女性青春期痤疮患者心理干预的调查分析

目的探讨心理干预在女性青春期痤疮治疗和预防中的必要性和重要作用。方法采用统一的自制生活事件量表及Eysenk个性问卷（EPQ），调查了100例女性青春期痤疮患者（病例组）和100例年龄相当正常女性（对照组）的生活事件发生频数、发生情况及问卷得分情况。结果女性青春期痤疮患者生活事件发生率高于正常女性（P〈0．01），而EPQ结果中的情绪稳定度（N）分值均数也高于正常女性（P〈0．01）。结论心理社会因素与女性青春期痤疮相关，在其治疗中应尽量进行科学的心理干预，促进康复。     

痤疮患者心理量化分析及护理

目的了解痤疮患者的心理并进行量化分析及护理。方法采用Cardiff痤疮心理评估量表对来我院门诊就诊的331例痤疮患者进行问卷式调查。结果痤疮影响了部分患者的心理健康,主要表现为焦虑、易怒和不自信,甚至干扰了他们的生活、影响择业。结论痤疮对于患者的心理具有一定程度的影响,应该引起皮肤科医护人员的重视,尤其是重度痤疮和文化程度低的患者。对不同程度的患者对其实施心理护理会达到很好疗效。     

青春期后痤疮影响因素的临床分析

目的探讨导致青春期后痤疮发病及病情加重的影响因素,为青春期后痤疮的治疗提供依据。方法选取204名就诊于惠州市皮肤病医院皮肤科门诊的青春期后痤疮患者及114名健康志愿者,参考文献自制问卷调查表进行问卷调查,并进行对照分析。结果两组间在家族史、睡眠时间不足6h,偏爱油腻和辛辣食物、抑郁及焦虑、油性皮肤方面差异有统计学意义(P<0.05)。结论青春期后痤疮与遗传、睡眠时间不足,饮食习惯、心理、油性皮肤有关。     

痤疮患者心理量化分析及护理

目的 了解痤疮患者的心理并进行量化分析及护理.方法 采用 Cardiff痤疮心理评估量表对来我院门诊就诊的331例痤疮患者进行问卷式调查.结果 痤疮影响了部分患者的心理健康,主要表现为焦虑、易怒和不自信,甚至干扰了他们的生活、影响择业. 结论 痤疮对于患者的心理具有一定程度的影响,应该引起皮肤科医护人员的重视,尤其是重度痤疮和文化程度低的患者.对不同程度的患者对其实施心理护理会达到很好疗效.     

不同时期痤疮患者中西医研究进展

痤疮是一种慢性炎症性皮脂腺病。近年来,痤疮的研究对象主要局限于青少年,对于青春期前痤疮和青春期后痤疮的研究较少。随着临床上痤疮患者发病越来越广泛,对于不同时期痤疮患者的研究逐步发展。不同年龄患者的临床特点、发病机制以及治疗有所不同。综合相关文献可以看出西医治疗痤疮主要采用抗生素、维A酸、糖皮质激素、抗雄激素等药物,中医主要采用脏腑辨证的方法治疗痤疮。根据不同年龄痤疮患者的病因和发病机制有针对性的采用中西医结合以及内外治法相结合的方法,治疗不同时期痤疮患者取得较好疗效。该文通过分析近年来研究不同时期痤疮患者的相关论文,总结青春期前、青春期和青春期后痤疮患者的临床特点,综述各个时期痤疮的病因、发病机制和治疗方法,并提出研究思路。     

药物面膜治疗外源性痤疮疗效观察

最近临床医生开始把痤疮分为内源性和外源性两种,前者是指青春期发生的痤疮,后者是指外部因素(如接触各种油类、氯、化妆品、清洁剂及机械摩擦、放射区域等)引起的痤疮。外源性痤疮以往提及很少,临床医生对其治疗几乎总是按内源性痤疮的常规处理方法进行,结果疗效甚微。本科门诊约有50％痤疮患者属于化妆品引起的,他们都有长期使用化妆品的历史,尤其是在油性皮肤上使用较为油性的粉底霜,以致毛孔阻塞,引起痤疮。我们采用药物面膜进行局部治疗,收到较为明显的疗效,现报告如下。     

