The role of timing of tourniquet release and cementing on perioperative blood loss in total knee replacement

The purpose of our study is to estimate the effect of tourniquet release and cementing in perioperative blood loss associated with total knee arthroplasty. Eighty patients were randomly allocated into two equal groups concerning the timing of tourniquet release. Group A: patients with tourniquet release and haemostasis before wound closure and group B: patients with tourniquet release after skin closure and compressive bandaging. These groups were further subdivided in two subgroups (+ and -) depending on cementing or not of the tibial tray only. The total blood loss averaged 961 ml in group A and 692 ml in group B, while it was estimated 763 ml in the cemented group and 890 ml in the non-cemented group. The total blood loss within subgroups was Group A+ 904 ml, Group A- 1017 ml, Group B+ 622 ml and Group B- 762 ml. The mean number of blood units transfused per patient was 4.7 in Group A and 4.0 in Group B, while the mean operating time was 79 min and 66 min, respectively. Complications such as deep vein thrombosis, haematomata and minor wound complications occurred in patients of Group A and Group B, 0 and 2, 0 and 2, 8 and 11, respectively. Intraoperative tourniquet release seems to be related with significantly greater blood loss (P<0.001) and demands in blood transfusion P<0.05 as well as a longer operating time (P<0.001). Cementing of total knee replacements has a better haemostatic role compared to non-cemented prosthesis (P<0.05). Even though complications were more in postoperative tourniquet release group, no statistically significant difference was found between group A and B. Postoperative tourniquet release seems to offer better conditions of haemostasis probably due to the better controlled fibrolytic activity.     

The timing of tourniquet release and 'retransfusion' drains in total knee arthroplasty: A stratified randomised pilot investigation

The timing of tourniquet release is a potential confounding factor in the use of retransfusion drains in total knee arthroplasty. A pilot randomised trial was performed using retransfusion drains to determine whether releasing the tourniquet after wound closure reduced the overall blood loss and allogenic transfusion rate. Forty eight patients undergoing total knee arthroplasty were randomly allocated to receive either a retransfusion drain or no drain. Within each group the tourniquet was released before or after wound closure at the discretion of the surgeon. The peri-operative fall in haemoglobin, allogenic blood transfusion rate and complication rate were measured. There was an overall transfusion rate of 16%. There was no difference in the peri-operative fall in haemoglobin or the allogenic transfusion rates between the No Drain and Retransfusion Drain groups for patients undergoing total knee arthroplasty. Furthermore, the timing of the tourniquet release did not alter these findings. The results of this study suggest that the timing of the tourniquet release does not impact upon the ability of retransfusion drains to reduce the peri-operative fall in haemoglobin or the requirement for allogenic blood transfusion in total knee arthroplasty.     

同期双侧全膝关节置换中止血带的使用策略

背景：止血带在双侧膝关节置换中通常被全程使用或双侧部分时间使用,但极少有人尝试一侧不使用,对侧部分时间使用。 目的：探讨在同期双侧全膝关节置换术中可行有效的止血带使用策略。 方法：纳入2013年1至12月解放军医学院骨科收治的双膝重度骨关节炎患者80例(160膝),施行初次同期双膝置换,按先左后右顺序施行,按照止血带使用策略将分为两组,每组40例。试验组左膝不用止血带,右膝部分时间使用止血带;对照组双侧均全程使用止血带。记录两组患者术中及置换后失血量,置换后3 d大腿肿胀率及疼痛目测类比评分,置换后3周及1年后膝关节功能美国膝关节协会评分。 结果与结论：两组患者围手术期总失血量差异无显著性意义(P > 0.05),但是试验组患者置换后失血量少于对照组(P < 0.05)。试验组患者置换后3 d疼痛目测类比评分明显低于对照组(P < 0.05),试验组患者置换后3 d左侧疼痛目测类比评分低于右侧(P < 0.05);试验组患者置换后3 d双侧大腿肿胀率明显低于对照组(P < 0.05),试验组左侧置换后3 d大腿肿胀率低于右侧(P < 0.05);早期美国膝关节协会评分试验组高于对照组,远期评分两组差异无显著性意义(P > 0.05)。提示同期双侧全膝关节置换中采用先置换侧不使用止血带后置换侧部分时间使用止血带的策略,可在不增加围手术期总失血量的情况下减轻置换后疼痛及肿胀,促进膝关节早期功能恢复。中国组织工程研究杂志出版内容重点：人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程     

