Nocturnal enuresis in pediatric sickle cell disease.

To assess the prevalence of nocturnal enuresis in children and adolescents with sickle cell disease (SCD) and associated factors, structured telephone interviews were conducted with primary caregivers of 217 children and adolescents with SCD aged 5 years or older. Prevalence, perceived causes, interventions undertaken, and emotional impact were assessed. Nocturnal enuresis was significantly higher for males (28.2% of males) than for females (11% of females), p = .002, and compared with cited population prevalence rates, nocturnal enuresis was significantly higher for children with SCD, p < .01. SCD was the most common reason given by primary caregivers for enuresis. Primary caregivers used a wide range of interventions for nocturnal enuresis, but few used empirically supported treatments for enuresis or spoke with their health care team about the enuresis. These data suggest that systematic assessment and intervention for nocturnal enuresis must be implemented in the follow-up care of children and adolescents with SCD.     

Nocturnal enuresis and psychosocial problems in pediatric sickle cell disease and sibling controls

To evaluate current and lifetime prevalence rates of nocturnal enuresis and psychosocial problems among children with sickle cell disease (SCD) in comparison with sibling controls, a structured interview and the Pediatric Symptom Checklist were administered to primary caretakers regarding 126 of their children aged 5 to 17 with SCD and 47 sibling controls. Lifetime rates of enuresis among children with SCD were comparable to similar studies, and exceeded population prevalence and sibling control rates. In addition, enuretic children had higher levels of total psychosocial problems on the Pediatric Symptom Checklist regardless of group status, although patterns of subscale differences varied by group and enuresis history after controlling for child age. These findings replicate and extend previous findings and provide further evidence to support a need for monitoring of hydration levels and screening for psychosocial problems among children with SCD and enuresis, as well as evaluation of the psychometric properties of psychosocial screening measures and identification of efficacious treatments for enuresis in children with SCD.     

Nocturnal enuresis

Nocturnal enuresis is a benign condition, yet needs treatment to relieve the child and parents of the accompanying anxiety and the stigma attached to it. It is defined as normal nearly complete evacuation of the bladder at a wrong place and time at least twice a month after the fifth year of life. The underlying cause of enuresis is functional and various proposed pathophysiological mechanisms like maturational delay, genetics, role of sleep, antidiuretic hormone, and bladder capacity are discussed. These factors have a bearing on the management. As no treatment plan is ideal, various treatment modalities currently available including good supportive care are elaborated and a plan of management discussed.     

Nocturnal enuresis

Childhood enuresis is a common socially disruptive problem. The possible pathophysiological factors include a disorder of sleep arousal, nocturnal polyuria, and low bladder capacity. The evaluation of a patient with nocturmal nuresis is aimed to exclude any organic pathology, UTI and voiding dysfunction. An approach to management of this common disorder is outlined.     

Nocturnal enuresis

Nocturnal enuresis (NE) is increasingly seen as part of a heterogeneous phenomenon that at times will include daytime lower urinary tract symptoms such as urgency, frequency and wetting – with reduced bladder storage, usually due to an overactive bladder. In turn, these may be associated with constipation and/or faecal soiling. This paper discusses these considerations in the management of NE.     

Determinants of nocturnal enuresis in homozygous sickle cell disease.

The determinants of nocturnal enuresis in homozygous sickle cell (SS) disease have been investigated in 16 enuretic and 16 age and sex matched non-enuretic children. Overnight fluid deprivation tests (8pm-8am) demonstrated no significant difference in maximum urine osmolality or urine volumes, although the latter tended to be higher in the enuretic children. Maximum functional bladder capacity, estimated by maximum voided volume during oral fluid loading, was lower and the ratio of overnight urine volume to maximum functional bladder capacity higher in the enuretic than the non-enuretic group. Enuretic children were more likely than non-enuretics to be considered deep sleepers by their family. High urine volumes may contribute to nocturnal enuresis in SS disease, although the similar values in enuretic and non-enuretic children implies that additional factors determine the presence of enuresis. Low maximum functional bladder capacity, and a high ratio of overnight urine volume to maximum functional bladder capacity, appear to be important determinants.     

