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E. Giostra C. Junet L. Rubbia Brandt S. Yerly J.‐P. Chave C. Samer L. Elkrief J. Vionnet T. Berney the Swiss HIV Swiss Transplant Cohort Studies 《American journal of transplantation》2016,16(8):2473-2478
Most countries exclude human immunodeficiency virus (HIV)‐positive patients from organ donation because of concerns regarding donor‐derived HIV transmission. The Swiss Federal Act on Transplantation has allowed organ transplantation between HIV‐positive donors and recipients since 2007. We report the successful liver transplantation from an HIV‐positive donor to an HIV‐positive recipient. Both donor and recipient had been treated for many years with antiretroviral therapy and harbored multidrug‐resistant viruses. Five months after transplantation, HIV viremia remains undetectable. This observation supports the inclusion of appropriate HIV‐positive donors for transplants specifically allocated to HIV‐positive recipients. 相似文献
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Jonas Paul DeMuro 《Surgical Practice》2014,18(4):191-192
Injury to the small bowel is uncommon after trauma. There are rare reported cases of delayed post‐traumatic stenosis of the small bowel occurring weeks, months or even years later. In this study, we present a case of a delayed stenosis that caused a small‐bowel obstruction three decades after the trauma. 相似文献
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Boris Schlenker Derya Tilki Michael Seitz Markus J. Bader Oliver Reich Peter Schneede Edwin Hungerhuber Christian G. Stief Christian Gratzke 《BJU international》2010,106(6):786-790
Study Type – Therapy (case series)Level of Evidence 4
OBJECTIVE
To retrospectively analyse the long‐term follow‐up of 54 patients treated with organ‐preserving laser therapy for penile carcinoma, as such therapy provides excellent cosmetic and functional results, but recurrence rates are high, which might impair the oncological outcome and worsen tumour‐related survival.PATIENTS AND METHODS
Between 1979 and 2008, 54 patients with penile carcinoma were treated with the neodymium‐doped yttrium‐aluminium‐garnet (Nd:YAG) laser at our institution; 11 were classified as having carcinoma in situ (Tis), 39 as T1 and four as T2.RESULTS
There was local recurrence in 16 patients (42%); the mean (range) time to local recurrence was 53 (9–132) months. In half the patients the time to local recurrence was >53 months, with the latest recurrence at 132 months after initial therapy of primary tumour. There was no statistically significant difference in recurrence rates with Tis or invasive penile carcinoma. In lymph‐node‐negative patients at initial presentation, there were no newly developed positive lymph nodes during the follow‐up.CONCLUSIONS
Organ‐preserving laser therapy showed a relatively high recurrence rate in patients with a long‐term follow up, but the oncological outcome and survival were not compromised by local recurrence. Therefore, laser therapy appears to be appropriate for treating premalignant lesions and early stages of penile carcinoma. Patients should be informed about the potential for late recurrence. 相似文献7.
Anneliese D. Heiner Abigail D. Smith Jessica E. Goetz Curtis M. Goreham‐Voss Kyle T. Judd Todd O. McKinley James A. Martin 《Journal of orthopaedic research》2013,31(6):887-893
A common in vitro model for studying acute mechanical damage in cartilage is to impact an isolated osteochondral or cartilage specimen with a metallic impactor. The mechanics of a cartilage‐on‐cartilage (COC) impact, as encountered in vivo, are likely different than those of a metal‐on‐cartilage (MOC) impact. The hypothesis of this study was that impacted in vitro COC and MOC specimens would differ in their impact behavior, mechanical properties, chondrocyte viability, cell metabolism, and histologic structural damage. Osteochondral specimens were impacted with either an osteochondral plug or a metallic cylinder at the same delivered impact energy per unit area, and processed after 14 days in culture. The COC impacts resulted in about half of the impact maximum stress and a quarter of the impact maximum stress rate of change, as compared to the MOC impacts. The impacted COC specimens had smaller changes in mechanical properties, smaller decreases in chondrocyte viability, higher total proteoglycan content, and less histologic structural damage, as compared to the impacted MOC specimens. If MOC impact conditions are to be used for modeling of articular injuries and post‐traumatic osteoarthritis, the differences between COC and MOC impacts must be kept in mind. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 887–893, 2013 相似文献
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Junchen Wang Xiaohui Zhang Zhen Sun Fuzhen Yuan 《The international journal of medical robotics + computer assisted surgery : MRCAS》2018,14(5)
Background: The limited field of view of the X‐ray image intensifier makes it difficult to cover a large target area with a single X‐ray image. X‐ray image stitching techniques have been proposed to produce a panoramic X‐ray image. Methods: This paper presents an efficient intensity‐based X‐ray image stitcher, which does not rely on accurate C‐arm motion control or auxiliary devices and hence is ready to use in clinic. The stitcher consumes sequentially captured X‐ray images with overlap areas and automatically produces a panoramic image. The gradient information for optimization of image alignment is obtained using a back‐propagation scheme so that it is convenient to adopt various image warping models. Results: The proposed stitcher has the following advantages over existing methods: (1) no additional hardware modification or auxiliary markers are needed; (2) it is robust against feature‐based approaches; (3) arbitrary warping models and shapes of the region of interest are supported; (4) seamless stitching is achieved using multi‐band blending. Experiments have been performed to confirm the effectiveness of the proposed method. Conclusion: The proposed X‐ray image stitcher is efficient, accurate and ready to use in clinic. 相似文献
