共查询到20条相似文献,搜索用时 15 毫秒
1.
Arora N Martins D Huston TL Christos P Hoda S Osborne MP Swistel AJ Tousimis E Pressman PI Simmons RM 《Annals of surgical oncology》2008,15(1):256-261
Background Sentinel lymph node biopsy (SLNB) is used to detect breast cancer axillary metastases. Some surgeons send the sentinel lymph
node (SLN) for intraoperative frozen section (FS) to minimize delayed axillary dissections. There has been concern that FS
may discard nodal tissue and thus underdiagnose small metastases. This study examines whether evaluation of SLN by FS increases
the false-negative rate of SLNB.
Methods A retrospective analysis of SLNB from 659 patients was conducted to determine the frequency of node positivity among SLNB
subjected to both FS and permanent section (PS) versus PS alone. Statistical analysis was performed by the χ2 square test, and a logistic regression model was applied to estimate the effect of final node positivity between the two
groups.
Results FS was performed in 327 patients and PS was performed in all 659 patients. Among patients undergoing both FS and PS (n = 327),
the final node positivity rate was 33.0% compared with 19.6% among patients undergoing PS alone (n = 332). After adjustment
for patient age, tumor diameter, grade, and hormone receptor status in a multivariate logistic regression model, there remained
an increased likelihood of final node positivity for patients undergoing both procedures relative to PS alone (adjusted odds
ratio, 2.1; 95% confidence interval, 1.3–3.6; P = .005).
Conclusions There was a higher rate of SLN positivity in specimens evaluated by both FS and PS. Therefore, evaluating SLN by FS does not
underdiagnose small metastases nor produce a higher false-negative rate. Intraoperative FS offers the advantage of less delayed
axillary dissections.
Presented in part at the 2007 New York Surgical Scientific Society Session. 相似文献
2.
Touch Preparation or Frozen Section for Intraoperative Detection of Sentinel Lymph Node Metastases From Breast Cancer 总被引:4,自引:3,他引:1
Menes TS Tartter PI Mizrachi H Smith SR Estabrook A 《Annals of surgical oncology》2003,10(10):1166-1170
Background:The preferred technique for intraoperative evaluation of the sentinel lymph node has not been determined. The purpose of this study was to compare the sensitivity and accuracy of intraoperative evaluation of the sentinel lymph node by touch preparation cytology and frozen section.Methods:A total of 117 patients with clinically node-negative breast cancer or ductal carcinoma-in-situ undergoing sentinel lymph node biopsy had intraoperative evaluation of the sentinel node by touch preparation, frozen section, or both. The results of the intraoperative evaluation were compared with the final histological results of hematoxylin and eosin (H&E) paraffin section and immunohistochemistry (IHC).Results:Twenty-six (57%) of the 46 patients with nodal involvement had metastases detected during surgery. The sensitivity of touch preparation for detecting macrometastases was 78%; for detecting all H&E metastases, including micrometastases, was 57%; and for detecting all metastases, including those seen on IHC, was 40%. The sensitivity of frozen section for detecting macrometastases was 83%; for detecting all H&E metastases, including micrometastases, was 78%; and for detecting all metastases, including those seen on IHC, was 64%. Both have a low sensitivity for micrometastases seen by H&E paraffin section: 57% and 78%, respectively. Neither detected micrometastases diagnosed by IHC only.Conclusions:Both touch preparation and frozen section seem to be accurate in detecting macrometastases, but not micrometastases. Intraoperative evaluation of the sentinel lymph node by touch preparation allows for a quick evaluation of the node without wasting significant tissue and without detecting occult microscopic metastases, which may be beneficial because the clinical importance of these has yet to be elucidated. 相似文献
3.
Shimazu K Tamaki Y Taguchi T Tsukamoto F Kasugai T Noguchi S 《Annals of surgical oncology》2008,15(6):1717-1722
Background Recently, many studies have demonstrated the feasibility and accuracy of sentinel lymph node (SLN) biopsy for patients treated
with neoadjuvant chemotherapy (NAC). However, no studies have been conducted to evaluate the accuracy of frozen section (FS)
analysis of SLN in NAC-treated patients. The aim was to evaluate the accuracy of intraoperative FS analysis of SLNs in breast
cancer patients treated with NAC in comparison with that in those not treated.