The limited use of a tourniquet during total knee arthroplasty: A randomized controlled trial

BackgroundTotal knee arthroplasty (TKA) is commonly performed using a tourniquet. However, some studies have reported that several complications were associated with the use of a tourniquet in TKA. In this study we investigate whether the limited use of a tourniquet in TKA would reduce complications and facilitate postoperative recovery.MethodsSixty patients were randomly divided into two groups (30 cases/group): group A using the tourniquet throughout the surgical procedure, and group B using the tourniquet starting from the cementation to the completion of the procedure. Operation time, total measured blood loss, and incidence of complications were all recorded.ResultsThere was no significant difference in operation time, total measured blood loss, and hemoglobin concentration between the two groups. Incidence of postoperative complications in group B was significantly decreased in comparison to that in group A. The limb circumference at 10 cm above the superior patellar pole or below the inferior patellar pole and the pain score in group B were significantly decreased compared with that in group A at any time point. Range of motion in group B was significantly increased at three and 5 days postoperatively in comparison to that in group A.ConclusionsThe limited use of a tourniquet in TKA provides the benefit of decreased limb swelling and knee joint pain while not compromising the operation time or blood loss and recovery.Level of evidenceLevel I (Therapeutic).Trial registration numberNCT02102581.     

Safety and efficacy of epsilon aminocaproic acid (EACA) as an antihemorrhagic drug in bilateral one stage total knee arthroplasty: A double-blind randomized controlled trial

BackgroundAntifibrinolytic drugs are widely used to minimize blood loss and transfusion requirements in total knee arthroplasty (TKA). Although tranexamic acid (TXA) has been widely studied for its use in TKA, there are limited studies on epsilon-aminocaproic acid (EACA).MethodsIn a double-blind randomized control trial, all patients (n = 91) operated with bilateral simultaneous TKA were randomly given either intravenous EACA or placebo (normal saline). A single surgeon performed the TKA with posterior-stabilized implants under tourniquet. A suction drain was placed and kept for 48 h postoperatively. The intraoperative blood loss and drain output were calculated. The postoperative hemoglobin (Hb), drop in Hb, total blood loss, and number of blood transfusions in each group were calculated.ResultsBoth of the groups were comparable in terms of age, sex, body mass index, and pre-operative Hb. There was a significant difference between the EACA group and control group in terms of intraoperative blood loss (150 ml vs. 165 ml, P = 0.01), drain output (494 ml vs. 1062 ml, P < 0.001), postoperative Hb (9.9 g/dl vs. 8.6 g/dl, P = 0.002), drop in Hb (2.2 g/dl vs. 3.1 g/dl, P = 0.026) and transfusion rate (median transfusion 0 vs. 1, P < 0.001). The total blood loss, as calculated by the Hb balance method, was significantly less (P < 0.001) in the EACA group (0.99 l) compared with the control group (2.71 l). None of the patients developed any adverse reaction/complication to the drug.ConclusionIntraoperative administration of EACA significantly decreased the blood loss and postoperative transfusion rates compared with no antifibrinolytic therapy in bilateral simultaneous TKA.     

Computer assisted versus conventional total knee replacement: a comparison of tourniquet time, blood loss and length of stay

Aims and introductionThe aim of this study was to assess whether navigated total knee arthroplasty (TKA) reduces peri-operative blood loss and post-operative length of stay when compared to conventional total knee arthroplasty techniques.Patients and methodsA retrospective case-note review of 143 patients undergoing primary elective total knee arthroplasty was carried out. Two surgeons in this institution perform conventional knee arthroplasty using intramedullary alignment with another two surgeons using the computer assisted technique. Blood losses were calculated using the Meunier et al. (2008) [23] method for calculation of peri-operative blood loss. This is based on changes in peri-operative blood indices compared to the patient's theoretical total blood volume which is calculated using the patient's pre-operative height and weight. Tourniquet time and post-operative length of stay for the two techniques of arthroplasty were also recorded.ResultsSixty eight patients underwent conventional TKA and 75 patients had navigated TKA's performed. This data showed no significant difference in blood loss (p = 0.56) or post-operative length of stay (p = 0.36). A significant difference in tourniquet time between the two techniques was demonstrated (p = 0.01).ConclusionIn this study there was no significant reduction in post-operative length of stay and peri-operative blood loss when using computer-assisted techniques. There was an increase in tourniquet time with the computer-assisted technique that may have implications upon work productivity for primary cemented knee arthroplasty.     

