重症胰腺炎RanSon标准与CT影象的相关性

目的探讨重症胰腺炎的Ranson标准与CT影象的相关性方法用BalthazarCT分级系统诊断的SAP31例,同时用Ranson标准再评价,并以50例BalthazarCT分级C级以下的轻症胰腺炎作为对照组.结果31例SAP患者Ranson标准的相对准确性仅为61.29%.当Ranson标准1～2项阳性时,SAP的可能性为32.25%,MAP的可能性为38%.结论单纯用Ranson标准评估急性胰腺炎的严重程度有漏误可能,CT检查快捷、准确、能及时发现局部并发症.临床上需CT与有关实验室检查结合才能全面估价病情.     

59例急性胰腺炎患者胃裸区受累情况及MSCT特点分析

目的探讨急性胰腺炎（AP）时胃裸区受累的多层螺旋CT（MSCT）的特点。方法回顾性分析59例AP患者的MSCT资料,重点观察胃裸区受累的MSCT表现特征、受累途径,分别统计不同Balthazar CT分级（Balthazar分级）患者胃裸区受累的发生率。结果 CT表现为胰周肾旁前间隙炎性病变与胃裸区炎性病变相连续39例;胰周肾旁前间隙病变与肾前筋膜间平面炎性病变相连续、后者再与胃裸区相连续8例;胰周肾旁前间隙炎性病变和肾前筋膜间平面炎性病变、共同累及胃裸区2例。胃裸区受累表现为胃裸区增宽,正常的脂肪密度影被水肿、浸润增厚的弥漫性或局限性软组织密度影或液性密度影所替代。CT分级为C、D、E级者胃裸区受累发生率依次为50.0%、68.4%、94.4%,两两比较,P均〈0.05。结论 MSCT可以准确、全面地显示胃裸区受累的解剖细节,胃裸区受累情况可在一定程度上反映AP的严重程度。     

甘油三酯水平与急性高甘油三酯血症性胰腺炎严重程度的关系

目的探讨血清甘油三酯(TG)水平与急性高甘油三酯血症性胰腺炎(AHTGP)严重程度之间的关系。方法回顾性分析2015年9月-2018年6月在首都医科大学附属北京安贞医院住院治疗的63例AHTGP患者,根据亚特兰大新分类标准,分为轻症急性胰腺炎组(MAP组,n=32)、中度重症急性胰腺炎组(MSAP,n=20)和重症急性胰腺炎(SAP,n=11)。记录AHTGP患者入院时和入院后48 h血清TG水平。符合正态分布的计量资料多组间比较采用单因素方差分析,不符合正态分布的计量资料多组间比较采用Kruskal-Wallis H检验;计数资料多组间比较采用χ~2检验; Spearman相关性分析用于评价数据间的相关性,受试者工作特征曲线(ROC曲线)用于评价指标的诊断效能。结果 3组患者入院后48 h血清TG水平、急性生理与慢性健康评分Ⅱ、改良CT严重程度指数、急性胰腺炎床旁严重程度指数和Ranson评分比较差异均有统计学意义(F=14. 423,χ~2值分别为44. 094、39. 654、30. 445、29. 426,P值均0. 05)。入院时血清TG水平仅与Ranson评分呈正相关(相关系数为0. 491,P 0. 001);入院后48 h血清TG水平与亚特兰大新分类标准、急性生理与慢性健康评分Ⅱ、改良CT严重程度指数、急性胰腺炎床旁严重程度指数和Ranson评分均呈正相关(相关系数分别为0. 396、0. 392、0. 400、0. 476、0. 400,P值均0. 05)。入院时和入院后48 h预测病情严重程度的曲线下面积分别为0. 652(P=0. 115)和0. 895 (P 0. 001),最佳阈值分别为34. 10 mmol/L和6. 95 mmol/L。结论入院后48 h血清TG水平在预测AHTGP严重程度上具有一定的临床价值。     

急性胰腺炎合并肝脏损害156例临床分析

目的分析急性胰腺炎合并肝脏损害的临床特点．方法对我院近3a收治的238例急性胰腺炎患者的临床资料进行分析，其中男112例，女126例，年龄6岁～83岁，平均年龄48．5岁．水肿型218例，坏死型20例．分析内容包括一般资料、诊断标准、病因、临床表现、实验室检查指标、B超、CT、病理类型及并发症等．全部数据都进行了统计学处理．结果在全部238例急性胰腺炎患者中，发现156例（占65．5％）合并不同程度的肝脏损害，女性明显多于男性．不同病因所致急性胰腺炎合并肝脏损害者无直接相关性，重症急性胰腺炎，较轻症者肝脏损害发生率高，损害程度严重，呈正相关系，肝功能异常多属可逆性．平均住院天数较同期无肝脏损害者明显延长．并发症多，预后差．结论肝脏损害的发生率及损害程度与急性胰腺炎的严重程度呈正相关性．     