Methods Patients with primary breast cancer either treated with NAC (n = 62) or not treated (n = 301) were included in this study. Intraoperatively, the largest cut surface (2-mm thickness) of the SLN was subjected to
FS analysis. Remainders of the SLN were formalin-fixed, serially sectioned at 2-mm thickness, and subjected to H&E staining
and immunohistochemistry. The largest diameter of metastases in the SLN was measured.
Results The sensitivity, specificity, and accuracy of FS analysis of SLNs were 74, 100, and 88%, respectively, for NAC-treated patients,
similar to the corresponding values of 71, 99, and 90% for non-NAC-treated patients. The sensitivity of FS analysis for macrometastases
was lower for NAC-treated patients (76%) than for non-NAC-treated patients (91%), while that for micrometastases and isolated
tumor cells was higher for NAC-treated patients (67%) than for non-NAC-treated patients (31%). However, neither of these differences
was statistically significant.
Conclusions Intraoperative FS analysis of SLNs is as accurate for NAC-treated as for non-NAC-treated patients, indicating that FS analysis
of SLNs is a clinically acceptable method for those receiving NAC. 相似文献
4.
Comparison of Frozen Section and Touch Imprint Cytology for Evaluation of Sentinel Lymph Node Metastasis in Breast Cancer 总被引:5,自引:2,他引:3
Background: Sentinel lymph node metastasis of breast cancer is evaluated by frozen section (FS) or touch imprint cytology (TIC). However, which of the two methods is superior remains controversial. Here we directly compared the sensitivity of these methods prospectively.Methods: The study included 208 SNs harvested from 107 consecutive patients with breast cancer who underwent sentinel lymph node biopsy. SNs were serially sectioned at 2-mm intervals, and two sections were subjected to intraoperative evaluation of FS with hematoxylin and eosin staining. TIC specimens were prepared from all cut surfaces and analyzed by Papanicolaou (TIC) and cytokeratin (TIC with immunohistochemistry; TIHC) immunohistochemistry.Results: Thirty-five SNs from 27 patients were positive by final histopathology. The sensitivity per sentinel lymph node of FS was 89%; it was 86% for TIC and 89% for TIHC. Among 173 negative SNs, the results of FS were concordant with final histopathology, but TIC and TIHC were positive in 1 and 5 histopathology-negative SNs, respectively. The sensitivity per patient of FS was 85%; it was 85% for TIC and 89% for TIHC. Among 80 patients with node-negative disease, the results of FS and TIC were concordant with final histopathology, whereas TIHC was positive in 3 patients (3.8% were upstaged). A slight improvement of sensitivity per patient was achieved by the combination of FS and TIC (to 89%) or FS and TIHC (to 93%).Conclusions: The sensitivity of FS was almost equivalent to that of TIC. TIHC had a better sensitivity than FS and TIC, but it upstaged a few node-negative patients. 相似文献
5.
临床腋淋巴结阴性乳腺癌前哨淋巴结研究 总被引:21,自引:2,他引:21
目的:探讨前哨淋巴结活检术(sentinel lymph node biopsy, SLNB)在乳腺癌治疗中的应用。方法:使用专利蓝和美蓝染色,对1999年9月~2001年4月连续收治的145例临床查体腋窝淋巴结阴性乳腺癌病人行前哨淋巴结活检术。结果:SLNB成功率为96.5%(140/145),假阴性率为23.5%,准确率为91.4%。病人年龄、肿瘤最大径、肿瘤部位、注射染料类型及是否活检对成功率和假阴性率无影响。结论:SLNB能够准确预测腋窝淋巴结的转移状况,在缩小手术范围、减少术后并发症的同时,提高了腋窝淋巴结分期的准确性;美蓝与专利蓝均可成功确定SLN。 相似文献
6.
