乳腺癌术后的乳房重建

乳房重建能纠正乳房切除术后的形体畸变和减少负面情绪影响,并且不影响乳腺癌的预后及监测。是否进行重建和重建策略的制订需要个体化,必须考虑患者的形体特点、全身情况、乳腺癌治疗计划和个人喜好。乳房重建大体分为假体重建和自体组织重建。假体重建中使用盐水或硅胶假体同样安全有效;自体组织重建通常使用腹部皮瓣,其中腹部游离皮瓣技术能有效保留腹部肌肉,减少术后腹部并发症。无论是假体重建或自体组织重建都有其优缺点,都需考虑后续放疗的影响。     

Breast

<正>209026 Relationship between breast cancer-related lymphoedema and VEGF-C and VGGFR-3/He Jianye (贺建业,DeptGen Surg,Anzhen Hosp,Cap Univ Med Sci, Beijing 100029)…∥Chin J Gen Surg. -2009,24(11). -900～903 Objective To study the distributionand clinicopath-ological characteristics between VEGF-C and peritumoral lymph vessels density (PlND) in breast cancer tissue,and to investigate the development and the mechanism of breast cancer-related lymphoedema(BCRL).     

Breast

<正>210378 Expression and significance of stromal CD10 and Ezrin inductal carcinoma in situ and invasive ductal carcinoma of breast/Zhang Rongju(张荣菊,Breast Cancer Research Key Lab Educat Minis Nation,Oncol Key Lab Tianjin,Tianjin Cancer Inst Cancer Hosp,Tianjin Med Univ,Tianjin 300060)…Chin J Exp Surg.-2010,27(6).-705～707     

Breast

Effect of PTEN on the cell growth and P13K/ AKT signal pathway in Tamoxifen-resistant breast cancer cell-line LCC2;Pacilitaxel in association with gemcitabine for anthracycine-resistant advanced breast cancer;Effect of uroacitides on the cell cycle progression and the expression of Cyclin D1 of breast cancer cells ; Relationship between expression of focal adhesion kinase, tumor suppressor gene PTEN-encoding protein and biological behaviors in breast carcinoma;……     

Breast

Significance of multidisplinary surgery in chest wall resection and reconstruction for selected patients with breast cancer, Relation between c-erbBl,c-erbB2,MAPK expression and resistance to tamoxifen in breast cancer cells in vitro, Observation and clinical significance of adjuvant chemotherapy-induced amenorrhea in premenopausal breast cancer patients,Effects of Syk （L） nuclear translocation on breast cancer cell invasion,     

Breast

Technique investigation of endoscopic axillary lymph node dissection by liposuction , The study on sentinel lymphatic channels by us. ing methylene blue in breast cancer patients , A study of the combination of vinorelbine and epirubicin as ncoadjuvant chemotherapy regimen in the treatment of locally advanced breast cancer , Epidermal growth factor receptor signaling pathway in tamoxifen-resistant breast cancer cells     

Breast

A retrospective study of 129 cases with immediate breast reconstruction after skin-sparing mastectomy for breast cancer; Expression of imprinted tmnor suppressor gene SLC22A18 in breast cancer; WWOX gene expression and aberrant CpG island hypermethylation of WWOX gene in breast cancer; Are there other axillary lymph node metastasis than positive sentinel lymph nodes containing micrometasrases and isolated tumor cells in patients with breast cancer.     

Breast

<正>209325 Clinical characteristics and survival in the operable breast cancer patients with different molecular subtypes/Zhang Huiming(张慧明,Dept Abdom Surg Oncol,Cancer Hosp(Inst),Chin Acad Med Sci Peking Union Med Col,Beijing 100021)…∥Chin J Oncol.-2009,31(6).-447～451Objective According to the immunohistochemical (IHC)test of ER,PR and HER-2,breast cancer can be divided into 4 different molecular subtypes:Luminal A subtype (ER or PR positive and HER-2 negative),Luminal B subtype (ER or PR positive and HER-2 positive),HER-2 sutype (ER and PR negative,HER-2 positive) and Basal-like subtype (ER,PR and HER-2 negative).This study was to analyze the clinical features of different breast cancer subtypes,and try to find the evidence of combined and individualized treatment for patients with breast cancer.Methods The data of 408 surgically treated breast cancer patients in the Cancer Hospital of Chinese Academy of Medical Sciences from January 1,2002 to December 31,2002 were collected and retrospectively analyzed.The clinicopathological features and recurrence,metastasis as well as survival of these four subtypes were compared.Results Of the 408 cases,Luminal A subtype accounted for 60.8% (248/408),Luminal Bsubtype 7.8% (32/408),HER-2 subtype 12.5%(51/408),and Basal-like subtype 18.9%(77/408).Basal-like subtype had less lymph mode metastases than other subtypes(P<0.05).HER-2 subtypes consisted of less patients aged 45 years or younger than other subtypes(P<0.05).Luminal B subtype contained less advanced cases than other subtypes(P<0.01).By August 2008,the median time of follow-up was 64 months (range,3-79 months).Fifty-eight cases presented local recurrence or metastasis,and 51 of them died of the disease.The 5-year overall survival rates (OS) for patients with Luminal A,Luminal B,Basal-like and HER-2 subtype were 89.83%,86.15%,79.85% and 86.70%,respectively.The 5-year disease-free survival (DFS) rates of the four subtypes were 83.52%,68.88% and 75.83%,respectively.The rate of local recur     

Breast

<正>209485 Characterization of hormone receptor statusin 5758 Chinese females with breast cancer/Gao Jidong(高纪东,Breast Caner Center,Dept Abdomin Surg Oncol,Cancer Hosp (Inst),Chin Acad Med Sci Peking Union Med Col,Beijing 100021)…∥ Chin J Oncol. -2009,31(9). -683～686     

早期乳腺癌65例保乳手术的临床分析

目的探讨早期乳腺癌的保乳治疗原则及方法。方法回顾分析本科自1995~2002年共8年间所完成的65例早期乳腺癌保乳手术病例的临床资料。结果术后患侧的乳房外形均较美观;5年生存率达到96.9%;复发率为6.2%。结论对早期乳腺癌患者施行保乳手术并且术后进行严格的综合治疗,可以收到满意的治疗效果,而且也满足了患者的美容需求,提高了生活质量。     

BRCA1与乳腺癌

<正>BRCA1(breast cancel susceptibility gene1,BRCA1)是世界上第一个被发现的家族性乳腺癌抑癌基因,定位于17q21,在乳腺癌高发家族中BRCA1的突变率为45%,在乳腺癌和卵巢癌均高发的家族中突变率为90%。研究BRCA1对乳腺癌早期诊断,临床分级,辅助化疗以及预后评估具有重要意义。     

乳腺囊性增生病与乳腺癌

乳腺囊性增生过去曾有许多名称,2003年WHO乳腺肿瘤组织学新分类取消了这些病名,采用各种病变单独命名的方案。本文从不同角度阐述了乳腺囊性增生与乳腺癌的关系,而目前临床上仍在使用乳腺囊性增生一词。     

乳腺癌保乳手术疗效分析

乳腺癌保乳手术主要是指乳房肿瘤局部扩大切除(肿块切除、腺叶切除、象限切除)加腋淋巴结清扫术。本中心从1994年12月～2001年12月共行保乳手术86例。