氨甲环酸联合不同抗凝药对全膝关节置换术围手术期失血量的影响

目的 探讨氨甲环酸与不同抗凝药联用对全膝关节置换术围手术期失血量的影响。 方法 纳入2014年10月至2019年10月初次行全膝关节置换术并符合标准的158例膝骨性关节炎患者,按氨甲环酸注射方法及术后使用抗凝药分为4组：A组,术中静脉注射氨甲环酸＋术后利伐沙班抗凝;B组,术中静脉注射氨甲环酸＋术后依诺肝素抗凝;C组,术中静脉＋局部注射氨甲环酸＋术后利伐沙班抗凝;D组,术中静脉＋局部注射氨甲环酸＋术后依诺肝素抗凝。各组患者一般情况、术前准备、手术方式及术后处理一致,比较其失血量、凝血功能、输血及围手术期不良事件的发生率。 结果 联合使用氨甲环酸的患者能有效控制总出血量、显性出血量、输血率及血浆D二聚体;术后使用利伐沙班或依诺肝素抗凝,出血量、输血率及围手术期不良事件发生率相当。 结论 TKA术中应用氨甲环酸静脉＋局部注射能有效减少围手术期的失血量、输血率及血浆D二聚体;术后使用利伐沙班或依诺肝素进行抗凝,两者对失血量及围手术期不良事件发生率的影响无明显差异。     

A randomised controlled trial investigating the effect of posterior capsular stripping on knee flexion and range of motion in patients undergoing primary knee arthroplasty

Increasing knee flexion following total knee arthroplasty (TKA) has become an important outcome measure. Surgical technique is one factor that can influence knee motion.In this study, it was hypothesised that stripping of the posterior knee capsule could improve flexion and range of motion (ROM) following TKA.Patients who were undergoing TKA were prospectively randomised into two groups — one group (62 patients) were allocated stripping of the posterior knee capsule (PCS), the other group (66 patients) no stripping (no-PCS).The primary outcome was change in flexion and ROM compared to pre-operative measurements at three time points; after wound closure, 3 months and 1 year post-operatively. Secondary outcomes were absolute measurements of flexion, extension, ROM and complications. All operations were performed by a single surgeon using the same implant and technique. All patients received identical post-operative rehabilitation.There was a significant gain in flexion after wound closure in the PCS group (p = 0.022), however there was no significant difference at 3 months or 1 year post-operatively. Absolute values of extension (p = 0.008) and flexion (p = 0.001) 3 months post-operatively were significantly reduced for the PCS group. The absolute value of ROM was significantly higher for the no-PCS group at 3 months (p = 0.0002) and 1 year (p = 0.005).There were no significant difference in the rate of complications.Posterior capsular stripping causes a transient increase in flexion that does not persist post-operatively. We do not recommend routine stripping of the posterior knee capsule in patients undergoing TKA.     

一期与分期修复双侧膝关节骨关节炎的临床效果比较

背景：当患者双侧膝关节发生退变性骨性关节炎时,是一期双侧同时全膝关节置换还是分期置换,目前仍存在争论。 目的：比较一期与分期全膝关节置换修复双侧膝关节骨性关节炎的效果。 方法：收集于2005年1月至2008年12月在在苏州大学附属第一医院进行治疗的双侧膝关节骨性关节炎患者,按照患者手术方法分为一期组(n=68)和分期组(n=71),采用Gemini MK II全膝关节系统分别进行一期全膝关节置换和分期全膝关节置换治疗。 结果与结论：与分期组相比,一期组患者手术时间、住院时间较短,平均术后输血量较大,医疗费用较低,但两组患者的术后膝关节功能、并发症、患者满意度情况差异无显著性意义,且至末次随访均未发现假体周围骨溶解。提示尽管一期双侧全膝关节置换增加患者的输血量,但是能够节约医疗费用、减少住院天数,因此是一种安全有效的治疗双侧膝关节骨关节炎的方法,值得推广应用。中国组织工程研究杂志出版内容重点：人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程全文链接：     