乳腺癌前哨淋巴结活检的研究进展 总被引:4,自引:0,他引:4
目的 报道乳腺癌前哨淋巴结活检的研究进展。方法 采用文献回顾的方法,对国外乳腺癌前哨淋巴结活检的历史、概念、活检技术以及临床应用等问题进行综述。结果 乳腺癌前哨淋巴结活检的操作方法还没有统一的标准,检出率及假阴性率变化范围广。结论 前哨淋巴结活检的临床应用还需要大量前瞻性多中心随机实验结果进一步论证。 相似文献
7.
A New Radiocolloid for Sentinel Node Detection in Breast Cancer 总被引:1,自引:0,他引:1
Hodgson N Zabel P Mattar AG Engel CJ Girvan D Holliday R 《Annals of surgical oncology》2001,8(2):133-137
Background:The optimal radioactive tracer and technique for sentinel lymph node localization in breast cancer is yet to be determined. The dilemma of small particle size with dispersion to second echelon nodes versus failure of migration of larger radiocolloids needs to be resolved. A new radiocolloid preparation with particle size under 0.1 micron was developed with excellent primary/post lymphatic entrapment ratio.Objective:To assess the feasibility of a new 99mTc radiocolloid cysteine-rhenium colloid in sentinel lymph node (SLN) localization for breast cancer.Methods:Forty-seven patients with newly diagnosed T1 or T2 breast cancer underwent injection of 99mTc-labeled cysteine-rhenium colloid followed by lymphoscintigraphy. Same day SLN biopsy with patent blue dye and intraoperative gamma probe to identify SLNs were performed.Results:SLN mapping and intraoperative localization were successful in 46/47 (98%) of patients. The blue dye radioactive tracer concordance was 94%. There was one false-negative in a patient with a nonpalpable tumor that underwent ultrasound-guided peritumoral radiocolloid injection.Conclusions:99mTc-cysteine-rhenium colloid is highly effective in identifying SLNs. It has the advantage of smaller particle size than sulfur colloid with easier lymphatic migration. It has a more neutral pH with less pain on injection and does not require filtration, thereby minimizing radiation exposure to technologists.Presented at the 53rd Annual Meeting of the Society of Surgical Oncology, New Orleans, Louisiana, March 16–19, 2000 相似文献
8.
Kühn T 《Breast care (Basel, Switzerland)》2011,6(3):185-191
The role of axillary surgery for the treatment of primary breast cancer is in a process of constant change. During the last decade, axillary dissection with removal of at least 10 lymph nodes (ALD) was replaced by sentinel lymph node biopsy (SLNB) as a staging procedure. Since then, the indication for SLNB rapidly expanded. Today's surgical strategies aim to minimize the rate of patients with a negative axillary status who undergo ALD. For some subgroups of patients, the indication for SLNB (e.g. multicentric disease, large tumors) or its implication for treatment planning (micrometastatic involvement, neoadjuvant chemotherapy) is being discussed. Although the indication for ALD is almost entirely restricted to patients with positive axillary lymph nodes today, the therapeutic effect of completion ALD is more and more questioned. On the other hand, the diagnostic value of ALD in node-positive patients is discussed. This article reflects today's standards in axillary surgery and discusses open issues on the diagnostic and therapeutic role of SLNB and ALD in the treatment of early breast cancer. 相似文献
9.
Zurrida S Galimberti V Orvieto E Robertson C Ballardini B Cremonesi M De Cicco C Luini A 《Annals of surgical oncology》2000,7(1):28-31
Background: Sentinel node (SN) biopsy may predict axillary status in breast cancer. We retrospectively analyzed more than 500 SN cases, to suggest more precise indications for the technique.Methods99mTc-labeled colloid was injected close to the tumor; lymphoscintigraphy was then performed to reveal the SN. The next day, during surgery, the SN was removed by using a gamma probe. Complete axillary dissection followed, except in later cases recruited to a randomized trial. The SN was examined intraoperatively by conventional frozen section, in later cases by sampling the entire node and using immunocytochemistry.Results: In the first series, the SN was identified in 98.7% of cases; in 6.7%, the SN was negative but other axillary nodes were positive; in 32.1%, the SN was negative by intraoperative frozen section but metastatic by definitive histology, prompting introduction of the exhaustive method. In the randomized trial, the SN was identified in all cases so far, the false-negative rate is approximately 6.5%, and in 15 cases, internal mammary chain nodes were biopsied.Conclusions: SN biopsy can reliably assess axillary status in selected patients. The problems are the SN detection rate, false negatives, and the intraoperative examination, which can miss 30% of SN metastases. Our exhaustive method overcomes the latter problem, but it is time consuming.Presented at the 52nd Annual Meeting of Society of Surgical Oncology, Orlando, Florida, March 4–7, 1999. 相似文献
10.
