农村维吾尔族成人慢性牙周炎与高血压的相关性

目的 探讨农村维吾尔族成人慢性牙周炎与高血压的相关性.方法 采用分层随机抽样的方法从新疆维吾尔自治区墨玉县364个自然村按容量比例概率抽样,随机抽取1415名维吾尔族成人(≥18岁),进行问卷调查、体格测量、实验室检查及口腔检查.依据慢性牙周炎的诊断标准,将调查对象分为牙周炎组和非牙周炎组,其中牙周炎组按其严重程度进一步分为:轻度牙周炎组,中度牙周炎组和重度牙周炎组.牙周炎与高血压的关系采用Spearman相关分析.应用logistic回归模型对高血压相关影响因素进行分析.结果 慢性牙周炎患病粗率为66.0％( 934/1415),高血压患病粗率为33.8％ (478/1415),非牙周炎及轻度、中度、重度牙周炎组高血压的患病比例为18.7％(90/481),35.1％ (131/373),32.3％ (62/192),52.8％ (195/369).Speaman相关分析结果显示牙周炎与高血压呈正相关(rs =0.273,P＜0.01).校正年龄、性别、体质指数、腰围、糖代谢异常、高脂血症、慢性肾脏病后,多因素logstic回归分析显示牙周炎组高血压患病风险为非牙周炎组的1.75倍(OR= 1.75,95％CI:1.30 ～2.36,P＜0.01),轻度牙周炎组高血压患病风险为非牙周炎组的1.76倍(OR=1.76,95％ CI:1.26 ～2.48,P＜0.01),中度牙周炎组高血压患病风险为非牙周炎组的1.21倍(OR= 1.21,95％ CI:0.80～1.84,P＞0.05),重度牙周炎组高血压患病风险为非牙周炎组的2.26倍(OR =2.26,95％ CI:1.57 ～3.26,P＜0.01).结论 农村维吾尔族成人慢性牙周炎与高血压独立相关.     

血清尿酸水平与冠状动脉左主干病变的相关性研究

目的 探讨血尿酸水平与冠状动脉左主干(LM)病变程度的关系. 方法根据冠状动脉造影结果将156例患者依据LM病变程度分为轻度狭窄组18例、中度狭窄组53例、重度狭窄组62例、完全闭塞组23例.分别检测每组患者血尿酸水平. 结果轻度狭窄组和中度狭窄组、重度狭窄组和完全闭塞组血尿酸水平分别为(368±56)μmol/L、(456±52)μmol/L、(486±58)μmol/L和(469±63)μmol/L,随冠状动脉左主干狭窄程度增加血尿酸水平逐渐升高(F=3.89,P=0.042),但完全闭塞组较重度狭窄组又出现血尿酸水平的下降(t=2.17,P=0.039). 结论冠心病患者的血清尿酸水平随冠状动脉左主干病变程度的加重而递增.     

非酒精性脂肪性肝病严重程度与代谢综合征的相关性研究

目的 探讨代谢综合征(MS)对非酒精性脂肪性肝病(NAFLD)严重程度的影响.方法 选择上海中医药大学附属普陀医院NAFLD患者148例,CT检查诊断脂肪肝,检测腰围、体质量指数、血压、肝功能、尿酸、血脂、血糖、胰岛素、胰岛素抵抗指数、超敏CRP及铁蛋白等指标,分析MS与不同严重程度NAFLD的关系.结果 轻、中、重组NAFLD的代谢综合征患病率分别为53.2％、52.4％、70.4％,按MS组分进行评分,MS组分重度组较轻度组升高(P=0.045).多元线性回归分析结果显示,AST(β=-0.320,P=0.025)、HOMA-IR(p=-0.978,P=0.015)及铁蛋白(β=-0.399,P=0.000)是影响NAFLD严重程度的独立预测因素.结论 伴有MS的NAFLD肝脏脂肪浸润程度较无MS的NAFLD更严重,且随着MS组分的增加,NAFLD肝脏脂肪浸润程度加重.     