急性胰腺炎患者血浆降钙素原的变化及其意义

目的探讨血浆降钙素原（PCT）水平对急性胰腺炎（AP）患者预后的预测价值。方法将入选的122例急性胰腺炎患者,根据Ranson评分标准分为轻型胰腺炎组（68例）和重型胰腺炎组（54例）,比较两组患者白细胞计数、中性粒细胞比值、血浆淀粉酶、脂肪酶、C反应蛋白（CRP）以及PCT水平。腹部CT检查评估两组患者CT严重指数（C鸭I）,评估CTSI和血浆PCT水平的相关性。结果（1）与轻型急性胰腺炎患者相比,重型组患者白细胞总数、中性粒细胞比值、血浆淀粉酶、脂肪酶、CRP以及PCT均明显升高,差异具有统计学意义（P〈0．05）;（2）Spearman相关分析提示CTSl分级与血浆PCT水平呈正相关（r=0．886,P〈0．05）。结论检测急性胰腺炎患者血浆PCT水平有利于对患者预后的评估。     

急性胰腺炎腹膜后间隙受侵CT表现与临床病程评价的相关性研究

目的探讨急性胰腺炎患者腹膜后间隙受侵CT表现与临床病程评价的相关性,为临床治疗提供参考数据。方法对我院2009年2月—2011年9月116例急性胰腺炎患者的CT影像资料与临床资料进行回顾性分析。结果 CT影像评价轻度15例,占12.93%;中度33例,占28.45%;重度68例,占58.62%。死亡25例,其中轻度9例(36.0%),中度5例(20.0),重度11例(44.0%)。临床病程分型轻度6例,占5.17%;重121例,占18.10%;重289例,占76.72%。死亡25例,其中轻症2例(8.0%),重15例(20.0%),重218例(75.0%)。结论急性胰腺炎腹膜后间隙受侵程度是评价病程程度的重要依据,呈正相关,但也与患者的年龄及其他合并症存在内在联系。     

急性重症胰腺炎的治疗—内外科方法疗效比较探讨

急性重症胰腺炎在临床上病情凶险,常常出现严重并发症,积极治疗是非常重要的.但外科或内科治疗各有利弊,如何选用治疗方法是临床上棘手的问题.本文通过对内外科治疗方法的对比, 进行如下分析.1 资料与方法1989年1月至1997年5月我院收住82例急性重症胰腺炎,男23例,女59例,年龄14～81岁,平均45.4岁.诊断标准参照1992年亚特兰大会议制定的标准:①急性胰腺炎出现胰外器官的损伤,包括心、脑、肺、肾、肝功能的损伤或衰竭及局部并发症;②Balthazar及Ranson CT诊断标准C级以上;③48h     

肥胖为急性胰腺炎患者早期独立的预后指标

目的研究基于亚洲人群肥胖诊断标准探讨肥胖在评估急性胰腺炎(AP)预后中的作用.方法分别采用Ranson标准、APACHE-Ⅱ评分和Balthazar CT分级系统对临床资料完整的42例AP患者入院时的病情严重程度作回顾性分析,若同时符合Ranson标准为≥3分,APACHEⅡ≥8分和Balthazar CT分级达到D级或E级者拟诊为重症急性胰腺炎(SAP).肥胖的诊断依据为体重指数(BMI)≥25 kg/m2.同时详细记录患者入院时的年龄、性别、病因及并发症情况.结果42例患者中SAP11例,轻型急性胰腺炎(MAP)31例.SAP患者平均BMI为(27.31±6.28)kg/m2,显著高于MAP患者平均BMI(22.41±4.72)kg/m2,AP时肥胖患者与非肥胖患者发展成SAP与年龄无相关性.AP时男性肥胖患者较男性非肥胖患者更易发展成SAP,且男性肥胖患者较女性肥胖患者SAP发生的危险度高.胆源性AP时肥胖患者SAP发病的危险度最高,且胆源性AP时肥胖患者较非肥胖患者更易发展成SAP.AP时肥胖与并发症无显著差异.结论肥胖可能是AP时早期独立的预后因素,尤其与一些相关因素如性别、病因联合应用时可能更具有评估性.     