Background: Recent data suggest sentinel lymph node biopsy (SLNBx) for invasive breast cancer (IBC) is widely performed in the United States, often outside of a clinical trial. We sought to describe SLNBx practice patterns in Canada, as well as criteria for abandonment of concurrent axillary lymph node dissection.Methods: All active (n = 1172) general surgeons in Canada were sent a 31-item questionnaire.Results: Of the 519 respondents who treated IBC, 138 (27%) performed SLNBx, whereas 378 (73%) did not. Surgeons who did not perform SLNBx most commonly cited a lack of adequate resources (64%). Of the 138 surgeons who performed SLNBx, 16% participated in one of the ongoing multicenter clinical trials. Of the 39 (28%) surgeons who abandoned routine concurrent axillary lymph node dissection, 20 (51%) performed <30 combined procedures before performing SLNBx alone. On multivariate analysis, surgical oncology training (P = .005), increasing proportion of practice devoted to breast disease (P < .001), and number of days per week in the operating room (P < .001) were associated with the use of SLNBx.Conclusions: In contrast to the United States, SLNBx for IBC in Canada was not as common, and few surgeons participated in clinical trials. Fellowship-trained surgical oncologists and surgeons with a high exposure to breast disease seemed to be most involved in the development of SLNBx for IBC.Presented at the 55th annual meeting of the Society of Surgical Oncology, Denver, Colorado, March 2002. 相似文献
11.
Background Sentinel lymph node biopsy (SLNB) has largely replaced axillary dissection (ALND) for axillary staging in early breast cancer.
However, intense pathologic evaluation is not routinely available intraoperatively; therefore, patients with SLN metastasis
may require a second surgery for completion ALND. We hypothesized that a single-section approach (by either frozen section
[FS] or touch preparation analysis [TPA]) could be accurate for intraoperative SLN evaluation.
Methods We performed a prospective, blinded study of patients undergoing SLNB for breast cancer from September 2004 to July 2006.
SLNs were bivalved along the long axis, underwent FS and TPA of the facing halves, followed by routine sentinel node processing
(serial sectioning with hematoxylin/eosin staining). A single pathologist reviewed all study slides and was blinded to the
permanent section interpretation.
Results We analyzed 233 nodes from 118 patients. Overall, 21% of patients (N = 25) had SLN metastasis by serial-section histopathology. Single-section FS and TPA had similar sensitivities (0.67 and
0.66, P = .82) and specificities (0.995 and 0.995, P = 1.0) for detection of SLN metastasis, yielding equivalent accuracies (95%). All micrometastases (<2 mm; N = 4) were missed by both techniques. False positives were rare—only one in each group (2% overall).
Conclusion Single-section TPA and FS have similar accuracies and can be safely used to identify the majority of patients with SLN metastasis,
sparing these patients a delayed ALND. False-negative results from TPA or FS occur in patients with micrometastatic disease,
for which the role of completion ALND remains controversial. 相似文献
12.
Dauphine CE Haukoos JS Vargas MP Isaac NM Khalkhali I Vargas HI 《Annals of surgical oncology》2007,14(3):1014-1019
Background Completion axillary lymph node dissection (cALND), performed after a positive sentinel lymph node biopsy (SLNB) in breast
cancer patients, often results in no additional positive nodes. Scoring systems have been published to aid in the prediction
of nonsentinel node metastasis. Our purpose was to assess the validity of these scoring systems in our patient population.