Cardiovascular disease predicts complications following bilateral total knee arthroplasty under a single anesthetic

IntroductionThis study evaluated the rate of perioperative complications of single anesthetic bilateral total knee arthroplasties (TKA) compared with staged procedures.MethodsThe records of all single anesthetic bilateral TKA performed between 1997 and 2007 at one large community hospital and one university hospital were retrospectively reviewed. Complete demographic data, preoperative co-morbidities and complications for 156 patients were compared to a matched staged bilateral TKA (n = 78) cohort.ResultsIn the single anesthetic bilateral TKA cohort, cardiovascular disease predicted postoperative myocardial (p < 0.01, Odds Ratio — 67.6), need for ICU admission (p < 0.01, Odds Ratio — 88.8), and days spent in ICU (p < 0.01), while cardiovascular disease did not significantly predict postoperative MI in the staged bilateral (p = 0.99, OR — 0).ConclusionPatients with cardiovascular disease are at higher risk for perioperative MI after single anesthetic bilateral TKA.     

Factors affecting outcome after total knee arthroplasty in patients with diabetes mellitus

PURPOSE: To compare the clinical outcome and complications following total knee arthroplasty (TKA) in diabetic and non-diabetic patients, and to identify diabetes-related risk factors for negative outcomes. MATERIALS AND METHODS: 222 primary TKAs in patients with diabetes were evaluated using Knee Society scores and Hospital for Special Surgery score. Postoperative complications were reviewed retrospectively. The mean follow-up was 53.2 months. The effect of diabetes-related factors and comparison with a matched control group were analyzed statistically. RESULTS: Significant improvements were noted in all the scores after TKA (p < 0.05). There was no statistical difference in clinical sores between the diabetic and non-diabetic patients. In multivariate analysis associating age, gender and body mass index with pain and knee score at the latest follow-up, the average knee scores in normal and overweight group were found to be significantly higher than those in the obese group. The diabetic patients had an increased overall incidence of postoperative complications (17.6%) compared with the control group (8.1%) (p < 0.05). Particularly, the rate of wound complications such as skin necrosis, bulla formation or erythema with drainage was higher in the diabetic group (p < 0.05). Diabetes-related factors did not influence the incidence of complications. Associated diseases were the only significant risk factors correlated with wound complications and meniscal bearing dislodgement. CONCLUSION: Patients with diabetes can benefit from TKA, even though diabetic patients are at an increased risk for overall postoperative and wound complications. Preoperative factors such as obesity and associated diseases may adversely affect the clinical outcome of TKA in diabetic patients.     

Comparison of early post-operative complications following unilateral or single-stage bilateral unicompartmental knee arthroplasty

BackgroundUnicompartmental knee arthroplasty (UKA) demonstrates excellent functional outcomes and patient satisfaction with low complication rates for single compartment knee arthritis. For patients with bilateral symptoms, single-stage bilateral UKA (SSBUKA) provides an alternative to staged procedures but may risk increased blood loss and systemic complications. Therefore, the purpose of this study is to compare 90-day postoperative complications between unilateral UKA and SSBUKA without exclusion for comorbidities.MethodsA retrospective review was completed for 555 consecutive patients having undergone UKA (317 unilateral and 238 bilateral). Data collection included patient demographics and 90-day complications. Independent t-tests (continuous) and Fishers' Exact tests (nominal) were performed to determine differences between unilateral UKA and SSBUKA patients.ResultsThe SSBUKA group had more male patients than the unilateral group (51.3% and 43.8%, respectively). There was no difference in age, body mass index or comorbidity classification. More SSBUKA patients experienced nausea than unilateral patients (17.6% and 11.0%), however, no significant differences were observed in the overall incidence of wound or systemic complications, and no transfusions were required. Significantly more unilateral patients (96.2%) were discharged home compared to SSBUKA (63.0%) (p < 0.001). Two SSBUKA (1.7%) and two unilateral UKA (0.6%) patients required readmission within 90-days with systemic complications.ConclusionsSSBUKA did not increase the risk of early postoperative systemic or wound complications, when performed in all patients with symptomatic disease without exclusion criteria as compared to patients undergoing unilateral UKA. Therefore, SSBUKA can safely be performed on the majority of patients who present to experienced high volume community hospitals.     

