biopsy, SLNB)在乳腺癌治疗中的应用。方法:使用专利蓝和美蓝染色,对1999年9月~2001年4月连续收治的145例临床查体腋窝淋巴结阴性乳腺癌病人行前哨淋巴结活检术。结果:SLNB成功率为96.5%(140/145),假阴性率为23.5%,准确率为91.4%。病人年龄、肿瘤最大径、肿瘤部位、注射染料类型及是否活检对成功率和假阴性率无影响。结论:SLNB能够准确预测腋窝淋巴结的转移状况,在缩小手术范围、减少术后并发症的同时,提高了腋窝淋巴结分期的准确性;美蓝与专利蓝均可成功确定SLN。 相似文献
14.
Axillary Recurrence After Sentinel Node Biopsy 总被引:3,自引:0,他引:3
Jeruss JS Winchester DJ Sener SF Brinkmann EM Bilimoria MM Barrera E Alwawi E Nickolov A Schermerhorn GM Winchester DJ 《Annals of surgical oncology》2005,12(1):34-40
Background Sentinel node biopsy (SNB) has evolved as the standard of care in the surgical staging of breast cancer. This technique is accurate for surgical staging of axillary nodal disease. We hypothesized that axillary recurrence after SNB is rare and that SNB may provide regional control in patients with microscopic nodal involvement.Methods With institutional review board approval, SNB was performed with peritumoral injection of 99mTc-labeled sulfur colloid. From 1996 to 2003, 1167 patients were entered into a prospective cancer database after surgical therapy; 916 patients consented to long-term follow-up. Fifty-two patients (5.7%) did not map successfully and were excluded, leading to a study population of 864 patients. The median follow-up was 27.4 months (range, 1–98 months).Results The median number of sentinel nodes harvested was 2, and 633 (73%) patients had negative sentinel nodes. Thirty (4.7%) of those sentinel node–negative patients underwent completion axillary dissection, whereas 592 (94%) patients were followed up with observation. A total of 231 (27%) had positive sentinel nodes: 158 (68%) of these patients underwent completion axillary dissection, and 73 (32%) were managed with observation alone. Two (.32%) patients who were sentinel node negative had an axillary recurrence; one of these patients had undergone completion axillary dissection. No patient in the observed sentinel node–positive group had an axillary recurrence (odds ratio, .37; P = .725).Conclusions On the basis of a median follow-up of 27.4 months, axillary recurrence after SNB is extraordinarily rare regardless of nodal involvement, thus indicating that this technique provides an accurate measure of axillary disease and may impart regional control for patients with node-positive disease. 相似文献
15.
Background Postoperative changes after axillary lymph node surgery may significantly alter breast cancer survivors’ (BCS) quality of
life. Although sentinel lymph node biopsy (SLNB) has less immediate morbidity than axillary lymph node dissection (ALND),
its long-term impact on shoulder abduction, arm swelling, and neurosensory changes has not been evaluated. The purpose of
this study was to compare long-term morbidity after SLNB or ALND and breast-conservation surgery.
Methods Female BCS who remained free of disease at least 3 years after ALND or SLNB for Stage I–III unilateral breast cancer completed
a symptom questionnaire and a brief neurosensory physical examination of the upper arm and axilla (range of motion, arm circumference,
and sensation to light touch with cotton and needle).
Results The mean age of the 187 participating BCS was 62 years. At a mean follow-up of 6.6 years after ALND and 4.9 years after SLNB,
most BCS had full abduction; only 10 cases (8 ALND, 2 SLNB) had a ≥2 cm proximal and/or distal circumference difference on
the ipsilateral side compared with the contralateral side. ALND was associated with a significantly greater likelihood of
subjective arm numbness (P < .001), chest or axillary numbness (P < .001), arm or hand swelling (P < .001), and objective neurosensory changes in the posterior axilla, medial and distal upper arm (P < .001). Operative procedure was the only significant predictor of neurosensory changes (P < .001).
Conclusion SLNB is associated with significantly less subjective and objective long-term morbidity than ALND. 相似文献
16.
Background: The significance of breast cancer sentinel lymph node (SLN) metastases detected only by immunohistochemistry staining (IHC) remains poorly understood. This study attempted to quantify the risk of non-SLN metastases.Methods: A prospectively collected database of 750 consecutive SLN biopsy procedures in breast cancer patients was reviewed. Medical records were reviewed to supplement the database.Results: SLNs were identified in 738 (98.4%) of these procedures in 723 patients. Of these, 151 patients (20.5%) had metastases detected by hematoxylin and eosin staining (H&E), and 33 (4.6%) of the 718 with known IHC staining results had metastases detected by IHC only. Twenty-eight (84.8%) of 33 patients with IHC-detected metastases underwent complete axillary lymph node dissection (CALND). The median primary tumor size was 2.0 cm among those undergoing CALND and 0.9 cm among the five patients treated without CALND (P = .10). Two of the 28 patients (7.1%) had additional metastases detected with CALND. These patients had a T3 or T4 invasive lobular primary tumor. Of 24 patients with T1 or T2 primary tumors and IHC-detected metastases who underwent CALND, none had additional metastases detected. Median follow-up was 14.5 months. All patients with IHC-detected SLN metastases were treated with adjuvant systemic therapy. None of the five patients with IHC-detected metastases not undergoing CALND has subsequently manifested clinical axillary disease.Conclusions: CALND could have been or was safely omitted in 29 of 29 patients with T1 or T2 primary tumors and metastases detected by IHC. Such patients should be counseled about this low risk before CALND is recommended. 相似文献
17.