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B. J. Levvey M. Harkess P. Hopkins D. Chambers C. Merry A. R. Glanville G. I. Snell 《American journal of transplantation》2012,12(9):2406-2413
Donation‐after‐Determination‐of‐Cardiac‐Death (DDCD) donor lungs can potentially increase the pool of lungs available for Lung Transplantation (LTx). This paper presents the 5‐year results for Maastricht category III DDCD LTx undertaken by the multicenter Australian National DDCD LTx Collaborative. The Collaborative was developed to facilitate interaction with the Australian Organ Donation Authority, standardization of definitions, guidelines, education and audit processes. Between 2006 and 2011 there were 174 actual DDCD category III donors (with an additional 37 potentially suitable donors who did not arrest in the mandated 90 min postwithdrawal window), of whom 71 donated lungs for 70 bilateral LTx and two single LTx. In 2010 this equated to an “extra” 28% of donors utilized for LTx. Withdrawal to pulmonary arterial flush was a mean of 35.2 ± 4.0 min (range 18–89). At 24 h, the incidence of grade 3 primary graft dysfunction was 8.5%[median PaO2/FiO2 ratio 315 (range 50–507)]. Overall the incidence of grade 3 chronic rejections was 5%. One‐ and 5‐year actuarial survival was 97% and 90%, versus 90% and 61%, respectively, for 503 contemporaneous brain‐dead donor lung transplants. Category III DDCD LTx therefore provides a significant, practical, additional quality source of transplantable lungs. 相似文献
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N. T. Hu J. S. H. Tsai S. M. Guo L. S. Shieh Y. Chen 《Optimal control applications & methods.》2011,32(4):433-475
This paper presents the low‐order multi‐rate linear time‐invariant decentralized trackers using the new observer‐based sub‐optimal method for a class of unknown sampled‐data nonlinear time‐delay system with closed‐loop decoupling. For the unknown sampled‐data nonlinear time‐delay system, we assume that the inner time delay is clearly known. Under this prerequisite, the appropriate (low‐) order decentralized linear observer for the unknown sampled‐data nonlinear system is determined by the off‐line observer/Kalman filter identification (OKID) method with artificial delay input and actual delay output. Then, the above observer has been further improved based on the proposed new observer‐based sub‐optimal approach. Sequentially, the decentralized tracker with the high gain property is proposed, so that the closed‐loop system has the decoupling property. The proposed approach constructs complete mathematics method including the concept of optimal control theory and state‐matching digital redesign technique and is quite useful for the complicated interconnected large‐scale sampled‐data nonlinear time‐delay system with unknown system equation. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
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Interleukin‐8 mediates neutrophil‐endothelial interactions in pig‐to‐human xenogeneic models
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Beth M. French Selin Sendil Krishna Mohan Sepuru Jolene Ranek Lars Burdorf Donald Harris Emily Redding Xiangfei Cheng Christopher T. Laird Yuming Zhao Benjamin Cerel Krishna Rajarathnam Richard N. Pierson III Agnes M. Azimzadeh 《Xenotransplantation》2018,25(2)
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M. Isola A. Zotti P. Carnier E. Baroni R. Busetto 《Transboundary and Emerging Diseases》2005,52(8):407-410
Radiographic examination and subsequent dual‐energy X‐ray absorptiometry scans of the hips were performed in seven dogs with monolateral Legg‐Perthes‐Calvé disease to quantify bone changes produced by osteonecrosis in the proximal femur on the affected and unaffected side. All dogs were found to be affected with grade 2 and 3 of the radiographic classification proposed by Ljunggren [Acta Orthop. Scand. (1967) vol. 95]. Bone mineral density (g/cm2) of the femoral neck and proximal femoral metaphysis were evaluated on the affected and unaffected side; we detected no differences in bone mineral density for both regions of interest within the population studied in relation to gender, body weight and side analysed nor between the affected and the unaffected limb. We therefore assume that radiographic areas of decreased density in the proximal femoral epiphysis during chronic stages of Legg‐Calvé‐Perthes disease do not alter the global mineral content of the scanned region. 相似文献
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Investigation of High‐Speed Erythrocyte Flow and Erythrocyte‐Wall Impact in a Lab‐on‐a‐Chip