成人左向右分流先天性心脏病封堵术前NT-proBNP浓度与肺动脉高压的临床意义

目的 通过检测成人左向右分流先天性心脏病介入封堵术前血浆氮末端脑钠肽前体(NT-proBNP)浓度,研究NT-proBNP与肺动脉高压(PAH)关系,为临床评价先天性心脏病相关性PAH的程度提供参考.方法 2010年6月-2010年10月成功封堵的先天性心脏病患者83例为病例组,选20名健康正常人作为对照组.依据肺动脉平均压(mPAP) 将病例组分为4组:正常PAH组(36例)、轻度PAH组(14例)、中度PAH组(12例)、重度PAH组(21例).所有患者术前均行右心导管检查,测右房、右室压力、肺动脉收缩压(SPAP)、肺动脉平均压(mPAP)、全肺阻力(PVR).测定患者术前血浆NT-proBNP浓度,分析与肺动脉压力相关性.结果 各PAH组血浆NT-proBNP水平明显高于正常对照组,重度PAH组>中度PAH组>轻度PAH组>无PAH组>正常对照组,差异有统计学意义(P<0.01).NT-proBNP水平与mPAP(r=0.893,P=0.000)、SPAP(r=0.921,P=0.000)、PVR(r=0.844,P=0.000)呈正相关.血浆NT-proBNP浓度67.5 pg/mL诊断轻度PAH灵敏度92.9%,特异度94.4%,曲线下面积92.9%;147.0 pg/mL诊断中度PAH灵敏度91.7%,特异度75.8%,曲线下面积79.5%;236.5 pg/mL诊断重度PAH灵敏度95.2%,特异度73.0%,曲线下面积97.8%.结论 成人左向右分流先天性心脏病患者血浆NT-proBNP水平随肺动脉压力升高而逐渐增加,可作为评价肺动脉高压的程度的一项指标.     

高龄急性冠状动脉综合征患者冠状动脉狭窄与肾功能的相关性

目的研究高龄急性冠状动脉综合征(ACS)患者的冠状动脉狭窄程度与肾功能指标的相关性。方法连续入选536例年龄≥80岁的ACS患者,根据Gensini评分将患者分为对照组66例,轻度狭窄组141例,中度狭窄组167例,重度狭窄组162例。比较各组肾功能指标与Gensini评分的相关性。结果与对照组比较,轻度狭窄组、中度狭窄组和重度狭窄组患者随着冠状动脉狭窄程度的加重,血清肌酐、尿素和胱抑素C水平明显升高(P<0.01),估算肾小球滤过率(eGFR)明显降低(P<0.05)。血清肌酐(r=0.1 93,P=0.000)、尿素(r=0.194,P=0.000)、胱抑素C(r=0.295,P=0.000)与Gensini评分呈正相关,eGFR(r=-0.160,P=0.001)与Gensini评分呈负相关。结论年龄≥80岁ACS患者冠状动脉狭窄程度与肾功能指标密切相关。血清胱抑素C水平最敏感。     

诱导痰嗜酸粒细胞与慢性持续期支气管哮喘病情严重程度的关系

目的 观察初诊不同病情严重程度慢性持续期支气管哮喘(简称哮喘)患者的诱导痰嗜酸粒细胞(eosinophil,EOS)比例变化,探讨二者之间的关系,并分析诱导痰EOS比例与肺功能的相关性.方法 收集专科门诊就诊的63例初诊慢性持续期哮喘患者,根据症状分为轻度持续、中度持续、重度持续3组,分别予诱导痰和肺功能检查.观察不同病情严重程度的患者气道炎症状况.对所得数据用SPSS 15.0软件分析,各组间总体分析采用Kruskal-Wallis法,两组间分析采用Mann-Whitney U test法.结果 ①慢性持续期患者诱导痰EOS比例随病情严重程度增加呈增高趋势,重度持续患者诱导痰EOS比例显著高于轻度持续患者(41.8%vs 17.8%,P=0.033),但轻度持续与中度持续、中度持续与重度持续患者之间比较诱导痰EOS比例差异无统计学意义(P>0.05);②诱导痰EOS比例与第1秒用力呼气容积差异无统计学意义(r=-0.111,P>0.05),与第1秒用力呼气容积/用力肺活量(%)差异无统计学意义(r=-0.154,P>0.05).结论 慢性持续期哮喘患者病情严重程度与诱导痰EOS比例有关,但症状不能完全反映气道炎症程度.评价哮喘患者的严重程度时应结合临床症状和气道炎症程度综合考虑.     