Methods For 39 consecutive patients who underwent cALND after a positive SLNB, scores were calculated using retrospective patient
data for each of the three scoring systems used. Receiver operating characteristics (ROC) curves were drawn, and the areas
under the curves were calculated to assess the discriminative power of each system. Univariate analysis was performed to assess
the predictability of individual patient and tumor characteristics.
Results Nonsentinel nodes were positive in 23 (59%) patients. The areas under the ROC curves were 0.63, 0.70, and 0.68, respectively.
The proportion of sentinel nodes that were positive and the total number of sentinel nodes retrieved were the only individual
predictors of nonsentinel node metastasis.
Conclusions Given the high incidence of retrieving no additional metastasis on cALND, individualized patient management according to risk
is desirable. Scoring systems provide additional information regarding the likelihood of metastasis in nonsentinel nodes,
but their predictability remains less than optimal. The use of scoring systems must be applied with caution until future studies
provide a more accurate assessment of risk for patients with a positive SLNB. 相似文献
13.
Background Sentinel node biopsy (SNB) for breast cancer has a false-negative rate of approximately 5%. Initial reports of follow-up show
lower axillary recurrence rates than expected. We performed axillary ultrasonography to determine whether occult recurrences
could be detected.
Methods In a community hospital setting, 289 patients who had SNB for breast cancer in a single surgeon’s practice underwent axillary
examination by the surgeon followed by axillary ultrasonography by a dedicated breast radiologist. Ultrasonography was performed
one time from 4 to 79 months (median, 25 months) after surgery. Five patients with suspicious nodes had ultrasound-guided
fine-needle aspiration, and one had a core biopsy.
Results No patient had suspicious nodes on clinical examination. Only six patients had ultrasound findings that warranted intervention.
Five patients had benign cytological characteristics, and one had a benign core biopsy result. No evidence of axillary recurrence
was found in any patient.
Conclusions Axillary ultrasonography did not detect occult metastases in any patient and is not recommended for routine follow-up after
SNB. The lack of ultrasound evidence of metastasis suggests that the recurrence rate is likely to remain low. 相似文献
14.
Sentinel Lymph Node Metastasis in Microinvasive Breast Cancer 总被引:7,自引:3,他引:4
Intra M Zurrida S Maffini F Sonzogni A Trifirò G Gennari R Arnone P Bassani G Opazo A Paganelli G Viale G Veronesi U 《Annals of surgical oncology》2003,10(10):1160-1165
Background:Ductal carcinoma in situ with microinvasion (DCISM) is a separate pathological entity, distinct from pure ductal carcinoma in situ (DCIS). DCISM is a true invasive breast carcinoma with a well-known metastatic potential. Currently, there is controversy regarding the indication for complete axillary dissection (CAD) to stage the axilla in patients with DCISM. The role of CAD is questioned given its morbidity and reported low incidence of axillary involvement. Sentinel lymph node biopsy (SLNB) may obviate the need for CAD in these patients without compromising the staging of the axilla and the important prognostic information.Methods:From March 1996 to December 2002, 4602 consecutive patients with invasive breast carcinoma underwent SLN biopsy. Of these, 41 patients with DCISM were selected.Results:Metastasis in the SLN were detected in 4 of 41 (9.7%) patients. Two of the 4 patients had only micrometastasis in the SLN. In three patients, the SLN was the only positive node after CAD.Conclusions:SLN biopsy should be considered as a standard procedure in DCISM patients. SLNB can detect nodal micrometastasis and accurately stage the axilla avoiding the morbidity of a CAD. Complete AD may not be mandatory if only the SLN contains micrometastatic disease. Informed consent is very important in the decision not to undergo CAD. 相似文献
15.
