正常耳与聋耳电诱发听性脑干反应实验动物的研究

目的 通过耳蜗外电刺激探讨正常听力与致聋家猫耳蜗EABR检测效果的差异性.方法 选取听力正常家猫,行蜗外EABR检测,刺激电极置于圆窗龛6点和12点方向,分别记录EABR;联合应用卡那霉素和利尿酸钠制备重度耳聋实验动物模型,行蜗外圆窗龛6点方向的EABR检测,比较不同耳蜗外位点及致聋前后EABR的差异.结果 圆窗龛6点方向时EABR阈值为529+27μA,Ⅲ波及Ⅳ波潜伏期为2.16+0.12ms,2.91+0.14ms,12点方向时阈值为545+44μA,Ⅲ波及Ⅳ波潜伏期为2.18±0.13ms,2.93±0.10ms,两者无统计学差异(P＞0.05);致聋前EABR阈值为525+23μA,Ⅲ波及Ⅳ波潜伏期为2.16±0.11ms,2.89±0.14ms,致聋后EABR阈值为558+37μA,Ⅲ波及Ⅳ波潜伏期为2.17±0.09ms,2.91±0.12ms,致聋前后阈值及波潜伏期相比均无统计学差异.结论 刺激电极位点位于圆窗龛6点和12点方向时,EABR阈值及Ⅲ、Ⅳ波潜伏期无统计学差异,但6点方向时波形更容易引出;聋耳EABR波形形态与正常耳EABR形态相似,致聋前与致聋后EABR阈值、Ⅲ波及Ⅳ波潜伏期相比均无统计学差异.     

豚鼠圆窗EABR、EMLR与ELLR特征分析

目的探讨豚鼠圆窗EABR、EMLR与ELLR特征,并分析相关刺激和记录参数。方法选取健康豚鼠6只(12耳),10%水合氯醛麻醉后开放听泡,刺激电极正极置于圆窗龛,刺激电极负极置于同侧乳突皮下,记录电极置于两外耳道口连线与颅正中线交叉处皮下,参考电极置于对侧乳突皮下,地极置于鼻尖皮下,在电刺激条件下通过体表电极记录EABR、EMLR与ELLR波形。结果豚鼠12耳均记录到分化良好且稳定的以III波为主的EABR波形,阈值为0.27±0.05mA,Ⅲ波潜伏期为1.95±0.29ms;7耳记录到EMLR波形,阈值为0.29±0.03mA,Na波潜伏期为6.40±0.44ms,Pa波潜伏期为13.00±1.80ms,Nb波潜伏期为25.23±4.72ms,Pb波潜伏期为38.05±5.32ms;7耳记录到ELLR波形,阈值为0.34±0.10mA,P1波潜伏期为82.96±17.61ms,N1波潜伏期为142.86±21.81ms,P2波潜伏期为202.71±20.83ms,N2波潜伏期为293.75±21.43ms。结论全麻下豚鼠圆窗EABR、EMLR与ELLR可以稳定地记录到,为EABR、EMLR、ELLR的临床应用奠定基础。     

蜗外电刺激诱发听性脑干反应的实现及电极位置对参数的影响

目的:探索微创圆窗龛电刺激诱发听性脑干反应(EABR)的可行性,并研究相关刺激和记录参数。方法:取10只(20耳)健康清洁级Hartley豚鼠,经鼓膜将刺激电极正极置于圆窗龛,刺激电极负极分别置于外耳道口的不同位置,分3组记录EABR:A组正负极间电场平行于蜗轴体表投影,B组电场垂直于蜗轴指向乳突方向,C组电场垂直于蜗轴指向颧骨方向。应用系列减少伪迹的方法、合适的刺激和记录参数来记录EABR。结果:20耳听力正常健康豚鼠,经圆窗龛电刺激均可记录到分化及重复良好的EABR波形。其中,A组电极位置较B、C组更易引出分化良好且稳定的EABR波形。A、B、C组EABR阈值分别为(0.54±0.11)、(0.62±0.12)、(0.70±0.14)mA。刺激强度为0.8 mA时A、B、C组潜伏期分别为(1.71±0.05)、(1.77±0.03)、(1.86±0.04)ms,3组之间比较差异有统计学意义(P<0.05)。结论:经圆窗龛电刺激可成功记录到EABR波形,当刺激电场平行于蜗轴方向时EABR波形分化良好且稳定,可为临床人工耳蜗植入术前EABR的测试提供参考。     

