裴氏着色霉致着色芽生菌病一例

患者,男,62岁.左下肢红斑结节10年余,逐渐加重1年.皮肤组织病理示真皮内可见散在棕色孢子样结构.PAS染色示真皮内见圆形、厚壁硬壳小体.真菌培养示着色霉属;菌落基因测序鉴定为裴氏着色霉.     

裴氏着色霉所致皮肤着色芽生菌病1例

报道1例前臂着色芽生菌病。患者女，46岁。左前臂斑块结节10余年，抗感染治疗无效，皮肤组织病理和真菌培养均符合着色芽生菌病。     

裴氏着色芽生菌病1例

患者女，40岁，10年前无明显诱因，左踝部出现米粒大红色结节，渐增大，增多，自学轻微痛痒，部分皮损表面破溃，有分泌物及黄色痂皮。曾外用糖皮质激素，抗真菌药及口服抗结核药物治疗，均无效。于2003年12月11日来我院就诊，体格检查：一般情况可，左侧小腿远端近踝部可见绿豆至黄豆大结节及斑块，结节质地硬，表面结灰黄色痂皮，挤压后可见脓性分泌物渗出，部分皮损融合。     

裴氏着色真菌致着色芽生菌病1例

患者男,70岁。左上肢斑块、瘢痕30余年,伴肘关节功能阻碍3年。左上肢泛发暗红色斑块,疤痕、结痂,伴肘关节活动障碍。真菌镜检见成堆硬壳小体和棕色分枝分隔菌丝、经真菌培养鉴定为裴氏着色真菌,组织病理PAS染色见棕红色分隔的硬壳小体。诊断:裴氏着色真菌所致着色芽生菌病。     

疣状瓶霉所致着色芽生菌病一例

患者,男,60岁。右手腕红斑结痂,缓慢扩展16年。皮肤科检查:右手腕4 cm×6 cm环形暗红斑,皮疹边界清晰,覆有渗出性痂。真菌镜检见棕黄色圆形厚壁孢子。25℃沙氏葡萄糖琼脂培养基培养形成黑绿色绒毛状菌落,镜下见具领状结构的瓶形产孢细胞和花朵样排列的小分生孢子。PAS染色见厚壁孢子。诊断:疣状瓶霉引起的皮肤着色芽生菌病。治疗:给予伊曲康唑胶囊口服及盐酸特比萘芬乳膏外用,同时45~50℃热敷后治愈。     

疣状瓶霉所致皮肤着色芽生菌病1例

QIANLijie,LILi,ZHANGQiangqiang[摘要]患者男,78岁。右手臂相继出现结节、破溃7年,右手腕部环绕1周带状红斑,浅表性溃疡伴鲜红色肉芽面,呈颗粒状,中央有黑点,边缘不清,覆有渗出性痂皮,约5cm×20cm;真菌镜检发现棕色黄色圆形厚壁孢子;小钢圈培养镜下显示全为瓶梗,分生孢子壁薄形椭圆,瓶口孢子成团聚集犹如花朵;组织病理示棘层增厚,真皮全层为不规则相互融合的多细胞肉芽肿。     

面部裴氏着色芽生菌病

报告1例裴氏着色芽生菌所致的面部着色芽生菌病.患者男,54岁.面部反复浸润性斑块1年,表面覆有鳞屑及黑色痂皮.皮损组织病理检查见淡褐色厚壁孢子.痂皮直接镜检见圆形厚壁暗棕色孢子及棕色分隔菌丝.真菌培养出黑色菌落,小培养见喙枝孢型及瓶型分生孢子梗,鉴定为裴氏着色芽生菌.口服伊曲康唑,疗效良好.     

紧密着色霉菌所致着色芽生菌病一例

患者男, 43岁,保管员。就诊前 3年工作时,左侧颈部皮肤不慎被铁屑刺伤如米粒大小,半年后局部出现黄豆大小的结节,暗红色,自认为是瘢痕。此后皮损缓慢发展扩大。 3年中先后在几家医院就诊,诊断为湿疹、神经性皮炎,给予相应的治疗无效。皮损也多次取鳞屑 10％ KOH涂片直接镜检,查见菌丝,改用多种抗真菌药外用治疗,见效甚微。 1999年 4月来本院门诊。当时所见局部有界限清楚的红色斑块,边缘隆起呈盘状,伴有毛孔扩张,中央有粘着性鳞屑而怀疑盘状红斑狼疮,遂予以活组织病理检查。 图 1患者临床皮损 图 2紧密着色霉菌的形态特点 …     

着色芽生菌病研究进展

着色芽生菌病是一种难治的真菌感染疾病。本文对该病的命名，病原学，流行病学，组织病理学和免疫学作了综合分析，对命名的统一，真菌学分类及鉴定标准和诊断作了全面讨论。有益于消除对此病认识上的一些混乱。     

着色芽生菌病一例

患者男,46岁,某宾馆垃圾清运员.因右膝关节下方皮损1年余,进行性增大于2008年2月17日来我科就诊.1年前右膝关节下方内侧区不明原因出现一元钱硬币大小斑块,上覆黄色厚痂,无自觉症状,自行用刀片削除.     