The effect of knee flexion during tourniquet inflation,fat pad excision and lateral tibial release on patellar subluxation during MIS TKA

We compared the distance of patellar subluxation (lateral patellar displacement) during MIS TKA arthrotomy among sequential variations of tourniquet application and soft tissue release in a consecutive series of 40 knees. The distance of patellar subluxation from the Whiteside's line was measured for every knee under four consecutive conditions; A) the tourniquet inflated with knee in full extension, B) no tourniquet pressure applied, C) the tourniquet inflated with knee in deep flexion, and D) the tourniquet inflated with knee in deep flexion and lateral tibial release (a limited subperiosteal soft tissue dissection including limited patellar fat pad excision and limited capsular release from the upper lateral tibial plateau). There were 28 women and 12 men with the average age of 70 years and the average BMI of 25.5. All knees had preoperative flexion more than 110°. The tourniquet pressure ranged from 280 to 300 mm Hg. The average skin incision length was 9 cm. The average measured distance of condition A, B, C and D were 10, 14.5, 15.8 and 22 mm, respectively with significant difference (p < 0.001). The distance of patellar subluxation correlated between conditions A) and C) (r², 0.67) and between conditions C) and D) (r², 0.72) in the studied group. However, there was no statistical difference of measured distance between group with condition B and C (p = 0.40). In conclusion, when MIS TKA is performed using the tourniquet, inflating the tourniquet with knee in deep flexion provided better arthrotomy exposure than the knee in full extension. Combined inflating tourniquet in deep knee flexion and lateral tibial release provided the greatest arthrotomy visualization.     

The effects of applying adhesion prevention gel on the range of motion and pain after TKA

A mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HA/CMC) has been shown to be effective for decreasing postoperative adhesions in various kinds of surgeries. We evaluated the clinical efficacy and safety of HA/CMC gel on the early postoperative range of motion and pain relief after total knee arthroplasty (TKA). Thirty one patients who underwent bilateral TKA as a single-stage procedure for primary osteoarthritis were included in the study. At the completion of surgery, among both knees, the HA/CMC gel was applied to one knee (the HA/CMC group) and HA/CMC gel was not applied to the other knee (the control group). The primary outcome measure was the early assessment of range of motion and the secondary outcome measures were the VAS pain scores and the number of complications in each group. Periarticular application of HA/CMC gel was safe without causing any wound problems or infection. However, local application of HA/CMC gel neither increased the range of motion nor reduced the pain during the early postoperative period of TKA.     

Deluxe-ps膝关节假体在一期双膝关节置换过程中的应用

背景：Deluxe-PS型人工膝关节假体是根据中国人膝关节解剖特点尤其是股骨髁的形态特征而设计的,其膝关节假体股骨髁内外侧距(M-L)较进口假体少3.5 mm。 目的：探讨Deluxe-ps膝关节假体行一期双膝关节置换中的近期疗效。 方法：纳入使用Deluxe-ps型膝关节假体行一期双侧膝关节置换的膝关节炎患者15例(30膝)设为实验组,对照组为同期采用P.F.C.Sigma膝关节假体行一期双侧膝关节置换的20例患者(40膝)。采用KSS评分和关节功能HSS评分、膝关节关节活动度评估两组手术前、后膝关节功能,对比两组手术时间、及术中输血量。 结果与结论：两组患者置换后均得到12-24个月随访,平均16个月。置换后患者膝关节疼痛均缓解,关节功能恢复满意。两组膝关节置换后与置换前KSS评分、HSS评分及膝关节关节活动度比较,差异均有显著性意义(P < 0.05)。置换后,两组间KSS评分和HSS评分及膝关节关节活动度,差异均无显著性意义(P > 0.05),两组间置换过程中出血量比较,差异均无显著性意义(P > 0.05),手术时间比较,差异有显著性意义(P < 0.05)。说明采用Deluxe-ps膝关节假体行一期双膝关节置换近期疗效满意。     

