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M. N. Zemtsova A. V. Zimichev P. L. Trakhtenberg R. S. Belen’kaya E. I. Boreko 《Pharmaceutical Chemistry Journal》2008,42(10):571-573
Antiviral agents were sought by using ethyl esters of 2-R-4-quinolinecarboxylic acids to synthesize the corresponding aryl
(heteryl) hydrazides. 2-Methyl-4-quinolinecarboxylic acid hydrazide was used to synthesize vinylogs containing a nitro group
in the substituent. The resulting compounds were tested for antiviral activity against ECHO virus type 6.
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 10, pp. 21–23, October, 2008. 相似文献
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O. V. Korenchenko Yu. Ya. Ivanov A. Yu. Aksinenko V. B. Sokolov I. V. Martynov 《Pharmaceutical Chemistry Journal》1992,26(6):489-492
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 26, No. 6, pp. 21–23, June, 1992. 相似文献
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G. V. Romanov O. K. Pozdeev G. Kh. Gil'manova T. Ya. Ryzhikova É. P. Semkina 《Pharmaceutical Chemistry Journal》1990,24(6):414-417
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 24, No. 6, pp. 28–30, June, 1990. 相似文献
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Synthesis and antiviral activity of helioxanthin analogues 总被引:3,自引:0,他引:3
Yeo H Li Y Fu L Zhu JL Gullen EA Dutschman GE Lee Y Chung R Huang ES Austin DJ Cheng YC 《Journal of medicinal chemistry》2005,48(2):534-546
A series of natural product analogues based on helioxanthin (2), with particular attention to modification of the lactone ring and methylenedioxy group, were synthesized and evaluated for their antiviral activities. Among them, lactam derivative 18 and helioxanthin cyclic hydrazide 28 exhibited significant in vitro antiviral activity against hepatitis B virus (EC(50) = 0.08 and 0.03 microM, respectively). Compound 18 showed the most potent antiviral activity against hepatitis C virus (55% inhibition at 1.0 microM). Compound 12, an acid-hydrolyzed product of helioxanthin cyclic imide derivative 9, was found to exhibit broad-spectrum antiviral activity against hepatitis B virus (EC(50) = 0.8 microM), herpes simplex virus type 1 (EC(50) = 0.15 microM) and type 2 (EC(50) < 0.1 microM), Epstein-Barr virus (EC(50) = 9.0 microM), and cytomegalovirus (EC(50) = 0.45 microM). Helioxanthin lactam derivative 18 also showed marked inhibition of herpes simplex virus type 1 (EC(50) = 0.29 microM) and type 2 (EC(50) = 0.16 microM). The cyclic hydrazide derivative of helioxanthin 28 and its brominated product 42 exhibited moderately potent activities against human immunodeficiency virus (EC(50) = 2.7 and 2.5 microM, respectively). Collectively, these molecules represent a novel set of antiviral compounds with unique structural features. 相似文献
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Synthesis and antiviral activity of oxaselenolane nucleosides 总被引:4,自引:0,他引:4
Chu CK Ma L Olgen S Pierra C Du J Gumina G Gullen E Cheng YC Schinazi RF 《Journal of medicinal chemistry》2000,43(21):3906-3912
As dioxolane and oxathiolane nucleosides have exhibited promising antiviral and anticancer activities, it was of interest to synthesize isoelectronically substituted oxaselenolane nucleosides, in which the 3'-CH(2) is replaced by a selenium atom. To study structure-activity relationships, various pyrimidine and purine oxaselenolane nucleosides were synthesized from the key intermediate, (+/-)-2-benzoyloxymethyl-1,2-oxaselenolane 5-acetate (6). Among the synthesized racemic nucleosides, cytosine and 5-fluorocytosine analogues exhibited potent anti-HIV and anti-HBV activities. It was of interest to obtain the enantiomerically pure isomers to determine if they have differential antiviral activities. However, due to the difficult and time-consuming nature of enantiomeric synthesis, a chiral HPLC separation was performed to obtain optical isomers from the corresponding racemic mixtures. Each pair of enantiomers of Se-ddC and Se-FddC was separated by an amylose chiral column using a mobile phase of 100% 2-propanol. The results indicate that most of the anti-HIV activity of both cytosine and fluorocytosine nucleosides resides with the (-)-isomers. 相似文献
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A. N. Evstropov V. E. Yavorovskaya E. S. Vorob'ev Z. P. Khudonogova L. N. Gritsenko E. V. Shmidt S. G. Medvedeva V. D. Filimonov T. P. Prishchep A. S. Saratikov 《Pharmaceutical Chemistry Journal》1992,26(5):426-430
Translated from Khimiko-farmatsevitcheskii Zhurnal, Vol. 26, No. 5, pp. 5–53, May, 1992. 相似文献
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S. A. Zotova I. S. Nikolaeva M. G. Il'ina A. N. Fomina 《Pharmaceutical Chemistry Journal》1989,23(2):156-159
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 23, No. 2, pp. 191–195, February, 1989. 相似文献
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