洛阳市维持性血液透析患者生活质量调查及影响因素分析

目的 通过对洛阳市维持性血液透析(maintenance hemodialysis,MHD)患者的生活质量进行调查,分析影响MHD患者生活质量的因素,为改善MHD患者生活质量提出依据.方法 采用质量调查问卷(Short-Form 36 Health Survey Questionnaire,SF-36)生活质量量表对洛阳市第一人民医院、洛阳市中心医院、河南科技大学第一附属医院、河南科技大学第三附属医院、解放军150医院、洛阳市第一中医院、洛阳市第二中医院352例MHD患者进行问卷调查,计算血液透析患者生活质量得分,与健康常模进行比较,分析影响MHD患者生活质量的因素.结果 研究组患者SF-36量表8个维度的得分显著低于健康常模(P＜0.05).MHD患者生活质量与性别、年龄、透析龄、血红蛋白、透析充分性(Kt/V)等因素有关.结论 MHD患者生活质量明显低于健康人群,年龄、性别、透析龄、血红蛋白、Kt/V是影响MHD患者生活质量的重要因素,改善这些因素有望提高MHD患者的生活质量.     

长程血液透析对维持性血液透析患者生活质量的影响

目的 研究长程血液透析(LSHD)对维持性血液透析(MHD)患者生活质量的影响.方法 选取首都医科大学附属北京友谊医院血液净化中心40例MHD患者,通过问卷调查和收集临床资料相结合的方法,进行前瞻性配对临床研究.根据临床资料、检验指标、睡眠质量将患者配对分组为普通透析(HD)组和LSHD组,各20例,进行6个月的临床试验,观察两组患者临床表现、生化指标及生活质量的情况.结果 LSHD组的Kt/V(1.73±0.36比1.41±0.23,P＜0.05)、血红蛋白[(124.67±9.08)比(110.55±9.01) g/L,P＜0.01]、血清白蛋白[(45.01±2.66)比(39.28±2.63) g/L,P＜0.01]显著高于HD组 ;血压控制比例(14/20比5/20,P=0.010)和睡眠质量(16/20比5/20,P=0.001)显著优于HD组 ;生活质量SF-36评分显著高于HD组(P＜0.05),差异均有统计学意义.结论 长程透析可以改善MHD患者睡眠质量、营养状况,从而改善生活质量.     

宁夏地区不同人群腹膜透析患者生活质量及其影响因素

目的探讨宁夏地区不同人群腹膜透析患者生活质量及其影响因素,旨在为临床工作中如何提高透析患者的生存质量提供依据。方法①选择行规律持续非卧床腹膜透析（continuous ambulatory peritoneal dialysis,CAPD）治疗6个月以上的109例慢性肾衰竭患者。收集患者的民族、年龄、性别、原发病因、受教育程度、年均收入、透析时间、透析方案及体质量指数（body mass index,BMI）等资料。按民族分为回族组和汉族组。②采用肾脏疾病生活质量简表（Medical Outcomes Study Health Status ShortForm,SF-36）评估患者的生活质量。③采用肾脏病膳食改良实验（Modifi—cationofDietinRenalDisease,MDI①）方程估计算患者的肾小球滤过率,以评估患者的残余肾功能。④采用主观综合性营养评估（subjective global assessment,SGA）及白蛋白等指标评估患者营养状况。⑤采用Charlson合并症指数评估患者合并症情况。⑥检测患者血浆全段甲状旁腺素（intactparathy—roidhormone,iPTH）及血钙、血磷水平以评估患者的钙磷代谢状况。结果①回族组、汉族组患者在年龄、性别、原发病因、受教育程度、年均收入、透析时间、透析方案及Charlson合并症指数等均无统计学差异（P〉0．05）。②与汉族组比较,回族组患者血钙、白蛋白、三酰甘油、总胆固醇及肾小球滤过率明显降低,iPTH水平明显升高,差异有统计学意义（P〈0．05）。③与汉族组比较,回族组的SGA评估的营养不良的发生率亦明显升高（47．5Z比24．6％）,有统计学差异（P〈O．05）。④与汉族组比较,回族组在SF-36评分[（52．90±20．68）比（42．78±19．46）]、生理健康评分[（53．27±22．91）比（39．47±20．22）]、精神健康评分E（58．30±22．68）比（46．10±22．76）]均明显下降,有统计学差异（P〈0．05）。⑤与汉族组比较,回族组在情感与精神状况[-（65．29±19．85）比（54．65±21．60）]和疼痛[（72．54±27．88）比（47．19±30．85）]两个维度评分也明显下降,均有统计学差异（P〈0．05）。⑥将2组存在差异的指标进行单因素相关分析及多元线性回归发现,不同人群和白蛋白水平与SF-36相关。结论回族、汉族腹膜透析患者生活质量SF-36、生理健康及精神健康存在一定的差异,回族患者明显低于汉族;白蛋白水平是影响患者生活质量的因素。     