165例青春期痤疮与心理健康分析

痤疮是一种好发于青春期男女常见的皮肤病,属于皮肤附属炎症疾病。由于青春期青少年生理和心理发生剧烈变化的时期。这段时期,青少年生理逐渐发育成熟,心理逐渐成长,同时也是容易受外界环境干扰。在青春期伴随着生理的发育,大多数青少年会患有痤疮,而痤疮带来的美容方面的影响,     

疏肝解郁益肾法配合心理疏导治疗女性青春期后痤疮临床观察

目的:探求安全、有效治疗女性青春期后痤疮的综合方法,观察运用疏肝解郁益肾法配合心理疏导治疗女性青春期后痤疮的临床疗效.方法:采用解郁消痤汤(柴胡、香附、牡丹皮、黄芪、龙胆草等)加减并配合心理疏导治疗女性青春期后痤疮66例为治疗组;采用口服罗红霉素治疗的59例为对照组,观察2组临床疗效.结果:治疗组总有效率为80.3％,对照组总有效率为52.5％,2组比较(P＜0.05).结论:药物治疗的同时,要注重精神调节的作用,运用疏肝解郁补肾法配合心理疏导治疗女性青春期后痤疮安全、有效.     

米诺环素联合0.1%阿达帕林5%过氧苯甲酰治疗寻常痤疮疗效观察

<正>痤疮是一种累及毛囊、皮脂腺的慢性炎症性疾病,其发病率为70%~87%,青春期多发,好发于皮脂溢出的部位[1]。皮损通常以痤疮、炎症性丘疹及脓疱多见,少数较重者可出现结节、囊肿。痤疮发生于人们最关注的面部,如果不积极的治疗,会对患者的心理健康带来不利的影响,会影响他们的生活质量。痤疮对青少年的心理和社交影响超过了哮喘和癫痫。2012年1月至2013年6月我科采用米诺环素口服联合     

大学生痤疮发病的影响因素调查

目的:探讨在校大学生痤疮发病的相关因素及对生活质量的影响.方法:采用无记名问卷方式对莆田学院在校生进行调查.所收集数据统一采用SPSS17.0软件处理分析.结果:发放调查表850份,回收802份,现患痤疮663例,总现患率为82.7％,男性:89.4％,女性:79.5％.两性间现患率的差异有统计学意义(x2=11.86,P＜0.01).结果显示便秘、腹泻、月经紊乱、日均洗脸次数(3次以上)、日均睡眠时间(＜8h)、日均接触电脑时间(＞2h)、父或(和)母亲有患过痤疮为危险因素.大部分痤疮患者认为痤疮影响他们的生活、就业和心理健康等.结论:处于青春期的大学生是痤疮的好发群体,有相当一部分大学生对痤疮缺乏正确的认识及采用不恰当的方式处理痤疮.痤疮对大学生的生活质量,特别是心理方面有较大的影响,因此有待于进一步的预防宣传,增加对痤疮相关知识的认识,减少痤疮所引起的困扰.     

Saffron （Crocus sativus L.） and major depressive disorder： a meta-analysis of randomized clinical trials

