共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Michael M. Dowling MD PhD Charles T. Quinn MD MS Zora R. Rogers MD George R. Buchanan MD 《Pediatric blood & cancer》2010,54(3):461-464
Silent cerebral infarctions (SCI) occur in up to 35% of children with sickle cell anemia (HbSS) but are rarely recognized during the initial 10–14 days when diffusion weighted magnetic resonance imaging (MRI) can differentiate acute infarctions from remote events. We report acute SCI in seven children with HbSS who had areas of restricted diffusion on MRI without persistent focal neurologic deficits. Four had acute SCI identified following acute anemic events. Our observations suggest that SCI are detectible in the acute phase, present with subtle neurologic symptoms, result in permanent neurologic injury, and may be caused by acute anemic events. Pediatr Blood Cancer 2010;54:461–464. © 2009 Wiley‐Liss, Inc. 相似文献
6.
7.
8.
9.
Sarah L. Reeves Hannah K. Jary Jennifer P. Gondhi Jean L. Raphael Lynda D. Lisabeth Kevin J. Dombkowski 《Pediatric blood & cancer》2019,66(6)
This study describes hydroxyurea use among children ages 1 to 17 with sickle cell anemia (SCA) enrolled in at least one year of Medicaid in six states from 2005 to 2012. Administrative claims were used to summarize the number of days’ supply of hydroxyurea dispensed by state and year. A total of 7963 children with SCA contributed 22 424 person‐years. Among person‐years with greater than 30 days of hydroxyurea, only 18% received at least 300 days of hydroxyurea, which varied by state. Following updated recommendations for all children with SCA to be offered hydroxyurea, strategies to increase hydroxyurea adherence among this population are needed. 相似文献
10.
11.
12.
13.
14.
Bone mineral density in children with sickle cell anemia 总被引:1,自引:0,他引:1
PURPOSE: We evaluated bone mineral density (BMD) and risk factors for poor bone mineralization in children with sickle cell anemia (SCA). PATIENTS AND METHODS: Twenty-five children with severe manifestations of SCA (frequent hospitalizations, growth delay, or need for chronic red cell transfusions) were enrolled. Bone density was assessed at lumbar spine and proximal femur with dual-energy X-ray absorptiometry (DXA), and Z-scores were calculated by comparison with age, sex, and ethnicity-specific reference data. RESULTS: The median age of the study population was 12.8 years (10.2-19.8 years). Calcium intake was inadequate in 60%, and serum 25-hydroxy vitamin D (25-OHD) level <50 nM in 74% of patients. Median Z-scores for lumbar spine (-2.3) and proximal femur (-1.7) were markedly reduced, and 64% (95% confidence interval, 43%-82%) of patients had low bone density. Z-scores were not related to age, growth delay, chronic transfusions, or ferritin level. CONCLUSION: Our results suggest that children with severe manifestations of SCA have low BMD, and possess significant deficits in dietary calcium and circulating vitamin D. 相似文献
15.
16.
17.
18.
Transfusion‐transmitted babesiosis leading to severe hemolysis in two patients with sickle cell anemia
下载免费PDF全文
![点击此处可从《Pediatric blood & cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Kristine Karkoska James Louie Abena O Appiah‐Kubi Lawrence Wolfe Lorry Rubin Sujatha Rajan Banu Aygun 《Pediatric blood & cancer》2018,65(1)
The intracellular parasites Babesia microti and Babesia duncani can be transmitted by blood transfusion and cause severe life‐threatening hemolytic anemia in high‐risk patients, including those with sickle cell disease. The rarity of the diagnosis, as well as its similar clinical presentation to delayed hemolytic transfusion reaction, may lead to a delay in diagnosis, as well as inappropriate treatment with steroids or other immunosuppressive agents. The morbidity caused by this disease in especially vulnerable populations justifies the need for a universal blood‐screening program in endemic areas. 相似文献
19.
Helton KJ Paydar A Glass J Weirich EM Hankins J Li CS Smeltzer MP Wang WC Ware RE Ogg RJ 《Pediatric blood & cancer》2009,52(1):85-91