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Objectives:To examine the policy and practice of HIV testing in genitourinary medicine clinics in the United Kingdom.

Design: All 176 consultants in charge of genitourinary medicine clinics in the United Kingdom were sent a policy and practice questionnaire. A self selected group of 53 clinics conducted a retrospective case note survey of the first 100 patients seen in each clinic in 1998.

Setting: Genitourinary medicine clinics in the United Kingdom.

Subjects: Consultants in charge of, and case notes of patients attending, genitourinary medicine clinics.

Interventions: None

Main outcome measures: Number of patients tested for HIV.

Results: Consultants' assessments of their rate of HIV testing often exceeded the actual rates of testing in the clinic as a whole. The majority of patients deemed to be at high risk requested an HIV test. The exception were heterosexuals who had lived in sub-Saharan Africa. Among attenders at high risk of HIV who did not request a test, 57/196 (29%) were not offered one by clinic staff. Two fifths (51/130) of consultants felt the proportion of patients tested in their clinic was too low. The commonest reason given for this was a lack of time, especially that of health advisers.

Conclusions: A substantial minority of people with HIV infection attending genitourinary medicine clinics fail to have their infection diagnosed. Two major reasons were identified. Firstly, a test was not always offered to those at high risk of HIV. Secondly, a lack of resources, mainly staff, which prevents some clinics from increasing their level of testing.

Key Words: screening; HIV; genitourinary medicine clinics

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I present a review of the current US Food and Drug Administration (FDA) guidelines for using cyclosporine A (CSA) to treat psoriasis, with particular emphasis on the period for which CSA may be administered. My concern is that, without violating the guidelines, CSA could be given for a prolonged period with only very brief time-outs. I also review the risks for renal toxicity, malignancy, and other side effects from prolonged administration.  相似文献   

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OBJECTIVE: Following a 9-year 60% decline, chlamydia positivity increased 46% from 1997 through 2004 among young sexually active women screened in Region X family planning clinics. The objective of this analysis was to systematically examine the influences of risk factors, changing laboratory test methods, and interclinic variability on chlamydia positivity during this period. STUDY DESIGN: We analyzed data from 520,512 chlamydia tests from women aged 15 to 24 years screened in 125 family planning clinics. Multivariate logistic regression modeling was used to adjust the annual risk of chlamydia for the demographic, clinical, and sexual risk behavior characteristics associated with infection and for the increasing use of more sensitive laboratory test methods. A generalized linear mixed model was used to adjust for interclinic variability. RESULTS: We found a significant 5% annual increase in the risk of chlamydia even after adjusting for risk factors including laboratory test characteristics (odds ratio 1.05, 95% confidence interval: 1.04, 1.06). Variability among the clinics where screening occurred did not account for the increase. CONCLUSIONS: Based on a review of all available data, we concluded that there was a true increase in chlamydia positivity over the 8-year period.  相似文献   

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BACKGROUND: Melanoma screening clinics (MSCs) have been set up in the U.K. to help allay public anxiety about potential skin cancers, and to permit the early detection of thin melanomas, thus improving prognosis. Public health campaigns have led to increased awareness of melanoma and increased numbers of referrals to MSCs. OBJECTIVES: To determine whether the MSC has had an impact on the number and thickness of melanomas detected over the past 8 years. METHODS: Data was analysed retrospectively for all patients attending the MSC since it was set up in 1997, until the end of 2004. We categorized patients with melanoma according to Breslow thickness, examined trends in referral to the clinic and analysed changes in the proportion of patients with a new diagnosis of melanoma. RESULTS: There were 15 970 patients who attended for screening; 403 primary invasive melanomas were detected, and 190 in situ melanomas. The number of new patients seen each year increased by over 230%, although the proportion of patients with melanoma detected declined. The Breslow thickness did not change over time. CONCLUSIONS: Our experience suggests that public awareness has increased and that the general practitioner threshold for referral has fallen but there has been no reduction in the thickness of those melanomas diagnosed.  相似文献   