Due to safety concerns and side effects of many antidepressant medications, herbal psychopharmacology research has increased, and herbal remedies are becoming increasingly popular as alternatives to prescribed medications for the treatment of major depressive disorder （MDD）. Of these, accumulating trials reveal positive effects of the spice saffron （Crocus sativus L.） for the treatment of depression. A comprehensive and statistical review of the clinical trials examining the effects of saffron for treatment of MDD is warranted. OBJECTIVE： The purpose of this study was to conduct a meta-analysis of published randomized controlled trials examining the effects of saffron supplementation on symptoms of depression among participants with MDD. SEARCH STRATEGY： We conducted electronic and non-electronic searches to identify all relevant randomized, double-blind controlled trials. Reference lists of all retrieved articles were searched for relevant studies. INCLUSION CRITERIA： The criteria for study selection included the following： （1） adults （aged 18 and older） with symptoms of depression, （2） randomized controlled trial, （3） effects of saffron supplementation on depressive symptoms examined, and （4） study had either a placebo control or antidepressant comparison group. DATA EXTRACTION AND ANALYSIS： Using random effects modeling procedures, we calculated weighted mean effect sizes separately for the saffron supplementation vs placebo control groups, and for the saffron supplementation vs antidepressant groups. The methodological quality of all studies was assessed using the Jadad score. The computer software Comprehensive Meta- analysis 2 was used to analyze the data. RESULTS： Based on our pre-specified criteria, five randomized controlled trials （n = 2 placebo controlled trials, n = 3 antidepressant controlled trials） were included in our review. A large effect size was found for saffron supplementation vs placebo control in treating depressive symptoms （M ES = 1.62, P 〈 0.001）, revealing that saffron supplementation significantly reduced depression symptoms compared to the placebo control. A null effect size was evidenced between saffron supplementation and the antidepressant groups （M ES = -0.15） indicating that both treatments were similarly effective in reducing depression symptoms. The mean Jadad score was 5 indicating high quality of trials. CONCLUSION： Findings from clinical trials conducted to date indicate that saffron supplementation can improve symptoms of depression in adults with MDD. Larger clinical trials, conducted by research teams outside of Iran, with long-term follow-ups are needed before firm conclusions can be made regarding saffron＇s efficacy and safety for treating depressive symptoms.     

Association between intervertebral disc degeneration and disturbances of blood supply to the vertebrae

Low back pain is a common public health problem in western industrialized societies and the world as well.Studies indicate that the prevalence rate ranges to 35%, with around 10% of patients from 12% becoming chronically disabled. It also places an enormous economic burden on society. Although the exact cause of low back pain has yet to be defined, intervertebral disc degeneration is considered a major source of it. Since patients with degenerative discs are often asymptomatic, the mechanisms of it are still unclear.     

Relevance of muscle biopsy for diagnosing multifocal motor neuropathy

Multifocal motor neuropathy （MMN） is a rare,.focal,inflammatory,demyelinating disease of the peripheral nerves with pure motor involvementJ MMN is clinically characterized by slowly progressive,asymmetric,distal,upper limb predominant weakness,in the absence of sensory disturbances） Weakness is usually multifocal and connected to a distinct motor nerve,such as the musculocutaneous nerve resulting in biceps weakness,the posterior interosseus nerve resulting in finger drop,the median,ulnar,or radial nerve resulting in dexterity problems or grip weakness,or the peroneal nerve resulting in a foot drop.Onset of clinical manifestations is between 20 and 50 years of age.The prevalence of MMN is reported as 1-2 per 100 000.2 MMN is three times more frequent in men as compared to women.     

痘苗病毒天坛株的减毒与其作为疫苗载体研究进展

1痘苗病毒天坛株的历史天花是人类历史上最可怕的传染病之一。天花由天花病毒（variola virus）引起,人是该病毒的惟一宿主。人感染天花病毒后的死亡率达到30%~40%[1]。世界上公认的对天花最早的准确记录来自中国,晋代药学家葛洪于公元430年左右,在《肘后备急方》中对天花有清楚的描述[1]。     

Chinese herbal medicine Xinfeng Capsule in treatment of rheumatoid arthritis： study protocol of a multicenter randomized controlled trial

