共查询到18条相似文献,搜索用时 88 毫秒
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61岁女性患者,四肢多发皮下结节3个月余.皮损组织病理:真皮及皮下组织内见大量由上皮样细胞和多核巨细胞组成的结节,结节内未见干酪样坏死,淋巴细胞和少量中性粒细胞浸润.抗酸染色、PAS染色均阴性.诊断:皮下结节型结节病.予以糖皮质激素、甲氨蝶呤治疗,2个月后皮损完全消退.随访1年,结节无复发. 相似文献
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患者,女,51岁。左膝肿块半年,右膝皮下结节1月余。双膝部皮损组织病理:真皮深部至皮下可见大的由组织细胞、上皮样细胞形成的结节,境界清楚,无干酪样坏死。网状纤维染色:(+),结节周围有网状纤维增生。诊断:结节病(皮下型)。予羟氯喹联合复方甘草酸苷治疗1个月后,结节明显消退。 相似文献
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报告1例同时表现为红斑和皮下结节的结节病。患者女,55岁。左眉暗红斑,颞部多发皮下结节2个月余。皮肤科检查:左侧眉弓直径约1 cm暗红斑,颞部多发皮下结节,直径0.5~1.5 cm,质硬,边缘不规则。皮损组织病理示:真皮或皮下脂肪层大量的上皮样细胞肉芽肿及多核巨细胞浸润,大部分呈裸结节。诊断:结节病。 相似文献
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<正>1临床资料患者女,56岁。因皮肤结节7年余,于2013年5月来我院就诊。患者7年前秋季,不明原因于双上肢皮肤出现大小不等结节,暗紫红色,无自觉症状。皮损冬季加重,夏季减轻,进行性加重,逐渐扩散,波及下肢、躯干、耳廓等处,出现斑块。因自发病以来无发热、咳嗽、咳痰、气喘、胸痛、多发性关节痛等症状,故一直未进行治疗。患者既往体健,否认结核、肝炎等传染病史,否认虫咬、外伤史,未问及系 相似文献
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皮下结节病是一种少见的结节病皮肤损害,病因不明,免疫反应是主要发病机制。临床表现为四肢的无痛性皮下结节,多伴有双侧肺门淋巴结肿大等系统损害。组织病理表现为皮下脂肪层和真皮深层的非干酪性上皮细胞样结节,周围有结缔组织包裹,结节周围少量淋巴细胞浸润。结合组织病理检查和影像学检查可明确诊断。糖皮质激素是首选治疗方法。肿瘤坏死因子-α拮抗剂、免疫抑制剂和光动力治疗也是可供选择的治疗手段之一。 相似文献
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皮下结节病是一种少见的结节病皮肤损害,病因不明,免疫反应是主要发病机制.临床表现为四肢的无痛性皮下结节,多伴有双侧肺门淋巴结肿大等系统损害.组织病理表现为皮下脂肪层和真皮深层的非干酪性上皮细胞样结节,周围有结缔组织包裹,结节周围少量淋巴细胞浸润.结合组织病理检查和影像学检查可明确诊断.糖皮质激素是首选治疗方法.肿瘤坏死因子-α拮抗剂、免疫抑制剂和光动力治疗也是可供选择的治疗手段之一. 相似文献
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A 61-year-old female with extensive subcutaneous epithelioid cell granuloma in the back and extremities had negative tuberculin reaction, positive anti-nuclear factor (ANF) and elevated serum angiotensin-converting enzyme (ACE) level while on oral clofibrate for one-and-a-half years because of hyperlipemia. She also suffered from ischemic heart disease with pericardial effusion and dependent edema. The skin surface temperatures over the lesions were about 2°C higher than those of the surrounding normal skin. The subcutaneous lesions cleared spontaneously within 4 months after clofibrate was discontinued. Tuberculin reaction became positive and serum ACE returned to the normal level. 相似文献
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A 41-year-old female visited our department complaining of asymptomatic subcutaneous nodules on the right forearm. She had been diagnosed as having Cushing syndrome due to an adrenal tumor 5-months previously. After she underwent surgery for the adrenal tumor, the subcutaneous nodules gradually increased in number. Physical examination showed ill-defined plate-like subcutaneous indurations on the bilateral lower extremities, buttocks, and right forearm. A biopsy of one of the subcutaneous indurations showed non-caseating epithelioid cell granulomas involving the hypodermis and subcutaneous tissues. The patient was diagnosed as having sarcoidosis based on the Japan Society of Sarcoidosis and Other Granulomatous Disorders 2015 criteria. Skin lesions decreased in size and had completely disappeared. Although the mechanism is unknown, there may be a possibility that the activity of sarcoidosis is suppressed by high cortisol concentrations due to Cushing syndrome. 相似文献
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临床资料患者,女,45岁。主因皮下结节伴咳嗽2个月于2010年10月11日就诊。2个月前突然发现左耳后及双下肢小腿散在数个皮下结节,无压痛,同时无明显诱因出现咳嗽,夜间尤剧烈,无发热、流涕 相似文献
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