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The objective of this study was to review and explore the top 15 currently used and the historically used herbal remedies in the treatment of psoriasis. Articles, press releases, message boards, product marketing sites, and patient education lines through the National Library of Medicine (www.pubmed.gov), National Psoriasis Foundation (www.psoriasis.org), Google (www.google. com), and Yahoo (www.yahoo.com) were reviewed. Despite widespread use of complementary and alternative medications, specifically herbals, there is limited scientific data regarding their benefits and interactions. Studies on the efficacy and side effect profiles of these remedies are needed. Additionally, both providers and patients need to be cognizant of both potential benefit distortion and adulteration of the herbal products.  相似文献   

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Guidelines have proliferated in recent years in all areas of medicine, sometimes with little evaluation of their effect. Referral guidelines for dermatology were compiled by the dermatologist at the Royal Surrey County Hospital in consultation with local general practitioners. An audit was undertaken to assess how appropriate referrals were just before and after distribution of the guidelines and was repeated 2 years later to determine whether they had made any significant impact. The results revealed a 40% increase in the number of appropriate referrals immediately after introduction of the guidelines, but this was not sustained 2 years later. Five common conditions accounted for two-thirds of inappropriate referrals before and after the guidelines were sent. The need for continued general practitioner education in dermatology to reinforce referral guidelines is demonstrated.  相似文献   

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OBJECTIVES: To characterise risk factors for the acquisition of genital warts and specifically to determine whether condoms confer protection from infection. METHODS: A retrospective case-control study comparing demographic, behavioural, and sexual factors in men and women with and without newly diagnosed genital warts, who attended Sydney Sexual Health Centre (SSHC), an inner city public sexual health centre, in 1996. Data were extracted from the SSHC database. Crude odds ratios (OR) were calculated to compare cases and controls and significant factors were then controlled for using multivariate logistic regression to obtain adjusted odds ratios (ORs). RESULTS: 977 patients with warts and 977 controls matched by sex and date of attendance were included. In both sexes, univariate analysis revealed that younger age, more lifetime sexual partners, failure to use condoms, greater cigarette smoking and alcohol consumption were associated with warts, and there was a negative association with previous infection with Chlamydia trachomatis, Neisseria gonorrhoeae, hepatitis B, and genital herpes. In males, on multivariate analysis, factors which remained significant were younger age, more lifetime sexual partners; failure to use condoms, greater cigarette smoking, and previous chlamydia. In women, factors which remained significant were younger age, more lifetime sexual partners, condom use, marital status, and previous infections with Chlamydia trachomatis and herpes. CONCLUSIONS: Independent risk factors for genital warts include younger age, greater number of lifetime sexual partners, and smoking. Consistent condom use significantly reduces the risk of acquiring genital warts.  相似文献   

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Animal models for atopic dermatitis: are they relevant to human disease?   总被引:3,自引:0,他引:3  
Over the last decade, animal models of atopic dermatitis (AD) have received increasing attention. They include NC/Nga mice, a hapten-induced mouse model, and transgenic and knockout mouse models. Although the pathogenesis of skin inflammation elicited in these models and that in AD are not quite the same, it is pertinent to ask what these animal models really tell us about the pathogenesis and possible therapies for the disease. NC/Nga mice may yield information relevant to the dissection of the crucial components of the pathophysiology of AD rather than the assessment of potentially therapeutic agents for its treatment. A hapten-induced mouse model created by repeated application of 2,4,6-trinitrochlorobenzene (TNCB) is a simple and reproducible one. This model offers several advantages over others: by changing hapten and the mouse strain used, various types of chronic inflammation, probably reflecting heterogeneity in clinical presentation of AD, can be induced; this model is also of enormous value in its high reproducibility as well as the ease of quantitative assessment by measuring ear thickness. Among various transgenic and knockout mouse models, the IL-18-transgenic mouse is one of the closest available mouse models of human AD, although the onset of the AD-like lesions in the IL-18-transgenic mice is such a late event. Although these mice all have significant disadvantages, it is important to review the current literature on the models in the hope that one may identify useful areas for investigation.  相似文献   

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