丹黄通脉胶囊联合辛伐他汀片治疗颈动脉粥样硬化斑块随机平行对照研究

[目的]观察丹黄通脉胶囊联合辛伐他汀治疗颈动脉粥样硬化(CAS)合并斑块疗效,评价丹黄通脉胶囊联合辛伐他汀稳定与消退斑块作用。[方法]使用随机平行对照方法,将64例门诊及住院患者按就诊顺序编号随机分为两组。对照组32例辛伐他汀10mg/次,1次/d,晚饭后服用。治疗组32例丹黄通脉胶囊,4粒/次,3次/d。西药治疗同对照组。治疗1年为1疗程。观测血脂、颈动脉内膜斑块面积、血液生化指标、不良反应。治疗1疗程,判定疗效。[结果]两组TC及TG均明显下降(P<0.05),LDL-C有所下降(P<0.05),HDL-C有所升高(P>0.05),治疗组优于对照组(P<0.05)。两组后颈动脉内膜斑块平均面积明显减小(P<0.01),治疗组优于对照组(P<0.05)。[结论]丹黄通脉胶囊联合辛伐他汀治疗CAS合并斑块疗效好、且不良反应较少。     

丹黄通脉胶囊联合辛伐他汀片治疗颈动脉粥样硬化斑块随机平行对照研究

[目的]观察丹黄通脉胶囊联合辛伐他汀治疗颈动脉粥样硬化（CAS）合并斑块疗效,评价丹黄通脉胶囊联合辛伐他汀稳定与消退斑块作用。[方法]使用随机平行对照方法,将64例门诊及住院患者按就诊顺序编号随机分为两组。对照组32例辛伐他汀10mg／次,1次／d,晚饭后服用。治疗组32例丹黄通脉胶囊,4粒／次,3次／d。西药治疗同对照组。治疗1年为1疗程。观测血脂、颈动脉内膜斑块面积、血液生化指标、不良反应。治疗1疗程,判定疗效。[结果]两组TC及TG均明显下降（P〈0．05）,LDL-C有所下降（P〈0．05）,HDL-C有所升高（P〉0．05）,治疗组优于对照组（P〈0．05）。两组后颈动脉内膜斑块平均面积明显减小（P〈0．01）,治疗组优于对照组（P〈0．05）。[结论]丹黄通脉胶囊联合辛伐他汀治疗CAS合并斑块疗效好、且不良反应较少。     

软坚散结方联合辛伐他汀治疗颈动脉粥样硬化20例

目的 分析软坚散结方联合辛伐他汀治疗颈动脉粥样硬化的临床疗效.方法 选择在本院接受治疗的颈动脉粥样硬化患者作为研究对象,随机分为给予软坚散结方联合辛伐他汀治疗的A组、辛伐他汀治疗的B组、软坚散结方治疗的C组,比较三组患者的治疗后血脂相关指标、颈动脉AP面积及IMT情况比较.结果 A组患者接受治疗后的HDL水平明显高于B组、C组患者（P＜0 05）,TC、TG、LDL水平明显低于于B组、C组患者（P＜0 05）;颈动脉AP面积及IMT均明显小于于B组、C组患者（P＜0 05）.结论 软坚散结方联合辛伐他汀治疗颈动脉粥样硬化可以有效优化患者的血脂情况,减少斑块面积及颈动脉内中膜厚度.     

辛伐他汀治疗颈动脉粥样硬化疗效观察

目的采用颈动脉超声定量评价辛伐他汀治疗颈动脉粥样硬化的疗效。方法治疗组给予辛伐他汀20 mg/d口服,对照组给予肠溶阿司匹林100 mg/d口服,共6个月。所有患者于服药前后检查相应生化指标,应用HPSONOS5500型彩色多普勒超声测定颈动脉内膜-中层厚度(IMT)及斑块面积,计算斑块数量。结果治疗组治疗后IMT变薄,斑块面积缩小,斑块数量无明显改变,总胆固醇、低密度脂蛋白水平均明显降低,肝肾功能无明显差异;对照组各指标治疗前后比较无显著性改变。结论坚持服用他汀类药物,可以达到稳定与消退斑块的作用。     

