A dual‐tuned transceive resonator for 13C{1H} MRS: two open coils in one

Proton‐decoupled, ¹³C nuclear MRS experiments require a RF coil that operates at the Larmor frequencies of both ¹³C and ¹H. In this work, we designed, built and tested a single‐unit, dual‐tuned coil based on a half‐birdcage open coil design. It was constructed as a low‐pass network with a resonant trap in series with each leg. Traps are tuned in alternate legs such that the two resonant modes arise from currents on alternate legs. The coil performance was compared with that of a dual‐tuned coil consisting of two proton surface coils operating in quadrature and a single surface coil for ¹³C transmission and reception. The half‐birdcage coil was shown to produce a more homogeneous RF field at each frequency and was more sensitive to a ¹³C signal arising from regions further from the coil surface. The applicability of the coil in vivo was demonstrated by acquiring a proton decoupled, natural abundance ¹³C glycogen signal from the calf of a normal volunteer. Copyright © 2013 John Wiley & Sons, Ltd.     

Low-cost inductively coupled stacked wireless RF coil for MRI at 3 T

Inductively coupled RF coils are an inexpensive and simple method to realize wireless RF coils in MRI. They are low cost and can greatly ease the MR scan setup and improve patient comfort, since they do not require bulky components such as cables, baluns, preamplifiers, and connectors. Previous works have typically used single-layer loops as wireless coils. In this work, we present a novel wireless coil, where two loops are stacked and decoupled with a shared capacitor. We found that such a stacked structure could increase the coil efficiency and SNR. Compared with the single-layer wireless coil, both electromagnetic simulation and MR experiment results demonstrate that the stacked wireless coil has a considerable SNR improvement of approximately 35%.     

VERSE‐guided parallel RF excitations using dynamic field correction

In parallel RF pulse design, peak RF magnitudes and specific absorption rate levels are critical concerns in the hardware and safety limits. The variable rate selective excitation (VERSE) method is an efficient technique to limit the peak RF power by applying a local‐only RF and gradient waveform reshaping while retaining the on‐resonance profile. The accuracy of the excitation performed by the VERSEd RF and gradient waveforms strictly depends on the performance of the employed hardware. Any deviation from the nominal gradient fields as a result of frequency dependent system imperfections violates the VERSE condition similarly to off‐resonance effects, leading to significant excitation errors and the RF pulse not converging to the targeted peak RF power. Moreover, for iterative VERSE‐guided RF pulse design (i.e. reVERSE), the k‐space trajectory actually changes at every iteration, which is assumed to be constant. In this work, we show both theoretically and experimentally the effect of gradient system imperfections on iteratively VERSEd parallel RF excitations. In order to improve the excitation accuracy besides limiting the RF power below certain thresholds, we propose to integrate gradient field monitoring or gradient impulse response function (GIRF) estimations of the actual gradient fields into the RF pulse design problem. A third‐order dynamic field camera comprising a set of NMR field sensors and GIRFs was used to measure or estimate the actual gradient waveforms that are involved in the VERSE algorithm respectively. The deviating and variable k‐space is counteracted at each iteration of the VERSE‐guided iterative RF pulse design. The proposed approaches are demonstrated for accelerated multiple‐channel spatially selective RF pulses, and highly improved experimental performance was achieved at both 3 T and 7 T.     

Wireless coils based on resonant and nonresonant coupled‐wire structure for small animal multinuclear imaging

Earlier work on RF metasurfaces for preclinical MRI has targeted applications such as whole‐body imaging and dual‐frequency coils. In these studies, a nonresonant loop was used to induce currents into a metasurface that was operated as a passive inductively powered resonator. However, as we show in this study, the strategy of using a resonant metasurface reduces the impact of the loop on the global performance of the assembled coil. To mitigate this deficiency, we developed a new approach that relies on the combination of a commercial surface coil and a coupled‐wire structure operated away from its resonance. This strategy enables the extension of the sensitive volume of the surface coil while maintaining its local high sensitivity without any hardware modification. A wireless coil based on a two parallel coupled‐wire structure was designed and electromagnetic field simulations were carried out with different levels of matching and coupling between both components of the coil. For experimental characterization, a prototype was built and tested at two frequencies, 300 MHz for ¹H and 282.6 MHz for ¹⁹F at 7 T. Phantom and in vivo MRI experiments were conducted in different configurations to study signal and noise figures of the structure. The results showed that the proposed strategy improves the overall sensitive volume while simultaneously maintaining a high signal‐to‐noise ratio (SNR). Metasurfaces based on coupled wires are therefore shown here as promising and versatile elements in the MRI RF chain, as they allow customized adjustment of the sensitive volume as a function of SNR yield. In addition, they can be easily adapted to different Larmor frequencies without loss of performance.     