Assessment of health-related quality of life in patients treated with hemodialysis in Serbia: influence of comorbidity, age, and income

The importance of measuring health-related quality of life (HRQoL) in patients on maintenance hemodialysis (HD) is being increasingly recognized, but few studies, especially from the Balkan region, have addressed this issue. The aims of this study were (i) to evaluate HRQoL in an outpatient university-affiliated dialysis facility in South Serbia; (ii) to determine the effects of age, presence of comorbidity, primary kidney disease, dose of HD, and family income; and (iii) to make comparisons of the HRQoL in Serbian patients on chronic HD with that reported by others previously. The study enrolled 192 patients on HD for more than 3 months. Comorbidity was assessed using the index of coexistent diseases (ICED), including two subindexes: index of disease severity (IDS) and index of physical impairment (IPI). Patient's self-assessment of HRQoL was measured by the 36-item short form health survey questionnaire (SF-36), encompassing eight summary scales and two summary dimensions. Ten of the baseline variables had significant associations with parameters of HRQoL. Fitting these variables in linear regression models resulted in 41.9% variance for physical dimension of HRQoL (physical component summary score [PCS]), and 32.5% for mental dimension of HRQoL (mental component summary score [MCS]). However, statistically significant effect had only IDS, IPI, and age for PCS, and income of patients for MCS. We found that an increase in IDS score for one unit is associated with a decrease of PCS by 13.2%, and SF-36 score (total quality of life) by 15.2%. The increase of IPI score by one unit decreases PCS by 16.1% and SF-36 score by 17.5%. A 5-year increase in age is associated with a decrease of PCS by 3.1%, and SF-36 score by 3.8%. The monthly income increase of 10 euros per family member increases MCS by 5.2% and SF-36 score by 3.0%. HRQoL in patients on HD was found markedly impaired. Comorbid conditions have negative and statistically significant correlation with parameters of HRQoL, and could explain poor HRQoL to a remarkable extent. Older age and poor income substantially reduce HRQoL in HD patients.     