抑郁对不同类型缺血性心力衰竭患者的预后影响

目的分析抑郁对不同类型缺血性心力衰竭患者的预后影响。方法纳入缺血性心力衰竭患者535例,其中射血分数保留的心力衰竭(HFpEF)241例、射血分数中间值的心力衰竭(HFmrEF)142例和射血分数减低的心力衰竭(HFrEF)122例。用患者健康问卷量表进行抑郁测评,分为抑郁组218例和正常组317例,抑郁包括轻度、中度、中重度和重度。随访36个月,失访30例。采用Kaplan-Meier曲线分析累积生存率。结果抑郁组总病死率高于正常组(39.00%vs 30.16%,P=0.040),Kaplan-Meier曲线分析显示,随抑郁程度加重累积生存率减低(P=0.000)。HFpEF和HFmrEF患者随抑郁程度加重总病死率无统计学差异(P=0.524,P=0.189);HFrEF患者随抑郁程度加重总病死率逐渐上升,不同抑郁程度总病死率有统计学差异(38.89%vs 52.94%vs 66.67%vs83.88%,P=0.014);HFpEF、HFmrEF、HFrEF累积生存率均随着抑郁程度加重而减低(P=0.000)。结论抑郁对不同类型缺血性心力衰竭患者预后影响存在差异,抑郁增加HFrEF患者总病死率。     

难辨梭状芽孢杆菌与炎症性肠病关系的初步研究

目的 通过对炎症性肠病(IBD)患者粪便中难辨梭状芽孢杆菌(Cd)的检测,了解IBD患者中该菌的感染情况及其与IBD的关系.方法 收集2009年12月至2011年1月上海交通大学医学院附属瑞金医院消化科确诊的IBD患者130例,包括溃疡性结肠炎(UC)患者60例及克罗恩病(CD)患者70例.同时收集肠易激综合征(IBS)患者及无肠道疾患的健康人群各60例为对照.通过聚合酶链反应( PCR)和Cd毒素快速测试试剂盒(CDTK)方法对粪便样本中毒素A、毒素B基因进行检测,采用SPSS软件进行统计分析.结果 纳入研究的130例IBD患者中,Cd感染者16例(12.3％),其中UC 10例(16.7％),CD 6例(8.6％);对照组中未发现Cd感染者(x2=15.779,P=0.000).处于活动期的IBD患者Cd感染率显著高于非活动期患者(x2=10.092,P=0.001).结肠型CD患者的感染率为4/14,显著高于其他类型的CD患者(x2=13.125,P=0.001).轻度UC患者Cd感染率为4.5％、中度为14.3％、重度为6/17(x2=6.667,P=0.037);轻度CD患者的Cd感染率为0％、中度为4.2％、重度为5/16,感染率随疾病严重程度的上升而增高(x2=13.907,P=0.000).使用广谱抗生素的患者与未使用者其Cd感染率差异无统计学意义(x2=1.414,p=0.378);免疫抑制剂与广谱抗生素同时使用者和单用广谱抗生素者Cd感染率差异亦无统计学意义(x2=0.330,P=0.962).结论 IBD患者中存在着一定的Cd感染率,尤其是处于疾病活动期的患者,感染率随IBD疾病严重程度的上升而增高.     

COPD患者肺动脉高压与急性加重的相关研究

目的 探讨COPD患者肺动脉高压对急性加重的预测作用.方法 收集2013至2015年因COPD急性加重入院的76例患者资料,随访8个月,记录心脏彩超所测收缩期肺动脉压(systolic pulmonary artery pressure,sPAP)、急性加重次数.结果 肺动脉压正常组和轻度肺动脉高压组间急性加重次数差异无统计学意义;中度、重度肺动脉高压组的急性加重次数均多于肺动脉压正常组、轻度肺动脉高压组,中度肺动脉高压组与重度肺动脉高压组的急性加重次数差异无统计学意义.肺动脉压力和有无急性加重发生的 ROC曲线下面积 AUC=0.786 (95% CI :0.684~0.887), P=0.000,最佳界值点为sPAP=50 mmHg,敏感度64%,特异度88.5%,阳性预测值91.2%,阴性预测值56.97%.结论 因COPD急性加重而住院的患者 sPAP>50 mmHg 可作为再次急性加重的预测因子,中重度肺动脉高压的COPD患者可发生更频繁的急性加重.     