骨导ABR测试信号经气放射对结果的影响

为了解骨导听性脑干反应(ABR)测试中骨导振荡器测试信号经气放射对结果的影响,本组用Dantec-Evolution诱发电位系统测试了正常听力年青人20名38耳和传导性聋13例21耳的骨导ABR.两组结果比较,在较高刺激强度正常组有较大的刺激伪迹,对Ⅰ波干扰较大.两组反应阈、Ⅰ、Ⅲ和Ⅴ波潜伏期、Ⅰ-Ⅲ和Ⅲ-Ⅴ波间期无显著差异,但Ⅰ-Ⅴ波间期的差异有统计学意义.这是由于正常组骨导振荡器经气放射的刺激伪迹对波Ⅰ的影响使Ⅰ-Ⅴ波间期缩短.本结果提示在用骨导ABR确定反应阈时可不考虑这个影响,但在用于蜗后病变定位诊断时要考虑经气放射的影响问题,     

刺激声强对AP和ABR各波潜伏期的影响

本实验观察了用短声同时记录正常豚鼠的AP和ABR各波潜伏期与刺激声强的关系。结果表明,APN_1、N_2波潜伏期随声强减低而递增的规律与ABR的Ⅰ、Ⅱ波基本相同。但N_3与Ⅲ波之间却有差异。此外,ABR的Ⅰ(N_1)～Ⅳ波间期随声强减低而逐渐缩短,其原因与Ⅱ～Ⅲ波间的波间期缩短有关。ABR的波Ⅲ与AP的N_3波是否同一起源尚需进一步研究。     

电诱发听性脑干反应在人工耳蜗植入中的应用

目的分析人工耳蜗植入患者耳蜗植入前电诱发听性脑干反应（electrical auditory brainstem response,EABR）的测试结果并初步探讨其意义。方法对14例不同病因、不同年龄的人工耳蜗植入患者耳蜗植入前进行测试,采用EMG外置电刺激器连接面神经探针作为刺激电极,采用Neuro Soft公司生产的Neruo Audio听觉诱发电位仪及调试软件进行EABR测试,测量并分析EABR波形,各波潜伏期和波间期,Ⅴ波波幅、阈值。结果EABR的Ⅱ、Ⅲ、Ⅳ、Ⅴ波与声诱发ABR相似,Ⅲ、Ⅴ波的潜伏期较声诱发ABR缩短,但Ⅲ~Ⅴ波间期与声诱发ABR相同。14例耳聋患者均记录到EABR的Ⅲ波/Ⅴ波,引出率为100％。4例极重度感音神经性聋未合并其他异常患者术中2.5、2.0 mA刺激Ⅲ、Ⅴ波典型,潜伏期和波间期均正常,术中神经反应遥测技术（neural response telemetru,NRT）引出,提示其听神经脑干传导通路无异常,预后效果良好。其他部分患者存在潜伏期延长或波形分化不良或刺激阈值较高等表现,提示可能由于不同因素所导致听觉传导通路异常。结论EABR是通过电刺激耳蜗来了解听觉系统对电刺激的生理反应,最接近人工耳蜗的工作状态,可以对患者听力康复的效果提供更准确的预测;特别是对于一些特殊患者,具有评估人工耳蜗植入效果的优势。而对各种特殊类型耳聋的人工耳蜗植入术前检测、术后评估数据仍需深入探索。     

电诱发听性脑干反应的电生理特征及其在人工耳蜗植入中的评估价值

目的:探讨电诱发听性脑干反应(EABR)的电生理特征及对残余听神经数量的评估作用。方法:用Bio-logic Navigator Pro诱发电位仪记录,通过Cochlear Nucleus 24CA植入体给予刺激,对23例人工耳蜗使用者进行术后EABR测试,并与行为学测试及神经反应遥测技术(NRT)结果相比较。结果:23例患儿均记录到EABR的Ⅲ～Ⅴ波,其波形特点及起源与ABR相似。EABR的阈值为(172.61±14.61)CL,阈上20CL时Ⅲ、Ⅴ波的潜伏期分别为(2.93±0.18)ms、(4.80±0.28)ms,较ABR相应缩短1～2ms,而Ⅲ-Ⅴ波间期不变,为(1.86±0.18)ms。EABR阈值与行为学结果、NRT阈值均有相关性,EABR的输入-输出函数曲线斜率与术后电刺激行为学动态范围有相关性(P<0.05)。结论:EABR能够客观反映听觉传导通路的功能状态,为预测残余的听神经数量提供了一定的参考价值。     

