共查询到20条相似文献,搜索用时 31 毫秒
1.
John L Moran Petra L Graham Sue Rockliff Andrew D Bersten 《Critical care (London, England)》2010,14(4):R134
Introduction
Current low (stress) dose corticosteroid regimens may have therapeutic advantage in severe sepsis and septic shock despite conflicting results from two landmark randomised controlled trials (RCT). We systematically reviewed the efficacy of corticosteroid therapy in severe sepsis and septic shock. 相似文献2.
David J Sturgess Thomas H Marwick Chris Joyce Carly Jenkins Mark Jones Paul Masci David Stewart Bala Venkatesh 《Critical care (London, England)》2010,14(2):R44
Introduction
Diastolic dysfunction as demonstrated by tissue Doppler imaging (TDI), particularly E/e' (peak early diastolic transmitral/peak early diastolic mitral annular velocity) is common in critical illness. In septic shock, the prognostic value of TDI is undefined. This study sought to evaluate and compare the prognostic significance of TDI and cardiac biomarkers (B-type natriuretic peptide (BNP); N-terminal proBNP (NTproBNP); troponin T (TnT)) in septic shock. The contribution of fluid management and diastolic dysfunction to elevation of BNP was also evaluated. 相似文献3.
Park HY Suh GY Song JU Yoo H Jo IJ Shin TG Lim SY Woo S Jeon K 《Critical care (London, England)》2012,16(1):R3
Introduction
The use of low-dose steroid therapy in the management of septic shock has been extensively studied. However, the association between the timing of low-dose steroid therapy and the outcome has not been evaluated. Therefore, we evaluated whether early initiation of low-dose steroid therapy is associated with mortality in patients with septic shock. 相似文献4.
Donnino MW Cocchi MN Salciccioli JD Kim D Naini AB Buettner C Akuthota P 《Critical care (London, England)》2011,15(4):R189-8
Introduction
Mitochondrial dysfunction is associated with increased mortality in septic shock. Coenzyme Q10 (CoQ10) is a key cofactor in the mitochondrial respiratory chain, but whether CoQ10 is depleted in septic shock remains unknown. Moreover, statin therapy may decrease CoQ10 levels, but whether this occurs acutely remains unknown. We measured CoQ10 levels in septic shock patients enrolled in a randomized trial of simvastatin versus placebo. 相似文献5.
Introduction
Refractory septic shock has dismal prognosis despite aggressive therapy. The purpose of the present study is to report the effects of terlipressin (TP) as a rescue treatment in children with catecholamine refractory hypotensive septic shock. 相似文献6.
Martin W Dünser Esko Ruokonen Ville Pettilä Hanno Ulmer Christian Torgersen Christian A Schmittinger Stephan Jakob Jukka Takala 《Critical care (London, England)》2009,13(6):R181-7
Introduction
It is unclear to which level mean arterial blood pressure (MAP) should be increased during septic shock in order to improve outcome. In this study we investigated the association between MAP values of 70 mmHg or higher, vasopressor load, 28-day mortality and disease-related events in septic shock. 相似文献7.
Corinne MP Buysse Lindy CAC Vermunt Hein Raat Jan A Hazelzet Wim CJ Hop Elisabeth MWJ Utens Koen FM Joosten 《Critical care (London, England)》2010,14(3):R124
Introduction
The purpose of this study was to evaluate associations between long-term physical and psychological outcome variables in patients who survived meningococcal septic shock (MSS) in childhood. 相似文献8.
Massimo Girardis Laura Rinaldi Lara Donno Marco Marietta Mauro Codeluppi Patrizia Marchegiano Claudia Venturelli the 'Sopravvivere alla Sepsi 'group of the Modena-University Hospital 《Critical care (London, England)》2009,13(5):R143
Introduction
The application in clinical practice of evidence-based guidelines for the management of patients with severe sepsis/septic shock is still poor in the emergency department, while little data are available for patients admitted to the intensive care unit (ICU). The aim of this study was to evaluate the effect of an in-hospital sepsis program on the adherence to evidence-based guidelines and outcome of patients with severe sepsis/septic shock admitted to the ICU. 相似文献9.
Caroline Guignant Nicolas Voirin Fabienne Venet Françoise Poitevin Christophe Malcus Julien Bohé Alain Lepape Guillaume Monneret 《Intensive care medicine》2009,35(11):1859-1867
Purpose
Improvements in survival after septic shock will most likely rely on our capacity to manage individualized therapies based on the measurement of rapidly accessible biomarkers. As the early phase of septic shock is dominated by severe alterations of the cardiovascular system, the predictive value for mortality of pro-vasopressin (pro-AVP) and pro-adrenomedullin (pro-ADM), two vasoactive pro-hormones, was assessed. 相似文献10.