The best method of pathological evaluation of sentinel lymph node in breast cancer has not been agreed upon. Immunohistochemical
(IHC) techniques have shown a greater sensitivity over conventional histology for the detection of micrometastais. The aim
of the study was to determine whether IHC for Epithelial Membrane Antigen (EMA) on the sentinel node could be more sensitive
than conventional histology for diagnosing micrometastasis in sentinel lymph nodes. Eighty-four clinically node negative breast
cancer patients underwent sentinel node biopsy at time of surgery for breast cancer. The node was subjected to conventional
histopathology as well as IHC for EMA. The sensitivity of histology viz a viz IHC for EMA for detection of sentinel node metastasis
was 88% and the specitficity was 96%. The overall diagnostic accuray of histology viz a viz IHC was 93%. There were 4 patients
with micrometastasis (<2.0 mm), which were positive on IHC but negative on histology. Two patients with poorly differentiated
breast cancer had a false negative IHC for EMA result as compared to histology. Immunohistochemistry for Epithelial Membrane
Antigen can increase the detection rate of micrometastasis in sentinel lymph node. This can have important bearing on deciding
the need of adjuvant systemic therapy. A false negative result for EMA may be seen in patients with poorly differential cancer.
Therefore the best policy seems to employ both histopathology and IHC for EMA for the comprehensive evaluation of sentinel
lymph node in breast cancer. 相似文献
16.
Background In breast cancer treatment, intraoperative sentinel lymph node (SLN) evaluation is used to identify patients who may potentially
benefit from immediate completion of axillary lymph node dissection.
Methods Prospectively collected breast cancer registry data identified 516 SLN biopsies between January 2003 and December 2005. Intraoperative
evaluation (IE) of the SLNs was performed in 479 axillae. Final pathology by hematoxylin and eosin and, for negative nodes,
by immunohistochemical stains was compared with the IE result. The effect of IE and final pathology on surgical treatment
was examined.
Results The sensitivities for IE of N0(i+) (n = 39), N1mi (n = 41), and N1a–3a (n = 89) metastases were 0%, 5%, and 63%, respectively.
The specificity was 99.7%. IE identified 57 (44%) of SLN-positive (N1mi and N1a–3a) axillae, thus resulting in synchronous
axillary lymph node dissection for those patients. Reoperation for false-negative IEs (N1mi or N1a–3a with negative IE) occurred
in only 27 axillae (39%).
Conclusions IE of SLNs has adequate sensitivity and excellent specificity. In addition to allowing patients to benefit from synchronous
surgery, IE helped patients to receive care in concordance with recommended practice guidelines. The false-negative IE of
SLNs highlights uncertainty with the clinical significance of axillary nodal staging when only small amounts of metastatic
disease are identified in the axilla. 相似文献
17.
Lymphovascular Invasion Enhances the Prediction of Non-Sentinel Node Metastases in Breast Cancer Patients With Positive Sentinel Nodes 总被引:17,自引:7,他引:10
Weiser MR Montgomery LL Tan LK Susnik B Leung DY Borgen PI Cody HS 《Annals of surgical oncology》2001,8(2):145-149
Background:Fifty percent of patients with sentinel lymph node (SLN) metastases have no metastatic disease in non-SLNs on axillary lymph node dissection (ALND). The goal of this study is to determine which patients have metastatic disease limited to the SLN, and, therefore, may not require completion ALND.Methods:Of the first 1000 patients undergoing SLN biopsy at Memorial Sloan-Kettering Cancer Center, using a combined blue dye and isotope technique, 231 (26%) had positive SLN. Of these, 206 underwent completion ALND. They are the study group for this report.Results:The likelihood of non-SLN metastasis was inversely related to three clinicopathologic variables: tumor size 1.0 cm; absence of lymphovascular invasion (LVI); and SLN micrometastases ( 2 mm). None of 24 patients with all three predictive factors had non-SLN metastases, whereas 58% of patients with none of the factors had disease in the non-SLN.Conclusion:Patients with small breast cancers, no LVI, and SLN micrometastases have a low risk of non-SLN metastases, and may not require completion ALND.Presented at the 53rd Annual Meeting of the Society of Surgical Oncology, New Orleans, Louisiana, March 16-19, 2000 相似文献
18.