Nocturnal enuresis in children. II--Diagnosis and treatment of nocturnal enuresis

The classification of the various types of urination disorders among children as well as the latest theories explaining the causes of nocturnal enuresis were presented in the first part of the article entitled "Nocturnal Enuresis in Children" (in "Medycyna Wieku Rozwojowego" 1998, II, 1 pp. 55-69). The second part of this article concentrates on the differential diagnostics of urination disorders amongst patients seeking help for nocturnal enuresis. The diagnostic model developed by the Urodynamic Unit at the Department of Paediatric Surgery, National Research Institute of Mother and Child can be applied in an outpatient clinic. Hospitalization of the patient is not necessary to carry out the study, meaning that the child is spared any additional stress. Currently applied methods for treating nocturnal enuresis by non-pharmacological methods are also discussed in this text.     

Sickle cell haemoglobinopathies in England.

Ninety-six Birmingham children with sickle cell disease were studied prospectively between 1969 and 1979. Thirty-five were homozygotes for HbS (SS), 12 had sickle thalassaemia (S thal), and 23 were double heterozygotes for HbS and C (SC). Twenty-six whose family studies were incomplete were classified as SS or S thal although most were thought to be SS. The average length of follow-up was 5.1 years. Four SS children and 1 SC child died, the annual mortality rates being 1.3% for SS and presumed SS, 0% for S thal, and 0.9% for SC children. The incidence of pulmonary illnesses and anaemic crises was greater than reported from Jamaica, while leg ulceration described there and in New York was not observed in Birmingham. Severe infections were less common than in the series reported from New York and no case of salmonella osteomyelitis was observed in Birmingham. In general the S thal and SC children had milder illnesses than the SS, and the SS children often showed impairment of growth and sexual maturation.     

Nocturnal enuresis is a common complication following cardiac transplantation.

AIMS: To investigate the incidence of nocturnal enuresis post-cardiac transplantation. METHODS: Seventy two cardiac transplantations have been performed in children under 16 years of age. All recipients who were alive and over 4 years of age at the time of the study received a questionnaire about urinary symptoms; 54 of the 57 eligible children participated. RESULTS: Twenty five children had persistent nocturnal enuresis post-transplantation. Thirteen of them had previously attained reliable night-time dryness but developed secondary nocturnal enuresis following transplantation, with three subsequently regaining dryness at ages 8, 12, and 17 years; 10 were still wetting mean age 12.3. Twelve children had not achieved night-time dryness when transplanted (all were under 4 years of age at the time) and continued to wet. Only one of these children achieved dryness (at age 12 using oxybutynin); the other 11 remained wet at night at a mean age of 9.3 years. Twenty nine children were dry at night post-transplantation, but 21 of them had nocturia at least three times a week. There is a significant difference in age at transplantation between the primary nocturnal enuretic children (mean age 2.0) and the secondary nocturnal enuretic children (mean age 7.4) as well as between the primary nocturnal enuretic children and the non-enuretic children (mean age 9.0). CONCLUSIONS: Transplanting young children frequently delays the normal attainment of night-time continence or causes them to start wetting again. It should not be dismissed as a minor problem as it causes low self-esteem and is socially limiting. It is important families are aware it is a direct result of the transplantation process.     

Nocturnal enuresis: sleep disturbance and behavioural patterns

Sleep pattern and behaviour was studied in 88 children with nocturnal enuresis and compared with 340 non-enuretic children. There were no differences in common psychosomatic complaints. Enuresis was almost three times more common in the families of the enuretic children than in the families of their non-enuretic peers. The enuretics were considered deep sleepers by their parents. A wake-up test showed that they were more difficult to arouse at night compared with controls ( p < 0.001). These results demonstrate that enuresis has a strong genetic link and enuretics are characterized as deep sleepers but do not display different day-time behavioural patterns compared with their non-enuretic peers.     

