IBD患者的结直肠癌有两种类型

挪威学者对67例发生结直肠癌的炎性肠病（IBD）患者进行的研究显示,大部分患者的癌症病变广泛,IBD发病年龄早。约1／4患者的癌症为局限性病变,这些患者IBD发病晚。该研究发表于《炎性肠病》（Inflamm BowelDis2009,15：1）。     

IBD合并EB病毒感染患儿外周血 NF-κB与病情进展的关系

目的 探讨炎症性肠病(IBD)合并人类疱疹病毒4型(EB)病毒感染患儿外周血核转录因子κB(NF-κB)与病情进展的关系。方法 选取2018年1月-2021年1月中国医科大学附属盛京医院收治的IBD合并EB病毒感染患儿88例,根据病情进展不同将其分为IBD活动组(n=46)和IBD缓解组(n=42),观察患儿疾病活动指标,另外分别抽取两组患儿5 ml静脉血,采取酶联免疫吸附法检测两组肿瘤坏死因子(TNF-α)水平,并利用逆转录聚合酶链反应(RT-PCR)检测血清中NF-κB水平。结果 IBD活动组临床疾病活动指数(CAI)评分、血沉、C-反应蛋白(CRP)及病理组织学评分分别为(12.84±3.27)分、(50.74±16.84)mm/h、(33.17±13.52)mg/L及(9.47±2.76)分均高于IBD缓解组(P<0.001);IBD活动组血清中NF-κB和TNF-α分别为(2.15±0.53)和(135.17±28.56)pg/ml均高于IBD缓解组(P<0.001);血清中TNF-α和NF-κB表达与IBD活动度均呈正相关(P<0.05)。结论 血清TNF...     

美沙拉嗪控释剂治疗炎症性肠病(IBD)的疗效和安全性

目的探讨美沙拉嗪控释剂治疗炎症性肠病的临床效果和安全性。方法选择2010年5月至2011年6月在我院确诊为炎症性肠病的患者54例,随机分为治疗组和对照组各27例,分别服用美沙拉嗪控释剂(1g/次,1次/d)和柳氮磺吡啶(1g/次,3次/d),疗程为8周。结果治疗组8周后总有效率81.48%(显效12例、有效10例、无效5例),不良反应发生率4.1%;对照组8周后总有效率66.67%(显效8例、有效10例、无效9例),不良反应发生率22.2%,两组总有效率及不良反应发生率比较有统计学差异(P<0.05)。结论美沙拉嗪控释剂对炎症性肠炎疗效确切,不良反应少,安全性较好。     

Hair EDX Analysis—A Promising Tool for Micronutrient Status Evaluation of Patients with IBD?

Micronutrient deficiencies can arise in various conditions, including inflammatory bowel diseases (IBD), and diagnosing these deficiencies can be challenging in the absence of specific clinical signs. The aim of this study was to evaluate the status of various trace elements hair concentration in IBD patients compared to a healthy control group and to identify potential correlations between the micronutrient status and relevant parameters related to disease activity. The concentrations of iron, magnesium, calcium, zinc, copper, manganese, selenium and sulfur in the hair of 37 IBD patients with prior diagnosed IBD (12 Crohn’s disease and 25 ulcerative colitis) and 31 healthy controls were evaluated by Energy Dispersive X-Ray spectroscopy (EDX). Significant differences in hair concentration profile of studied trace elements were identified for IBD patients compared to healthy controls. A significantly decreased hair concentration of iron, magnesium, calcium and selenium and a significantly increased sulfur hair concentration were observed in IBD patients at the time of evaluation. A decreased hair calcium concentration (r = −0.772, p = 0.003) and an increased sulfur concentration (r = 0.585, p = 0.046) were significantly correlated with disease activity. Conclusion: Hair mineral and trace elements evaluation may contribute to a proper evaluation of their status in IBD patients and improving the management of nutritional status of IBD patients.     

Extra-intestinal manifestation of IBD in Veszprém county (of Hungary): results of a 25-years follow-up study

INTRODUCTION: IBD is a systemic disease associated with a number of extraintestinal manifestations (EIM). The author's aim was to determine the prevalence and features of EIM in a large IBD population in Veszprém county in a 25-year follow-up study. PATIENTS AND METHODS: 873 IBD patients were enrolled in the study (UC: 619, m/f: 317/302, age at presentation: 38.3 yrs, disease duration: 11.2 yrs; CD: 254, m/f: 125/129, age at presentation: 32.5 yrs, disease duration: 9.2 yrs). Intestinal, extraintestinal symptoms and laboratory tests were monitored regularly. Any alteration suggesting an EIM was investigated by specialist. RESULTS: A total of 21.3% of patients with IBD patients had EIM (UC: 15.0%, CD: 36.6%). Age at presentation did not affect the likelihood of EIM. Prevalence of EIM was higher in women and in CD, ocular complications and PSC were more frequent in UC. In UC there was an increased tendency of EIM in patients having a more extensive disease. In CD patients colonic location increased the frequency of axial and type-1 peripheral arthritis. In UC positive family history increased the risk of joint (OR: 3.63) complications. Joint complications were more frequent in CD (22.4%) than in UC (10.2%, p < 0.01). PSC was present in 1.6% in UC and 0.8% in CD. Dermatological complications were present in 3.8% in UC and 10.2% in CD, the rate of ocular complications was around 3% in both diseases. Erythema nodosum, pyoderma gangrenosum and uveitis were the most frequent manifestations among them. Rare complications were glomerulonephritis, autoimmune haemolytic anaemia and celiac disease. CONCLUSION: The prevalence of EIM in Hungarian IBD patients was in concordance with data from Western countries. The high number of EIM supports a role for complex follow-up in these patients.