Size‐adaptable 13‐channel receive array for brain MRI in human neonates at 3 T

Neonatal brain injury suffered by preterm infants and newborns with some medical conditions can cause significant neurodevelopmental disabilities. MRI is a preferred method to detect these accidents and perform in vivo evaluation of the brain. However, the commercial availability and optimality of receive coils for the neonatal brain is limited, which in many cases leads to images lacking in quality. As extensively demonstrated, receive arrays closely positioned around the scanned part provide images with high signal‐to‐noise ratios (SNRs). The present work proposes a pneumatic‐based MRI receive array that can physically adapt to infant head dimensions from 27‐week premature to 1.5 months old. Average SNR increases of up to 68% in the head region and 122% in the cortex region, compared with a 32‐channel commercial head coil, were achieved at 3 T. The consistent SNR distribution obtained through the complete coil size range, specifically in the cortex, allows the acquisition of images with similar quality across a range of head dimensions, which is not possible with fixed‐size coils due to the variable coil‐to‐head distance. The risks associated with mechanical pressure on the neonatal head are minimal and the head motion is restricted. The method could be used in coil designs for other age groups, body parts and subjects.     

Uncompromised MRI of knee cartilage while incorporating sensitive sodium MRI

Sodium imaging is able to assess changes in ion content, linked to glycosaminoglycan content, which is important to guide orthopeadic procedures such as articular cartilage repair. Sodium imaging is ideally performed using double tuned RF coils, to combine high resolution morphological imaging with biochemical information from sodium imaging to assess ion content. The proton image quality of such coils is often harshly degraded, with up to 50% of SNR or severe acceleration loss as compared to single tuned coils. Reasons are that the number of proton receive channels often severely reduced and double tuning will degrade the intrinsic sensitivity of the RF coil on at least one of the nuclei. However, the aim of this work was to implement a double‐tuned sodium/proton knee coil setup without deterioration of the proton signal whilst being able to achieve acquisition of high SNR sodium images. A double‐tuned knee coil was constructed as a shielded birdcage optimized for sodium and compromised for proton. To exclude any compromise, the proton part of the birdcage is used for transmit only and interfaced to RF amplifiers that can fully mitigate the reduced efficiency. In addition, a 15 channel single tuned proton receiver coil was embedded within the double‐resonant birdcage to maintain optimal SNR and acceleration for proton imaging. To validate the efficiency of our coil, the designed coil was compared with the state‐of‐the‐art single‐tuned alternative at 7 T. B1+ corrected SNR maps were used to compare both coils on proton performance and g‐factor maps were used to compare both coils on acceleration possibilities. The newly constructed double‐tuned coil was shown to have comparable proton quality and acceleration possibilities to the single‐tuned alternative while also being able to acquire high SNR sodium images.     