Nocturnal enuresis: a placebo controlled trial of two antidepressant drugs.

A multicentre, randomised, double blind treatment trial was set up comparing imipramine (a tricyclic antidepressant with anticholinergic action), mianserin (a quadricyclic antidepressant without anticholinergic activity), and placebo, (a) possibly to identify an effective alternative drug and (b) to elucidate the action of imipramine in enuretic children. Eighty children (65 boys, 15 girls) aged 5-13 years, wet three or more nights a week, were studied. Exclusions were a urinary tract infection or abnormality, other organic illness, or severe emotional disorders. After a four week assessment, 25 children were randomised to eight weeks'' treatment with imipramine 25 mg, 26 to mianserin 10 mg and 29 to placebo, followed by four weeks without treatment. Dry nights and a wetness score were recorded throughout. During treatment, imipramine was superior to both placebo and mianserin (p < 0.001) in achieving dry nights and reducing wetness scores. It led to a definite improvement in 72% of children. Mianserin produced a mildly beneficial effect that was not superior to placebo. No side effects were recorded. Mianserin would not be a satisfactory alternative treatment for nocturnal enuresis. The efficacy of imipramine is unlikely to be the result of its antidepressant activity.     

Nocturnal enuresis: application of evidence-based medicine in community practice

AIM: To report the outcomes and follow-up at 2 years of children with monosymptomatic nocturnal enuresis (MNE) managed in a private paediatric community practice utilising body-worn alarms and supportive programmes. METHODS: 522 consecutive children presenting with MNE were assessed and managed with a comprehensive supportive programme and body-worn alarm. Data were recorded prospectively and outcomes assessed at 6 and 24 months. RESULTS: 505 proceeded with management. A total of 79.0% achieved initial dryness within a median of 10 weeks. Of those achieving initial dryness 73.0% had remained dry at 6-month follow-up and 64% had remained dry at 24 months. A total of 99.2% follow-up was achieved. Nineteen per cent of children required more than 16 weeks management with 56% achieving dryness. More girls achieved dryness than boys and in a shorter time. There was no gender difference in relapse rates at 6 and 24 months. No difference in achieving initial success was found with respect to initial severity of wetting, nor age. Relapse rates were unrelated to gender, age, or initial severity. CONCLUSION: MNE can be successfully managed using body-worn alarms achieving good initial and long-term complete dryness, without the need for expensive pharmacologic intervention. A strong supportive programme can make the management less arduous for child and family.     

Nocturnal enuresis is a common complication following cardiac transplantation

Aims: To investigate the incidence of nocturnal enuresis post-cardiac transplantation. Methods: Seventy two cardiac transplantations have been performed in children under 16 years of age. All recipients who were alive and over 4 years of age at the time of the study received a questionnaire about urinary symptoms; 54 of the 57 eligible children participated. Results: Twenty five children had persistent nocturnal enuresis post-transplantation. Thirteen of them had previously attained reliable night-time dryness but developed secondary nocturnal enuresis following transplantation, with three subsequently regaining dryness at ages 8, 12, and 17 years; 10 were still wetting mean age 12.3. Twelve children had not achieved night-time dryness when transplanted (all were under 4 years of age at the time) and continued to wet. Only one of these children achieved dryness (at age 12 using oxybutynin); the other 11 remained wet at night at a mean age of 9.3 years. Twenty nine children were dry at night post-transplantation, but 21 of them had nocturia at least three times a week. There is a significant difference in age at transplantation between the primary nocturnal enuretic children (mean age 2.0) and the secondary nocturnal enuretic children (mean age 7.4) as well as between the primary nocturnal enuretic children and the non-enuretic children (mean age 9.0). Conclusions: Transplanting young children frequently delays the normal attainment of night-time continence or causes them to start wetting again. It should not be dismissed as a minor problem as it causes low self-esteem and is socially limiting. It is important families are aware it is a direct result of the transplantation process.