BACKGROUND： Rheumatoid arthritis （RA）, as a common systemic inflammatory autoimmune disease, affects approximately 1 in 100 individuals. Effective treatment for RA is not yet available because current research does not have a clear understanding of the etiology and pathogenesis of RA. Xinfeng Capsule, a patent Chinese herbal medicine, has been used in the treatment of RA in recent years. Despite its reported clinical efficacy, there are no large-sample, multicenter, randomized trials that support the use of Xinfeng Capsule for RA. Therefore, we designed a randomized, double-blind, multicenter, placebo-controlled trial to assess the efficacy and safety of Xinfeng Capsule in the treatment of RA. METHODS AND DESIGN： This is a 12-week, randomized, placebo-controlled, double-blind, multicenter trial on the treatment of RA. The participants will be randomly assigned to the experimental group and the control group at a ratio of 1：1. Participants in the experimental group will receive Xinfeng Capsule and a pharmaceutical placebo （imitation leflunomide）. The control group will receive leflunomide and an herbal placebo （imitation Xinfeng Capsule）. The American College of Rheumatology （ACR） Criteria for RA will be used to measure the efficacy of the Xinfeng Capsule. The primary outcome measure will be the percentage of study participants who achieve an ACR 20% response rate （ACR20）, which will be measured every 4 weeks after randomization. Secondary outcomes will include the ACR50 and ACR70 responses, the side effects of the medications, the Disease Activity Score 28, RA biomarkers, quality of life, and X-rays of the hands and wrists. The first four of the secondary outcomes will be measured every 4 weeks and the others will be measured at baseline and after 12 weeks of treatment. DISCUSSION： The result of this trial will help to evaluate whether Xinfeng Capsule is effective and safe in the treatment of RA. TRIAL REGISTRATION： This trial has been registered in ClinicalTrials.gov. The identifier is N CT01774877.     

WHO西太区与世界中医药学会联合会中医名词术语国际标准比较研究：八纲辨证（三）

The Chinese characters 寒 and 热, 虚, and 实 are quite common concepts in Chinese language. However in traditional Chinese medicine （TCM）, they are used as four principles in syndrome differentiation. In terms of translation, 寒 and 热 are very easy to understand and can be simply translated as ＂cold＂ and ＂heat＂. But the transla- tion of 虚 and 实 used to be a problem. For a quite long time in translation practice,     

Gene expression profiles of ERCC1, TYMS, RRM1, TUBB3 and EGFR in tumor tissue from non-small cell lung cancer patients

Background Personalized medicine becomes essential in lung cancer treatment, however lung-cancer-related gene expression profiles in Chinese patients remain unknown. In this study, the correlation of gene expression profiles and clinical characteristics in non-small-cell lung cancer （NSCLC） was investigated. Methods Seventy-six Chinese patients with NSCLC were enrolled in the study to investigate mRNA expression profiles of excision repair cross complement group 1 （ERCC1）, thymidylate synthetase （TYMS）, ribonucleotide reductase （RRM1）, class Ill 13-tubulin （TUBB3）, and epidermal growth factor receptor （EGFR） genes and their correlation with patient clinical characteristics. A novel liquidchip technology was used to detect mRNA expression levels in formalin fixed paraffin embedded tumor pathology samples. The relationships between gene expression and clinical characteristics were assessed using the Mann-Whitney test. Results ERCC1 mRNA levels were higher in tumors from patients with metastatic disease than patients with non- metastatic disease （P=-0.021）, and higher in adenocarcinomas than squamous cell carcinomas （P=0.006）. Increased TUBB3 mRNA expression levels were found in patients with performance status （PS） 1 in comparison with PS 0 （P=0.049）, with poorly differentiated tumors in comparison with tumors that were moderately and well differentiated （P 〈0.000 1）, and with advanced stage in comparison with early stage disease （P 〈0.000 1）. Conclusions ERCC1 mRNA levels were higher in metastatic adenocarcinoma NSCLC; TUBB3 mRNA levels were significantly higher in poorly differentiated tumors and in advanced stage NSCLC, which indicates the poor prognosis.     

高维列联表资料的统计分析与SAS软件实现（六）

非条件logistic回归分析方法的主要算法是采用最大似然法对参数进行估计。最大似然法在大样本前提下进行参数估计是非常有效的,但当处理样本量小的数据,特别是按多个定性变量进行分层且每一层中样本量很小时,