糖尿病患者诱发电佐的反应与临床参量的关系

目的 了解2型糖尿病（DM）患者的视觉诱发电位（VEP），脑干听觉诱发电位（BAEP）、体感诱发电位（SEP）、事件相关电位（ERP）的表现与临床参量的关系。方法 用Nicolet Viking TV型肌电图/诱发电位仪对30例2型DM患者（DM组）及年龄和性别与之匹配的本院医务人员正常人30例（对照组）进行VEP，BAEP，SEP，ERP检测。应用SPSS统计软件分析DM组的EP表现及其与临床参量（病程、血糖、血脂、肾功能、血管病变）的关系。结果 DM组（1）VEP异常20例，BAEP异常18例，MNSEP异常为20例，PTNSEP异常22例，EPR异常11例。（2）VEP的P100潜伏期（PL）明显延长，BAEP的左侧Ⅰ波PL、双侧Ⅴ波PL，波幅（Amp）和各波间期（IPL）明显异常，SEP周围电位N9至皮层电位P25/P38的PL，Amp以及ERP中N2，P3a，P3b的PL，Amp都有明显异常，与对照组比较（F=5.131-45.213,t=2.695-3.472,P&;lt;0.05-0.01）。（3）EP改变与各临床参量有关。结论 DM患者VEP，BAEP，SEP，ERP都有不同程度异常。异常程度和病程平行。     

2型糖尿病患者诱发电位研究

目的 :了解 2型糖尿病 (2DM )患者的诱发电位 (EP) ,包括视觉 (VEP)、脑干听觉 (BAEP)、体感 (SEP)和事件相关电位 (ERP)的表现。方法 :用NicoletVikingTV型肌电图 /诱发电位仪对 3 0例 2DM病人 (DM组 )及 3 0例正常人 (对照组 )进行VEP、BAEP、SEP、ERP检测。比较两组间EP各项参数的差异。结果 :DM组VEP异常 2 0例(66 7% ) ,BAEP异常 18例 (60 % ) ,上肢正中神经SEP(MNSEP)及下肢胫后神经SEP(PTNSEP)异常分别为 2 0例(66 7% )和 2 2例 (73 3 % ) ,ERP异常 11例 (3 6 7% ) ,表现为波形缺失、波潜伏期 (PL)延长及波幅 (Amp)下降。DM组VEPP10 0 的PL ,BAEP中Ⅰ波PL ,Ⅴ波PL及Amp和各波间期 (IPL) ,MNSEP中N9～P2 0 ,PTNSEP中N9～P3 8的PL及Amp、ERP中N2 、P3 的PL及Amp异常与对照组比较差异均有显著意义 (P <0 0 5或P <0 0 0 1)。结论 :DM患者VEP、BAEP、SEP、ERP都有不同程度异常 ,EP是检测DM神经病变的敏感指标。     

脑震荡的多形式诱发电位研究

目的 研究脑震荡患者的多形式诱发电位变化。方法 对 26例急性期脑震荡患者行视觉诱发电位 (VEP)、脑干听觉诱发电位 (BAEP)、体感诱发电位 (SEP)及事件相关电位 (ERP)检测,并与年龄、身高匹配的健康者对比。结果 VEP、 BAEP、 SEP、 ERP及 EEG异常率分别为 30.8％、 69.2％、 50％、 61.5％、 38.5％;其中有两项诱发电位异常者占 80.8％,较 EEG异常率高 (P     

脑外伤后综合征患者的脑诱发电位研究

目的 探讨脑外伤后综合征(PTBIS)患者的脑诱发电位改变特点及脑诱发电位对PTBIS患者脑功能的评定价值。方法 对38例PTBIS患者进行正中神经体感诱发电位(SEP)、脑干听觉诱发电位(BAEP)及事件相关电位(ERP)检测，并与性别、年龄相匹配的健康者对比。结果 SEP、BAEP及ERP异常率分别为71．1％、38．9％、50％。SEP异常主要为P15、N60波波峰潜伏期延长和N20波波幅降低，BAEP异常主要为Ⅲ、V波波峰潜伏期延长或I～Ⅲ、I～V峰间期延长，ERP异常主要为P3潜伏期延长。结论 多项诱发电位异常提示PTBIS患者存在大脑半球、脑干功能的损害及认知功能障碍，脑诱发电位检查为PTBIS患者的脑功能评定提供了一种敏感、客观的电生理学手段。     