大前庭水管综合征患者ABR和人工耳蜗术后EABR反应特征分析北大核心CSCD

目的探讨大前庭水管综合征(LVAS)患者的听性脑干反应(ABR)及人工耳蜗植入术后电诱发听性脑干反应(EABR)的特点,为LVAS患者人工耳蜗植入围手术期的电生理监测反应特征提供参考。方法选择2013年1月至2016年3月在我院行人工耳蜗植入的14例大前庭水管综合征患者。记录人工耳蜗植入前ABR反应阈值及潜伏期,观察声诱发短潜伏期负反应(ASNR)的表现,并统计该波的出现概率。记录患者术后EABR波形、V波阈值及III、V波潜伏期,计算III、V波引出率及EABR分级。比较ABR的V波和EABR的V波的潜伏期差异。比较ABR出现与不出现ASNR组的EABR反应阈值和V波潜伏期差异。结果 14例患者中有5例术前ABR可引出ASNR,9例无ASNR,V波潜伏期6.6～8.15ms。人工耳蜗植入后有13例引出有意义的EABR波形,平均EABR阈值为190.8CL,平均III波潜伏期为1.80ms,平均V波潜伏期为3.59ms,有1例EABR未引出反应。根据Gibson EABR分级标准,ASNR组与无ASNR组EABR波形分化无明显差异。ASNR组EABR阈值177.5CL,无AS-NR组阈值196.7CL,二者有统计学差异。ASNR组V波潜伏期4.71ms,无ASNR组V波潜伏期4.68ms,二者无统计学差异。EABR的V波潜伏期比ABR的V波潜伏期短,二者有统计学差异。结论 LVAS患者的ABR反应中出现ASNR波是其听力学特征性表现之一,但EABR记录不到相应的短潜伏期负反应。EABR的V波潜伏期较ABR短。植入前存在ASNR的大前庭水管综合征患者具有较低的植入后EABR反应阈。     

不同月龄婴儿的ABR正常值分析

目的 获取6月龄内婴儿的听性脑干反应(auditory brainstem response,ABR)正常值范围并分析其特点.方法 2006年5月至2008年5月对听力正常、出生40天～7月龄的60例婴儿进行ABR检测,根据平均年龄分为A(6周龄)、B(3月龄)、C(6月龄)组,每组20例(40耳);对照组为听力正常的成人20例(40耳),平均年龄25.2岁.对各组的ABR结果进行统计分析.结果 各组100 dB nHL ABR的波Ⅰ、Ⅲ、Ⅴ潜伏期的正常值范围分别为:A组:1.49±0.08、4.42±0.16、6.61±0.25 ms;B组:1.47±0.07、4.35±0.20、6.50±0.25 ms;C组:1.45±0.07、4.17±0.15、6.32±0.22 ms;对照组:1.45±0.07、3.79±0.11、5.49±0.20 ms;三组婴儿80 dB nHL ABR的波Ⅰ、Ⅲ、Ⅴ潜伏期的正常值范围分别为:A组:1.63±0.08、4.52±0.17、6.74±0.26 ms;B组:1.64±0.11、4.44±0.20、6.67±0.26 ms;C组:1.60±0.11、4.27±0.16、6.43±0.24 ms.随刺激声强度降低,ABR各波潜伏期延长.各月龄组婴儿的波Ⅲ、Ⅴ潜伏期、Ⅰ-Ⅲ、Ⅰ-Ⅴ波间期均比成人延长,且随婴儿月龄增加逐渐缩短,但6月龄时仍未达到成人水平.各月龄组ABR反应阈差异无统计学意义.结论 不同月龄婴儿的波Ⅰ潜伏期与成人相近;各月龄婴儿的ABR反应阈无明显差异,且与成人相近.     

