2021年对本刊有突出贡献的审稿专家名单

审稿是保证期刊质量的重要环节。2021年,本刊总编、副总编.编委、通讯编委和审稿专家对于审稿工作付出了大量的时间和精力,在此,对辛勤付出的所有专家致以崇高的敬意和衷心的感谢!审稿数量超高10篇的专家包括(按照审稿数量的多少排序):冯波、窦京涛、李红(贵州)、高昕媛、肖建中、赵一鸣、李洪梅、关海霞、胡承、龚凤英、周健、李惠琴、张朝云、蔡晓凌、张军霞、吴红花、房辉、周洁、李健榕、徐向进、赵芳、滕晓春、李鸿、秦贵军、李成乾、黄凌宁、郭辉、杨少玲。     

《中国艾滋病性病》稿约

1 刊登范围《中国艾滋病性病》杂志（原《中国性病艾滋病防治》）是由卫生部主管、中国性病艾滋病防治协会主办的学术刊物,为中国科技核心期刊。刊登艾滋病、性病的流行病学、病原学、诊断、治疗、预防和心理学、社会学等研究的原始工作论文,介绍国内外研究进展的学术文章。辟有专报、论著、工作研究、短篇报道、综述、学术讨论、学术报告、病例分析、经验交流、管理、国内外信息等栏目。     

不同银屑病亚型患者血液学检验指标变化及其意义

目的 本研究目的在于观察血液学指标在不同型别银屑病中的变化规律,从中发掘检查意义.方法 查找本院收治的银屑病患者病历资料,对相关数据进行回顾性分类与整理,将患者分局临床标准分为寻常型、关节病型、脓疱型及红皮病型四组,比较四组患者之间血液学指标的差别.结果 各组IgA、IgM、TGAb水平差异无统计学意义;寻常型银屑病患者的WBC显著高于红皮病型患者;脓疱型患者的IgG、ESR、CRP、UA、Alb、TP、WBC、NEUT%、LYMPH%、MONO%、EO%、PLT、TGAb与脓疱型患者有显著差异,ESR、CRP、UA、Alb、TP、WBC、NEUT%、LYMPH%、EO%、PLT、RBC、TGAb与红皮病型患者有显著差异;IgG、ESR、CRP、Alb、TP、NEUT%、LYMPH%、EO%、PLT与关节病型银屑病患者有显著差异.脓疱型患者TSH水平显著高于其他三组患者.结论 不同类型的银屑病可造成的血液指标变化各不相同,相关指标的检验结果 有助于对疾病的分型,从而辅助临床对治疗和预后进行判断.     

《中国脑血管病杂志》稿约

《中国脑血管病杂志》为研究脑血管病的专业学术期刊,报道脑血管病临床诊断、治疗及基础研究的相关信息。本刊遵循普及与提高、民主与争鸣相结合的办刊方针,力求促进脑血管病研究的发展。1.本刊设有专家论坛、临床研究、基础研究、影像学诊断、新技术、经验交流、论著摘要、病例报告、综述、讲座、介入治疗、病例透视等栏目。     

《中国脑血管病杂志》稿约

《中国脑血管病杂志》为研究脑血管病的专业学术期刊,报道脑血管病临床诊断、治疗及基础研究的相关信息。本刊遵循普及与提高、民主与争鸣相结合的办刊方针,力求促进脑血管病研究的发展。 1．本刊设有专家论坛、临床研究、基础研究、影像学诊断、新技术、经验交流、论著摘要、病例报告、综述、讲座、     

经营管理创新 科学技术创新 《中国卫生产业》征稿函

本刊欢迎有关医疗卫生经营管理理论研究与实践应用、临床医学、医院改革、思想工作、医德医风以及科室、质量、人事、科研、教学、护理、药事、病案、财务、设备、后勤和医院文化等与医院管理相关的各个方面文章。读者对象:各级医院院长、医院管理者;医疗机构科研人员、管理人员;医务工作者;医学院校的师生以及关注医疗卫生事业发展的广大爱好者。     

2020年对本刊有突出贡献的审稿专家名单

审稿是保证期刊质量的重要环节2020年,本刊编委、通讯编委和审稿专家对于审稿工作付出了大量时间和精力,在此.对辛勤付出的所有审稿专家致以崇高的敬意和衷心的感谢!其中,审稿超过数量超过10篇的专家包括(按照审稿数量由高至低排序):冯波、窦京涛、肖建中、赵一鸣、肖新华、邢小燕、吴红花、周健、陆菊明、许樟荣、薛耀明、张朝云、李全民、颜晓东、龚凤英、蔡晓凌、邵加庆、秦贵军、章秋、杨兵全、严孙杰、陈莉明、高昕媛、常宝成、武晓泓、乌正赍、包玉倩、王煜非、汪志红、王海宁、李虹、关海霞、徐勇、刘静、房辉、吕肖锋、李洪梅和李红(贵州)。     