老年腹膜透析患者生存质量的影响因素

目的 探讨持续不卧床腹膜透析(CAPD)老年患者的生存质量状况,并初步探讨影响老年CAPD患者生存质量的各种因素.方法 选取我院2011年至2014年4月期间收治的年龄大于60岁的行持续不卧床腹膜透析治疗的63例老年患者,按年龄分为＜70岁和≥70岁两组,使用SF-36量表调查患者的生存质量.结果 两组患者年龄[(63.93±2.97)vs(73.57±3.22)岁]、Charlson合并症指数(3.4+±2.3 vs 5.0± 3.1)、Karnofsky活动指数(82±9 vs72± 16)、合并心血管并发症(x2=9.921,P=0.002)差异有统计学意义(均P＜0.05).两组患者SF-36量表中8个维度比较差异无统计学意义(均P＞ 0.05);在躯体健康相关生存质量方面差异有统计学意义(P=0.031).相关性分析显示,SF-36总分与Kamofsky活动指数(r=0.046,P=0.000)、残肾功能(r=0.314,P=0.012)呈正相关;与焦虑指数(r=-0.318,P=0.014)、抑郁指数(r=-0.341,P=0.006)呈负相关.躯体健康相关生存质量与年龄(r=-0.337,P=0.007)、是否合并心血管并发症(r=-0.333,P=0.008)、抑郁指数(r=-0.369,P=0.003)呈负相关;与Karnofsky活动指数(r=0.507,P=0.000)、残余肾功能(r=0.268,P=0.034)呈正相关性.精神健康相关生存质量与焦虑指数(r=-0.327,P=0.009)、抑郁指数(r=-0.267,P=0.034)呈负相关;与Karnofsky活动指数(r =0.321,P=0.01)、残余肾功能(r=0.283,P=0.025)呈正相关.结论 对于老年腹膜透析患者而言,年龄、焦虑指数、抑郁指数、Karnofsky活动指数、残肾功能、心血管并发症的发生都可能会影响其生存质量.     

维持性血透患者的心理状态研究

研究我国血透患者的心理状况并进行针对性的心理治疗。方法 采用症状自评量表(SCL90-R)、多维度健康状况心理控制源量表(MHLC)、艾森克个性问卷(EPQ)及终末期肾脏病(ESRD)患者专用的生活质量表对北京六个医院透析中心的92名维持性血透患者进行了心理状态的研究,并与美国及加拿大相同的研究进行了比较分析。结果 本组的血透存在着抑郁、焦虑、恐怖等心理障碍,出现心理障碍的比例显著高于美国同类患者(P<0.01),且焦虑的发生率高于美国同类患者(P<0.01)。这些障碍与MHLC中机遇项分(CED)显著相关(P<0.01)。EPQ中神经质项分高者倾向于发生抑郁、焦虑等心理障碍。本组的血透患者客观生活质量较加拿大同类患者低(P<0.01),但在总的生活满意度上没有显著性差异。生活质量与心理及躯体因素均呈显著相关,心理障碍与躯体症状也显著相关(P<0.01)。结论 本组的血透患者心理状态与美国加拿大同类患者相比既有相同之处,又有特殊之处。我们应该兼顾病人的躯体和精神两方面的健康,努力提高他们的生活质量。     

冠状动脉旁路移植术后病人生存质量探讨

目的观察研究冠状动脉旁路移植（CABG）术病人术前、术后生存质量（QoL）。方法分为体外循环手术组（ONCAB）和非体外循环手术（OPCAB）组，于手术前1周内、术后3个月和6个月进行西雅图心绞痛调查表（SAQ）和SF-36量表的测评。结果SAQ各项内容评分，术前以心绞痛稳定状态（AS）得分最低，术后各项目有明显好转；SF-36的生理健康内容（PCS）和心理健康内容（MCS）在术后均有不同程度改善；ONCAB和OPCAB两组之间各纬度得分在术后3．6个月比较差异均无统计学意义。结论冠状动脉旁路移植术后病人生活质量提高。ONCAB和OPCAB组生存质量比较差异无统计学意义。     

高通量血液透析对维持性血液透析患者营养状况的影响

目的 探讨高通量血液透析（high-flux hemodialysis,HFHD）对维持性血液透析（maintain hemodialysis,MHD）患者营养状况的影响。方法 将MHD的终末期肾脏疾病患者48例,随机分为低通量血液透析（low-flux hemodialysis,LFHD）组和高通量血液透析（high-flux hemodialysis,HFHD）组,每组24例。分别于治疗前和治疗后24周检测血红蛋白（Hb）、血浆白蛋白（Alb）、转铁蛋白（transferrin,TRF）、营养不良-炎症评分（malnutrition inflammation score,MIS）等观察指标。结果 2组治疗前比较,Hb、Alb、TRF、MIS无统计学差异（P〉0．05）;HFHD组治疗后Hb、Alb、TRF较其治疗前增高,MIS较其治疗前降低（P〈0．05）;2组治疗后,HFHD组Hb、Alb、TRF较LF-HD组增高,MIS较LFHD组降低（P〈0．05）。结论 HFHD可有效改善MHD患者的营养状况。     