脑干听觉诱发电位和体感诱发电位对昏迷患者预后的判断

目的 脑干听觉诱发电位(BAKP)和体感诱发电位(SEP)与昏迷患预后密切相关，探讨BAEP和SKP判断昏迷患脑功能状态的可行性和准确性。方法 采用丹麦Dantec公司生产Neuromatic2000型肌电图诱发电位仪。检查ICU病房中36例昏迷患的BAEP和SEP.BAEP分析Ⅲ-Ⅴ波,SEP分析P15、N20、P25波。检查结果分为正常和异常项后分为好转和死亡。结果 36例患，BAEP正常12例，异常24例。SEP正常13例，异常23例。好转13例，死亡23例。当SEP异常时，死亡率明显高于SEP正常时。而同时伴有BAEP异常时，死亡率更高。14例患SEP检查P15、N20、P25波均消失，12例死亡，病死率为86％。5例患BAEP检查Ⅲ-Ⅴ波和SEP检查P15、N20、P25波均消失，全部死亡，病死率为100％。结论 BAEP和SEP的正常与否与昏迷患的预后有密切关系(P＝O．011)、SEP异常是判定的主要根据。BAEP和SEP相结合，则可以提高判断的准确性。对昏迷患进行动态的BAEP和SEP观察可提高判断的准确性。     

脑干听觉诱发电位和体感诱发电位对昏迷患者预后的判断

目的脑干听觉诱发电位(BAEP)和体感诱发电位(SEP)与昏迷患者预后密切相关,探讨BAEP和SEP判断昏迷患者脑功能状态的可行性和准确性。方法采用丹麦Dantec公司生产Neuromatic2000型肌电图诱发电位仪。检查ICU病房中36例昏迷患者的BAEP和SEP。BAEP分析III-V波,SEP分析P15、N20、P25波。检查结果分为正常和异常。预后分为好转和死亡。结果36例患者,BAEP正常12例,异常24例。SEP正常13例,异常23例。好转13例,死亡23例。当SEP异常时,死亡率明显高于SEP正常时。而同时伴有BAEP异常时,死亡率更高。14例患者SEP检查P15、N20、P25波均消失,12例死亡,病死率为86%。5例患者BAEP检查III-V波和SEP检查P15、N20、P25波均消失,全部死亡,病死率为100%。结论BAEP和SEP的正常与否与昏迷患者的预后有密切关系(P=0.011)。SEP异常是判定的主要根据。BAEP和SEP相结合,则可以提高判断的准确性。对昏迷患者进行动态的BAEP和SEP观察可提高判断的准确性。     

应用神经电生理检测评估弥漫性轴索损伤患者脑功能状态及其预后

目的探讨神经电生理对弥漫性轴索损伤预后的评估价值. 方法采用日本光电公司生产 ME-543K型肌电图诱发电位仪.检查 ICU病房中 85例弥漫性轴索损伤患者的脑干听觉诱发电位( BAEP)分析 III-V波,体感诱发电位( SEP)分析 P15, N20, P25波.检查结果分为正常和异常.预后分为好转和死亡. 结果 85例患者中好转 60例,死亡 25例. BAEP正常 24例,异常 61例, SEP正常 25例,异常 60例.当 SEP异常时,病死率明显高于 SEP正常时.而同时伴有 BAEP异常时,病死率更高. 30例患者 SEP检查 P15, N20, P25波均消失,其中 25例死亡,病死率为 83.3%. 5例患者 BAEP检查 III～ V波和 SEP检查 P15, N20, P25波均消失,全部死亡,异常率为 100%. 结论BAEP和 SEP的正常与否与弥漫性轴索损伤的预后有密切关系( P=0.01). SEP异常是判定的主要根据. BAEP和 SEP相结合,则可以提高判断的准确性.对弥漫性轴索损伤患者进行动态的 BAEP和 SEP观察可提高判断的准确性.     

