高血压合并左室肥厚患者晚期糖基化产物与血管紧张素Ⅱ的相关性研究

目的探讨血清晚期糖基化产物（AGEs）与血浆血管紧张素Ⅱ（AngⅡ）在原发性高血压（EH）合并左心室肥厚（LVH）患者中的水平及二者的相关性。方法分别用双抗体夹心酶联免疫吸附试验（ELISA）及放射免疫法（RIA）测定50例健康者（对照组）,85例高血压患者的血清AGEs及血浆AngⅡ含量。根据LVMI把高血压患者分为52例EH患者（EHN-LVH组）和33例EH合并LVH患者（EHLVH组）。结果与对照组比较,EH组AngⅡ、AGEs含量均增高,EHNLVH组P〈0.05,EH-LVH组P〈0.01;相关性分析显示EH患者AGEs与AngⅡ呈正相关;LVMI值与AGEs、AngⅡ呈正相关。结论AGEs和AngⅡ与EH及EH-LVH的发生发展有关,且二者存在相互作用。     

血清血小板源性生长因子在脑出血患者中的临床意义

目的探讨血清血小板源性生长因子在脑出血患者中的临床意义。方法选取在我院收治的脑出血患者88例为治疗组,另选取同期健康体检的40例健康者为对照组,对比分析2组血清PDGF及与NIHSS评分的相关性。结果治疗组脑出血后第2天、第8天血清PDGF含量、血小板PDGF的表达水平均明显高于对照组,差异有统计学意义(t=20.156、12.896、13.024、13.138,P0.05);治疗组脑出血后第8天血清PDGF含量、血小板PDGF的表达水平均明显低于第2天,第12天明显低于第2天及第8天,差异均有统计学意义(P0.05);血清PDGF含量与NIHSS评分呈正相关(r=0.780,P0.001)。结论脑出血患者血清PDGF含量及血小板PDGF表达水平明显增高,可作为脑出血的早期诊断指标,且由血清PDGF水平的高低可判断患者神经功能受损程度。     

原发性高血压患者左室舒张功能与血清瘦素浓度的关系

目的 探讨原发性高血压(EH)患者左室舒张功能与血清瘦素(Leptin)浓度关系的临床研究。方法 采用放免法测定30例正常人和54例EH患者的血清瘦素浓度。用多普勒组织成像(DTI)技术检测正常人及EH患者二尖瓣环舒张早期运动速度(Ea)、舒张晚期运动速度(Aa)及Ea/Aa,比较其测定值与血清瘦素浓度的相关性。结果 患者组二尖瓣环DTI参数明显低于正常对照组(P<0.01);患者组血清瘦素浓度与Ea、Ea/Aa呈负相关(r=-0.41 P<0.01,r=-0.43 P<0.01)。结论 检测血清瘦素浓度有利于EH患者左室舒张功能受损程度的判断。     

血清TGF-β1和VEGF与脑梗死患者颈动脉粥样斑块易损性的相关性

目的探讨血管内皮细胞生长因子(VEGF)和转化生长因子-β1(TGF-β1)与脑梗死患者颈动脉粥样硬化斑块易损性的关系。方法收集96例急性期动脉粥样硬化性脑梗死患者和30名健康对照者。采取酶联免疫法检测血清VEGF和TGF-β1水平;采用彩色多普勒超声对脑梗死患者的颈动脉粥样硬化情况进行评估,并将脑梗死患者分为伴易损性颈动脉斑块组、伴稳定性颈动脉斑块组和无颈动脉粥样硬化组,分析血清VEGF和TGF-β1水平与脑梗死患者颈动脉粥样硬化易损斑块的相关性。结果脑梗死患者血清VEGF水平明显高于对照组,而TGF-β1水平明显低于对照组(P0.01);伴易损性颈动脉斑块的脑梗死患者血清VEGF水平明显高于伴稳定性颈动脉斑块的脑梗死患者(P0.01),而TGF-β1水平明显低于伴稳定性颈动脉斑块的脑梗死患者(P0.01);VEGF水平与颈动脉斑块易损性呈正相关(r=0.493,P0.01),而TGF-β1水平与颈动脉斑块易损性呈负相关(r=-0.524,P0.01)。结论 VEGF和TGF-β1在脑梗死的发病和脑缺血损伤中可能起重要的作用,TGF-β1高表达和脑梗死患者颈动脉粥样硬化斑块稳定性之间存在密切联系,TGF-β1具有稳定颈动脉粥样硬化斑块的作用。     