乌鲁木齐市汉族老年人糖代谢异常的流行病学调查

目的 调查乌鲁木齐市60岁以上老年汉族居民糖尿病和糖尿病前期的患病率以及分布特点.方法 对乌鲁木齐市2个社区的居民进行查体及75 g葡萄糖耐量试验,共调查2210例,其中60岁以上老年人(老年组)为1231例,40～59岁中年人(中年组)951例.糖尿病诊断标准采用1999年WHO标准.结果 老年组糖尿病和糖尿病前期的患病率分别为32.2%、29.0%,标化后分别为25.6%、23.1%;较中年组患病率高(分别为12.3%、20.9%),差异有统计学意义(x2=192.62,P＜0.05);老年组糖耐量受损(IGT)患病率(21.6%)高于中年组(13.9%),差异有统计学意义(x2=20.97,P＜0.05);单IFG患病率在老年组与中年组间差异无统计学意义;老年组代谢综合征患病率为52.2%,高于中年组(33.7%),差异有统计学意义(x2=73.77,P＜0.05).回归分析结果显示,糖尿病家族史、高血压、高甘油三酯血症是老年人糖尿病发生的危险因素(x2=44.34,P＜0.05).结论 老年汉族人群糖尿病、IGT及代谢综合征的患病率均高于中年人群,必须重点采取干预措施.     

培哚普利治疗原发性高血压的临床观察

目的观察培哚普利对原发性高血压的降压作用及副反应。方法３７例轻中度原发性高血压患者予培哚普利共８周，评价对随诊血压及２４ｈ动态血压的影响。结果治疗４周收缩压（ＳＢＰ）无明显降低（Ｐ＞０．０５），舒张压（ＤＢＰ）明显降低（Ｐ＜０．００１），８周ＳＢＰ、ＤＢＰ均明显降低（Ｐ＜０．００１），随诊血压降压有效率分别为５４．１％（４周）及６７．６％（８周），２４ｈ动态血压曲线８周时呈明显下降，除咳嗽外未发现其他严重副反应。结论培哚普利对轻中度原发性高血压是安全有效的降压药物。     

2008年天津市地方性氟中毒病区成人氟骨症流行病学调查

目的 了解2008年天津市地方性氟中毒病区成人氟骨症的流行现状,为防治工作提供科学依据.方法 2008年4-6月,在天津市氟中毒轻、中、重病区,采用分层抽样方法抽取55个村,检测饮用水水氟,对16岁以上人群进行氟骨症临床检查;在55个病村中按轻、中、重分层抽取20个病村,对患者或疑似患者进行氟骨症X线检查.结果 在轻、中、重病区,水氟几何均值分别为1.35、3.44、5.49 mg/L,临床氟骨症检出率分别为6.4%(385/6016)、6.5%(757/11723)、27.8%(1538/5539).随年龄的增长,氟骨症检出率逐渐增高(r=0.534,P<0.01),临床病情也随年龄增长(H=84.813,P<0.01).轻、中、重病区X线氟骨症检出率分别为36.7%(44/120)、20.6%(33/160)、39.4%(43/109).随年龄的增长,氟骨症X线检出率逐渐增高(r=0.990,P<0.01),X线下病情也随年龄增长(H=25.169,P<0.01).临床、X线氟骨症检出率男女比较差异无统计学意义(X2=0.343、3.532,P均>0.05).结论 天津市氟骨症病区成人氟骨症尚存在一定程度的流行,地方性氟中毒尚未达到完全控制.仍应坚持病区改水以改善病情.     

代谢综合征与前循环脑梗死相关性的研究

目的 研究代谢综合征(MS)及其各组分与前循环脑梗死(ACI)的关系.方法 ACI组271例,诊断符合<中国脑血管病防治指南>脑梗死牛津郡社区卒中研究分型标准,并经CT或MRI证实;对照组147例,均为门诊健康体检者.观察MS在ACI组和对照组的患病率、MS各组分水平以及MS对ACI的危险度.MS诊断采用修订后的中国人MS诊断标准.结果 ACI组和对照组MS的患病率分别为43.17%和19.05%,两组差异有统计学意义(P<0.01).ACI组MS各组分水平与对照组间差异均有统计学意义(P值均<0.05).MS使ACI发病的危险增加3.7倍(P<0.01).结论 MS与ACI关系密切,MS是ACI的重要危险因素.     