三种临床评分标准对急性胰腺炎预后的评估价值比较

目的研究APACHEⅡ、Ranson、Balthazar CT严重指数(CT severity index,CTSI)三种临床评分标准对轻症及重症急性胰腺炎(AP)的评估价值。方法回顾性研究AP患者355例。分析各临床评分标准与禁食天数、住院天数的相关性。用受试者工作特征曲线(ROC曲线)分析各临床评分标准判断重症AP的敏感性和特异性,分析各临床评分标准对局部和全身并发症的预见能力。结果355例患者中,诊断轻症273例,重症82例。轻症和重症AP患者三种临床评分分值差异均有统计学意义(P<0.05)。三种临床评分分值与AP患者禁食天数、住院时间均显著相关。CTSI标准的敏感性最高为77%,曲线下面积(AUC)最大为0.85。CTSI对局部并发症预见能力最高,Ranson标准对全身并发症的预见能力最高。结论CTSI标准是临床判断重症AP最有效的指标,将三种临床评分标准结合起来能更准确地评估急性胰腺炎的预后。     

急性胰腺炎纵隔扩散途径的MR表现

[目的]研究急性胰腺炎(Acute pancreatitis,AP)胰周积液向纵隔扩散的MR表现及解剖基础,以及与急性胰腺炎MR严重指数(MR severity index,MRSI)的相关性。[方法]回顾分析69例因AP入院并进行MR检查患者。观察分析胰周积液向纵隔扩散的解剖途径并进行分级;AP的严重程度用MRSI评分分级并统计分析胰周积液与MRSI评分相关性。[结果]69例中,88.40%患者有不同程度胰周积液。胰周积液向纵隔扩散时食管裂孔受累31.14%,主动脉裂孔8.05%,下腔静脉裂孔3.25%。胰周积液评分与MRSI正相关(r=0.449,P0.01)。[结论]AP伴发胰周积液较常见,胰周积液通过膈肌裂孔向纵隔扩散。胰周积液也可以作为评价AP严重程度的辅助指标。     

体质指数、血糖和血清三酰甘油与急性胰腺炎病情严重程度的关系

尽早对急性胰腺炎（AP）的病情严重程度作出准确评估,有助于快速诊断重症病例．及时开始正确的治疗。近年来,临床上起病时伴有代谢综合征（MS）的AP患者日趋多见。目的：探讨体质指数（BMI）、血糖和血清三酰甘油（TG）水平这三项MS组分指标与AP病情严重程度和预后的关系。方法：回顾2007年10月～2010年10月新疆医科大学第一附属医院住院AP患者的临床资料,分析入院时BMI、血糖、血清TG水平与Ranson评分、BalthazarCT分级、CT严重度指数（CTSI）的关系。结果：共398例AP患者纳入研究,重症患者的BMI、血糖、血清TG水平显著高于轻症患者（尸〈O．05）。Ranson评分≥3、BalthazarCT分级为D／E级和CTSI≥3的AP患者,BMI、血糖、血清TG水平分别显著高于Ranson评分〈3、BalthazarCT分级为A／B／C级和CTSI〈3的AP患者（P〈0．05）。根据Pearson相关系数,BMI、血糖、血清TG水平中的任意一项与Ranson评分、BahhazarCT分级、CTSI中的任意一项均呈显著正相关（P〈0．05）。结论：人院时BMI、血糖和血清TG水平能反映AP病情严重程度．可作为AP预后评估的参考指标。     

血小板异常评估急性胰腺炎严重程度的临床价值

目的 探讨血小板在急性胰腺炎（AP）患者中的变化及与AP严重程度和预后的关系.方法 比较重症急性胰腺炎（SAP）组和轻症急性胰腺炎（MAP）组血小板的计数变化.SAP组进一步分为血小板降低组和血小板正常组,比较两组局部并发症和多器官功能不全综合征（MODS）的发生率、病死率以及胰腺坏死程度与血小板计数（PLT）之间的关系,并分析差异有无统计学意义.分析血小板与APACHEⅡ评分系统、BISAP评分系统、CT评分系统、Ranson评分系统之间的相关性.结果 AP患者重症组与轻症组相比,PLT下降,血小板平均体积（MPV）升高,两组比较差异有统计学意义（P＜0.05）,PDW及PCT差异无统计学意义（P＞0.05）;SAP患者发病前3d首次PLT计数（＜100×109/L）的比例明显多于MAP组,差异有统计学意义（P＜0.001）;血小板降低组中局部并发症患者、MODS患者及病死率明显高于血小板正常组,两者相比差异有统计学意义（P ＜0.05）;SAP中胰腺坏死程度与血小板计数水平呈负相关性（P＜0.05）;血小板计数水平与CTSI评分标准相关性最强,其次是APACHEⅡ评分系统,而与Ranson评分系统无明显相关性.结论 血小板计数能够比较准确地反映AP的严重程度和预后,尤其在预测SAP局部并发症、MODS、坏死程度中有较高的临床价值.     