圆茄子炒炖，长茄子凉拌

夏季，各式各样的茄子登上了老百姓的餐桌。紫皮的茄子中含有丰富的天然抗氧化剂芦丁，其他蔬菜难以企及。除此之外，茄子还含有蛋白质、脂肪、碳水化合物、膳食纤维、胡萝卜素、维生素A、维生素B。、维生素B：、维生素C、维生素E及钙、钾、镁、锌、硒等矿物质。     

第10次中国中西医结合学会全国心血管病学术会议

由中国中西医结合学会全国心血管病专业委员会主办、南昌大学第一附属医院承办的“第10次全国心血管病专业委员会换届选举、学术会议暨心血管病新进展学习班”拟于2010年11月初在南昌市召开,此次会议会议的口号为“传承、创新”,会期2天。会议的内容主要为冠心病、高血压病、心肌炎、心肌病、风心病、心律失常、心力衰竭、高血脂、代谢综合征等的中医、西医、中西医结合的预防、诊断和治疗,以及基础研究、外科、介入治疗、循证医学、社区医疗和护理学等。     

青海省青南高原棘球蚴病流行状况

青海省南部高原属“世界屋脊”——青藏高原的腹地,行政区域包括玉树、果洛、黄南3个藏族自治州的玉树、称多、杂多、治多、昂欠、曲麻莱、玛沁、达日、甘德、班玛、久治、玛多、同仁、尖扎、河南和泽库。这些县大部分海拔在3     

胰岛素瘤的解剖分布特点分析

目的胰岛素瘤是最常见的胰腺神经内分泌肿瘤，因其临床表现多样，导致诊断困难。影像学诊断尤其是超声内镜(EUS)在胰岛素瘤的诊断中起着重要作用，拥有较高的敏感性和特异性。本研究拟通过明确胰岛素瘤的解剖分布特点，以期有助于提高影像学的诊断准确率和降低漏诊率，尤其是在教育和培训实践中对于EUS的学习者更具有指导价值。 方法回顾性分析解放军总医院第一医学中心病案资料数据库1993年1月至2019年11月经外科手术、病理确诊为胰岛素瘤的患者的临床资料，检索方法采取搜索术后病理诊断为"胰岛素瘤"的病例，通过查阅病例的方法，提取出胰岛素瘤的大小和解剖分布等数据，进一步分析其特点。 结果共检索到确诊为胰岛素瘤的患者116例，其中，男45例、女71例，年龄13～76岁，平均年龄(44.4±14.85)岁。胰岛素瘤单发110例(94.8%)、多发6例(5.2%)。位置分布：头颈部46例(39.7%)，单发45例、多发1例；体尾部68例(58.6%)，单发65例、多发3例；全胰腺多发2例(1.7%)。病变大小特点：最大径0.4～3.4 cm，平均大小(1.53±0.58)cm。≤1 cm 29例、>1 cm而≤1.5 cm41例、>1.5 cm而≤2.0 cm28例，≤3 cm 15例，>3 cm 3例。年龄与肿瘤的大小相关，≤44岁患者肿瘤平均大小为(1.36±0.51)cm、>44岁患者肿瘤平均大小为(1.70±0.60)cm，P<0.05。头颈部的肿瘤大于体尾部的肿瘤，头颈部肿瘤平均大小(1.66±0.63)cm，体尾部(1.42±0.52)cm，P<0.05。 结论胰岛素瘤在胰腺体尾部较头颈部更好发；绝大多数单发，但可以全胰腺多发；多数小于1.5 cm，肿瘤的大小与患者年龄和肿瘤的解剖分布相关。     