A dedicated eight‐channel receive RF coil array for monkey brain MRI at 9.4 T

The neuroimaging of nonhuman primates (NHPs) realised with magnetic resonance imaging (MRI) plays an important role in understanding brain structures and functions, as well as neurodegenerative diseases and pathological disorders. Theoretically, an ultrahigh field MRI (≥7 T) is capable of providing a higher signal‐to‐noise ratio (SNR) for better resolution; however, the lack of appropriate radiofrequency (RF) coils for 9.4 T monkey MRI undermines the benefits provided by a higher field strength. In particular, the standard volume birdcage coil at 9.4 T generates typical destructive interferences in the periphery of the brain, which reduces the SNR in the neuroscience‐focused cortex region. Also, the standard birdcage coil is not capable of performing parallel imaging. Consequently, extended scan durations may cause unnecessary damage due to overlong anaesthesia. In this work, assisted by numerical simulations, an eight‐channel receive RF coil array was specially designed and manufactured for imaging NHPs at 9.4 T. The structure and geometry of the proposed receive array was optimised with numerical simulations, so that the SNR enhancement region was particularly focused on monkey brain. Validated with rhesus monkey and cynomolgus monkey brain images acquired from a 9.4 T MRI scanner, the proposed receive array outperformed standard birdcage coil with higher SNR, mean diffusivity and fractional anisotropy values, as well as providing better capability for parallel imaging.     

Noise correlations and SNR in phased‐array MRS

The acquisition of magnetic resonance spectroscopy (MRS) signals by multiple receiver coils can improve the signal‐to‐noise ratio (SNR) or alternatively can reduce the scan time maintaining a reliable SNR. However, using phased array coils in MRS studies requires efficient data processing and data combination techniques in order to exploit the sensitivity improvement of the phased array coil acquisition method. This paper describes a novel method for the combination of MRS signals acquired by phased array coils, even in presence of correlated noise between the acquisition channels. In fact, although it has been shown that electric and magnetic coupling mechanisms produce correlated noise in the coils, previous algorithms developed for MRS data combination have ignored this effect. The proposed approach takes advantage of a noise decorrelation stage to maximize the SNR of the combined spectra. In particular Principal Component Analysis (PCA) was exploited to project the acquired spectra in a subspace where the noise vectors are orthogonal. In this subspace the SNR weighting method will provide the optimal overall SNR. Performance evaluation of the proposed method is carried out on simulated ¹H‐MRS signals and experimental results are obtained on phantom ¹H‐MR spectra using a commercially available 8‐element phased array coil. Noise correlations between elements were generally low due to the optimal coil design, leading to a fair SNR gain (about 0.5%) in the center of the field of view (FOV). A greater SNR improvement was found in the peripheral FOV regions. Copyright © 2009 John Wiley & Sons, Ltd.     

An embedded four‐channel receive‐only RF coil array for fMRI experiments of the somatosensory pathway in conscious awake marmosets

fMRI has established itself as the main research tool in neuroscience and brain cognitive research. The common marmoset (Callithrix jacchus) is a non‐human primate model of increasing interest in biomedical research. However, commercial MRI coils for marmosets are not generally available. The present work describes the design and construction of a four‐channel receive‐only surface RF coil array with excellent signal‐to‐noise ratio (SNR) specifically optimized for fMRI experiments in awake marmosets in response to somatosensory stimulation. The array was designed as part of a helmet‐based head restraint system used to prevent motion during the scans. High SNR was obtained by building the coil array using a thin and flexible substrate glued to the inner surface of the restraint helmet, so as to minimize the distance between the array elements and the somatosensory cortex. Decoupling between coil elements was achieved by partial geometrical overlapping and by connecting them to home‐built low‐input‐impedance preamplifiers. In vivo images show excellent coverage of the brain cortical surface with high sensitivity near the somatosensory cortex. Embedding the coil elements within the restraint helmet allowed fMRI data in response to somatosensory stimulation to be collected with high sensitivity and reproducibility in conscious, awake marmosets. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.     

Experimental verification of SNR and parallel imaging improvements using composite arrays