Computed tomography and magnetic resonance imaging in the assessment of acute pancreatitis

BACKGROUND & AIMS: This study aimed to compare the accuracy of magnetic resonance imaging (MRI) with computed tomography (CT) in assessing acute pancreatitis (AP) and to explore the correlation between MRI findings and clinical outcome. METHODS: Patients with AP were investigated by contrast-enhanced CT and MRI on admission and 7 and 30 days thereafter. MRI was performed with intravenous secretin and contrast medium. Balthazar's grading system was used to measure CT and MRI severity indices (CTSI and MRSI, respectively). RESULTS: Thirty-nine patients (median age, 47 years; range, 15-86) were studied. AP was of biliary etiology in 19 patients (49%). On admission, AP was assessed clinically as severe in 7 patients (18%). A strong correlation was demonstrated between CTSI and MRSI on admission and 7 days later. MRSI on admission correlated with the following: the Ranson score, C-reactive protein levels 48 hours after admission, duration of hospitalization, and clinical outcome regarding morbidity, including local and systemic complications. Considering the Ranson score as the gold standard, MRI detected severe AP with 83% (58-96, 95% CI) sensitivity, 91% (68-98) specificity vs. 78% (52-93) and 86% (63-96) for CT. Magnetic resonance cholangiopancreatography after i.v. secretin injection showed pancreatic duct leakage in 3 patients (8%). CONCLUSIONS: MRI is a reliable method of staging AP severity, has predictive value for the prognosis of the disease, and has fewer contraindications than CT. It can also detect pancreatic duct disruption, which may occur early in the course of AP.     

磁共振弥散加权成像对急性胰腺炎严重性分级的诊断价值

目的 探讨磁共振弥散加权成像（DWI）及表观弥散系数（ADC）值对急性胰腺炎（AP）严重性分级的诊断价值.方法 收集57例AP及13例正常胰腺含有DWI的磁共振成像（MRI）资料.参照Balthazar CT分级标准,将AP的MRI表现分为相应的A、B、C、D、E5级,测量炎症胰腺及正常胰腺的ADC值.应用单因素方差分析（ANOVA）对各级别AP之间、各级别与正常胰腺之间的ADC值进行统计学分析.结果 57例AP的MRI分为A级6例,B级9例,C级11例,D级10例,E级21例.炎症胰腺在DWI图像均呈高信号（100％）.A、B、C、D、E级AP的平均ADC值分别为（1.138 ±0.024）、（1.289±0.179）、（1.513 ±0.156）、（1.554 ±0.248）、（1.938±0.567） ×10-3 mm2/s,正常胰腺的ADC值为（1.687±0.129）×10-3mm2/s.A、B级AP的ADC值显著低于E级（P值均＜0.01）及正常胰腺（P值均＜0.05）,C级的ADC值低于E级（P＜0.05）,其余各级别之间,C、D、E级与正常胰腺之间的ADC值差异均无统计学意义（P值均＞0.05）.结论 磁共振DWI有利于Balthazar分级中形态变化不明显的A级及B级AP的早期诊断,但ADC值对AP严重性的分级诊断无明显价值.     

Balthazar computed tomography severity index is superior to Ranson criteria and APACHE Ⅱ scoring system in predicting acute pancreatitis outcome

