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1.
A bilateral ovarian tumor composed of mixed Brenner tumor and struma ovarii in the right ovary and mature cystic teratoma in the left ovary, is described. Mixed Brenner tumor and struma ovarii is rare; eight cases are reviewed. In this case, in addition to the typical Brenner tumor and struma ovarii, some nests composed of both Brenner tumor and struma ovarii in one nest were found in the right ovarian tumor. Immunohistochemically, the struma ovarii is stained for thyroglobulin, and Brenner nests showed various degrees of positive stain for thyroglobulin, which is a specific finding. Brenner tumor, in this case, may produce thyroglobulin or have a receptor to thyroglobulin or analog of thyroglobulin. The origin of mixed Brenner tumor and struma ovarii may be germ cell, as described in some literature, or the Brenner tumor may be of a metaplastic nature, although the Brenner tumor is fourfold the size of struma ovarii in the case presented. 相似文献
2.
Ovarian tumor composed only of Brenner tumor and struma ovarii is very rare; only 6 cases have been reported in the English literature, to the best of the author's knowledge. A 66-year-old woman underwent right oophorectomy because of torsion of right ovarian cyst. Macroscopically, the ovarian cyst was hemorrhagic and red. Cystic content was hemorrhagic fluid. Microscopically, the cyst walls were composed only of Brenner tumor (50% in area) and struma ovarii (50% in area). Hemorrhage and ischemic changes were seen. Other elements were not recognized. No malignant transformation was noted. These two elements were separately present, and no mergers between them were recognized. Immunohistochemically, the Brenner tumor element was positive for cytokeratins (AE1/3 and CAM5.2) and Ki67 (labeling=3%), but negative for thyroglobulin, TTF-1, p53, CA125, and vimentin. The struma ovarii element was positive for cytokeratins (AE1/3 and CAM5.2), thyroglobulin, TTF-1 and Ki67 (labeling=5%), but negative for p53, CA125 and vimentin. The findings suggests that there were cases of ovarian cyst composed only of Brenner tumor and struma ovarii, that such a case may be monodermal mature cystic teratoma or the Brenner tumor element was derived from surface epithelium in the preexisting struma ovarii, and that such a tumor manifest as cystic torsion. 相似文献
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4.
Struma ovarii is an ovarian mature teratoma composed exclusively or predominantly of thyroid tissue. Malignant transformation
of struma ovarii is rare and poorly understood, although this process is thought to be similar to carcinogenesis in malignant
tumors of differentiated thyroid tissue originating in the thyroid gland. Genetic alterations in the mitogen-activated protein
kinase pathway, including mutations of BRAF, RAS, and RET genes, have been implicated in the development of differentiated thyroid carcinoma arising in the thyroid gland. We report
here a case with RAS mutation detected in a malignant struma ovarii. The patient is a 38-year-old female who had a 2.4 cm ovarian cyst noted incidentally
on a first trimester ultrasound. She proceeded to ovarian cystectomy post-delivery, with pathologic examination detecting
a papillary thyroid carcinoma, follicular variant, arising in a cystic teratoma. The tumor was tested for BRAF, RAS, and RET/PTC mutations. HRAS codon 61 mutation was identified. This is the first report of RAS mutation detected in the follicular variant of papillary carcinoma arising in a struma ovarii. It provides evidence that
tumors developing in this setting involve molecular mechanisms similar to those implicated in tumors developing in the thyroid
gland. 相似文献
5.