裴氏着色真菌病1例报告

目的：患69岁，男性，右足背及跟部增殖损害12年，皮损逐渐增生，扩大呈疣状增生，经多方治疗无明显疗效，实验室检查证实为裴氏着色真菌感染，经特比奈芬治疗后症状逐渐消退，治疗反应良好。     

Chromoblastomycosis Caused by Fonsecaea pedrosoi

We report herein a case of chromoblastomycosis caused by Fonsecaea (F.) pedrosoi in a 39-year-old male, who showed multiple, asymptomatic, scaly erythematous plaques on the left shin for 12 months. Histopathologically, chronic granulomatous inflammation and either sclerotic or muriform cells were observed. The fungal culture produced typical black colonies of F. pedrosoi. The DNA sequence of the internal transcribed spacer (ITS) region of the clinical sample was 100% match to that of F. pedrosoi IFM 47061 (GenBank accession number {"type":"entrez-nucleotide","attrs":{"text":"AB240943","term_id":"81295273","term_text":"AB240943"}}AB240943). The patient was treated with 200 mg of itraconazole daily, for 3 months. Skin lesions were improved. In Korea, only 9 cases of chromoblastomycosis, including this case, have been reported until now. The etiologic agent was F. pedrosoi in the majority of cases (6/9;67%). The incidence of chromoblastomycosis was slightly higher in female, and the upper limbs were more affected than the lower limbs in patients.     

裴氏着色真菌致病性的动物实验研究

目的　构建着色真菌病动物模型并探讨裴氏着色真菌的致病性。方法　对免疫正常和免疫抑制小鼠腹腔接种裴氏着色真菌 ,第 15 ,3 0 ,60天时处死进行肉眼观察、病理及真菌检查。结果　两组小鼠腹腔内脏及系膜有多发性黑色结节 ,病理检查可见坏死、脓肿、肉芽肿、棕色菌丝及硬壳细胞 ;真菌检查见裴氏着色真菌 ,两组小鼠均 10 0 %发生感染 ;15天时免疫正常组较免疫抑制组损害程度重。结论　裴氏着色真菌小鼠腹腔接种成功建立着色真菌病模型 ;本模型可作为着色真菌病实验研究手段     

Successful treatment of chromoblastomycosis caused by Fonsecaea pedrosoi using imiquimod

Chromoblastomycosis (CBM) is a fungal infection caused by fungi belonging to the order Chaetothyriales, and caused mainly by Fonsecaea pedrosoi. The classic treatment, based on itraconazole and/or terbinafine as well as physical approaches, is considered complex and ineffective due to the high rate of relapses. Thus, new strategies are needed to manage CBM; in this regard, the present work reports the evolution of lesions in patients successfully treated with imiquimod. Of note, classic treatment was not effective in healing the lesions of two of them, but single topical treatment with imiquimod healed the lesions.     

Chromoblastomycosis Caused by Phialophora richardsiae

Chromoblastomycosis is a chronic fungal disease of the skin and subcutaneous tissues caused by a group of dematiaceous (black) fungi. The most common etiologic agents are Fonsecaea pedrosoi and Cladophialophora carrionii, both of which can be isolated from plant debris. The infection usually follows traumatic inoculation by a penetrating thorn or splinter wound. Several months after the injury, painless papules or nodules appear on the affected area; these papules then progress to scaly and verrucose plaques. We report a case of chromoblastomycosis caused by Phialophora richardsiae, which has been rarely associated with chromoblastomycosis. The case involved a 43-year-old male, who for the past 2 months had noted an erythematous, pustulous plaque that was somewhat dark brown in color on his right shin; the plaque also had intermittent purulent discharge and crust formation. On histopathological examination, chronic granulomatous inflammation and sclerotic cells were seen. The tissue fungus culture grew out the typical black fungi of P. richardsiae, which was confirmed by polymerase chain reaction. The patient has been treated with a combination of terbinafine and itraconazole for 3 months with a good clinical response.     

疣状瓶霉致皮肤着色真菌病一例及致病菌的辅酶Q和DNA序列测定

目的报告1例疣状瓶霉致皮肤着色真菌病,并探讨其致病菌的实验室特征。方法皮损组织病理学检查、真菌学检查,分离株辅酶Q检测、DNA序列鉴定。结果该病表现为慢性疣状增殖性斑块,病程长,外伤后易发病。真皮层可见棕色厚壁孢子。菌落生长缓慢,需观察4周。小培养沙氏琼脂培养基无特殊结构,马铃薯葡萄糖琼脂见瓶梗多生长于短侧枝或气生菌丝顶端,玉米粉琼脂Ⅰ见瓶梗多侧生于菌丝,后两者其他结构相同。辅酶Q系统检测及LSUrDNA D1/D2区域碱基序列测定,与标准菌株比较完全相同。结论我国该病较少见,确诊需作真菌培养及组织病理,应同时采用沙氏琼脂培养基、马铃薯葡萄糖琼脂、玉米粉琼脂Ⅰ3种培养基培养。辅酶Q检测及分子生物学鉴定可排除表型不同的干扰,有利于进一步鉴定菌种。