血栓弹力图在OSAHS并发慢性心力衰竭患者中的应用价值

目的 通过血栓弹力图评估阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea hypopnea syndrome,OSAHS）并发慢性心力衰竭（CHF）患者的血凝状态,探讨血栓弹力图在OSAHS并发CHF患者中的应用价值。 方法 选择确诊为OSAHS并发CHF患者60例,按照2015年我国《阻塞性睡眠呼吸暂停低通气综合征诊治指南（基层版）》诊断标准中的睡眠呼吸指数（AHI）,将OSAHS并发CHF患者分为轻度组（20例,AHI 5~15次/h）、中度组（20例,AHI 16~30次/h）和重度组（20例,AHI>30次/h）。另随机选取同一时段我院健康体检者20例作为正常对照组,所有入组患者均记录一般情况,包括年龄、身高、体质量、性别、高血压病、吸烟史、饮酒史、腰围、睡眠监测结果、血栓弹力图结果（R值、MA值）。 结果 ①随着OSAHS并发CHF患者体质量指数（body mass index,BMI）的升高,AHI相应增大,差异有统计学意义（P<0.05）。②OSAHS并发CHF患者各组与正常对照组比较,R值明显减小,差异有统计学意义（P<0.05）。OSAHS并发CHF患者各组间R值比较,差异有统计学意义（P<0.05）。③OSAHS并发CHF患者各组与正常对照组比较,MA值明显增大,差异有统计学意义（P<0.05,P<0.01）。OSAHS并发CHF患者各组间MA值比较,差异有统计学意义（P<0.05,P<0.01）。 结论 OSAHS并发CHF患者病情越重R值越小、MA值相应增大。     

新疆维吾尔自治区汉、维吾尔和哈萨克族人群正常血压和高血压前期状况分析

目的 探讨新疆维吾尔自治区汉、维吾尔和哈萨克族35岁及以上成年人正常血压和高血压前期分布状况,高血压前期的患病率及其危险因素.方法 采用整群随机抽样法,对新疆维吾尔自治区乌鲁木齐市、克拉玛依市、阜康市、吐鲁番地区、和田地区、阿勒泰地区、伊犁哈萨克自治州7个市及地区汉、维吾尔和哈萨克族35岁及以上成年人进行血压和危险因素情况的横断面调查.结果 共随机抽取新疆维吾尔自治区汉、维吾尔和哈萨克族35岁以上人群16 460名,实际完成调查的人数共14 618名.正常血压占24.90%;高血压前期患病率标准化后为34.24%,其中汉族为37.34%,维吾尔族为32.95%,哈萨克族为30.62%.男性高血压前期患病率高于女性(35.58%比31.53%,P<0.01).45岁及以上男性和女性汉族和维吾尔族人群高血压前期患病率均随年龄增长而呈降低趋势,35岁及以上男性和女性哈萨克族人群高血压前期患病率随年龄增长而呈降低趋势(P均<0.05).多因素非条件logistic回归分析显示,甘油三酯≥1.7 mmol/L、年龄≥45岁、空腹血糖≥7.0 mmol/L和体质指数≥24.0 kg/m2是高血压前期的危险因素,女性是高血压前期的保护因素.结论 新疆维吾尔自治区35岁及以上汉、维吾尔和哈萨克族人群中正常血压者较少,而高血压前期的患病率较高,并与多种危险因素相关.