Imad Abboud Nicolas Lerolle Saik Urien Jean-Marc Tadié Françoise Leviel Jean-Yves Fagon Christophe Faisy 《Critical care (London, England)》2009,13(4):R120-8
Introduction
In septic patients, an unpredictable response to epinephrine may be due to pharmacodynamic factors or to non-linear pharmacokinetics. The purpose of this study was to investigate the pharmacokinetics of epinephrine and its determinants in patients with septic shock. 相似文献11.
Purpose
To quantify the effects of minor variations in the definition and measurement of systemic inflammatory response syndrome (SIRS) criteria and organ failure on the observed incidences of sepsis, severe sepsis and septic shock. 相似文献12.
Philippe Seguin Bruno Laviolle Patrick Guinet Isabelle Morel Yannick Mallédant Eric Bellissant 《Critical care (London, England)》2005,10(1):R32
Introduction
Microcirculatory blood flow, and notably gut perfusion, is important in the development of multiple organ failure in septic shock. We compared the effects of dopexamine and norepinephrine (noradrenaline) with those of epinephrine (adrenaline) on gastric mucosal blood flow (GMBF) in patients with septic shock. The effects of these drugs on oxidative stress were also assessed. 相似文献13.
Purpose
Low-dose steroids have shown contradictory results in trials and three recent meta-analyses. We aimed to assess the efficacy and safety of low-dose steroids for severe sepsis and septic shock by Bayesian methodology. 相似文献14.
Jean-François Georger Olfa Hamzaoui Anis Chaari Julien Maizel Christian Richard Jean-Louis Teboul 《Intensive care medicine》2010,36(11):1882-1889
Purpose
To examine the consequences of administration of norepinephrine on muscle tissue oxygenation in severely hypotensive septic shock patients. 相似文献15.
Textoris J Fouché L Wiramus S Antonini F Tho S Martin C Leone M 《Critical care (London, England)》2011,15(4):R176-6
Introduction
Current guidelines recommend maintaining central venous oxygen saturation (ScvO2) higher than 70% in patients with severe sepsis and septic shock. As high levels of ScvO2 may reflect an inadequate use of oxygen, our aim was to evaluate the relation between maximal ScvO2 levels (ScvO2max ) and survival among intensive care unit (ICU) patients with septic shock. 相似文献16.
Torgersen C Luckner G Schröder DC Schmittinger CA Rex C Ulmer H Dünser MW 《Intensive care medicine》2011,37(9):1432-1437
Purpose
To evaluate the association between concomitant arginine-vasopressin (AVP)/hydrocortisone therapy and mortality in severe septic shock patients. 相似文献17.
van Hees HW Schellekens WJ Linkels M Leenders F Zoll J Donders R Dekhuijzen PN van der Hoeven JG Heunks LM 《Critical care (London, England)》2011,15(5):R233
Introduction
ICU-acquired muscle weakness commonly occurs in patients with septic shock and is associated with poor outcome. Although atrophy is known to be involved, it is unclear whether ligands in plasma from these patients are responsible for initiating degradation of muscle proteins. The aim of the present study was to investigate if plasma from septic shock patients induces skeletal muscle atrophy and to examine the time course of plasma-induced muscle atrophy during ICU stay. 相似文献18.
Sadaka F O'Brien J Migneron M Stortz J Vanston A Taylor RW 《Critical care (London, England)》2011,15(2):R89-7
Introduction
The use of human recombinant activated protein C (rhAPC) for the treatment of severe sepsis remains controversial despite multiple reported trials. The efficacy of rhAPC remains a matter of dispute. We hypothesized that patients with septic shock who were treated with rhAPC had an improved in-hospital mortality compared to patients with septic shock with similar acuity who did not receive rhAPC. 相似文献19.
Carolina Ruiz Glenn Hernandez Cristian Godoy Patricio Downey Max Andresen Alejandro Bruhn 《Critical care (London, England)》2010,14(5):R170
Introduction
Previous studies have suggested that high volume hemofiltration (HVHF) may contribute to revert hypotension in severe hyperdynamic septic shock patients. However, arterial pressure stabilization occurs due to an increase in systemic vascular resistance, which could eventually compromise microcirculatory blood flow and perfusion. The goal of this study was to determine if HVHF deteriorates sublingual microcirculation in severe hyperdynamic septic shock patients. 相似文献20.
Karlsson S Heikkinen M Pettilä V Alila S Väisänen S Pulkki K Kolho E Ruokonen E;Finnsepsis Study Group 《Critical care (London, England)》2010,14(6):R205