Mitsuaki Ishida Tomoko Arimoto Kaori Sandoh Kimiaki Okano Yusuke Ebisu Hiroko Ito Mio Matsumoto Tomomi Mizokami Masato Kita Hidetaka Okada Koji Tsuta 《Diagnostic cytopathology》2019,47(3):218-221
Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68‐year‐old Japanese female was found to have a solid tumor with small cystic components in the left ovary, and bilateral salpingo‐oophorectomy was performed. The Papanicolaou smear of the imprint cytological specimen of the left ovarian tumor revealed presence of two distinct components. The first component included thyroid follicles, which was composed of flat sheets of polygonal epithelial cells without nuclear groove and intranuclear inclusion. The other component was composed of trabecular clusters of columnar cells containing round to slender nuclei with “salt and pepper” chromatin. Immunocytochemical analysis revealed that synaptophysin was expressed in the latter component. Therefore, a cytodiagnosis of strumal carcinoid was made. Histopathological analyses confirmed the diagnosis of strumal carcinoid. Albeit rare, carcinoid tumor occurs in the ovary, and the recognition of characteristic nuclear features and cellular arrangement leads to correct cytodiagnosis. Presence of struma ovarii component suggests an ovarian origin. Moreover, immunocytochemical analysis for neuroendocrine markers aids its differential diagnosis from granulosa cell tumor and carcinoma arising from struma ovarii. 相似文献
6.
Flavin R Smyth P Crotty P Finn S Cahill S Denning K Jinghuan Li O'Regan E O'Leary J Sheils O 《International journal of surgical pathology》2007,15(2):116-120
Struma ovarii is an extremely rare tumor that occasionally undergoes malignant transformation. Because struma ovarii is composed of thyroid tissue, it is conceivable that the pathogenetic events involved in thyroid follicular transformation may take place also in struma ovarii. The authors describe a case of a classical variant of papillary thyroid carcinoma arising in a struma ovarii of a 22-year-old female. The tumor was heterozygous for BRAF T1799A mutation. No ret/ PTC-1 or ret/PTC-3 rearrangements were detected. This finding would suggest that malignant struma ovarii is similar histologically and genetically to primary papillary thyroid carcinoma. 相似文献
7.
Benign and malignant struma ovarii 总被引:2,自引:0,他引:2
P S Hasleton P Kelehan J S Whittaker R W Burslem L Turner 《Archives of pathology & laboratory medicine》1978,102(4):180-184
Three cases of struma ovarii are reported, two of which were benign, and one which was malignant. Immunoperoxidase studies confirmed that the tumors secreted triiodothyronine and thyroxine, but no carcinoembryonic antigen nor alpha-fetoprotein. In the case of the malignant struma ovarii, the patient's thyroid was histologically normal, and thus the possibility of a metastasis to the ovary from a primary thyroid carcinoma was excluded. 相似文献
8.
Simone Sibio Francesco Borrini Paolo Sammartino Fabio Accarpio Daniele Biacchi Giuliana Caprio Franco Iafrate Anna Maria Baccheschi Tommaso Cornali Angelo Di Giorgio 《Endocrine pathology》2010,21(3):199-203
Brenner tumor and struma ovarii, two uncommon ovarian tumors arising alone or together with dermoid cysts or adenomas, are
both rare entities. Both tumors rarely become malignant and rarely metastasize. Few published reports describe coexisting
Brenner tumor and malignant struma ovarii. Patients in whom these malignancies coexist only occasionally have peritoneal spreading,
strumosis, or a history of thyrotoxicosis. The patient we describe, a 74-year-old woman, presented with a 2 months’ history
of lower abdominal pain and episodic intestinal subocclusion due to a complex pelvic mass. The mass consisted predominantly
of a Brenner tumor associated with struma ovarii containing a single small island of thyroid tissue that had undergone malignant
transformation into a well-differentiated papillary carcinoma and also normal thyroid tissue that had spread to the peritoneum.
The patient underwent radical surgical treatment and after 7 years follow-up is disease free. 相似文献
9.
A 45-year-old woman with papillary carcinoma arising in struma ovarii which involved one ovary without dissemination is presented. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Histopathological examination revealed malignant struma ovarii of the papillary type. The flow cytometric analysis revealed an hypodiploid DNA content (DNA index:0.67). Since these are rare tumors, there is no universal exact protocol for the treatment and follow-up of patients with malignant struma ovarii. More data are needed to determine the prognosis and management in preferring mode of therapy. 相似文献
10.