益气活血方联合胺碘酮治疗心律失常随机平行对照研究

[目的]观察益气活血方联合胺碘酮治疗心律失常疗效。[方法]使用随机平行对照方法,将76例住院患者按病志号抽签简单随机分为两组。对照组38例胺碘酮,0.1~0.2g/次,3次/d,口服。治疗组38例益气活血方(黄芪、苦参、太子参、生地、甘草炙、瓜蒌皮各30g,丹参20g,虎杖、茵陈各15g,当归、半夏各12g,郁金、川芎、黄连各10g),1剂/d,水煎200mL,早晚口服;胺碘酮治疗同对照组。连续治疗30d为1疗程。观测临床症状、心律、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效16例,有效20例,无效2例,总有效率94.73%。对照组显效13例,有效16例,无效9例,总有效率76.32%。治疗组疗效优于对照组(P0.05)。[结论]益气活血方联合胺碘酮治疗心律失常效果显著,值得推广。     

滋肾养肝化痰消瘀方联合西药治疗动脉粥样硬化随机平行对照研究

[目的]观察滋肾养肝化痰消瘀方联合西药治疗动脉粥样硬化疗效。[方法]使用随机平行对照方法,将102例住院患者按抽签法简单随机分为两组。对照组51例辛伐他汀,20mg/次,3次/d,口服;硫酸氢氯吡格雷,75mg/次,1次/d,口服。治疗组51例滋肾养肝化痰消瘀方(地龙12g,淫羊藿15g,桂枝12g,首乌制15g,黄连12g,毛冬青15g,干姜6g,当归15g),1剂/d,水煎300mL,早晚口服;西药治疗同对照组。连续治疗7d为1疗程。观测临床症状、动脉内膜中层厚度、粥样硬化斑块面积、血脂、不良反应。连续治疗2疗程,判定疗效。[结果]动脉内膜中层厚度及粥样硬化斑块面积两组均有改善(P0.01),治疗组改善优于对照组(P0.01)。血脂两组均有改善(P0.05),治疗组改善优于对照组(P0.05)。[结论]滋肾养肝化痰消瘀方联合西药治疗动脉粥样硬化效果显著,值得推广。     

益气活血方联合常规西药治疗冠心病心绞痛随机平行对照研究

[目的]观察益气活血方联合常规西药治疗冠心病心绞痛疗效。[方法]使用随机平行对照方法,将96例门诊患者按抽签法分为两组。对照组46例硝酸异山梨酯,10mg/次,3次/d,口服;阿司匹林肠溶片,100mg/次,1次/d,口服;辛伐他汀,10mg/次,1次/d,睡前口服。治疗组50例①益气活血方(黄芪、党参各30g,白术、茯苓各12g,麦冬、五味子、白芍、生地各15g,丹参30g,当归15g,川芎12g,大枣9g,甘草炙6g),1剂/d,水煎2次,150mL/次,共300mL,3次/d,口服;②抗血小板、调脂等西药治疗。连续治疗28d为1疗程。观测临床症状、心律、心电图、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效27例,有效25例,无效4例,总有效率92.85%。对照组显效16例,有效13例,无效11例,总有效率72.50%。治疗组疗效优于对照组(P0.05)。[结论]益气活血方联合常规西医治疗冠心病心绞痛疗效显著,值得推广。     

益气活血方联合西药治疗气虚血瘀型冠心病随机平行对照研究

[目的]观察益气活血方联合西药治疗气虚血瘀型冠心病疗效。[方法]使用随机平行对照方法,将70例住院患者按抛硬币法随机分为两组。对照组35例常规治疗,硝酸酯类、阿司匹林及硝苯地平等。治疗组35例益气活血方(黄芪40g,丹参20g,西洋参、焦山楂、川芎、炙远志各10g,酸枣仁20g,当归15g,郁金、熟地各10g,地龙15g,枳壳、甘草各10g),1剂/d,水煎200mL,早晚口服;西药治疗同对照组。连续治疗10d为1疗程。观测临床症状、心电图、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组显效13例,有效16例,无效6例,总有效率82.86%。对照组显效12例,有效14例,无效9例,总有效率74.29%。治疗组疗效优于对照组(P0.05)。两组指标均有改善(P0.05),治疗组改善优于对照组(P0.05)。[结论]益气活血方联合西药治疗气虚血瘀型冠心病效果显著,值得推广。     