血液透析和腹膜透析患者生存质量的多中心调查

目的评估我国广东省南部血液透析(血透)和腹膜透析(腹透)患者生存质量的状况;比较血透和腹透患者生存质量差异;探讨影响血透和腹透患者生存质量的基本因素.方法采取多中心研究方法.病例选自广东省南部,而主要是广州市的9家大医院的维持性血透、腹透3个月以上的患者,其中血透180例,腹透122例.使用KDQOL-SFTM表进行问卷调查,根据Hays RD提供的方法进行评分.结果 (1)血透患者肾脏病和透析相关生存质量(KDTA)总分为51.2±10.6,SF-36总分为48.2±19.9;腹透患者KDTA总分为56.3±12.3,SF-36总分为47.8±16.8.血透多数领域评分较欧美日同类报道为低;腹透仅部分领域低于香港特别行政区,但总体评分与香港特别行政区同类报道无显著差异.(2)比较研究提示腹透总体评分高于血透,但进一步的分层研究提示血透与腹透的生存质量差异主要是在透析的前2年.(3)血透男性患者在KDTA和SF-36及其它5个领域优于血透女性患者;而腹透男女患者之间KDTA和SF-36总分无显著差异.无论男女,腹透患者在多个领域均优于同性别血透患者.(4)血透患者的青年组(＜45岁)与中年组(45～60岁)、老年组(＞60岁)相比,在KDTA和SF-36总体水平无显著差异,仅在体能相关领域高于中老年组.腹透患者青年组在KDTA和SF-36总分以及多个分支领域明显高于中老年组患者,同时,腹透患者在不同年龄组的多个领域优于同年龄段血透患者.(5)在生存质量的总体变化趋势方面,血透患者初始的生存质量较低,透析1～2年时的生存质量逐渐提高,2～4年处于高峰,以后开始下降;腹透患者生存质量的趋势KDTA比较平稳,但2年后SF-36呈明显下降趋势.(6)多元回归分析提示,对KDTA和SF-36总体生存质量的影响因素分别为透析方式、年龄、性别和透析时间.结论 (1)广东省南部,而主要是广州市的血透和腹透患者生存质量状况的总体水平仍低于西方国家和香港特别行政区.(2)慢性肾衰竭患者一体化治疗的前2年可首选腹透.(3)血透和腹透患者的KDTA和SF-36生存质量的趋势不同,腹透不仅适合老年患者,更适合年轻患者和女性患者.(4)透析方式、透析时间、性别和年龄影响透析患者的生存质量,但影响程度和领域各不相同.     

Health-related quality of life in adults after repair of congenital diaphragmatic defects--a questionnaire study

Background and Aim

Long-term respiratory, gastrointestinal, and vertebral sequelae are common after repair of congenital diaphragmatic defects (CDDs). The aim of this study was to assess the effect of these sequelae on the health-related quality of life (HRQoL) of adult survivors after CDD repair.

Materials and Methods

A questionnaire, including 36-Item Health Survey Form (SF-36), 36-item Gastrointestinal Quality of Life Index (GIQLI), 55-item Psychosocial Survey, 9-item survey for Respiratory Symptoms-Related Quality of Life Index, and a symptoms query, was sent to 94 adult survivors of CDD and to 400 healthy control subjects. One SD lower than the age-adjusted national average in the 36-Item Health Survey Form score for physical or mental health was considered as low HRQoL.