Pathogenesis of carcinoma of the papilla of Vater

Most adenomas and carcinomas of the small intestine and extrahepatic bile ducts arise in the region of the papilla of Vater. In familial adenomatous polyposis (FAP) it is the main location for carcinomas after proctocolectomy. In many cases symptoms due to stenosis lead to diagnosis at an early tumor stage. In about 80%, curative intended resection is possible. Operability is the most relevant prognostic factor. Most ampullary carcinomas resp. carcinomas of the papilla of Vater develop from adenomatous or flat dysplastic precursor lesions. They can be sited in the ampulloduodenal part of the papilla of Vater, which is lined by intestinal mucosa. They also can develop in deeper parts of the ampulla, which are lined by pancreaticobiliary duct mucosa. Intestinal-type adenocarcinoma and pancreaticobiliary-type adenocarcinoma represent the main histological types of ampullary carcinoma. Furthermore, there exist unusual types and undifferentiated carcinomas. Many carcinomas of intestinal type express the immunohistochemical marker profile of intestinal mucosa (keratin 7?, keratin 20+, MUC2+). Carcinomas of pancreaticobiliary type usually show the immunohistochemical profile of pancreaticobiliary duct mucosa (keratin 7+, keratin 20?, MUC2?). Even poorly differentiated carcinomas, as well as unusual histological types, may conserve the marker profile of the mucosa they developed from. These findings underline the concept of histogenetically different carcinomas of the papilla of Vater which develop either from intestinal- or from pancreaticobiliary-type mucosa of the papilla of Vater. Molecular alterations in ampullary carcinomas are similar to those of colorectal as well as pancreatic carcinomas, although they appear at different frequencies. In future studies, molecular alterations in ampullary carcinomas should be correlated closely with the different histologic tumor types. Consequently, the histologic classification should reflect the histogenesis of ampullary tumors from the two different types of papillary mucosa.     

Demonstration of the mechanism of action of biguanides

Summary Palmitic acid oxidation in rat diaphragm homogenate is depressed by biguanide concentrations that are still incapable of inhibiting oxidative phosphorylation. Glucose oxidation is not directly effected by the same biguanide concentrations: however, the inhibitory effect of palmitic acid on glucose oxidation is partly removed by biguanides. Inhibition of fatty acid oxidation, which accounts for most of the metabolic effects caused by these drugs, can be regarded as the fundamental mechanism of action of biguanides. There is some evidence suggesting that these drugs might interact with carnitine, thus preventing long-chain fatty acids from being transported across the mitochondrial membrane to the site of oxidation. Traduzione a cura degli AA.     

Lack of correlation of degree of villous atrophy with severity of clinical presentation of coeliac disease

BACKGROUND AND AIM: Both the clinical presentation and the degree of mucosal damage in coeliac disease vary greatly. In view of conflicting information as to whether the mode of presentation correlates with the degree of villous atrophy, we reviewed a large cohort of patients with coeliac disease. PATIENTS AND METHODS: We correlated mode of presentation (classical, diarrhoea predominant or atypical/silent) with histology of duodenal biopsies and examined their trends over time. RESULTS: The cohort consisted of 499 adults, mean age 44.1 years, 68% females. The majority had silent coeliac disease (56%) and total villous atrophy (65%). There was no correlation of mode of presentation with the degree of villous atrophy (p=0.25). Sixty-eight percent of females and 58% of males had a severe villous atrophy (p=0.052). There was a significant trend over time for a greater proportion of patients presenting as atypical/silent coeliac disease and having partial villous atrophy, though the majority still had total villous atrophy. CONCLUSIONS: Among our patients the degree of villous atrophy in duodenal biopsies did not correlate with the mode of presentation, indicating that factors other than the degree of villous atrophy must account for diarrhoea in coeliac disease.     

氯硝柳胺悬浮剂的毒性评价

目的评价氯硝柳胺悬浮剂的毒性，为现场大规模应用灭螺提供依据。方法按照中华人民共和国国家标准GB 15670-1995《农药登记毒理学试验方法》和鱼类毒性试验方法进行。结果经口、经皮肤的LDso雌、雄性大鼠均>5 000 mg/kg，经呼吸道的LCso雌、雄性大鼠均>5 000mg/m3，该药经口、经皮肤、经呼吸道毒性均属微毒类药物；兔眼用药后，观察期内无不良反应，对眼无刺激性；皮肤用药后对皮肤无刺激性。与氯硝柳胺原药、氯硝柳胺乙醇胺盐原药和氯硝柳胺乙醇胺盐可湿性粉剂相比，氯硝柳胺悬浮剂对鱼急性毒性最低。结论氯硝柳胺悬浮剂属微毒类药物，对鱼的毒性低于其乙醇胺盐可湿性粉剂，适合于现场应用。     