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To better understand erythrocyte high‐speed motion, collision characteristics, and collision‐induced hemolysis probability in rotary blood pumps, a visual experimental investigation of high‐speed erythrocyte flow and erythrocyte‐wall collision in a lab‐on‐a‐chip was performed. The erythrocyte suspension was driven by a microsyringe pump connected to the microchip, and the erythrocyte flow and erythrocyte‐wall impact process were observed and imaged by an optical microscope and a high‐speed camera. Two types of microchips with different impact surfaces (flat and curved) were employed. The motion and deformation features before and after collision were studied in detail. The results show that erythrocytes not only move along the flow direction in the flow plane but also rotate and roll in three‐dimensional space. Erythrocytes keep discoid shape during the movement in the straight channel, but their deformations during collision are mainly classified into two types: erythrocyte structure is still stable and the erythrocyte performance can be ensured to a certain extent in the TypeA deformation, while the TypeB deformation makes the membrane more likely to fracture on the stretched side, increasing the probability of hemolysis. Furthermore, the movements and deformations of the erythrocytes after collision are analyzed and classified into two types: bouncing and slipping. Moreover, a simulation method for the flow in microchip was performed and validated through a comparison of the streamlines and experimental erythrocytes tracks, which can be further employed to predict the high‐speed blood flow, associated with collision process in mechanical blood pump. 相似文献
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N‐acetyl‐seryl‐aspartyl‐lysyl‐proline mediates the anti‐fibrotic properties of captopril in unilateral ureteric obstructed BALB/C mice
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Gary C.W. Chan Hao Jia Wu Kam Wa Chan Wai Han Yiu Ailis Zou Xiao Ru Huang Hui Yao Lan Kar Neng Lai Sydney C.W. Tang 《Nephrology (Carlton, Vic.)》2018,23(4):297-307
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Lucia Savarino Giovanni Padovani Massimo Ferretti Michelina Greco Elisabetta Cenni Giorgio Perrone Francesco Greco Nicola Baldini Armando Giunti 《Journal of orthopaedic research》2008,26(12):1569-1576
Alternative bearing surfaces for total hip arthroplasty, such as metal‐on‐metal and ceramic‐on‐ceramic, offer the potential to reduce mechanical wear and osteolysis. In the short and medium term, the second generation of metal‐on‐metal bearings demonstrated high systemic metal ion levels, whereas ceramic‐on‐ceramic bearings showed the lowest ones. We aimed to verify whether the long‐term ion release in metal‐on‐metal subjects was still relevant at a median 10‐year follow‐up, and whether a fretting process at the modular junctions occurred in ceramic‐on‐ceramic patients and induced an ion dissemination. Serum levels were measured in 32 patients with alumina‐on‐alumina implants (group A), in 16 subjects with metal‐on‐metal implants (group B), and in 47 healthy subjects (group C). Group B results were compared with medium‐term findings. Cobalt and chromium levels were significantly higher in metal‐on‐metal implants than in ceramic‐on‐ceramic ones and controls. Nevertheless, ion levels showed a tendency to decrease in comparison with medium‐term content. In ceramic‐on‐ceramic implants, ion values were not significantly different from controls. Both in groups A and B, aluminum and titanium release were not significantly different from controls. In conclusion, negligible serum metal ion content was revealed in ceramic‐on‐ceramic patients. On the contrary, due to the higher ion release, metal‐on‐metal coupling must be prudently considered, especially in young patients, in order to obtain definitive conclusions. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 相似文献
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The Estimation of Second‐Generation HR‐pQCT From First‐Generation HR‐pQCT Using In Vivo Cross‐Calibration
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Sarah L Manske Erin M Davison Lauren A Burt Duncan A Raymond Steven K Boyd 《Journal of bone and mineral research》2017,32(7):1514-1524
Second‐generation high‐resolution peripheral quantitative computed tomography (HR‐pQCT) provides the highest resolution in vivo to assess bone density and microarchitecture in 3D. Although strong agreement of most outcomes measured with first‐ (XCTI) and second‐ (XCTII) generation HR‐pQCT has been demonstrated, the ability to use the two systems interchangeably is unknown. From in vivo measurements, we determined the limits of estimating XCTII data from XCTI scans conducted in vivo and whether that estimation can be improved by linear cross‐calibration equations. These data are crucial as the research field transitions to the new technology. Our study design established cross‐calibration equations by scanning 62 individuals on both systems on the same day and then tested those cross‐calibrations on the same cohort 6 months later so that estimated (denoted as XCTII*) and “true” XCTII parameters could be compared. We calculated the generalized least‐significant change (GLSC) for those predictions. There was strong agreement between both systems for density (R2 > 0.94), macroarchitecture (R2 > 0.95), and most microarchitecture outcomes with the exception of trabecular thickness (Tb.Th, R2 = 0.51 to 0.67). Linear regression equations largely eliminated the systematic error between XCTII and XCTII* and produced a good estimation of most outcomes, with individual error estimates between 0.2% and 3.4%, with the exception of Tt.BMD. Between‐system GLSC was similar to within‐XCTI LSC (eg, 8.3 to 41.9 mg HA/cm3 for density outcomes). We found that differences between outcomes assessed with XCTI and XCTII can be largely eliminated by cross‐calibration. Tb.Th is poorly estimated because it is measured more accurately by XCTII than XCTI. It may be possible to use cross‐calibration for most outcomes when both scanner generations are used for multicenter and longitudinal studies. © 2017 American Society for Bone and Mineral Research. 相似文献