Abstract：

Objective To investigate the situation of normal blood pressure and prevalence and risk factors of prehypertension in Han, Uygur and Hazakh population ≥35 years old of Xinjiang Uygur autonomous region.Methods Random samples were used to analyze the incidence of normal blood pressure and prehypertension in 3 nationalities based on data from Han, Uygur and Hazakh residents living in 7 areas (Urumqi,Ke lamayi, Fukang, the Turfan Basin locality, Hetian locality, Altay locality,and Yili Hazakh autonomous prefecture) in Xinjiang Uygur autonomous region.Results A total of 16 460 subjects were selected with cluster sampling, and eligible data of 14 618 subjects were actually analyzed in Han, Uygur and Hazakh population ≥35 years old of Xinjiang Uygur autonomous region.Incidence of normal blood pressure was 24.9% and the prevalence of prehypertension was 34.24% (35.6% fro male and 31.5% for female, P<0.01) in Han, Uygur and Hazakh population ≥35 years old in Xinjiang Uygur autonomous region.The prevalence of prehypertension was 37.34%, 32.95% and 30.62% in Han, Uygur and Hazakh population, respectively. The prevalence of prehypertension decreased with increasing age in Han and Uygur population ≥45 years old, and in Hazakh population≥35 years old (all P<0.05).Multiple logistic regression analysis revealed that hypertriglyceridemia≥1.7 mmol/L, age≥45 years old, fasting plasma glucose≥7.0 mmol/L and body mass index≥24.0 kg/m2 were risk factors while the female was a protective factor of prehypertension. Conclusion The people with normal blood pressure is few and the prevalence of prehypertension is high in Han, Uygur and Hazakh population ≥35 years old of Xinjiang Uygur autonomous region, and it is associated with many risk factors.     

新疆维吾尔族和汉族老年人轻度认知功能障碍的现况调查

目的 了解新疆维维吾尔(维)、汉两民族老年人轻度认知功能障碍(mild cognitive impairment,MCI)的患病情况及分布特点,为深入研究MCI的病因及其防治提供依据. 方法 根据美国精神病学会精神障碍诊断和统计手册第4版修订版(DSM-IV)中轻度认知功能障碍的临床诊断标准,采用随机、分层、整群抽样方式,抽取新疆南疆、东疆及乌鲁木齐地区年龄≥60岁的维族、汉族老年人,应用现场问卷调查与入户调查相结合的方法对老年人进行MCI患病情况调查. 结果 共调查2986人,其中维族1519人,汉族1467人;男性1435人,女性1551人.(1)按2000年全国人口普查年龄构成标化率,新疆维、汉两民族老年人群总MCI粗患病率为10.21%,标化患病率为10.58%;维族、汉族老年人MCI粗患病率分别为9.61%和10.84%,标化患病率分别为10.29%和10.86%,维、汉两民族MCI粗患病率比较,汉族略高于维族,但差异无统计学意义(χ~2=1.225,P>0.05);(2)本次抽样调查人群中,男性、女性MCI粗患病率分别9.34%和11.03%,标化患病率分别为9.26%和11.62%.不同性别间粗患病率比较,差异无统计学意义(χ~2=2.314,P>0.05);(3)维族60～69岁、70～79岁和80岁及以上老年人MCI患病率分别为6.83%、13.22%和22.22%,汉族则分别为8.64%、12.50%和19.30%,两民族不同年龄段MCI粗患病率之间的差异均有统计学意义,且随着年龄的增长MCI患病率逐渐增加(χ_(趋势)~2=34.753和χ_(趋势)~2=14.081,均P<0.05);(4)维、汉两民族不同文化程度MCI患病率之间的差异均有统计学意义,且随受教育程度的增高MCI患病率呈现逐渐降低的趋势(χ_(趋势)~2=14.785和χ_(趋势)~2=21.059,均P<0.05;). 结论 新疆维、汉两民族老年人MCI患病率较高,不同年龄、不同文化程度老年人MCI患病率存在差异,且均随年龄的增长MCI患病率逐渐增加,随文化程度的增高MCI患病率逐渐降低.     

Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia

OBJECTIVE: Recent studies have shown that pre-eclamptic women present a high prevalence of periodontitis, suggesting that active periodontal disease may play a role in the pathogenesis of pre-eclampsia. The present study analysed the effect of periodontal disease in the concentrations of serum high-sensitivity C-reactive protein (hs-CRP), and its association with pre-eclampsia. METHODS: A case-control study was carried out in Cali-Colombia, comprised of 398 pregnant women (145 cases and 253 controls) who were believed to have periodontal disease, between 28 and 36 weeks of gestational age. Pre-eclampsia cases were defined as blood pressure > or = 140/90 mmHg and proteinuria > or = 0.3 g/24 h. Controls were pregnant women with normal blood pressure, without proteinuria, matched by maternal age, gestational age and body mass index. Sociodemographic data, obstetric risk factors, periodontal state, subgingival microbial composition and hs-CRP levels were determined in both groups. RESULTS: The case and control groups were comparable for sociodemographic characteristics. In women with pre-eclampsia and confirmed periodontal disease (n = 138), hs-CRP levels increased according to the severity of the disease (gingivitis median 4.14 mg/dl; mild periodontitis median 4.70 mg/dl; moderate/severe periodontitis median 8.8 mg/dl; P = 0.01). A similar tendency was observed in controls with periodontal disease (n = 251), but it did not reach statistical significance (gingivitis median 5.10 mg/dl; mild periodontitis median 5.12 mg/dl; moderate/severe periodontitis median 6.90 mg/dl; P = 0.07). A significant difference in hs-CRP levels was observed in pre-eclamptic women with moderate/severe periodontitis compared to controls (P = 0.01). CONCLUSION: These findings suggest that chronic periodontitis may increase hs-CRP levels in pregnant women and lead to complications such as pre-eclampsia.     