全膝关节置换术与单髁置换术治疗膝关节单间室骨关节炎的疗效比较

目的 比较全膝关节置换术(TKA)与膝关节单髁置换术(UKA)治疗膝关节单间室骨关节炎的临床疗效。方法 对2012年3月—2015年3月徐州医科大学附属医院骨科88例行TKA或UKA治疗单间室骨关节炎并获得随访患者的临床资料进行回顾性分析,依据不同手术方法分为TKA组48例(48膝)和UKA组40例(40膝)。采用美国特种外科医院(HSS)膝关节评分,评价疗效。比较两组患者手术时间、术中出血量、术后引流量,术后第1天、3天、1周血红蛋白水平和术后第3天血红蛋白较术前的下降量,以及末次随访时关节活动度和疗效。结果 两组患者手术顺利,88例患者获随访6~36个月,平均20.25个月。TKA组手术时间(85.77±7.61)min多于UKA组的(80.50±6.82)min,术中出血量(103.54±17.68)mL多于UKA组的(74.75±11.82)mL,术后引流量(420.21±68.80)mL多于UKA组的(241.75±53.05)mL,差异均有统计学意义(t=3.389、t'=8.787、t'=13.411,P值均＜0.01)。两组术前血红蛋白水平差异无统计学意义(P＞0.05);TKA组术后第1天、3天、1周血红蛋白均低于UKA组,术后第3天血红蛋白较术前的下降量高于UKA组,差异均有统计学意义(P值均＜0.05)。UKA组术后膝关节屈曲至90°所需时间为(7.33±3.02)d,短于TKA组的(12.63±3.10)d(t=8.086,P＜0.01);末次随访UKA组患者膝关节屈曲角度为116.98°±13.71°,大于TKA组的125.13°±15.95°(t=2.576,P＜0.01)。TKA组和UKA组HSS评分优、良、可、差者分别为25、19、3、1例和23、15、2、0例,其优良率分别为91.67%(44/48)和95.00%(38/40),差异无统计学意义(Z=0.603,P＞0.05)。两组患者中仅TKA组发生深静脉血栓1例,经介入治疗后痊愈;其余患者无手术并发症发生。结论 UKA与TKA治疗膝关节单间室骨关节炎均能获得满意的临床疗效,但UKA具有出血少、手术时间短、功能恢复快等优点。     

同时双侧全膝表面置换与单侧全膝关节置换围手术期康复的比较

背景：目前对于双膝严重骨性关节炎行两组同时双侧全膝表面置换的围手术期康复的相关研究尚不多见。 目的：比较双膝骨性关节炎两组同时双侧全膝表面置换术与单侧全膝关节置换围手术期康复训练的效果。 方法：两组医生对59例(118膝)患者双膝骨性关节炎同台同时全膝表面置换,与同期80例单膝骨性关节炎行单侧全膝关节置换患者(对照组)进行疗效比较。两组患者置换前均进行康复教育及预备康复,置换后康复方法标准一致。 结果与结论：同时双侧全膝表面置换组置换前通过压腿平均减小屈曲畸形角度11.2°(5°~22°)。置换后3~6周,股四头肌、腘绳肌肌力5级,较置换前平均增加0.8级;平均ROM≥95°(110±15) °;无痛行走500 m以上;独自无痛上下10级楼梯,无肿胀;出院时HSS评分较置换前增加。置换后3个月没有发现松动表现及不良反应,其康复疗效与对照组对比差异无显著性意义。表明,在围手术期对双膝骨性关节炎两组医生行同时双侧全膝表面置换,通过系统而量化的康复,有利于减少置换中截骨量和置换后并发症,促进患者膝关节功能恢复,与单侧全膝关节置换相比康复结果无明显差异。     