Results

Sixty-nine patients with CDD (72%) and 162 (41%) control subjects returned the questionnaire. The initial presentation was critical in less than 10% of patients with CDD. Forty-five patients with diaphragmatic hernia had primary closure; in 1 patient with diaphragmatic hernia, a patch was used. Twenty-four patients had plication of diaphragmatic eventration. The incidence of gastroesophageal reflux (20% vs 2%), recurrent intestinal obstruction (7% vs 0%), and recurrent abdominal pain (12% vs 2%) was significantly higher in patients with CDD than in control subjects, whereas no difference in the incidence of respiratory, musculoskeletal, or other health problems not associated with CDD was found. Scores in GIQLI, Psychosocial Survey, and Respiratory Symptoms-Related Quality of Life Index did not differ between patients with CDD and control subjects. Health-related quality of life was low in 17 (25%) of 69 patients with CDD, which exceeded 1.5 times the expected value. There was no correlation between the type or severity of the primary defect and HRQoL at the time of the study.

Conclusion

Most adults with repaired CDD have good or satisfactory HRQoL. Congenital diaphragmatic defect-associated symptoms with or without acquired diseases significantly impair HRQoL in one fourth of the patients.     

Health-related quality of life after hip replacement

Abstract Total hip replacement is widely known to be effective in the management of pain and functional status. Instead, less is known regarding patients perspective through the measurement of health-related quality of life. A retrospective study was conducted to evaluate patient-relevant outcomes in a homogeneous sample of patients who underwent total hip replacement. Long-term results were evaluated through a self-administered questionnaire and clinical examination. We were able to re-contact 84.8% of patients at the follow-up, at an average of 7.35 years. The results confirm the value of the treatment of hip arthritis, demonstrating the impact of hip replacement on physical function and pain and consequently on the improvement of quality of life.     

Correlation between quality of life and mineral metabolism in maintenance hemodialysis patients

Objective With multi-center investigation, to assess the life quality of patients with maintained hemodialysis (MHD) in Liaoning Province and to explore the relationship among the mineral metabolism, the life quality of the patients with MHD, and the repeated hospitalization within the latest three years. Methods 1192 patients with hemodialysis (at least 3 months) from January to March in 2015 at ten blood purification centers in Liaoning Province were selected for the cross - sectional survey. The Kidney Health-related Quality of Life (HRQOL) version 1.3 was used to evaluate the MHD patients' life quality. The total length of hospitalization was divided into four groups: 0 days, 3 to 15 days, 16 to 30 days and above 30 days. Results When serum calcium value ranged from 2.1 to 2.5 mmol/L, kidney - disease component summary (KDCS), mental component summary (MCS), physical component summary (PCS) and SF-36+KDCS corresponded to a higher value (P＜0.05). When serum phosphorus value ranged from 1.13 to 1.78 mmol/L, KDCS and SF-36+KDCS corresponded to a higher value (P＜0.05). When the calcium phosphorus product value ranged from 40.68 to 49.94, MCS corresponded to a higher value (P＜0.05). KDCS showed a linear correlation with age (P＜0.001), dialysis age, serum calcium (less than or equal to 2.5 mmol/L) (P＜0.05); PCS showed a linear correlation with age (P＜0.001) and dialysis age (P＜0.05); SF-36+KDCS showed a linear correlation with age (P＜0.001), and serum calcium (less than or equal to 2.5 mmol/L) (P＜0.05), while age and dialysis age were negatively correlated. The hospitalization days showed a linear correlation with age, dialysis age (P＜0.001) and serum phosphorus, calcium phosphorus product value (P＜0.05), while dialysis age and calcium phosphorus product value were negatively correlated. Among different groups of total hospitalization days in three years, age, hemodialysis age, serum calcium, serum phosphorus, calcium-phosphorus product value and quality of life values were all statistically significant (P＜0.05). Conclusions The life quality of patients with MHD were correlated with serum calcium, phosphorus, calcium and phosphorus product value, iPTH, dialysis age and age, while age and dialysis age were of negative correlation. The total number of hospitalization days in 3 years was closely linearly correlated with age and dialysis age, significantly correlated with serum phosphorus, calcium and phosphorus product value, while dialysis age, calcium and phosphorus product value were in a negative correlation. The total number of hospitalization in 3 years was correlated with the patients' age, dialysis age, serum calcium, serum phosphorus, calcium and phosphorus product value and quality of life.     