辛伐他汀在颈动脉粥样硬化治疗中的应用

目的:分析辛伐他汀在颈动脉粥样硬化治疗中的应用效果。方法:选择我院2009年10月—2010年9月收治的颈动脉粥样硬化102例按照随机数字表法分为两组,对照组51例采用常规治疗,观察组51例在对照组的基础上加用辛伐他汀治疗,对两组的临床治疗情况进行观察比较。结果:治疗后两组患者的颈总动脉内膜-中层厚度(IMT)、斑块面积明显缩小,观察组变化更明显,组间差异有统计学意义(P<0.05);两组患者治疗过程中均无严重不良反应发生。结论:辛伐他汀在颈动脉粥样硬化治疗中的应用效果满意,且无严重不良反应发生,安全性好,值得临床关注。     

清热解毒方治疗冠心病随机平行对照研究

[目的]观察清热解毒方治疗冠心病疗效。[方法]使用随机平行对照方法,将200例住院患者按抽签法分为两组。对照组100例辛伐他汀,20mg/次,1次/d,口服。治疗组100例清热解毒方(黄芪20g,松针、葛根、赤芍各10g),3g/次,3次/d,开水冲服。连续治疗14d为1疗程。观测临床症状、生化指标、安全性分析、不良反应。连续治疗2疗程,判定疗效。随访28d,观测复发率。[结果]治疗组痊愈27例,显效70例,无效3例,总有效率97.00%。对照组痊愈13例,显效40例,无效47例,总有效率53.00%。治疗组疗效优于对照组(P0.01)。生化指标(CRP、TG、TC)两组均有改善(P0.01),治疗组改善优于对照组(P0.01)。安全性分析(血常规、尿常规)两组检测均正常。[结论]清热解毒方制疗冠心病效果显著,值得推广。     

益气活血化痰通络方对颈动脉粥样硬化患者T细胞亚群影响的研究

目的:观察益气活血化痰通络方对颈动脉粥样硬化患者T细胞亚群的影响。方法:将61例诊断为颈动脉粥样硬化且中医辨证为气虚痰瘀证的老年患者(年龄≥60岁)随机分为治疗组(益气活血化痰通络方每日1剂加阿托伐他汀20 mg/d)与对照组(阿托伐他汀20 mg/d),治疗周期为12周。用药前后,观察两组T细胞亚群、血脂及中医证候的变化。结果:两组具有基线同质性,治疗12周后,治疗组中医证候改善优于对照组(P<0.01)。治疗组低密度脂蛋白低于对照组(P<0.05)。治疗组Th细胞、Th/Ts、NK细胞低于对照组(P<0.05)。治疗前后,两组患者血常规、肝功能、肾功能等安全指标未出现明显异常。结论:益气活血化痰通络方可以调节颈动脉粥样硬化患者的T细胞亚群水平,其作用机制可能与改善炎症反应有关。     

益气活血化痰汤为主治疗带状疱疹后神经痛疗效观察

目的观察益气活血化痰汤治疗带状疱疹后神经痛的临床疗效。方法将60例带状疱疹后神经痛患者随机分为对照组和治疗组,各30例;对照组口服盐酸曲马多片,治疗组15服曲马多片和益气活血化痰汤,疗程4周。结果治疗组愈显率为93．3％,对照组为60．0％（P〈0．05）;治疗后两组VAS评分均有明显降低（P〈0．01）,且治疗组VAS评分低于对照组（P〈0．05）。结论益气活血化痰汤治疗带状疱疹后神经痛疗效确切。     

疏肝活血方治疗乳痈僵块随机对照临床研究

目的观察疏肝活血方治疗乳痈僵块的临床疗效。方法将60例乳痈僵块病例随机分为治疗组、对照组,每组30例。治疗组予内服中药疏肝活血方,对照组口服乳癖消,均治疗3个月。观察两组不同时间点乳房肿块积分、乳腺彩超数值,并评价临床疗效。结果治疗组总有效率达96.7%,对照组为93.3%,两组疗效差异有统计学意义（P〈0.05）。组内比较,两组30d、60d、90d肿块积分和乳腺彩超数值差异均有统计学意义（P〈0.05）;组间比较,30d、60d、90d肿块积分和彩超数值差异均有统计学意义（P〈0.05）。结论疏肝活血方可有效缩小或消除乳痈僵块。     