血友病患者全膝置换围手术期的凝血因子替代治疗

背景：世界血友病协会的治疗指南明确表示,关节置换应当在保证患者凝血因子活性的情况下进行。 目的：观察血友病关节炎患者行人工膝关节置换围手术期凝血因子替代治疗的安全性和有效性。 方法：1997/2006在血液内科的配合下,围手术期行凝血因子Ⅷ和Ⅸ活性水平监测,根据指南制定常规流程,进行因子Ⅷ(冻干人凝血因子Ⅷ)或因子Ⅸ(凝血酶原复合物)的替代治疗,对4例血友病关节炎患者共6个膝关节行人工膝关节置换治疗。 结果与结论：围手术期应用凝血因子进行常规替代治疗,血友病患者围手术期出血量与类风湿关节炎和骨关节炎患者差异无显著性意义(P=0.885)。置换后早期3个膝关节出现关节内血肿或肌肉出血,其中1例患者因凝血因子抑制性抗体形成,导致1侧膝关节置换后伤口裂开,行扩创清理后,伤口愈合良好。4例患者6个膝关节置换后没有晚期感染、假体松动、移位和断裂等并发症发生。所有4例患者置换前膝关节KSS评分平均28.2分,功能评分平均35分。置换后KSS评分85.2分,功能评分87分,与普通类风湿关节炎和骨关节炎膝关节置换后评分相似,但平均住院天数延长约3倍,住院费用为普通膝关节置换的2.5~3倍。结果显示凝血因子的替代治疗和凝血因子水平监测是保证血友病关节炎行人工膝关节置换最后成功的关键。     

Is a tourniquet beneficial in total knee replacement surgery?: A meta-analysis and systematic review

Proponents of tourniquets postulate that they optimise intra-operative visibility and reduce blood loss. This study compared the outcomes of tourniquet assisted to non-tourniquet assisted total knee replacement (TKR). A systematic review was undertaken of the electronic databases Medline, CINAHL, AMED and EMBASE, in addition to a review of unpublished material and a hand search of pertinent orthopaedic journals. The evidence-base was critically appraised using a tool from the Cochrane Bone, Joint and Muscle Trauma Group. Fifteen studies were identified evaluating 16 outcome measures and parameters of 1040 TKRs in 991 patients. There was a significantly greater intra-operative blood loss in non-tourniquet compared to tourniquet assisted surgery (p = 0.004). There was no significant difference between the groups for total blood loss or transfusion rate (p = 0.22; p = 0.48). There was a trend for greater complications in tourniquet compared to non-tourniquet patients. There was no difference between the groups for any other outcome measure assessed. In conclusion, this systematic review has found that there is no advantage to using a tourniquet in knee replacement surgery for reduction of transfusion requirements.     

Mortality and perioperative complications after unicompartmental knee arthroplasty

Aim of studyUnicompartmental knee arthroplasty (UKA) has been increasingly utilized over the past decade secondary to favorable reports of better range of motion, higher activity levels, and increased patient satisfaction compared with total knee arthroplasty (TKA). The aim of this study was to determine the 90-day incidence of perioperative complications and mortality of patients undergoing UKA.MethodsOne thousand consecutive UKA in 828 patients were retrospectively reviewed. A retrospective review was performed to evaluate 90-day perioperative complication and mortality rates.ResultsThere were zero deaths during the study period. Twelve percent of surgeries were complicated by variances within the 90-day postoperative period. There was one deep venous thrombosis (0.1%) and no pulmonary emboli. Cardiovascular complications were infrequent. Three patients had a myocardial infarction (0.31%), one developed congestive heart failure (0.1%), one angina (0.1%), and three had arrhythmias (0.31%). Secondary procedures were performed in 15 patients during the follow-up period: seven were manipulations under anesthesia for arthrofibrosis, one was an arthroscopic removal of retained cement, one arthroscopic removal of a drain, one repeat wound closure after a dehiscence secondary to a fall, one open reduction internal fixation for a supracondylar femur fracture, three irrigation and debridement procedures for an aseptic hematoma, and one radical debridement with later successful conversion to a total knee arthroplasty for a periprosthetic infection.ConclusionThis study supports the notion that UKA is a safe procedure that is associated with a low rate of mortality and serious post-operative complications.Level of evidenceLevel IV, therapeutic study case series.