贵阳市维持性血液透析患者生活质量调查

目的了解贵阳市终末期。肾脏疾病（end stage renal disease,ESIm）接受维持性血液透析患者的一般状况、病因构成和生活质量现状。方法收集贵阳市12个血液透析中心ESRD血液透析患者756例患者的一般资料、透析方法、肾脏病和生活质量问卷（KDQOL-SF36量表）等信息并进行分布特征描述。结果756例患者中,男女之比为1．45：1．00;平均年龄（49．1±14．7）岁,原发病前三位分别为慢性肾小球肾炎407例（占53．84％）、糖尿病肾脏病132例（占17．46％）、高血压。肾损害124例（占16．40％）;患者月均总医疗费用为（6072．55±3381．01）元;不同透析时间的血液透析患者’肾脏病和透析相关生活质量各维度得分具有显著差异（P〈0．05）。结论贵阳市维持血液透析患者中,其原发病以慢性肾小球肾炎为主;透析时间〉60个月的血液透析患者生活质量、一般健康相关生活质量各维度得分较低。     

Distress from lower urinary tract symptoms and its effect on the quality of life in Swedish men

BackgroundLower urinary tract symptoms (LUTS) are common in men and while symptoms have been described as being associated with distress, less attention has been paid to Quality of Life (QoL). The aim of this study was to describe how distress from LUTS affects QoL in men.MethodsThe study included 1008, 40–80 year-old, men living in a municipality in Sweden. Participants completed the SF-36 Health Survey and the Danish Prostatic Symptom Score (DAN-PSS). The SF-36 questionnaire measures health status in eight general areas and the DAN-PSS questionnaire measures severity, frequency and distress resulting from LUTS.ResultsIn all, 63% of the men reported that they experienced some degree of distress related to LUTS. The mean SF-36 scores were significantly lower in all the dimensions evaluated among men who experienced low distress from nocturia, daytime frequency, straining and post micturition dribbling than among men without distress from these symptoms. Furthermore, men with low distress from weak stream reported lower SF-36 scores for all evaluated dimensions except for physical functioning (PF) than men without distress from weak stream. Men with moderate/major distress from incomplete emptying had a decreased QoL compared to men with low distress from incomplete emptying.ConclusionsDistress from lower urinary tract symptoms reduced QoL in men. Even when low distress is experienced, QoL is reduced. Identification of the distress impact on QoL is warranted to restore QoL, but also to identify optimal treatment.     

The effect of self-care education through teach back method on the quality of life in hemodialysis patients

BackgroundSelf-care education can play an important role in improving the quality of life in hemodialysis patients.PurposeThe purpose of this study was to determine the effect of self-care education with teach back method on the quality of life in hemodialysis patients.MethodsIn this pre- and post-test clinical trial, 45 patients with end-stage renal disease undergoing hemodialysis at Sina hospital in Tehran were included. Patient education was done with teach back method. The duration of training were 3 sessions and the time of each session lasted from 45 minutes to one hour. To collect data from patients, a demographic questionnaire was used and to assess the quality of life of patients, kidney disease quality of life-short form before and after education was used. A significant level of 5% was determined.ResultsThe mean age of patients was 58.49 ± 9.97 years. Among the dimensions of quality of life before education, the highest score was for physical role (64.24 ± 7.68) and the lowest was related to job status (28.33 ± 11.06). After training, the most score was related to emotional role (71.15 ± 2.84) and the least was related to job status (43.87 ± 11.54). A significant difference between the quality of life at before and after education was seen (P = 0.000).ConclusionThis study showed that self-care education through teach back method improves the quality of life in hemodialysis patients. Therefore, it is recommended that nurses in the hemodialysis unit implement self-care education through teach back method as an important task.     