血清BDNF、TGF-β1与卒中后肢体痉挛患者预后的关系

目的 探讨血清脑源性神经营养因子(BDNF)、转化生长因子-β1 (TGF-β1)与卒中后肢体痉挛患者预后的关系.方法 选取2017年1月至2020年12月海南省干部疗养院就诊的104例卒中后肢体痉挛患者为观察组,50例卒中未发生肢体痉挛患者为对照组.检测两组血清BDNF、TGF-β1水平,分析血清BDNF、TGF-β...     

急性脑出血患者血清IL-6和TGF-β1含量变化及临床意义

目的探讨白介素-6(IL-6)和转化生长因子β1(TGF-β1)在脑出血的发病过程中所起的作用、临床意义及二者的关系.方法采用双抗体夹心ELISA法对30例急性脑出血患者在起病后第1、3、7、14天连续检测IL-6、TGF-β1浓度.结果脑出血组在病程第1、3、7天三个时间点的血清IL-6水平明显增高(P＜0.05), TGF-β1水平明显减低(P＜0.05), 至第14天血清IL-6水平、TGF-β1水平则均接近正常水平; 血清IL-6水平在病程第1天达到峰值(P＜0.05), TGF-β1在病程第3天为低谷值(P＜0.05); 脑出血患者血清IL-6水平与出血量大小呈正相关(r=0.743, P＜0.05), 而TGF-β1水平与出血量大小无关(r=0.125, P＞0.05); 神经功能缺损程度与血清IL-6水平呈正相关(r=0.625, P＜0.05), 而与TGF-β1水平无关(r=0.204, P＞0.05); IL-6水平与TGF-β1水平无明显相关性(r=0.289, P＞0.05).结论 IL-6、TGF-β1与脑出血的病理生理过程密切相关.IL-6浓度测定对判断脑出血的病情严重程度具有一定的意义.     

老年原发性高血压患者血清肾素与交感神经活性的相关性

目的研究老年原发性高血压患者血清肾素与交感神经活性之间的相关性。方法选取我院50例老年原发性高血压患者(观察组)与50例血压正常的健康体检者(对照组),分别检测2组血清肾素、肾上腺素、去甲肾上腺素、肾素、醛固酮、血管紧张素水平,分析老年原发性高血压患者的血清肾素与交感神经活性之间的关系。结果观察组血清肾素、肾上腺素及去甲肾上腺素水平与对照组相比,差异有统计学意义(P0.05)。老年原发性高血压患者的血清肾素与肾上腺素、去甲肾上腺素水平呈正相关关系。结论老年原发性高血压中血清肾素通过交感神经活性对其造成影响。     