不同周龄早产儿听性脑干反应的初步研究

目的了解不同周龄早产儿及同龄足月儿听性脑干反应(ABR)的发展变化,探讨早产儿听力损失的早期诊断时机和诊断标准。方法按照周龄的不同将听功能正常的早产儿分成3组(34~37周龄儿为A组,37 1~44周龄儿为B组,50~54周龄儿为C组),3月龄健康足月儿为D组,分别进行ABR测试,比较各组ABR的各波潜伏期和波间期的变化,并进行统计学分析。结果与足月儿相比,早产儿ABR波形较为简单,波间期较长;随着周龄的增加,波Ⅰ引出率逐渐增加,波Ⅰ、Ⅲ、Ⅴ潜伏期和Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期逐渐缩短。70dB nHL短声刺激下,A组与C、D两组比较,B组与C组比较各波潜伏期及波间期的差异有统计学意义;A组与B组的波Ⅲ潜伏期的差异有统计学意义。50~54周龄(相当于足月儿3月龄)的早产儿,与同龄健康足月儿相比,ABR各波潜伏期和波间期均无统计学差异。30dB nHL短声刺激下各组ABR波Ⅴ潜伏期随周龄增加而缩短,其差异有统计学意义。结论①早产儿听力损失的早期诊断,可以在推算周龄为50~54周时进行,诊断标准可参考同龄健康足月儿;②ABR阈值正常,但潜伏期和波间期异常的早产儿要定期随访。     

Hearing threshold assessment in young children with electrocochleograpy (EcochG) and auditory brainstem responses (ABR): Experience at the University Hospital of Ferrara

Objective

Electrophysiological evaluation is a fundamental procedure for the diagnostic assessment of hearing loss during infancy; in these cases, information concerning threshold level and auditory perception is particularly useful to establish a correct hearing rehabilitation program (hearing aids and cochlear implants).Purpose of this study is to underline the role of auditory brainstem responses (ABR) and electrocochleography (EcochG) in the definition of hearing loss in a selected group of children, referred to the Audiology Department of the University Hospital of Ferrara, for a tertiary level audiological assessment.

Methods

A retrospective study of the paediatric patient database at the Audiology Department of the University Hospital of Ferrara has been performed. In a period between January 2000 and December 2007, a total of 272 paediatric cases have been identified (544 ears).An EM 12 Mercury apparatus has been used for the electrophysiological threshold identification (ABR and EcochG). Recordings were carried out under general anaesthesia, in a protected enviroment.

Results

In 19 of the 272 paediatric cases selected—38 ears (7%), the results of threshold evaluation through ABR were uncertain. The Ecochg recording resulted crucial for the final diagnosis in terms of definition of the hearing threshold level, and it was then possible to ensure the better hearing rehabilitation strategy.

Conclusions

ABR has to be considered the first choice in hearing assessment strategy, either for screening or for diagnosis in newborns as well as in non-collaborating children; ECochG still may be considered a reliable diagnostic tool.     

听性稳态反应在新生儿听力评估中的应用

目的 探讨听性稳态反应(auditory steady-state responses,ASSR)在新生儿听力评估中的准确性及应用价值.方法 对30例(60耳)畸变产物耳声发射(distortion product otoacoustic emission,DPOAE)正常的新生儿和45例(78耳)DPOAE异常的新生儿进行ASSR与听性脑干反应(auditory brainstem response audiome-try,ABR)测试,比较ASSR与ABR阈值差异有无统计学意义,并进行两者反应阈的相关性分析.结果 ①DPOAE正常组:ASSR 250 Hz反应阈与ABR阈值差异有统计学意义(P＜0.05),ASSR平均阈值及4 000 Hz反应阈与ABR阈值差异无统计学意义(P＞0.05),ASSR的250、500、1 000 Hz反应阈与ABR阈值相关性不明显,但2 000、4 000 Hz反应阈与ABR阈值有明显的相关性;②DPOAE异常组:ASSR的250～4 000 Hz阈值及平均阈值与ABR阈值差异均无统计学意义(P＞0.05).ASSR各频率反应阈与ABR阈值均有显著的相关性.结论 ASSR可以比较准确地评估听力筛查正常新生儿的平均听阈和中、高频听阈以及听力筛查未通过新生儿的各频率听阈.     