维持性血液透析患者营养状况的评价与分析

对43例维持性血液透析患者的营养状况进行评估与影响因素分析。方法 采用膳食分析、人体学测量和生化免疫测定,并对可能影响营养状况的常见因素进行分析。结果 血液透析患者的能量摄入,一些主要的人体学指标,生化和免疫指标均显著低于对照组。蛋白质和能量摄入、酸中毒及红细胞生成素对营养指标有影响。结论 血液透析患者中存在着营养不良,纠正有关的影响因素有助于改善患者的营养状况。     

心理干预对维持性血液透析患者精神状况和生活质量的影响

目的探讨维持性血液透析（MHD）患者精神状况与生活质量的相关性,并进行针对性的心理干预,旨在改善其患者的精神状况及生活质量。方法将具有完整生活质量评定资料的180例男性MHD患者随机分为精神症状组（A组）104例和非精神症状组（B组）76例。采用健康相关生活质量量表（SF-36）评估180例MHD患者生活质量;分别用Beck抑郁问卷（BDI）并制成量表、汉密尔顿焦虑量表（HAMA）评估患者抑郁、焦虑症状,比较2组间生活质量的差异。结果MHD患者抑郁、焦虑症状的发生率分别为18．89％（34／180）和38．89％（70／180）。精神症状评分与生活质量8项指标中7项呈负相关,A组的生活质量明显低于B组患者（P〈0．05）。心理干预治疗后,心理干预组（A1组）的生活质量明显高于非心理干预组（A2组）（P〈0．05）。结论血液透析患者精神症状发生率较高,与患者生活质量密切相关。针对性的心理干预治疗可明显改善MHD患者的精神症状,提高其患者的生活质量。     

Assessment of frailty and its influence factors in maintenance hemodialysis patients

Objective To investigate the frailty in maintenance hemodialysis (MHD) patients and its influence factors. Methods A total of 127 adults undergoing hemodialysis from January 2015 and January 2016 in our center were recruited. Their clinical data and blood biochemical data were collected. Frailty was assessed using Fried's Frailty Phenotype. Quantification of coronary artery calcification (CACs) was determined by multi-slice spiral computed tomography (MSCT). According to the frailty scores, patients were divided into non-frailty, pro-frailty and frailty group. Their in clinical and biochemical index as well as CACs were compared. The correlations of frailty scores with above index were assessed by Spearman's correlation. Multiple logistic regression analysis was applied to evaluate the effect factors of frailty on MHD patients. Results Among 127 selected patients, 46(36.22%) patients without frailty, 45(35.43%) patients with pro-frailty, and 36(28.35%) patients with frailty. The age, diabetes, haemoglobin, albumin, pre-albumin, C-reactive protein, fibroblast growth factor 23 (FGF23), CACs and left ventricular end-diastolic dimension (LVEDD) of the 3 groups had statistical differences (all P＜0.05). The degrees of calcification among 3 groups were also different statistically (F=31.769, P＜0.001). In patients with MHD, frailty was positively correlated with age (r=0.545, P＜0.001), diabetes (r=0.236, P=0.008), C-reactive protein (r=0.245, P=0.006), FGF23 (r=0.189, P=0.034) and CACs (r=0.396, P＜0.001), while negatively correlated with haemoglobin (r=-0.257, P=0.004), albumin (r=-0.380, P＜0.001), pre-albumin (r=-0.313, P＜0.001). Age (OR=1.076), C-reactive protein (OR=1.176), albumin (OR=0.796) and artery calcification (OR=2.465) were independent influence factors for frailty in MHD patients (all P＜0.05). Conclusions The prevalence of frailty is high among MHD patients. Frailty is associated with age, C-reactive protein, albumin and artery calcification in MHD patients.