Effect of Shoushen granule on arterial elasticity in patients with carotid atherosclerosis:a clinical randomized controlled trial

OBJECTIVE: To investigate the effectiveness of Shoushen granule,Chinese herbal preparation,on carotid artery elasticity in patients with carotid atherosclerosis.METHODS: The total of 156 carotid atherosclerosis patients were randomly divided into the intervention group(83 cases,treated with Shoushen granule) and the control group(73 cases,treated with pravastatin). Brachial-ankle pulse wave velocity(ba PWV) and Ankle-Brachial Pressure Index(ABI)were measured by automated arteriosclerosis detector. The changes of common carotid artery intima-media thickness(IMT) and parameters of the carotid artery elasticity in patients,including stiffness parameter(β),pressure-strain elastic modulus(Ep),arterial compliance(Ac),augmentation index(AI),and pulse wave velocity β(PWVβ) were detected by Echo-Tracking(ET) technique before and after 24 week treatment. In the meantime,levels of blood lipid,and liver and renal function were measured respectively.RESULTS: After 24 weeks,ba PWV,IMT and parameters of the carotid artery elasticity(β,Ep,AI and PWVβ) were markedly decreased in intervention group compared with those of before treatment(P 0.01),but the level of Ac was increased significantly(P 0.01). And there were no significant differences compared with control group on the same period(P 0.05).CONCLUSION: In this pilot study,it was demonstrated ET technology and automated arteriosclerosis detector could be used to evaluate carotid artery elasticity effectively,and the action of Shoushen granule on carotid atherosclerosis might be related to the regulation of carotid artery elasticity.     

益气活血化痰法联合颅内外血管搭桥术治疗缺血性脑血管病的疗效观察

目的 采用氙CT评价益气活血化痰法联合颅内外血管搭桥术治疗缺血性脑血管病的疗效.方法 回顾14例患者的临床资料,对中药联合手术治疗前后的氙CT脑血流灌注平均值及mRS平均分进行分析比较.结果 术后患者的脑血流量较术前增加,mRS评分改善（P＜0.05）.结论 益气活血化痰法联合颅内外血管搭桥术治疗缺血性脑血管病可改善患者术侧的脑血流量,降低致残率,改善预后.     

益气活血通脉汤联合西药治疗心绞痛

目的研究益气活血通脉汤联合西医常规治疗对心绞痛患者心绞痛发作、心电图及血脂水平的影响。方法将本院2015年1月-2017年12月收治的70例心绞痛患者作为研究对象,按照随机数字表法分为对照组与联合组,各35例。对照组采取西医常规治疗,联合组在对照组治疗基础上联合益气活血通脉汤治疗。比较2组患者心绞痛发作次数、持续时间、心电图疗效及治疗前后血脂水平的差异。结果治疗后1个月,2组心绞痛发作次数和持续时间较治疗前均改善,且联合组改善程度较对照组明显(均P 0.05);联合组心电图总有效率为85.71%,较对照组的62.86%明显提高(P 0.05);2组血脂水平较治疗前均降低,且联合组较对照组降低幅度更为显著(P 0.05)。结论益气活血通脉汤联合西药常规治疗心绞痛,可有效减少心绞痛发作次数,降低血脂水平,提高临床疗效。     

自拟健脾化痰活血汤与西药治疗高胆固醇血症的随机对照研究

目的：对比分析自拟健脾化痰活血汤与西药治疗高胆固醇血症的临床疗效。方法：以应用辛伐他汀治疗的60例高胆固醇血症患者为对照组,以应用自拟健脾化痰活血汤治疗的60例患者为试验组,比较两组患者临床疗效。结果：试验组患者治疗后6个月总有效率显著高于对照组,两组比较差异显著（P<0.05）。结论：自拟健脾化痰活血汤治疗高胆固醇血症,可有效改善患者病情,降低血清胆固醇,具有广泛临床应用价值。     

Efficacy and safety of Yiqi Huoxue Jiedu decoction for the treatment of advanced epithelial ovarian cancer patients: a double-blind randomized controlled clinical trial