视觉、体感及脑干听觉诱发电位对多发性硬化诊断价值的对比分析

目的比较视觉诱发电位(VEP)、正中神经体感诱发电位(SEP)及脑干听觉诱发电位(BAEP)3者在多发性硬化(MS)诊断中的不同价值。方法35例MS患者分别进行VEP、SEP、BAEP中的一项或多项检查,并与临床症状体征进行对照分析。结果MS患者VEP、SEP、BAEP的异常率分别为81.5%、76.2%、52%,其中有相应视神经、躯体感觉、脑干损害者VEP、SEP、BAEP的异常率分别为84.6%、83.3%、69.2%,而无相应症状体征者3者的异常率分别为78.6%、73.3%、33.3%。结论诱发电位对MS的诊断具有重要价值,在确定MS的临床病灶和发现亚临床病灶方面VEP敏感性稍高于SEP,但明显高于BAEP。联合检测VEP、SEP、BAEP将有助于提高MS诊断的阳性率。     

帕金森病患者视觉、脑干及体感诱发电位改变的临床研究

目的研究帕金森病(PD)患者视觉诱发电位(VEP)、脑干诱发电位(BAEP)及体感诱发电位(SEP)的改变及其临床意义。方法应用神经电生理检查仪对46例PD患者分别进行VEP、BAEP、SEP检查,并与健康对照组50例作对照。结果PD组VEP的P100潜伏期(115.3±10.7)m s较健康对照组(103.5±9.2)m s明显延长(P<0.01);PD组P100潜伏期延长与PD患者的病程及病情呈正相关(r=0.49,0.43,P<0.01);PD组BAEP的Ⅲ-Ⅴ及Ⅰ-Ⅴ波间期较健康对照组明显延长(P<0.05);SEP各波潜伏期及波幅两组比较差异无显著性意义。结论PD患者的VEP和BAEP均有不同程度的改变,提示PD患者可伴有脑干听觉传导通路与视觉传导通路损害。     

慢性阻塞性肺病患者脑干听觉诱发及体表面感觉诱发电位检测的临床意义

目的　了解慢性阻塞性肺病患者脑干听觉诱发电位(BAEP)及体表面感觉诱发电位(SEP)的变化。 方法　应用丹迪公司Keypoit型神经肌电描记仪对32例慢阻肺患者进行BAEP及SEP检测,并与35例同龄健康 人的检测结果作比较。结果　慢阻肺患者组BAEP显示V波潜伏期和Ⅰ～Ⅴ、Ⅲ～Ⅴ波峰间潜伏期明显延长,Ⅰ 波、Ⅲ波潜伏期基本正常。SEP显示P40、N45、P60、N75潜伏期均明显延长。结论　慢阻肺患者存在广泛脑功能损 害,BAEP和SEP检测能早期发现慢阻肺患者神经精神亚临床损害。     

诱发电位对2型糖尿病患者视觉功能的损害(英文)

目的通过对2型糖尿病患者进行视觉诱发电位(VEP)的检测,了解患者视觉中枢受损程度以及相关因素。方法用NicoletVikingⅣ型肌电图/诱发电位仪对30例2型糖尿病患者(DM组)及年龄和性别与之匹配的健康正常体检者30例(对照组)进行视觉诱发电位的检测应用SPSS统计软件采用t检验和直线相关分析的方法比较两组间VEP各项参数的差异,分析DM组VEP各项参数的变化与病程、血糖、血脂、肾功能之间的关系。结果DM组20例(66.7%)有异常,与对照组比较P100潜伏期明显延长(F=14.417,P<0.01),波幅下降无显著性差异(F=2.886,P>0.05)。DM组VEP参数的改变与血糖、肾功能损害相关(t=3.7069,r=-0.370,χ2=4.00,P<0.05)。结论VEP检测能较早期的反映患者视觉中枢的病变。控制血糖、保护肾功能有利于减轻患者视觉中枢的损害。     

Visual, long-latency auditory and brainstem auditory evoked potentials in migraine: relation to pattern size, stimulus intensity, sound and light discomfort thresholds and pre-attack state