血吸虫童虫生长发育及其机制的研究进展

血吸虫童虫是宿主免疫系统攻击的重要靶标,包括皮肤型、肺型和肝门型童虫。宿主分子对童虫生长发育具有重要作用。童虫生长发育机制包括免疫调节、信号转导、性别发育及凋亡等。肌动蛋白、组织蛋白酶、烯醇化酶和葡萄糖基转移酶等分子为血吸虫童虫生长发育的重要分子。本文对血吸虫童虫生长发育及其机制的研究进展做一综述。     

124例耐多药结核分枝杆菌基因突变特征分析

目的对临床分离的耐多药结核分枝杆菌相关基因的突变特征进行分析。方法对124例耐多药结核分枝杆菌以及50株敏感株的耐药相关基因(包括异烟肼inh A、kat G、oxyR-ahp C间隔区以及利福平rpo B)进行序列测定,分析其基因突变情况。结果异烟肼耐药inh A基因突变率为14.5%;kat G基因突变率为70.2%(87/124),主要位于315位;oxyR-ahp C间隔区突变率为15.3%;inh A、kat G两种基因同时突变率75.0%,三种基因同时突变率为89.5%。利福平rpo B基因突变的检出率高达95.2%,突变主要发生在531、526、516位点。结论我省耐多药菌异烟肼耐药相关基因最常见突变为kat G 315、inh A C-T(-15)、axyR-ahp C间隔区(-10)C-T,利福平为rpo B531、526、516。结合MDR-TB耐药相关基因的特征分析,可以建立一种快速、准确、特异的适合于我省的检测结核菌耐多药性的新方法。     

Assessment of quality of life of parents of children with juvenile chronic arthritis

The aim of the study was to assess the quality of life (QOL) and the psychological status of parents of children with juvenile chronic arthritis (JCA). The QOL, anxiety and depression of the parents of 28 children with JCA were evaluated and compared to those of the parents of 28 healthy children. Mothers of JCA children and mothers of healthy children reported similar QOL. The reported anxiety and depression levels were similar for mothers and fathers in both groups. The parents of children with pauciarticular-type JCA reported lower QOL and higher levels of anxiety and depression than the parents of children with other types, namely polyarticular and systemic JCA. These findings may be explained by the fact that the pauciarticular patients had shorter disease duration and were less frequently seen in the outpatient clinic. The QOL of mothers of children with JCA was found to be slightly impaired in the group of children with pauciarticular JCA. Future larger studies are needed to confirm these results, as the number of subjects in the three groups was rather low. Received: 26 September 2001 / Accepted: 8 February 2002     

治疗高血压药物的经济学评价

重视高血压治疗中的经济学评价,对利用我国有限的卫生资源来遏制高血压对人民群众的危害有着重要的现实意义。药物经济学对于药物治疗的成本和治疗的结果给予同样的关注。因为治疗高血压的费用,不仅涉及药物价格,还包括患者的危险水平,降压疗效和对临床终点事件的影响,以及治疗的依从性和安全性。因此药物经济学更强调整体成本和价-效比。低危病人,若非药价低廉,治疗的价-效比不够理想。而在高危的患者,价-效比越小越经济而不是药费越便宜越好。     

Numerical Simulation of the Effect of Rate of Change of Glucose on Measurement Error of Continuous Glucose Monitors

Background

A 5-day in-patient study designed to assess the accuracy of the FreeStyle Navigator® Continuous Glucose Monitoring System revealed that the level of accuracy of the continuous sensor measurements was dependent on the rate of glucose change. When the absolute rate of change was less than 1 mg•dl⁻¹•min⁻¹ (75% of the time), the median absolute relative difference (ARD) was 8.5%, with 85% of all points falling within the A zone of the Clarke error grid. When the absolute rate of change was greater than 2 mg•dl⁻¹•min⁻¹ (8% of the time), the median ARD was 17.5%, with 59% of all points falling within the Clarke A zone.

Method

Numerical simulations were performed to investigate effects of the rate of change of glucose on sensor measurement error. This approach enabled physiologically relevant distributions of glucose values to be reordered to explore the effect of different glucose rate-of-change distributions on apparent sensor accuracy.

Results

The physiological lag between blood and interstitial fluid glucose levels is sufficient to account for the observed difference in sensor accuracy between periods of stable glucose and periods of rapidly changing glucose.

Conclusions

The role of physiological lag on the apparent decrease in sensor accuracy at high glucose rates of change has implications for clinical study design, regulatory review of continuous glucose sensors, and development of performance standards for this new technology. This work demonstrates the difficulty in comparing accuracy measures between different clinical studies and highlights the need for studies to include both relevant glucose distributions and relevant glucose rate-of-change distributions.