人工耳蜗植入者EABR、NRT与ESR检测

目的探讨应用客观检测方法评价人工耳蜗植入患者术后听觉传导功能并指导术后调试的可行性。方法对39名人工耳蜗植入者分别选取第3、10、20电极,进行电诱发听性脑干反应(electric allyevok edaudito rybrainstem responses,EABR)、神经反应遥测(neuralresponset elemetry,NRT)、电刺激镫骨肌反射(electricall yevokedstap ediusresponses,ESR)检测及主观心理物理测试,测定EABR、电诱发听神经复合动作电位(electricallyevokedcompoundactionpotentials,ECAP)、ESR阈值、主观阈值(T-levels)和主观最大舒适强度(C-levels),分别对EABR、ECAP阈值与主观阈值,ESR阈值与主观最大舒适强度进行相关性研究。结果EABR平均阈值分别为158.63±10.86、159.71±11.17、152.92±10.82电流级(currentlevel,CL);ECAP平均阈值分别为188.71±15.19、194.61±10.21、185.07±11.52CL;ESR平均阈值分别为210.10±16.16、209.81±14.24、204.55±12.90CL。EABR阈值与主观阈值间、ESR阈值与最大舒适强度间显著相关(P<0.01);ECAP阈值与主观阈值间无显著相关性(P>0.05)。结论EABR是判断人工耳蜗植入者听觉传导功能的有效客观方法;EABR和ESR阈值的测定可协助判断人工耳蜗植入者的主观阈值和最大舒适强度。     

Auditory brainstem responses as a clinical evaluation tool in children after perinatal encephalopathy

Auditory brainstem responses (ABR) reveals the neurophysiological status of the neural axis. In this study we compared the ABR of healthy children, under 1-year-old, with children who suffered from perinatal encephalopathy (PE). OBJECTIVE: The purpose of this study was to characterize the ABR differences between children with PE and healthy children in order to identify groups with specific neurophysiological profiles, associated with their neurological condition. METHODS: Thirty-six children with perinatal encephalopathy (PE) and 36 healthy children, ages 1-12 months, were studied. The variables considered were: latencies of waves I, II, N1, III, V, and N2; interpeak latency interval (IPL) of waves I-III, III-V, and I-V; as well as amplitudes of waves I, III, and V. The results were analyzed using ANOVA, as well as Ji(2), and Ward's cluster analysis. RESULTS: The absolute latencies of the ABR showed an inverse correlation with the children's age. Latencies of waves I, II, N1, V, and N2, IPL III-V, and amplitude of waves III and V show significant differences (p<0.05) between healthy and PE children. Children with PE showed greater absolute latencies and larger wave amplitudes than the control group. Ward's cluster analysis, used to define the groups with similar functional characteristics, revealed three groups: fast, intermediate, and slow-responders, depending on their wave latencies and IPL wave amplitudes. These groups were gender- (p<0.03), age- (p<0.0001), and neurological damage- (p<0.01) related. CONCLUSIONS: Our data clearly show that the ABR obtained from PE children differ from ABR obtained from healthy children. PE infants showed larger wave latencies, intervals amplitudes than the control group. Three functional profiles resulted from the groups established using the Ward's method, and these indicate their neurological functional condition.     

人工耳蜗植入者电听性脑干反应测试

目的　通过对人工耳蜗植入者的电听性脑干反应 (electricallyevokedauditorybrainstemresponses,EABR)检测 ,探讨术后患者的电听觉传导通路的功能状态和EABR阈值。方法　对 6例人工耳蜗植入患者术后进行EABR检测。分别选取近耳蜗底转、中部和近蜗顶部三个固定部位的蜗内电极作为刺激电极 ,进行EABR记录 ,将所测EABR阈值与主观阈值和NRT(neuralresponsetelemetry)阈值进行比较。结果　 6例患者 ,用 175电流级 (currentlevel)的刺激强度 ,每一部位都可记录到清晰易识别、重复性良好的EABR波形 ,在耳蜗底转 ,中部和蜗顶部电极测得EABR波Ⅲ平均潜伏期分别为 1.83± 0 .19、1.80± 0 .18、1.6 8± 0 .2 3ms ,波Ⅴ平均潜伏期分别为 3.90± 0 .16、3.74±0 .18、3.6 2± 0 .2 4ms;测得EABR平均阈值分别为 16 5 .33± 7.6 6、16 2 .6 7± 7.2 8、15 3.33± 8.0 2电流级。结论　EABR是了解人工耳蜗植入者听觉传导功能的存在及测定人工耳蜗植入术后听觉阈值的客观方法之一     