Composite MRI arrays consist of triplets where two orthogonal upright loops are placed over the same imaging area as a standard surface coil. The optimal height of the upright coils is approximately half the width for the 7 cm coils used in this work. Resistive and magnetic coupling is shown to be negligible within each coil triplet. Experimental evaluation of imaging performance was carried out on a Philips 3 T Achieva scanner using an eight‐coil composite array consisting of three surface coils and five upright loops, as well as an array of eight surface coils for comparison. The composite array offers lower overall coupling than the traditional array. The sensitivities of upright coils are complementary to those of the surface coils and therefore provide SNR gains in regions where surface coil sensitivity is low, and additional spatial information for improved parallel imaging performance. Near the surface of the phantom the eight‐channel surface coil array provides higher overall SNR than the composite array, but this advantage disappears beyond a depth of approximately one coil diameter, where it is typically more challenging to improve SNR. Furthermore, parallel imaging performance is better with the composite array compared with the surface coil array, especially at high accelerations and in locations deep in the phantom. Composite arrays offer an attractive means of improving imaging performance and channel density without reducing the size, and therefore the loading regime, of surface coil elements. Additional advantages of composite arrays include minimal SNR loss using root‐sum‐of‐squares combination compared with optimal, and the ability to switch from high to low channel density by merely selecting only the surface elements, unlike surface coil arrays, which require additional hardware. Copyright © 2014 John Wiley & Sons, Ltd.     

A 22‐channel receive array with Helmholtz transmit coil for anesthetized macaque MRI at 3 T

The macaque monkey is an important model for cognitive and sensory neuroscience that has been used extensively in behavioral, electrophysiological, molecular and, more recently, neuroimaging studies. However, macaque MRI has unique technical differences relative to human MRI, such as the geometry of highly parallel receive arrays, which must be addressed to optimize imaging performance. A 22‐channel receive coil array was constructed specifically for rapid high‐resolution anesthetized macaque monkey MRI at 3 T. A local Helmholtz transmit coil was used for excitation. Signal‐to‐noise ratios (SNRs) and noise amplification for parallel imaging were compared with those of single‐ and four‐channel receive coils routinely used for macaque MRI. The 22‐channel coil yielded significant improvements in SNR throughout the brain. Using this coil, the SNR in peripheral brain was 2.4 and 1.7 times greater than that obtained with single‐ or four‐channel coils, respectively. In the central brain, the SNR gain was 1.5 times that of both the single‐ and four‐channel coils. Finally, the performance of the array for functional, anatomical and diffusion‐weighted imaging was evaluated. For all three modalities, the use of the 22‐channel array allowed for high‐resolution and accelerated image acquisition. Copyright © 2013 John Wiley & Sons, Ltd.     

Performance evaluation of a 32‐element head array with respect to the ultimate intrinsic SNR

The quality of an RF detector coil design is commonly judged on how it compares with other coil configurations. The aim of this article is to develop a tool for evaluating the absolute performance of RF coil arrays. An algorithm to calculate the ultimate intrinsic signal‐to‐noise ratio (SNR) was implemented for a spherical geometry. The same imaging tasks modeled in the calculations were reproduced experimentally using a 32‐element head array. Coil performance maps were then generated based on the ratio of experimentally measured SNR to the ultimate intrinsic SNR, for different acceleration factors associated with different degrees of parallel imaging. The relative performance in all cases was highest near the center of the samples (where the absolute SNR was lowest). The highest performance was found in the unaccelerated case and a maximum of 85% was observed with a phantom whose electrical properties are consistent with values in the human brain. The performance remained almost constant for 2‐fold acceleration, but deteriorated at higher acceleration factors, suggesting that larger arrays are needed for effective highly‐accelerated parallel imaging. The method proposed here can serve as a tool for the evaluation of coil designs, as well as a tool to guide the development of original designs which may begin to approach the optimal performance. Copyright © 2009 John Wiley & Sons, Ltd.     

An optimization framework to maximize signal‐to‐noise ratio in simultaneous multi‐slice body imaging