We aimed to estimate primary sensory evoked potential (EP) amplitude, amplitude-intensity functions and habituation in migraine patients compared with healthy control subjects and to investigate the possible relation to check size, sound and light discomfort thresholds, and the time to the next attack. Amplitudes of cortical visual evoked potentials (VEP, check size 8' and 33'), cortical long latency auditory evoked potential (AEP NIP1; 40, 55 and 70 dB SL tones) and brainstem auditory evoked potential (BAEP wave IV-V; 40, 55 and 65 dB SL clicks) were recorded and analysed in a blind and balanced design. The difference between the response to the first and the second half of the stimulus sequence was used as a measure of habituation. Twenty-one migraine patients (16 women and five men, mean age 39.3 years, six with aura, 15 without aura) and 22 sex- and age-matched healthy control subjects were studied (18 women and four men, mean age 39.5 years). Low sound discomfort threshold correlated significantly with low levels of BAEP wave IV-V amplitude habituation (r = -0.30, P = 0.05). VEP an AEP amplitudes, habituation, and amplitude-intensity function (ASF) slopes did not differ between groups when ANOVA main factors were considered. Control group VEP habituation was found for small check stimuli (P = 0.04), while potentiation was observed for medium sized checks (P = 0.02). The eight migraine patients who experienced headache within 24 h after the test tended to have increased BAEP wave IV-V ASF slopes (P = 0.08). This subgroup did also have a significant VEP habituation to small checks (P = 0.04). No correlation was found between different modalities. These results suggest that: (i) VEP habituation/potentiation state and brainstem activatio state may depend on the attack-interval cycle in migraine; (ii) VEP habituation/ potentiation may depend on spatial stimulus frequency; (iii) phonophobia (and possibly photophobia) may depend more on subcortical (brainstem) function than on cortical mechanisms; (iv) low cortical preactivation in migraine could not be confirmed; (v) EP habituation and ASF analysis may reflect sensory modality-specific, not generalized, central nervous system states in migraine and healthy control subjects.     

脑白质疏松症的诱发电位研究与血管因素的相关性

目的:探讨诱发电位对脑白质疏松症(leukoaraiosia,LA)的临床诊断价值及与血管因素的相关性。方法:选择45例经颅脑CT或MRI证实的单纯LA患者及部分伴有脑梗死的患者,并以60名正常健康老年人作对照,进行体感诱发电位(SEP)、脑干听觉诱发电位(BAEP)、脑干视觉诱发电位(VEP)检测。结果:LA患者中,SEP总异常率95.6%,其潜伏期和波幅均较对照组明显升高(P<0.05);BAEP总异常率71.1%,其各波潜伏期和峰间期较对照组明显延长(P<0.001);VEP总异常率64.4%,其各波潜伏期较对照组延长显著(P<0.001)。3种诱发电位的时间参数及波幅的异常率及异常程度均随LA的病损程度的加重而增加。LA并脑梗死患者3种诱发电位的异常率及异常程度明显高于单纯LA组。结论:在LA的临床早期,虽然还未出现典型的临床表现,但脑电生理已出现异常,诱发电位的检测可以作为早期诊断该病的一个敏感的辅助检测方法。LA并脑梗死患者诱发电位的异常率及异常程度明显高于单纯LA组,提示LA与血管因素有明显相关性。     

不同诱发电位评价猴实验性变态反应性脑脊髓炎的价值

目的探讨不同诱发电位评价猴实验性变态反应性脑脊髓炎 (experimental allergic encephalomyelitis, EAE)的价值. 方法选择 5年前制作的 8只 EAE猴为实验组,另选 13正常猴作对照组,分别进行脑干听觉诱发电位 (brainstem auditory evoked potential, BAEP)、脑干三叉神经诱发电位 (brainstem trigeminal evoked potential, BTEP)、体感诱发电位 (somatosensory evoked potential, SEP)检测. 结果 EAE猴 BAEP的Ⅲ-Ⅴ峰间期为 (3.0± 0.63)ms, BTEP的 T1-T7、 T3-T7峰间期为 (2.53± 0.67)、 (1.68± 0.37)ms, SEP的 P40-N21峰间期为 (13.38± 3.61)ms, BAEP、 BTEP及 SEP各波峰间期与对照组相比明显延长. BAEP、 BTEP、 BAEP+ BTEP及下肢 SEP检查 EAE猴异常率分别是 50%, 50 %, 62%及 81%. 结论 BAEP, BTEP, SEP都可以检出 EAE猴中枢神经系统的损害,其中下肢 SEP阳性率最高, BAEP和 BTEP联合检查可使阳性率增高.     

脑干听觉诱发电位在儿童脑外伤后综合征诊断中的应用

[目的]探讨脑干听觉诱发电位（BAEP）对儿童脑外伤后综合征（PTBS）诊断价值.[方法]对照分析24例PTBS患儿与24例正常儿童的BAEP的Ⅰ、Ⅲ、Ⅴ波峰潜伏期（PL）,Ⅰ~Ⅲ、Ⅲ~Ⅴ峰间潜伏期（IPL）的差异.[结果]PTBS患儿BAEPⅠ波PL与对照组相比差异无显著意义（P〉0.05）.BAEP其他波PL及IPL均延长,与对照组有显著差异（P＜0.05）.[结论]BAEP筛查有助于PTBS患儿的早期发现.     

