Someone Who Cares

The aim of this inquiry was to gain an understanding of laymen's experiences and opinions about general health check-ups. Medical experts often draw attention to unwanted effects, especially the risk of creating worry and of recommending and even giving unnecessary medical treatment. By using a qualitative research method with unstructured interviews we wanted to explore the participants' conceptions of health, their expectations before and their perceived benefits after health checks and whether the check-up gave rise to negative feelings. The participants held broad views on health and, possibly as a consequence, also great expectations of health check-ups. Consequences of the check-ups were that examinees felt encouraged to change their life style, had learnt to handle risk factors for disease, and after some time, reported feeling better. The individual attention and care, which in general did not differ from other caring situations described in the literature, was highlighted as an important factor for a positive result. Worries afterwards either did not exist or could be rationalized by knowing the causes of abnormalities and receiving guidance from the medical staff.     

New ways to turn on NKT cells

Natural killer T (NKT) cells are CD1d-restricted, lipid antigen-reactive T cells with powerful immunoregulatory potential. The prototypic antigen for NKT cells is a marine sponge-derived glycolipid, α-galactosylceramide (α-GalCer), but this is not normally encountered in the mammalian environment. Thus, there is great interest in the identification of more physiological stimuli for NKT cells, and numerous studies have shown that NKT cells are capable of responding to a range of microbial lipid-based antigens. Two new studies expand our understanding of environmental NKT cell stimuli, with one showing that CD1d-restricted NKT cell antigens are present within common house dust extract (HDE), whereas the other shows that NKT cells can respond to innate stimuli irrespective of the presence of foreign microbial antigens. Collectively, these two investigations indicate that NKT cells are far more likely to encounter foreign antigens, or innate activating signals, than previously recognized, suggesting a more central role for these cells in the immune system.