正常新生儿听性脑干反应测试结果分析

目的　分析新生儿听性脑干反应(auditorybrainstemresponses,ABR)的基本特征,为国内开展新生儿ABR检测及听力筛选提供依据。方法　对80名正常新生儿(160耳)的ABR测试结果进行分析,并与正常听力青年人测试结果进行比较。结果　130dBpeSPL强度短声刺激下,正常新生儿波Ⅰ、波Ⅲ、波Ⅴ的检出率均为100%。波Ⅴ反应阈为61.94±6.87dBpeSPL,显著高于正常听力青年人。新生儿波潜伏期和波间期均较正常听力青年人延长,波间期Ⅲ-Ⅴ/Ⅰ-Ⅲ比值显著低于正常听力青年人。结论　70dBpeSPL短声是较为适宜的新生儿ABR听力筛选的声刺激;性别及左、右耳差异不影响新生儿ABR筛选;新生儿听觉通路存在一个不断完善的成熟过程,但其脑干上、下部的发育并不是完全同步的。     

不同年龄组大鼠听性脑干反应结果分析

目的　探讨老化时听性脑干反应 (auditorybrainstemresponses,ABR)的变化及其意义。方法　分别对幼年 ( <1月龄 )、成年 ( 2～ 3月龄 )及老年 ( 2 2～ 2 4月龄 )Wistar大鼠各 10只进行ABR测定 ,并分析有关数据。结果　老年大鼠ABR反应阈值范围在 4 0～ 80dBSPL ,较成年组平均高出 2 1.5 0dBSPL(P <0 .0 1) ,90dBSPL强度剌激声下波Ⅰ、Ⅱ潜伏期延长 (P <0 .0 1,P <0 .0 5 ) ,Ⅰ～Ⅲ波间期缩短 (P <0 .0 1)。结论　提示老年大鼠不仅周围听路发生病变 ,中枢听路亦存在病变     

Auditory brainstem responses in neonatal hyperbilirubinemia and effect of therapy

Objectives; To determine the effect of neonatal hyperbilirubinemia on auditory brainstem responses (ABRs) and evaluate ABR responses to lowering of bilirubin levels.Study Design: prospective case control trialSetting: tertiary referral center.Patients: 60 neonates (40 cases & 20 controls). Term appropriate for date(AFD) neonates with uncomplicated birth history and bilirubin level of ≥ 13 mg/dL were included as cases, those with bilirubin value of < 13 mg/dL were taken as controls.Interventions; First BERA examination was carried out within 24 hrs of the diagnosis of hyperbilirubinemia and repeat examination was done when total serum bilirubin came down to < 13 mg/dL with treatment. Comparisons were made between cases (before & after therapy) and controlResults; No abnormality in neonates with bilirubin < 18 mg/dL. Abnormal ABRs were observed in 24(60%) of the 40 cases studied, with therapy it reverted back to normal in 15(62%). The commonest abnormality noted was prolonged latency of wave V(42.5%), followed by prolonged latency of wave III(35%) and wave I(22.5%). Prolonged latency of wave I was found in only those with bilirubin > 20mg/dL. Inter peak latency of wave IV (Brain stem conduction time) was prolonged in 8 cases; it reverted to normal in all cases. Prolonged inter peak latency of wave I–III was observed in 7 cases, of which it reverted to normal in 6. Absent waves reappeared in 4 out of 5 cases, but abnormal amplitude ratios reverted to normal in only one of the 7 cases in which it was abnormal.Conclusions; about 60% of term A FD neonates with serum bilirubin of > 18mg/dL will demonstrate ABR changes. Most of these changes revert to normal early after therapy, indicating need for aggressive therapy in this subgroup of neonates.     

Auditory evaluation in Parkinsonian patients

Twenty Parkinson’s disease (PD) patients (mean age 69.9 years) and 24 normal individuals’ (mean age 63.8) both ears were investigated by brainstem auditory evoked potentials (BAEPs) and pure tone audiometry (PTA). There were no statistically significant age differences between the patients and control subjects. PTA results were significantly elevated for PD patients in 4,000 and 8,000 Hz (P < 0.05). Parkinsonian patients showed significantly increased latencies in wave V and I–V interpeak latencies (P < 0.05). The results of this study suggest that PTA and BAEPs could be affected in parkinson disease.     

紫杉醇对豚鼠听阈的影响

目的：探讨紫杉醇对豚鼠听阈的影响。方法：将30只雌性豚鼠随机分为6组（1个对照组和5个实验组,每组5只）,实验组分别予以不同剂量紫杉醇腹腔内注射,检测用药前、后各组动物ABR阈值。结果：实验组听力水平用药后均显著减低,相关分析显示,总药量与听力损失程度之间无显著相关性。结论：紫杉醇可导致轻到中度听力损失。