多发性硬化患者的视觉、脑干听觉诱发电位测定及其意义

目的；探讨视觉诱发电位（VEP）、脑干听觉诱发电位（BAEP）对多发性硬化（MS）的诊断意义。方法：对20例临床诊断为MS的患者进行VEP、BAEP检测，并与对照组进行比较分析。结果：MS患者VEP、BAEP的异常率分别为70％和55％。VEP、BAEP异常者中，各有72％和63％的患者，临床有相应的症状；各有28％和37％的患者临床无相应症状。结论：VEP、BAEP检测对MS的诊断有重要意义。     

脑瘫患儿脑干听觉诱发电位的分析

目的:分析脑性瘫痪患儿的脑干听觉诱发电位(BAEP)特点及其应用价值。方法:检测132例确诊的脑性瘫痪患儿的BAEP,分析其波形、波峰潜伏期(PL)、峰间潜伏期(IPL)及波幅比值等异常情况。结果:132例BAEP总异常率为83.3%(109/132),其中Ⅴ波异常103耳、Ⅲ波异常94耳、Ⅰ波异常38耳(包括重叠异常)。Ⅴ波反应阈值可疑异常31例(23.5%)、轻度异常51例(38.6%)、中度异常21例(15.9%)、重度异常6例(4.5%)。结论:脑瘫患儿BAEP异常率高,主要表现为中枢性听觉传导功能障碍,早期检测BAEP有助于其全面康复。     

Early detection of neurological involvement in IDDM and NIDDM. Multimodal evoked potentials versus metabolic control

Clarification of the extent and mechanisms of damage to the central nervous system in diabetes is a frontier of current neurological research. Our aim was to obtain ample electrophysiological documentation of possible neurological abnormalities in both insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetic patients with a short duration of disease and without overt complications, taking into account metabolic control. Group 1 comprised 11 IDDM patients, and group 2 included 14 NIDDM patients treated with diet alone; the duration of disease was less than 4 yr, and no concomitant clinical complications were present. Age- and sex-matched normal subjects formed groups 3 and 4. Pattern visual evoked potentials (VEP), brain stem auditory evoked potentials (BAEP), and somatosensory evoked potentials (SEP; after the stimulation of both median and tibial nerves) were recorded in all subjects, and metabolic control was evaluated in terms of glycemia and glycosylated hemoglobin. In group 1, significant abnormalities were found in the latency values of VEP, median SEP, and tibial SEP compared with control subjects. Similar latency abnormalities were shown in group 2 for VEP, median SEP, and tibial SEP values and for wave I latency of BAEP. Glycosylated hemoglobin values were correlated with BAEP and SEP abnormalities in many patients in both groups. Furthermore, in group 2, glycemic values correlated with SEP abnormalities. We therefore conclude that neurophysiological abnormalities are present at different levels in IDDM and NIDDM patients only a few years after clinical diagnosis and before the appearance of overt complications, and these abnormalities seem to be correlated with metabolic control status.     

诱发电位对急性缺血性脑卒中认知功能预测价值对比

目的 探讨不同类型诱发电位：脑干听觉诱发电位（BAEP）;体感诱发电位（SEP）;事件相关电位（ERP）对急性缺血性脑卒中（AICA）患认知功能的预测价值。方法 回顾性分析16例痴呆组和30例非痴呆组急性期诱发电位检测结果。结果 二组ERP的异常率有非常明显差异（P＜0．01）,SEP,BAEP无明显差异（P＞0．05）。结论 AICA患急性期ERP异常结合临床后,可作为将来发生痴呆的简易指标。     

Visual Evoked Potential in Patients with Migraine

SYNOPSIS
Using pattern reversal stimuli, visual evoked potentials (VEP) were measured between attacks in 40 (6 classic and 34 common) migraine sufferers, and in 20 control subjects. While there were no statistically significant differences between the groups in mean P wave latency or in mean P wave amplitude, there were some intriguing individual findings in some of the migraine patients. Nine had P wave latencies more than 2 SD above the control mean; 6 had more than 2 SD increases above control in P wave amplitude; 3 had simultaneous increases in both latencies and amplitudes. In almost all the cases with these unusual values, the tracing had been done close in time to a migraine attack.