老年非小细胞肺癌三维适形放射治疗靶区选择探讨

目的探讨老年晚期非小细胞肺癌（NSCLC）三维适形放射治疗（3R-CRT）不同靶区的设计对放射治疗效果及放射性损伤的影响。方法回顾分析94例应用3D-CRT治疗的65岁以上、病理确诊的NSCLC病人,其中以原发病灶、同侧肺门及淋巴引流区为放疗靶区的病例36例（A组）;以原发病灶及累及淋巴结为靶区的病例58例（B组）,比较两组的近期疗效、远期疗效和放射损伤的情况。结果两组近期疗效、中位生存期（MST）、1及2年生存率比较差异均无显著性（P〉0.05）。两组放射性食管炎发生率比较差异有统计学意义（χ2=4.182、4.795,P〈0.05）,放射性肺炎、骨髓抑制及心脏损伤发生率差异无显著性（P〉0.05）。结论老年NSCLC病人淋巴结区预防照射和累及野放疗,预后无明显差异,累及野放疗可减少放射性食管炎发生率,建议对老年病人采取累及野照射。     

THE ISOLATION AND BIOLOGICAL ACTIVITIES OF RABBIT γM- AND γG-ANTI-SALMONELLA TYPHIMURIUM ANTIBODIES

Rabbit γM- and γG-anti-S. typhimurium antibodies were isolated by combined immune specific and physical methods and some of their properties in immunological systems were measured. γM-Antibody was detectable at lower concentrations and revealed a higher specific activity than the γG-globulins. Indirect studies indicated that the γG-globulin was the more "avid" immunoglobulin. Treatment of the γM-globulin with the reducing agent 2-ME decreased but did not destroy the immune activity of the subunits. The results confirm the necessity of analysis of purified immunoglobulin antibodies to evaluate the significance of their biological properties secondary to their interaction with antigens.     

γA-BLOOD GROUP ANTIBODIES

The serological characteristics of γA-anti-A and anti-B were studied using, as a source, either colostrum, or fractions relatively rich in γA obtained from selected potent antisera. γA-anti-A and anti-B were never hemolytic nor did they sensitize red cells to agglutination by anticomplement globulin sera. γA-anti-A, like γG-anti-A and unlike γM-anti-A was unaffected by heating at 56°C for 3 hr. On the other hand in the following three characteristics the behavior of γA fell between that of γG- or γM-anti-A: sensitivity to inactivation by 2-mercaptoethanol, ease of neutralization by A substance and degree of enhancement of agglutination in a medium of serum rather than saline. The agglutination produced by γA-anti-A was regularly enhanced by addition of anti-γA-globulin serum. In searching for γA-blood group antibodies of other specificities the following sera were tested: anti-D (32 examples); anti-c (2 examples); anti-Le^a or -Le^b (3 examples); anti-K (3 examples); anti-Fy^a (3 examples), and anti-Jk^a (3 examples). Only 3 sera, all containing anti-D, sensitized red cells to agglutination by anti-γA. There were no discrepancies between results obtained with four different anti-γA-globulin sera. Approximately half the sera were fractionated on DEAE-cellulose, and the fractions rich in γA tested for their ability to sensitize red cells to agglutination by anti-γA; no additional examples of γA-antibodies were detected. One of the three examples of γA-anti-D appeared in the serum of a woman during the course of deliberate reimmunization. γA-anti-D appeared only after three intravenous injections of red cells although the γG-anti-D titer rose considerably after a single injection. 3 yr after a fourth injection of Rh-positive cells γA-anti-D, as well as γG-anti-D, was still present in the serum.     

抗纤维蛋白单克隆抗体的制备和鉴定

用XL-FN颗粒、D-D、FN单体等作为免疫原获得一组小鼠单克隆抗体。除了3个与FG有交叉反应,其余均只与XL-FN和/或其片段反应。其中SZ-58、SZ-60及SZ-63与血浆凝块的结合反应不受血浆或全血影响。在免疫印迹电泳中,SZ-63主要识别D-D,而SZ-58不识别任何区带。SZ-58、SZ-60可抑制血浆凝固,并对ADP诱导的血小板聚集有程度不同的抑制作用。SZ-60可与固相化的FG结合而与溶解态的FG无结合反应。结果提示,SZ-58、SZ-60、SZ-63对XL-FN反应的特异性较高,因此可应用于体内血栓显像而SZ-63同时又可应用于D-D检测。     

臭氧联合靶点射频热凝术治疗腰椎间盘脱出症

目的:探讨臭氧联合靶点射频热凝术治疗腰椎间盘脱出症的疗效.方法:将150例腰椎间盘脱出症患者随机分为观察组与对照组各75例.观察组采用盘内臭氧注射联合靶点射频热凝术治疗,对照组仅盘内臭氧注射治疗.结果:观察组总有效率为94.7％,明显高于对照组;治疗后1月两组患者的VAS评分均低于治疗前(P＜0.01),观察组与对照组比较差异有统计学意义(P＜0.05).结论:臭氧联合靶点射频热凝术治疗腰椎间盘脱出症是一种有效的治疗方法,疗效优于单纯臭氧组.     

LOCALIZATION OF ANTIBODIES IN GROUP I AND GROUP II γ-GLOBULINS

A wide assortment of antibodies has been analysed by qualitative and quantitative techniques for their content of group I- and group II-type γ-globulin molecules. These included Rh antibodies, isoagglutinins, thyroglobulin antibodies, dextran antibodies, and teichoic acid antibodies. All the antibodies studied showed the presence of both groups. However, the ratio of the two varied widely in different individuals and diverged markedly from the ratio in the total γ-globulin of the individual. Two antibodies isolated from the serum of the same individual showed different ratios for the two groups.