AIM: Acute pancreatitis (AP) is a process with variable involvement of regional tissues or organ systems.Multifactorial scales included the Ranson, Acute Physiology and Chronic Health Evaluation (APACHE Ⅱ) systems and Balthazar computed tomography severity index (CTSI).The purpose of this review study was to assess the accuracy of CTSI, Ranson score, and APACHE Ⅱ score in course and outcome prediction of AP.METHODS: We reviewed 121 patients who underwent helical CT within 48 h after onset of symptoms of a first episode of AP between 1999 and 2003. Fourteen inappropriate subjects were excluded; we reviewed the 107 contrastenhanced CT images to calculate the CTSI. We also reviewed their Ranson and APACHE Ⅱ score. In addition, complications,duration of hospitalization, mortality rate, and other pathology history also were our comparison parameters.RESULTS: We classified 85 patients (79%) as having mild AP (CTSI ＜5) and 22 patients (21%) as having severe AP (CTSI ≥5). In mild group, the mean APACHE Ⅱ score and Ranson score was 8.6±1.9 and 2.4±1.2, and those of severe group was 10.2±2.1 and 3.1±0.8, respectively. The most common complication was pseudocyst and abscess and it presented in 21 (20%) patients and their CTSI was 5.9±1.4. A CTSI ≥5 significantly correlated with death,complication present, and prolonged length of stay.Patients with a CTSI ≥5 were 15 times to die than those CTSI ＜5, and the prolonged length of stay and complications present were 17 times and 8 times than that in CTSI ＜5,respectively.CONCLUSION: CTSI is a useful tool in assessing the severity and outcome of AP and the CTSI ≥5 is an index in our study. Although Ranson score and APACHE Ⅱ score also are choices to be the predictors for complications,mortality and the length of stay of AP, the sensitivity of them are lower than CTSI.     

Balthazar computed tomography severity index is superior to Ranson criteria and APACHE Ⅱ scoring system in predicting acute pancreatitis outcome

AIM: Acute pancreatitis (AP) is a process with variable involvement of regional tissues or organ systems. Multifactorial scales included the Ranson, Acute Physiology and Chronic Health Evaluation (APACHE II) systems and Balthazar computed tomography severity index (CTSI). The purpose of this review study was to assess the accuracy of CTSI, Ranson score, and APACHE II score in course and outcome prediction of AP. METHODS: We reviewed 121 patients who underwent helical CT within 48 h after onset of symptoms of a first episode of AP between 1999 and 2003. Fourteen inappropriate subjects were excluded; we reviewed the 107 contrast-enhanced CT images to calculate the CTSI. We also reviewed their Ranson and APACHE II score. In addition, complications, duration of hospitalization, mortality rate, and other pathology history also were our comparison parameters. RESULTS: We classified 85 patients (79%) as having mild AP (CTSI <5) and 22 patients (21%) as having severe AP (CTSI > or =5). In mild group, the mean APACHE II score and Ranson score was 8.6+/-1.9 and 2.4+/-1.2, and those of severe group was 10.2+/-2.1 and 3.1+/-0.8, respectively. The most common complication was pseudocyst and abscess and it presented in 21 (20%) patients and their CTSI was 5.9+/-1.4. A CTSI > or =5 significantly correlated with death, complication present, and prolonged length of stay. Patients with a CTSI > or =5 were 15 times to die than those CTSI <5, and the prolonged length of stay and complications present were 17 times and 8 times than that in CTSI <5, respectively. CONCLUSION: CTSI is a useful tool in assessing the severity and outcome of AP and the CTSI > or =5 is an index in our study. Although Ranson score and APACHE II score also are choices to be the predictors for complications, mortality and the length of stay of AP, the sensitivity of them are lower than CTSI.     

急性胰腺炎多层螺旋CT灌注参数与临床病情评估系统的关系研究

目的 探讨急性胰腺炎(AP)患者胰腺CT灌注的变化以及与临床常用AP病情评估系统的关系,评价CT灌注参数的临床应用价值.方法 2006年8月至2008年4月行胰腺CT灌注成像120例,其中正常胰腺34例,AP患者86例.采用德国Siemens somatom Sensation 64层螺旋CT进行灌注扫描,获取灌注参数血流量(BF)、血容量(BV)、峰值时间(TTP)和表面通透性(PS),并与APACHEⅡ评分、Ranson评分、CRP、CTSI、腹痛缓解时间、住院天数、局部并发症发生率进行相关性分析.结果 AP组平均BF、BV、TTP、PS分别为(113.57±50.04)ml·100 ml~(-1)·min~(-1)、(146.61±45.11)ml/L、(148.88±21.16)0.1 s、(119.53±52.36)0.5 ml·100 ml~(-1)·min~(-1),与正常对照组相比,BF、BV明显下降(P<0.05),TTP、PS变化无统计学意义.AP患者的CT灌注参数BF、BV与APACHEⅡ评分、Ransont评分、CRP、CTSI存在相关性(P<0.05),与腹痛缓解时间、住院天数、局部并发症发生率也存在相关性(P<0.05).结论 AP患者胰腺血流灌注降低,灌注参数BV、BF与临床常用AP病情评估系统存在相关关系,提示CT灌注成像在AP病情评估中具有良好的临床应用前景.     