Malignant struma ovarii: a case report 总被引:1,自引:0,他引:1
Bolat F Erkanli S Kayaselcuk F Aslan E Tuncer I 《Pathology, research and practice》2005,201(5):409-412
Malignant struma ovarii is a rare form of the ovarian germ cell tumors. Hence, diagnosis and management of malignant struma ovarii have not been clearly defined. We present the case of a 34-year-old woman with papillary carcinoma arising in struma ovarii. The malignant component of this tumor was detected after laparoscopic removal, and a re-staging operation was performed afterwards. There was no evidence of clinical malignancy or metastases. In this paper, clinical features, treatment guidelines, diagnostic features, and immunohistochemical characteristics of this tumor are reviewed. 相似文献
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12.
Kim E Bae TS Kwon Y Kim TH Chung KW Kim SW Ro J Lee ES 《Journal of Korean medical science》2007,22(3):568-571
Teratomas comprise the most common extragonadal germ cell tumors in childhood. Most teratomas involving the thyroid are benign and occur in children. However, the adult cases reported are mostly malignant and commonly arise in the thyroid. We report a case of a 31-yr-old female with a huge neck mass. Pathologic examination revealed it to be malignant teratoma composed of primitive neuroepithelial tissue with primitive neural tubes and loose myxoid to fibrous immature mesenchymal stroma. The patient underwent extensive evaluation of the thyroid gland with computed tomography (CT) scan and positron emission tomography (PET) scan, which revealed no evidence of metastatic disease. She underwent total thyroidectomy with bilateral modified radical neck dissection, intensive chemotherapy and radiotherapy. At 22-months of follow-up, the patient has remained euthyroid and showed no evidence of recurrence. This is the first case, to our knowledge, of malignant thyroid teratoma with a exuberant primitive neuroectodermal tumor component in Korea. 相似文献
13.
Ovarian strumal carcinoid--report of a case that matastasized 总被引:2,自引:0,他引:2
Ovarian teratomas are known for their ability to form a wide variety of tissues. One unusual example of this potential is the strumal carcinoid in which the thyroid tissue is found in intimate association with carcinoid tumor. Although considered as a malignant transformation of struma ovarii, it is almost always benign. We report a rare case of strumal carcionid in a 44 year old lady who had metastasis in the contralateral ovary, myometrium and lungs. 相似文献
14.
Navarro MD Tan MA Lovecchio JL Hajdu SI 《Annals of clinical and laboratory science》2004,34(1):107-112
Struma ovarii are specialized teratomas consisting of thyroid tissue with various microscopic features, ranging from benign to malignant. We report a rare form of malignant struma ovarii, composed exclusively of a follicular variant of papillary thyroid carcinoma with capsular invasion, which occurred in a 65-yr-old woman. 相似文献
15.
Balasch Juan; Pahisa Jaime; Marquez Manuel; Ordi Jaime; Fabregues Francisco; Puerto Bienvenido; Vanrell Juan A. 《Human reproduction (Oxford, England)》1993,8(12):2075-2079
Malignant struma ovarii is a very rare tumour, with considerablecontroversy concerning the necessary histologic features formalignancy. Still more infrequent is the condition termed metastaticovarian strumosis or simply benign strumosis orstrumatosis and characterized by the presence of peritonealimplants of mature thyroid tissue occurring in struma ovarii.Strumosis should not be confused with malignancy.Presented is a case of metastatic ovarian strumosisin a 36-year-old woman with primary infertility who underwentthree in-vitro fertilization (IVF) cycles with ovarian stimulation.She received hormonal treatment for 6 months after her lastIVF because of persistent enlarged ovarian follicleswhich were in fact thyroid follicles. 相似文献
16.