乳腺癌前哨淋巴结活检的研究进展 总被引:4,自引:0,他引:4
目的 报道乳腺癌前哨淋巴结活检的研究进展。方法 采用文献回顾的方法,对国外乳腺癌前哨淋巴结活检的历史、概念、活检技术以及临床应用等问题进行综述。结果 乳腺癌前哨淋巴结活检的操作方法还没有统一的标准,检出率及假阴性率变化范围广。结论 前哨淋巴结活检的临床应用还需要大量前瞻性多中心随机实验结果进一步论证。 相似文献
18.
van der Ploeg IM Kroon BB Antonini N Valdés Olmos RA Rutgers EJ Nieweg OE 《Annals of surgical oncology》2008,15(4):1025-1031
Background At our institution, tracer fluids are administered in the primary breast cancer and, in addition to the ones in the axilla,
sentinel nodes outside the axilla are rigorously pursued. The objective of the present study of sentinel node-negative breast
cancer patients was to determine the lymph node recurrence rates in the axilla and elsewhere, the false-negative rates, and
the survival.
Methods Between January 1999 and November 2005, 1,019 breast cancer patients underwent a sentinel node biopsy. In 748 of them, 755
sentinel node biopsies did not reveal a tumor-positive sentinel node and they did not undergo axillary node dissection. Metastases
were revealed in 284 sentinel node biopsies performed in the remaining 271 patients: 247 in the axilla, 20 outside the axilla,
and 17 both in the axilla and elsewhere. The median follow-up duration was 46 months.
Results Two of the 748 sentinel node-negative patients developed an axillary lymph node recurrence (0.25%) and two others developed
a supraclavicular lymph node recurrence (0.25%). The overall lymph node recurrence rate was 0.5%. The false-negative rates
were 1.4% overall, 0.8% for the axilla, and 5.1% for the extra-axillary nodes. After five years, 95.9% of all sentinel node-negative
patients were alive and 89.7% were alive without evidence of disease.
Conclusion The low recurrence and false-negative rates and promising survival figures show that our lymphatic mapping method with intralesional
tracer administration is accurate for the axilla. Outside the axilla, 5.1% of involved sentinel nodes were missed. 相似文献
19.
A New Radiocolloid for Sentinel Node Detection in Breast Cancer 总被引:1,自引:0,他引:1
Hodgson N Zabel P Mattar AG Engel CJ Girvan D Holliday R 《Annals of surgical oncology》2001,8(2):133-137
Background:The optimal radioactive tracer and technique for sentinel lymph node localization in breast cancer is yet to be determined. The dilemma of small particle size with dispersion to second echelon nodes versus failure of migration of larger radiocolloids needs to be resolved. A new radiocolloid preparation with particle size under 0.1 micron was developed with excellent primary/post lymphatic entrapment ratio.Objective:To assess the feasibility of a new 99mTc radiocolloid cysteine-rhenium colloid in sentinel lymph node (SLN) localization for breast cancer.Methods:Forty-seven patients with newly diagnosed T1 or T2 breast cancer underwent injection of 99mTc-labeled cysteine-rhenium colloid followed by lymphoscintigraphy. Same day SLN biopsy with patent blue dye and intraoperative gamma probe to identify SLNs were performed.Results:SLN mapping and intraoperative localization were successful in 46/47 (98%) of patients. The blue dye radioactive tracer concordance was 94%. There was one false-negative in a patient with a nonpalpable tumor that underwent ultrasound-guided peritumoral radiocolloid injection.Conclusions:99mTc-cysteine-rhenium colloid is highly effective in identifying SLNs. It has the advantage of smaller particle size than sulfur colloid with easier lymphatic migration. It has a more neutral pH with less pain on injection and does not require filtration, thereby minimizing radiation exposure to technologists.Presented at the 53rd Annual Meeting of the Society of Surgical Oncology, New Orleans, Louisiana, March 16–19, 2000 相似文献
20.
乳腺癌腔镜前哨淋巴结活检83例临床分析 总被引:1,自引:1,他引:1
目的探讨染料法腔镜腋窝前哨淋巴结活检在乳腺癌中的可行性和临床意义。方法应用亚甲蓝染色法对83例Ⅰ、Ⅱ期乳腺癌行腔镜前哨淋巴结活检(ESLNB),然后行腔镜腋窝淋巴结清扫(EALND)。对获取的全部淋巴结行病理检查,评价前哨淋巴结检出率、准确率及假阴性率。结果83例中73例检出前哨淋巴结,检出率87.9%(73/83)。ESLNB准确率97.3%(71/73),灵敏性88.2%(15/17),特异性100.0%(56/56)。结论染料法腔镜腋窝前哨淋巴结活检临床可行,能够对早期乳腺癌进行准确分期,但体重指数高、肿瘤部位在内侧、术前肿瘤切除活检、腔镜技术欠熟练等是影响前哨淋巴结检出的主要因素。 相似文献