Parallel imaging is essential for the acceleration of abdominal and pelvic 2D multi‐slice imaging, in order to reduce scan time and mitigate motion artifacts. Controlled Aliasing In Parallel Imaging Results IN Higher Acceleration (CAIPIRINHA) accelerated imaging has been shown to increase the signal‐to‐noise ratio (SNR) significantly compared with in‐plane parallel imaging with similar acceleration. We hypothesize that for CAIPIRINHA‐accelerated abdominal imaging the consistency of image quality and SNR is more difficult to achieve due to the subject‐specific coil sensitivity profiles, caused by (1) flexible coil placement; (2) variations in anatomy; and (3) variations in scan coverage along the superior–inferior direction. To test this, a mathematical framework is introduced that calculates the (retained) SNR for in‐plane and simultaneous multi‐slice (SMS)‐accelerated acquisitions. Moreover, this framework was used to optimize the sampling pattern by maximizing the local SNR within a region of interest (ROI) through non‐linear, RF‐induced CAIPIRINHA slice shifts. The framework was evaluated on 14 healthy subjects and the optimized sampling pattern was compared with in‐plane acceleration and CAIPIRINHA acceleration with linear slice shifts, which are primarily used in brain imaging. We demonstrate that the field of view (FOV) in the superior–inferior direction, the coil positioning and the individual anatomy have a large impact on the image SNR (changes up to 50% for varying coil positions and 40% differences between subjects) and image artifacts for simultaneous multi‐slice acceleration. Consequently, sampling patterns have to be optimized for acquisitions employing different FOVs and ideally on an individual basis. Optimization of the sampling pattern, which exploits non‐linear shifts between slices, showed a considerable SNR increase (10–30%) for higher acceleration factors. The framework outlined in this article can be used to optimize sampling patterns for a broad range of accelerated body acquisitions on an individual basis. Copyright © 2015 John Wiley & Sons, Ltd.     

Low SAR 31P (multi‐echo) spectroscopic imaging using an integrated whole‐body transmit coil at 7T

Phosphorus (³¹P) MRSI provides opportunities to monitor potential biomarkers. However, current applications of ³¹P MRS are generally restricted to relatively small volumes as small coils are used. Conventional surface coils require high energy adiabatic RF pulses to achieve flip angle homogeneity, leading to high specific absorption rates (SARs), and occupy space within the MRI bore. A birdcage coil behind the bore cover can potentially reduce the SAR constraints massively by use of conventional amplitude modulated pulses without sacrificing patient space. Here, we demonstrate that the integrated ³¹P birdcage coil setup with a high power RF amplifier at 7 T allows for low flip angle excitations with short repetition time (T_R) for fast 3D chemical shift imaging (CSI) and 3D T₁‐weighted CSI as well as high flip angle multi‐refocusing pulses, enabling multi‐echo CSI that can measure metabolite T₂, over a large field of view in the body. B₁⁺ calibration showed a variation of only 30% in maximum B₁ in four volunteers. High signal‐to‐noise ratio (SNR) MRSI was obtained in the gluteal muscle using two fast in vivo 3D spectroscopic imaging protocols, with low and high flip angles, and with multi‐echo MRSI without exceeding SAR levels. In addition, full liver MRSI was achieved within SAR constraints. The integrated ³¹P body coil allowed for fast spectroscopic imaging and successful implementation of the multi‐echo method in the body at 7 T. Moreover, no additional enclosing hardware was needed for ³¹P excitation, paving the way to include larger subjects and more space for receiver arrays. The increase in possible number of RF excitations per scan time, due to the improved B₁⁺ homogeneity and low SAR, allows SNR to be exchanged for spatial resolution in CSI and/or T₁ weighting by simply manipulating T_R and/or flip angle to detect and quantify ratios from different molecular species.     

Diffusion tensor imaging using multiple coils for mouse brain connectomics

The correlation between brain connectivity and psychiatric or neurological diseases has intensified efforts to develop brain connectivity mapping techniques on mouse models of human disease. The neural architecture of mouse brain specimens can be shown non‐destructively and three‐dimensionally by diffusion tensor imaging, which enables tractography, the establishment of a connectivity matrix and connectomics. However, experiments on cohorts of animals can be prohibitively long. To improve throughput in a 7‐T preclinical scanner, we present a novel two‐coil system in which each coil is shielded, placed off‐isocenter along the axis of the magnet and connected to a receiver circuit of the scanner. Preservation of the quality factor of each coil is essential to signal‐to‐noise ratio (SNR) performance and throughput, because mouse brain specimen imaging at 7 T takes place in the coil‐dominated noise regime. In that regime, we show a shielding configuration causing no SNR degradation in the two‐coil system. To acquire data from several coils simultaneously, the coils are placed in the magnet bore, around the isocenter, in which gradient field distortions can bias diffusion tensor imaging metrics, affect tractography and contaminate measurements of the connectivity matrix. We quantified the experimental alterations in fractional anisotropy and eigenvector direction occurring in each coil. We showed that, when the coils were placed 12 mm away from the isocenter, measurements of the brain connectivity matrix appeared to be minimally altered by gradient field distortions. Simultaneous measurements on two mouse brain specimens demonstrated a full doubling of the diffusion tensor imaging throughput in practice. Each coil produced images devoid of shading or artifact. To further improve the throughput of mouse brain connectomics, we suggested a future expansion of the system to four coils. To better understand acceptable trade‐offs between imaging throughput and connectivity matrix integrity, studies may seek to clarify how measurement variability, post‐processing techniques and biological variability impact mouse brain connectomics.     