Axillary lymph node status is a prognostic marker in breast cancer management, and axillary surgery plays an important role in staging and local control. This study aims to assess whether a combination of sentinel lymph node biopsy (SLNB) using patent blue dye and axillary node sampling (ANS) offers equivalent identification rate to dual tracer technique. Furthermore, we aim to investigate whether there are any potential benefits to this combined technique. Retrospective study of 230 clinically node-negative patients undergoing breast-conserving surgery for single T1–T3 tumours between 2006 and 2011. Axillae were staged using a combined blue dye SLNB/ANS technique. SLNs were localized in 226/230 (identification rate 98.3 %). Three of one hundred ninety-two patients with a negative SLN were found to have positive ANS nodes and 1/4 failed SLNB patients had positive ANS nodes. Thirty-four of two hundred twenty-six patients had SLN metastases and 11/34 (32.4 %) also had a positive non-sentinel lymph node on ANS. Twenty-one of twenty-four (87.5 %) node-positive T1 tumours had single node involvement. Nine of thirty-eight node-positive patients progressed to completion axillary clearance (cALND), and the rest were treated with axillary radiotherapy. Axillary recurrence was nil at median 5 year follow-up. Complementing SLNB with axillary node sampling (ANS) decreases the unavoidable false-negative rate associated with SLNB. Appropriate operator experience and technique can result in an SLN localization rate of 98 %, rivalling a dual tracer technique. The additional insight offered by ANS into the status of non-sentinel nodes has potential applications in an era of less frequent cALND. 相似文献
19.
Intradermal Radiocolloid and Intraparenchymal Blue Dye Injection Optimize Sentinel Node Identification in Breast Cancer Patients 总被引:15,自引:8,他引:7
David C. Linehan MD Arnold D. K. Hill MCh FRCSI Timothy Akhurst MD Henry Yeung MD Samuel D. J. Yeh MD Katherine N. Tran BA Patrick I. Borgen MD Hiram S. Cody III MD 《Annals of surgical oncology》1999,6(5):450-454
Background: Radiotracer and blue dye mapping of sentinel lymph nodes (SLN) have been advocated as accurate methods to stage the clinically negative axilla in breast cancer patients. The technical aspects of SLN biopsy are not fully characterized. In this study we compare the results of intraparenchymal (IP) and intradermal (ID) injection of Tc-99m sulfur colloid, to establish an optimal method for SLN localization.Methods: 200 consecutive patients had SLN biopsy performed by a single surgeon. Of these, 100 (Group I) had IP injection and 100 (Group II) had ID injection of Tc-99m sulfur colloid. All patients had IP injection of blue dye as well. Endpoints included (1) successful SLN localization by lymphoscintigraphy, (2) successful SLN localization at surgery, and (3) blue dye–isotope concordance (uptake of dye and isotope by the same SLN).Results: Isotope SLN localization was successful in 78% of Group I and 97% of group II patients (P < .001). When isotope was combined with blue dye, SLN were found in 92% of group I and 100% of Group II (P < .01). In cases where both dye and isotope were found in the axilla, dye mapped the same SLN as radiotracer in 97% of Group I and 95% of Group II patients.Conclusions: The dermal and parenchymal lymphatics of the breast drain to the same SLN in most patients. Because ID injection is easier to perform and more effective, this technique may simplify and optimize SLN localization. 相似文献
20.
目的总结乳腺癌前哨淋巴结活检(SLNB)的研究现状和进展。方法复习近年来国内外的相关文献,对乳腺癌SLNB的概念、适应证、活检技术、提高检出准确率的方法、病理学检查方法、转移灶类型、临床应用等进行综述。结果 SLNB的适应证在不断扩大。示踪剂、影像学检查和病理学检查技术的发展有助于对乳腺癌前哨淋巴结(SLN)状态的评估。乳腺癌SLNB的操作方法还没有统一的标准,对其能否指导选择性的腋窝淋巴结清扫的争议较大,且SLNB的SLN检出率及假阴性率变化范围较大。结论 SLNB已成为乳腺癌外科治疗的重要辅助手段,但其操作尚需进一步规范,其临床应用范围还需要大量前瞻性、多中心的随机试验进一步论证。 相似文献