抑郁症和双相障碍患者血清血小板衍生生长因子表达水平

目的:探讨血清血小板衍生生长因子(PDGF)表达水平与抑郁症和双相障碍临床症状间的关系。方法:通过Elisa法测定抑郁症患者(抑郁组,n=57)、双相障碍患者(双相组,n=31)和健康人(对照组,n=30)血清PDGF水平。使用汉密尔顿抑郁量表(HAMD)、蒙哥马利-阿斯伯格抑郁量表(MADRS)、杨氏躁狂评定量表(YMRS)和汉密尔顿焦虑量表(HAMA)对患者进行临床症状评估。各组血清PDGF水平与各量表评分进行相关性分析。结果:(1)抑郁组和双相组血清PDGF水平与HAMD评分和MADRS评分呈正相关(P0.01);两组YMRS评分与血清PDGF水平无相关;HAMA评分与双相组血清PDGF水平呈正相关(P0.05)。(2)抑郁组、双相组血清PDGF水平与对照组差异有统计学意义(P均0.01),抑郁组和双相组之间血清PDGF水平差异有统计学意义(P0.05)。结论:抑郁症和双相障碍患者血清PDGF水平显著低于正常水平,并与临床症状严重程度有关,这可能与PDGF对神经的保护机制有关。     

重症肌无力患者血清TGF-β1和sICAM-1的检测及其临床意义

目的探讨转化生长因子-β1(TGF-β1)及可溶性细胞间粘附分子(sICAM-1)在重症肌无力(MG)发病中的作用及其临床意义.方法采用酶联免疫吸附ELISA方法,测定了32例MG患者及30名正常对照组(NC)血清TGF-β1和sICAM-1的水平.结果与NC组相比,MG患者血清TGF-β1明显降低(P＜0.01),而sICAM-1水平则明显升高(P＜0.01).与轻型组比较,重型组TGF-β1水平明显降低(P＜0.01),而sICAM-1水平则明显升高(P＜0.01).动态观察显示,治疗后随着病情的好转,TGF-β1水平逐渐升高,而sIMCA-1水平则逐渐下降.结论TGF-β1和sICMA-1可能参与了MG的发病机制,且与病情的轻重有密切关系.     

原发性高血压患者血压水平与血清瘦素及脂联素水平的相关性

目的 探讨原发性高血压患者血压水平与血清瘦素及脂联素水平的相关性.方法 分别应用放射免疫分析和ELISA对94例初诊原发性高血压患者(其中34例为原发性高血压1级,29例原发性高血压2级,31例原发性高血压3级)进行血清瘦素和脂联素测定,并与35名正常健康人作比较.结果 原发性高血压组血清瘦素水平均高于正常人组(P＜0.05),而血清脂联素水平则明显低于正常人组(P＜0.05).Pearson直线相关分析表明,各组血清中瘦素浓度与其血压水平均呈正相关:正常人组r=0.658, P＜0.05;原发性高血压1级组r=0.684, P＜0.05;原发性高血压2级组r=0.729, P＜0.05;原发性高血压3级组r=0.663, P＜0.05.脂联素浓度与血压水平均呈负相关:正常人组r=-0.598, P＜0.05;原发性高血压1级组r=-0.671, P＜0.05; 原发性高血压2级组r=-0.753, P＜0.05; 原发性高血压3级组r=-0.776, P＜0.05.结论 原发性高血压的发生与血清瘦素水平和血清脂联素水平有密切关系.     

Physical and Sexual Abuse and Neglect and Eating Disorder Symptoms

For eating-disordered patients with a history of post-traumatic stress, childhood abuse and neglect, and dissociative disorder, eating behavior symptoms may function as a rational response to unmetabolized traumatic experiences. This paper will review trauma-based theory, dissociation, abreactive, and ego-states therapy as they apply to eating disorder patients.     

Efficacy and Effectiveness of Child and Adolescent Psychotherapy and Pharmacotherapy

Decades of intervention research have produced a rich body of evidence on the effects of psychotherapies and pharmacotherapies with children and adolescents. Here we summarize and critique that evidence. We review findings bearing on the efficacy of psychosocial treatments and medications under controlled experimental conditions. We also report evidence, where available, on the effectiveness of both classes of treatment with clinically referred youth treated in real-world clinical contexts. In general, the large body of evidence on efficacy contrasts sharply with the small base of evidence on effectiveness. Addressing this gap through an enriched research agenda could contribute importantly to linking scientific inquiry and clinical practice—to the benefit of both ventures. This is one element of a multifaceted agenda for future research and for synthesis of research, which will require the interplay of multiple disciplines related to child and adolescent mental health.     