OBJECTIVE: To further evaluate the complementary effect of Yiqi Huoxue Jiedu decoction(YHJD) on patients with advanced epithelial ovarian cancer(EOC).METHODS: All 330 enrolled participants diagnosed with stage Ⅲc EOC were randomly divided into two groups that received YHJD or a placebo. The primary end point was health-related quality of life(HRQL) measured by the functional assessment of cancer therapy-ovary cancer(FACT-O) questionnaire. The secondary end point was progression-free survival(PFS).RESULTS: A total of 299 participants completed the trial with 153 and 146 in YHJD and control groups,respectively. After 6 months of treatment, YHJD increased physical wellbeing(PWB), functional wellbeing(FWB), additional concerns(AC), and the trial outcome index(TOI)(P 0.05) by various degrees compared with the baseline. YHJD also had notable advantages over the placebo at 3 and 6 months in terms of PWB, FWB, AC(P 0.05), and TOI(P 0.01).In addition, YHJD had a significant advantage in terms of PFS compared with the placebo(21 vs18 months, P 0.05). No adverse events were reported.CONCLUSION: YHJD is an effective and safe choice as a complementary therapy to improve HRQL and prolong PFS of stage Ⅲc EOC patients.     

益气活血中药防治动脉粥样硬化的研究

动脉粥样硬化是冠心病最主要的病理基础,中医认为气虚血瘀是冠心病的基本病机,临床多采用益气活血中药治疗.益气药多见黄芪、人参及其有效成分的提取物,活血药多围绕丹参、三七、红花、当归和川芎等进行研究.笔者通过查阅近10年的文献发现,益气活血中药及其有效成分都表现出较好的抗动脉粥样硬化作用,益气加活血中药配伍效果强于单纯益气...     

Acupuncture and moxibustion for the elderly patients with depression:A randomized controlled trial

Objective:To identify the effects of acupuncture and moxibustion therapy by soothing liver and regulating mind on the quality of life among the elders with depression.Methods:This was a single-blind,randomized,controlled trial of 75 elders with depression conducted in Guangdong Province,China,in January to December 2010.Eligible patients were randomly divided into three treatment groups.22 patients received acupuncture and moxibustion treatment of soothing liver and regulating mind[group A,in acupuncture procedure:Hegu(合谷 L14),Taichong(太冲 LR3),Baihui(百会 GV20)and Yinting(印堂 GV29)were selected,in moxibustion procedure,bilateral Geshu(膈俞 BL17)and Danshu(胆俞 BL19)were selected,the moxibustion cones was placed on the acupoints,five cones were given to each point.In intradermal needling procedure,Xinshu(心俞 BL15),and Ganshu(肝俞 BL18)were selected].28 patients received acupoint shallow puncturing treatment(group B,patients received the same acupoints as in the group A,with a 2-3 mm needling depth and no needle sensation was required.A shorter duration of moxibustion and only 1-2 mm of needle body was inserted into the points when intradermal needling).25 patients received non-acupoint shallow puncturing treatment(group C,patients received non-acupoint shallow puncturing at points 10 mm lateral to LI4 and LR3,10 mm left side of GV20 and GV29 in acupuncture procedure;10 mm lateral to BL17 and BL19 in moxibustion procedure;10 mm lateral to BL15 and BL18 in intradermal needling procedure,with the same manipulation method as that in the group B).In all three groups,the treatment was given twice a week for 12 weeks.The Short Form(36)Health Survey(SF36)and TCM Symptom Scale Score as clinical efficacy and quality of life were used to quantitatively assess patients' outcomes before and after treatment.Results:The TCM Symptom Scale scores showed significant differences between the group A and C,and between group B and C(both P0.05),while there was no significant difference between group A and B(P0.05).An item-by-item analysis of the SF36 showed the elders in group A obtained the highest scores at each time point after treatment(all P0.05).Among the results,mental health and report health transition items showed no significant differences between the group A and group B at time point of after treatment(all P0.05).Vitality and social functioning items at a month after treatment time point,social functioning and report:health transition items at 3 months after treatment time point,role emotional item at after treatment time point showed no significant differences between the group B and group C(all P0.05).Conclusions:The therapeutic effect of acupuncture and moxibustion by soothing liver and regulating mind can obviously improve the quality of life of depression elders.