Alice Dobi Sun A. Kim Ming Zhang Edward Iames Ihab Lamzabi 《Diagnostic cytopathology》2020,48(4):360-363
Highly differentiated follicular carcinoma of ovary (HDFCO) is a rare entity known to arise in struma ovarii. Clinical presentation and radiological features mimic other cystic ovarian neoplasm. Thus, intraoperative diagnosis of this entity can be challenging. We hereby report a HDFCO case of a 52‐year‐old woman, who presented with significant abdominal bloating for 3 months. Imaging showed a 11.7 cm left adnexal‐mixed cystic and solid mass, adhering to the bowel with ascites. The mass was examined intraoperatively and showed multilocular cysts filled with straw or red brown‐colored gelatinous fluid. Microscopically, the tumor consisted of small and large follicles with proteinous material and bland‐looking cuboidal cells, suspicious for struma ovarii or granulosa cell tumor with extensive cystic changes, while imprint cytology slides showed watery colloid with cracking artifact favoring the former. However, the adherence to the bowel suggested HDFCO, and prompted surgical staging. The histology of the ovarian mass in the permanent section resembled goiterous thyroid tissue with invasion of endocervical stroma, uterine wall and colonic serosa, and presence of tumor nodules in omentum leading to the diagnosis of HDFCO. Due to striking resemblance of HDFCO to benign thyroid goiter, searching for invasive and metastatic foci is crucial for correct diagnosis. In addition, intraoperative imprint cytology revealing colloid with cracking artifact is helpful for differentiating struma ovarii and/or HDFCO from other ovarian lesions. 相似文献
17.
Clear cell carcinomas are considered as high-grade tumor often with poor prognosis. We describe 2 cases of clear cell carcinomas of the ovary mimicking benign or less aggressive tumors encountered in the female genital track. The first case is mimicking a benign monodermal teratoma, the so-called struma ovarii, and the second mimicking a carcinoid tumor. 相似文献
18.
Non-neoplastic granulosa cells within ovarian vascular channels: a rare potential diagnostic pitfall
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AIMS: To describe six cases seen in consultation in which artefactual vascular involvement within the ovary by benign granulosa cells caused diagnostic confusion. METHODS/RESULTS: In five cases, the initial favoured diagnoses of the submitting pathologists were metastatic carcinoma (three cases) and immature neural elements within a teratoma (two cases). In two cases, the ovary contained a benign cystic teratoma (one with struma ovarii), in two cases endometriosis, in one case follicular cysts, and in the other no pathological lesion was present. In all cases, several small ovarian vascular channels contained cohesive groups of cells with mildly atypical nuclei and cytoplasm, which varied from scant to abundant and eosinophilic. In four cases, mitotic figures were identified. The cells were morphologically consistent with benign granulosa cells and were associated in four cases with a nearby follicle lined by similar cells. There was no evidence of a mass lesion, grossly or histologically, to suggest a granulosa cell tumour. The nature of the cells was confirmed using immunohistochemistry for alpha inhibin and calretinin in one case. CONCLUSIONS: This phenomenon is probably an artefact secondary to surgical trauma or sectioning within the laboratory; alternatively, it could be related to ovulation. It is important that this benign process is not misinterpreted as cancer, either primary or metastatic, which may prompt inappropriate treatment or investigations that are not needed. 相似文献
19.
S M Lele R N Sawh P Zaharopoulos A Adesokan M Smith J M Linhart C D Arrastia H R Krigman 《Modern pathology》2000,13(4):466-470
The majority of ovarian sex cord tumors with annular tubules (SCTAT) are benign neoplasms that arise sporadically. In patients who have Peutz-Jeghers syndrome (PJS), ovarian SCTAT is often an incidental finding. Malignant behavior in SCTAT has heretofore been reported only in sporadic cases. We report a case of bilateral, malignant SCTAT developing in a 47-year-old woman who had PJS, originally diagnosed as adenocarcinoma on cervicovaginal cytology. Cervicovaginal and peritoneal fluid cytologic preparations were characterized by pseudopapillary clusters and three-dimensional tubes of tumor cells with scanty cytoplasm and high nuclear: cytoplasmic ratio. Examination of surgical resection specimens revealed bilateral, solid ovarian tumors composed of simple and complex annular tubules with hyaline cores, typical of SCTAT. Tumor emboli were present within salpingeal lymphovascular spaces and in both right and left pelvic lymph nodes. Flow cytometry of tumor cells demonstrated a diploid phenotype. This case represents the first documented example of bilateral, malignant SCTAT arising in a patient who had PJS, presenting with an atypical cervicovaginal smear. 相似文献