急性胰腺炎患者并发消化性溃疡的危险因素分析

目的探讨急性胰腺炎（AP）患者并发消化性溃疡（PU）的临床特征,并分析并发PU的危险因素。方法回顾性分析2008年1月-2012年1月本院收治的156例AP患者的临床资料。所有患者入院后48 h内均进行胃镜检查,以评估其PU和幽门螺杆菌感染情况。应用Ranson评分、APACHEⅡ评分和CT严重指数评估AP严重程度。应用独立样本t检验和χ2检验对伴发PU和无PU的AP患者临床特征进行统计学分析,同时应用单因素和多因素Logistic回归分析AP患者并发PU的危险因素。结果156例AP患者中,88例患者胃镜检出PU,检出率为56.4%。88例PU患者中,只有28（31.8%）例检测到幽门螺杆菌。28例幽门螺杆菌阳性的PU患者中,22例发生胃溃疡,6例同时发生胃溃疡和十二指肠溃疡,没有发现单独的十二指肠溃疡;而60例幽门螺杆菌阴性PU患者中,25例发生胃溃疡,26例发生十二指肠溃疡,9例同时发生胃溃疡和十二指肠溃疡。单因素Logistic回归分析发现,男性、酒精源性胰腺炎、吸烟、饮酒、高甘油三酯水平和高C反应蛋白水平、APACHEⅡ评分≥8分与AP患者并发PU显著相关。然而,多因素Logistic回归分析发现,只有APACHEⅡ评分≥8分（OR=8.54,95%CI：4.52～16.15,P〈0.01）是AP患者并发PU的独立危险因素。结论 AP患者容易并发PU,而幽门螺杆菌感染率较低。APACHEⅡ评分≥8分是AP患者并发PU的独立危险因素。     

Diagnosing acute pancreatitis and assessing its severity by enhanced computed tomography: Correlations with Ranson’s assessment method

Using the criteria of the Japanese Ministry of Health and Welfare for evaluation of the severity of acute pancreatitis based on computed tomography (CT), we assessed the CT grade of 104 patients with acute pancreatitis. The CT assessments were compared with the status of acute pancreatitis in these patients, assessed using Ranson’s system of objective prognostic signs by which acute pancreatitis is classified as “mild”, “moderate”, or “severe.” A CT grade of I corresponded to Ranson’s mild category; CT grades II and III corresponded to moderate, and CT grades IV and V corresponded to servere. Some patients with a CT grade of IV or V died, whereas none of the patients with CT grades of I, II, or III succumbed to the condition. This study confirmed that enhanced CT provides an accurate CT grading of acute pancreatitis. We emphasize the necessity of using enhanced CT for determining the severity of acute pancreatitis, not only on admission but also during hospitalization if the patient’s condition should become exacerbated.     

急性胰腺炎严重程度与血脂代谢异常的相关性及其预后研究

目的 探讨急性胰腺炎严重程度与血脂代谢异常的相关性及其预后.方法 选择急性胰腺炎患者128例,并根据严重程度将128例患者分为轻症急性胰腺炎（MAP）组80例,重症急性胰腺炎（SAP）组48例.比较两组患者的性别、年龄、体质量指数（BMI）以及糖尿病、酗酒的比例,观察两组患者血脂水平,分析血脂水平与急性胰腺炎严重度的相关性,并比较两组患者的预后.结果 SAP组男性患者比例明显高于MAP组,两组患者BMI均高于对照组,且SAP组BMI明显高于MAP组（P＜0.05）;SAP组伴有糖尿病、有酗酒史的比例明显高于MAP组（P＜0.05）.MAP组、SAP组患者血清三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）均明显高于对照组（P＜0.05）,两组患者血清高密度脂蛋白胆固醇（HDL-C）则明显低于对照组;SAP组患者TG、LDL-C明显高于MAP组,HDL-C则明显低于MAP组（P＜0.05）.急性胰腺炎患者APACHE Ⅱ评分与TG、LDL-C呈正相关,与HDL-C呈负相关（P＜0.05）.SAP组患者的感染、脓肿、坏死、假性囊肿、急性肺损伤或ARDS发生率明显高于MAP组（P＜0.05）.结论 急性胰腺炎的严重程度与脂代谢异常有一定的相关性,两者相互影响;脂代谢异常程度也影响着急性胰腺炎的预后.治疗急性胰腺炎时应在积极控制胰腺炎症的同时降低血脂水平,防止和减少胰腺坏死.