DYNAmic Multi‐coIl TEchnique (DYNAMITE) shimming of the rat brain at 11.7 T

The in vivo rat model is a workhorse in neuroscience research, preclinical studies and drug development. A repertoire of MR tools has been developed for its investigation; however, high levels of B₀ magnetic field homogeneity are required for meaningful results. The homogenization of magnetic fields in the rat brain, i.e. shimming, is a difficult task because of a multitude of complex, susceptibility‐induced field distortions. Conventional shimming with spherical harmonic (SH) functions is capable of compensating for shallow field distortions in limited areas, e.g. in the cortex, but performs poorly in difficult‐to‐shim subcortical structures or for the entire brain. Based on the recently introduced multi‐coil approach for magnetic field modeling, the DYNAmic Multi‐coIl TEchnique (DYNAMITE) is introduced for magnetic field shimming of the in vivo rat brain and its benefits for gradient‐echo echo‐planar imaging (EPI) are demonstrated. An integrated multi‐coil/radiofrequency (MC/RF) system comprising 48 individual localized DC coils for B₀ shimming and a surface transceive RF coil has been developed that allows MR investigations of the anesthetized rat brain in vivo. DYNAMITE shimming with this MC/RF set‐up is shown to reduce the B₀ standard deviation to a third of that achieved with current shim technology employing static first‐ through third‐order SH shapes. The EPI signal over the rat brain increased by 31%, and a 24% gain in usable EPI voxels could be realized. DYNAMITE shimming is expected to critically benefit a wide range of preclinical and neuroscientific MR research. Improved magnetic field homogeneity, together with the achievable large brain coverage of this method, will be crucial when signal pathways, cortical circuitry or the brain's default network are studied. Together with the efficiency gains of MC‐based shimming compared with SH approaches demonstrated recently, DYNAMITE shimming has the potential to replace conventional SH shim systems in small‐bore animal scanners. Copyright © 2014 John Wiley & Sons, Ltd.     

Rat brain MRI at 16.4T using a capacitively tunable patch antenna in combination with a receive array

For MRI at 16.4T, with a proton Larmor frequency of 698 MHz, one of the principal RF engineering challenges is to generate a spatially homogeneous transmit field over a larger volume of interest for spin excitation. Constructing volume coils large enough to house a receive array along with the subject and to maintain the quadrature symmetry for different loading conditions is difficult at this frequency. This calls for new approaches to RF coil design for ultra‐high field MR systems. A remotely placed capacitively tunable patch antenna, which can easily be adjusted to different loading conditions, was used to generate a relatively homogeneous excitation field covering a large imaging volume with a transversal profile similar to that of a birdcage coil. Since it was placed in front of the animal, this created valuable free space in the narrow magnet bore around the subject for additional hardware. To enhance the reception sensitivity, the patch antenna was combined with an actively detunable 3‐channel receive coil array. In addition to increased SNR compared to a quadrature transceive surface coil, we were able to get high quality gradient echo and spin‐echo images covering the whole rat brain. Copyright © 2012 John Wiley & Sons, Ltd.     

