Formation of a tetraene from 18beta-glycyrrhetic acid (author's transl)]

Formation of a Tetraene from 18β-Glycyrrhetic Acid . Starting from 18β-glycyrrhetic acid, 30nor-11α-methyl-3β, 11β-dihydroxyoleantriene (12, 18, 20) ( 5 ) and 30nor-11-methyl-3β-hydroxyoleantetraene (9, (11), 12, 18, 20) ( 7 ) have been synthesized.     

Polychlorodibenzo-p-dioxins (author's transl)]

Polychlorodibenzo-p-dioxins (chlorodioxins) appear most frequently by heating of chlorophenols in alkaline solution specially when producing organic derivatives. Consequently chlorodioxins may contaminate several industrial chemical products largely used, for instance, as pesticides. Occasionally, chlorodioxins are also synthesized from chlorophenols or their derivatives in situ during industrial processes. Chlorodioxins are the cause of chloracne and chick edema which killed thousands of broiler chickens in the U.S.A. Furthermore chlorodioxins seem to be foetotoxic possible even for man. The present paper is the first part of our work. It is a review of the chemical and toxicological properties of chlorodioxins. We hope to publish later a review of analytical methods and the results of our analyses.     

Pyranylidene-anthrones (author's transl)]

Pyranylidene-anthrones . The 2,6-diphenyl-pyrones 1a , 1b and the distyrylpyrones 13a – e react with anthrone in acetic anhydride to the pyranylidene-anthrones 3a , 3b and 14a – e . Condensation, hydrogenation, oxidation and substitution reactions of these compounds are described.     

Dihydroisoquinoline-rearrangement (author's transl)]

Dihydroisoquinoline-Rearrangement . The synthesis of 1-picolyl-1,2-dihydroisoquinoline 7 is reported. With acids 7 gives not the expected rearrangement, but elimination of the C- 1 -substituent leading to the products 8 and 9 . Surprisingly this elimination-reaction occurs also in the polar solvents methanol or water at room temperature in quantitative yield.     

The antiviral activity of performic acid (author's transl)]

Under the experimental conditions chosen by the authors, it was demonstrated that the antiviral activity of performic acid against Coxsackie virus B 1 is greater than that of peracetic acid.     

Fluorimetric in situ-determination of acetylsalicylic acid (author's transl)]

Fluorimetric in Situ-Determination of Acetylsalicylic Acid . The quantitative fluorimetric in situ-determination of acetylsalicylic acid by thin layer chromatography is described. The method is used for single dose analysis (content uniformity) and based on anthranilic acid as internal standard. The reproducibility is of the order of 1,1% and 2,4% for single tablets (relative standard deviation).     

1,8-Naphthyridine-derivatives from dehydrogenative cyclization (author's transl)]

1,8-Naphthyridine-Derivatives from Dehydrogenative Cyclization . The mercuric EDTA dehydrogenation of 3-(3-aminopropyl)-substituted 1-methylpiperidines yields products with substitution in the 2- and 6-position of the piperidine ring. The reaction in 6-position gives exclusively 6-piperidones, while attack of the 2-position yields octahydro-1,8-naphthyridines, which are partially hydrolysed to 2-piperidones. With 1,7,7-trimethyl-decahydro-1,8-naphthyridine an aminal could be isolated as an intermediate in a double dehydrogenation for the first time.     

Imidazo(4,5-g)quinolines (author's transl)]

Imidazo[4,5-g]quinolines . Two ways for the preparation of the heterotricycle imidazo[4,5-g]quinoline ( 8b ) and two of its partially reduced derivatives, 5,6,7,8-tetrahydro-imidazo[4,5-g]quinoline ( 8c ) and 4,4a,5,6,7,8,8a,9-octahydro-imidazo[4,5-g]quinoline ( 8d ), are described.     

Isoxazolo(5.4-b)pyridines (author's transl)]

Isoxazolo (5.4-b)Pyridines NMR and IR-spectra of 12 isoxazolo (5.4-b)pyridine-5-carboxylic acid esters are described. The amine and hydroxyl proton resonance positions in the NMR spectra and the bands of the NH/OH and C = O stretching vibrations in the IR spectra show the existence of a chelated form between the NH (OH) proton and the ester carbonyl group. The influence of lanthanide shift reagents on the proton groups in the isoxazolopyridine system is investigated.     

Methaqualon-like benzothienopyrimidines (author's transl)]

Methaqualon-like Benzothienopyrimidines A group of basically substituted 2-methyl-3-(o-tolyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3- d]-pyrimidin-4(3H)-ones Ia–d was synthesized by cyclization of the corresponding 2-acylamino-5,6,7,8-tetrahydrobenzo[b]thiophene-3-carboxylic o-toluidides. The methaqualone analogues 4a and 4b were also prepared, preferably via the ethoxymethylene compunds 3a and 3b .     

Studies on the metabolism of l-asparaginic acid (author's transl)]

After infusion of DL-asparaginic acid (Inzolen) during operation the pharmacokinetics of L-aspartic acid were followed by means of enzymatic determinations in serum and urine samples. The level of L-aspartic acid in the serum increases during the infusion of 250 ml of Inzolen-Infusion (18.54 g DL-aspartic acid) from an original value of 2 mg/l to a maximal value of 156 mg/l, reached at the end of the infusion. Two hours after the termination of infusion, the aspartic acid level returns almost to its original value. Only 20% of the infused L-aspartic acid is excreted unmetabolized.     

Androsace septentrionalis (author's transl)]

Morphology, culture requirements, and medicinal effects of Androsace septentrionalis L. (Primulaceae) are described. In mice, water extracts of the plant (.5 ml/100g body weight) produced disturbances of the menstrual cycle and infertility after copulation. Histological studies showed enlargement of glandular mucosa cells and increased uterine connective tissue. Compared with controls, more corpora lutea were found in the fallopian tubes of treated animals. The plant is used in Siberian folk medicine for angina, heart diseases, epilepsy, gonorrhea, and as a contraceptive. The contraceptive and tranquilizing effects of the water extract of Androsace were evident in this experimentation.     

On the enteral absorption of valproic acid (author's transl)]

The absorption of valproic acid (dipropylacetic acid, DPA)--administered by capsules (free valproic acid) and dragees (valproate sodium)--has been studied. Regarding their bioavailability, both forms of administration examined are equivalent, which means that they are representing therapeutical alternatives.