Presence and severity of anorexia and bulimia among male and female Omani and non-Omani adolescents

OBJECTIVE: The population of Oman is a heterogeneous mix of nationalities providing a natural setting for studying the cross-cultural differences in the presence and severity of eating disorders as well as an opportunity for evaluating the performance of measurement instruments for these disorders. METHOD: Disordered eating screening instruments (the Eating Attitude Test and the Bulimic Investigatory Test) were administered to Omani teenagers, non-Omani teenagers, and Omani adults. RESULTS: On the Eating Attitude Test, 33% of Omani teenagers (29.4% females and 36.4% males) and 9% of non-Omani teenagers (7.5% of males and 10.6% females) showed a propensity for anorexic-like behavior. On the Bulimic Investigatory Test, 12.3% of Omani teenagers showed a propensity for binge eating or bulimia (13.7% females and 10.9% males). Among the non-Omani teenagers, 18.4% showed a tendency toward bulimia, with females showing a slightly greater tendency than males. In contrast, barely 2% of Omani adults showed either a presence of or a severity of disorderly behavior with food. CONCLUSION: Omani teenagers scored significantly higher than other ethnic groups and Omani adults. This finding is discussed in the light of emerging evidence from many parts of the world suggesting that cultural transition, compounded by demographic constraints, plays a significant role in abnormal eating attitudes.     

Physical and Sexual Abuse and Neglect and Eating Disorder Symptoms

Abstract

For eating-disordered patients with a history of post-traumatic stress, childhood abuse and neglect, and dissociative disorder, eating behavior symptoms may function as a rational response to unmetabolized traumatic experiences. This paper will review trauma-based theory, dissociation, abreactive, and ego-states therapy as they apply to eating disorder patients.     

Micro-affirmations and Recovery for Persons with Mental Health and Alcohol and Drug Problems: User and Professional Experience-Based Practice and Knowledge

Recurrent factors contributing to a recovery process from co-occurring mental health and addiction problems mentioned by users and professionals have been analyzed as part of working alliances and helpful relationships. Still, we lack knowledge about how helpful relationships are developed in daily practice. In this article, we focus on the concrete construction of professional helpful relationships. Forty persons in recovery and fifteen professionals were interviewed. The interviews were analyzed according to thematic analysis, resulting in three themes presented as paradoxes (1) My own decision, but with the help of others; (2) The need for structures and going beyond them; and (3) Small trivial things of great importance. Micro-affirmations have a central role in creating helpful relationships by confirming the individuals involved as more than solely users or professionals. More attention and appreciation should be paid to practices involving micro-affirmations.

     

Opiate and digitalis receptor assays distinguish between neuroexcitant and inactive organochlorines and between anesthetics and convulsants

Specific binding of [3H]naloxone to rat brain tissue in vitro was inhibited by the excitant organochlorinated insecticides (OCI), by ether (E) and octanol (OCT), and by the convulsant indoklon (IND) and its anesthetic isomer, isoindoklon (ISO). In the presence of 100 mM NaCl the inhibition of naloxone binding by E, OCT and ISO was greatly potentiated, whereas that by OCI and IND was attenuated. KCl (100 mM) was equally effective as NaCl on the action of anesthetics, but the effect of the excitant drugs was, in contrast to NaCl, unaffected by KCl. Specific binding of [3H]ouabain in the absence of Na, was depressed by anesthetics and enhanced by neuroexcitants. In the presence of NaCl, which by itself inhibits ouabain binding to brain, both anesthetics and excitants enhanced ouabain binding. DDE, a non-insecticidal analog of DDT, and the dimethyl derivative of the OCI, lindane, were inactive in the receptor assays. These observations point to a unique isolated system which responds consistently to anesthetic agents as a class and, in a different way, to neuroexcitant compounds.