Urinary complaints in nondisabled elderly people with age-related white matter changes: the Leukoaraiosis And DISability (LADIS) Study

OBJECTIVES: To investigate, in a cohort of nondisabled elderly people, the association between urinary complaints and severity of age‐related white matter changes (ARWMC). DESIGN: Cross‐sectional data analysis from a longitudinal multinational study. SETTING: The Leukoaraiosis And DISability Study, assessing ARWMC as an independent predictor of the transition from functional autonomy to disability in elderly subjects. PARTICIPANTS: Six hundred thirty‐nine subjects (288 men, 351 women, mean age 74.1±5.0) with magnetic resonance imaging (MRI)‐detected ARWMC of different severity. MEASUREMENTS: ARWMC severity was graded on MRI as mild, moderate, and severe (Fazekas scale). MRI assessment also included ARWMC volumetric analysis and the count of infarcts. Urinary complaints (nocturia, urinary frequency, urgency, incontinence) were recorded based on subjects' answers to four questions. RESULTS: In comparing the three ARWMC severity groups, there was a significant difference only in prevalence of urgency, with 16% of subjects in the mild severity group, 17% in the moderate severity group, and 25% in the severe group (P=.03). Adjusting for age, sex, lacunar and nonlacunar infarcts, diabetes mellitus, and use of diuretics, severe ARWMC retained an independent effect in the association with urinary urgency (odds ratio=1.74, 95% confidence interval=1.04–2.90, severe vs mild group). Subjects with urinary urgency also had higher ARWMC volumes (25.2, vs 20.4 mm³ in those without urinary urgency; P<.001). Urgency was confirmed to be associated with the severe degree of ARWMC, irrespective of complaints of memory, gait disturbances, or history of depression. CONCLUSION: In a cohort of nondisabled elderly people, severe ARWMC were associated with urinary urgency, independent of other potential confounders and vascular lesions of the brain.     

The occurrence and extent of Helicobacter pylori colonization and antral and body gastritis profiles in an Estonian population sample

A series of 143 subjects representing an Estonian urban population was examined for the occurrence and extent (absent, mild, moderate, severe) of Helicobacter pylori colonization in antral and body biopsy specimens (Giemsa staining). These data were correlated with the presence and grade of chronic gastritis (normal, mild, moderate, or severe superficial chronic gastritis; mild, moderate, or severe atrophic gastritis) in the antrum and the body. Gastritis of any grade was found in the antrum and/or the body in 140 (98%) subjects. The overall extent of H. pylori colonization in the whole series did not differ between the antrum and the body. Of 93 subjects with superficial gastritis, H. pylori was found in the antrum and/or the body in 87 (94%) cases. Of 47 subjects with atrophic gastritis in the antrum and/or the body. H. pylori was not found in 12 (25%). In subjects with gastritis the absence of H. pylori either in the antrum or in the body was relatively common (in 30 of 143 subjects). The grade of superficial gastritis showed a highly significantly positive correlation with the extent of H. pylori colonization in the antrum but not in the body. Correspondingly, the grade of atrophic gastritis in the antrum correlated negatively to the grade of colonization. The total absence of H. pylori was particularly associated with the absence of gastritis in the antrum. Conversely, severe body H. pylori colonization was found in subjects who had atrophic antral gastritis, and severe antral colonization in subjects who had at least moderate superficial antral gastritis and who showed a coexistent normal or slight superficial gastritis in the body.(ABSTRACT TRUNCATED AT 250 WORDS)