Whole‐body radiofrequency coil for 31P MRSI at 7 T

Widespread use of ultrahigh‐field ³¹P MRSI in clinical studies is hindered by the limited field of view and non‐uniform radiofrequency (RF) field obtained from surface transceivers. The non‐uniform RF field necessitates the use of high specific absorption rate (SAR)‐demanding adiabatic RF pulses, limiting the signal‐to‐noise ratio (SNR) per unit of time. Here, we demonstrate the feasibility of using a body‐sized volume RF coil at 7 T, which enables uniform excitation and ultrafast power calibration by pick‐up probes. The performance of the body coil is examined by bench tests, and phantom and in vivo measurements in a 7‐T MRI scanner. The accuracy of power calibration with pick‐up probes is analyzed at a clinical 3‐T MR system with a close to identical ¹H body coil integrated at the MR system. Finally, we demonstrate high‐quality three‐dimensional ³¹P MRSI of the human body at 7 T within 5 min of data acquisition that includes RF power calibration. Copyright © 2016 John Wiley & Sons, Ltd.     

Comparison of RF body coils for MRI at 3 T: a simulation study using parallel transmission on various anatomical targets

The performance of multichannel transmit coil layouts and parallel transmission (pTx) RF pulse design was evaluated with respect to transmit B₁ (B₁ ⁺) homogeneity and specific absorption rate (SAR) at 3 T for a whole body coil. Five specific coils were modeled and compared: a 32‐rung birdcage body coil (driven either in a fixed quadrature mode or a two‐channel transmit mode), two single‐ring stripline arrays (with either 8 or 16 elements), and two multi‐ring stripline arrays (with two or three identical rings, stacked in the z axis and each comprising eight azimuthally distributed elements). Three anatomical targets were considered, each defined by a 3D volume representative of a meaningful region of interest (ROI) in routine clinical applications. For a given anatomical target, global or local SAR controlled pTx pulses were designed to homogenize RF excitation within the ROI. At the B₁ ⁺ homogeneity achieved by the quadrature driven birdcage design, pTx pulses with multichannel transmit coils achieved up to about eightfold reduction in local and global SAR. When used for imaging head and cervical spine or imaging thoracic spine, the double‐ring array outperformed all coils, including the single‐ring arrays. While the advantage of the double‐ring array became much less pronounced for pelvic imaging, with a substantially larger ROI, the pTx approach still provided significant gains over the quadrature birdcage coil. For all design scenarios, using the three‐ring array did not necessarily improve the RF performance. Our results suggest that pTx pulses with multichannel transmit coils can reduce local and global SAR substantially for body coils while attaining improved B₁ ⁺ homogeneity, particularly for a “z‐stacked” double‐ring design with coil elements arranged on two transaxial rings. Copyright © 2015 John Wiley & Sons, Ltd.     

Development of a 7 T RF coil system for breast imaging

In ultrahigh‐field MRI, such as 7 T, the signal‐to‐noise ratio (SNR) increases while transmit (Tx) field (B₁⁺) can be degraded due to inhomogeneity and elevated specific absorption rate (SAR). By applying new array coil concepts to both Tx and receive (Rx) coils, the B₁⁺ homogeneity and SNR can be improved. In this study, we developed and tested in vivo a new RF coil system for 7 T breast MRI. An RF coil system composed of an eight‐channel Tx‐only array based on a tic‐tac‐toe design (can be combined to operate in single‐Tx mode) in conjunction with an eight‐channel Rx‐only insert was developed. Characterizations of the B₁⁺ field and associated SAR generated by the developed RF coil system were numerically calculated and empirically measured using an anatomically detailed breast model, phantom and human breasts. In vivo comparisons between 3 T (using standard commercial solutions) and 7 T (using the newly developed coil system) breast imaging were made. At 7 T, about 20% B₁⁺ inhomogeneity (standard deviation over the mean) was measured within the breast tissue for both the RF simulations and 7 T experiments. The addition of the Rx‐only array enhances the SNR by a factor of about three. High‐quality MR images of human breast were acquired in vivo at 7 T. For the in vivo comparisons between 3 T and 7 T, an approximately fourfold increase of SNR was measured with 7 T imaging. The B₁⁺ field distributions in the breast model, phantom and in vivo were in reasonable agreement. High‐quality 7 T in vivo breast MRI was successfully acquired at 0.6 mm isotropic resolution using the newly developed RF coil system.