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目的 探讨小鼠哮喘模型中miRNAs的差异表达情况.方法 将24只BALB/c小鼠随机分为正常对照组、卵清蛋白处理组、地塞米松治疗组各8只,使用血细胞分析仪检测每组肺泡灌洗液中嗜酸性粒细胞(EOS)、嗜中性粒细胞(NEU)、巨噬细胞(MAC)和淋巴细胞(LYM)的表达情况,通过ELISA的方法 检测每组肺泡灌洗液中白细... 相似文献
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Badreldeen Ahmed Mandy Abushama Majeda Khraisheh J. Dudenhausen 《The journal of maternal-fetal & neonatal medicine》2015,28(15):1856-1863
The purpose of this review is to discuss the established role of ultrasound (US) in the management of pregnancy complicated by diabetes mellitus (DM), as well as new developments with regard to the use of US in this situation. We choose to explore the role of US in pregnancy complicated by DM in three areas:
(1) Role of US in estimation of fetal weight.
(2) Role of US in diagnosis of congenital malformation.
(3) Role of US in monitoring diabetic pregnant patients. 相似文献
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David G. Penman Sub-Specialty Senior Registrar Ross M. Fisher Senior Registrar † Helen R. Noblett Consultant † Peter W. Soothill Professor 《BJOG : an international journal of obstetrics and gynaecology》1998,105(3):328-331
Objective To describe the incidence of gastroschisis and to identify possible aetiological factors.
Design A retrospective case review study.
Setting The South West Region of England.
Population All known cases of gastroschisis were identified from the regional fetal medicine, ultrasound, pathology and neonatal surgery databases. Datasets to be collected were agreed prospectively and included demographic, past medical, family and obstetric information for all pregnancies conceived between January 1987 and December 1995.
Results In the first eight years the incidence was 1.61 10,000 but in 1995 a highly statistically significant rise to 4.4/ 10,000 was found ( P = 0.0009 ). The increased incidence was not associated with changes in maternal age, proportion of primigravidae, use of tobacco or illicit drugs, conception while taking the oral contraceptive pill, or an increase in the number of teenage pregnancies. The median maternal age at last menstrual period for pregnancies with gastroschisis was 20.4 years which was much younger than the national average of 28 years. Thirty-seven percent of these conceptions occurred during the first quarter of the year compared with the expected 25%.
Conclusions The incidence of gastroschisis has risen to a higher level than previously reported which, despite a marked association with young maternal age at conception, is not due to an increase in the teenage pregnancy rate. As the average length of inpatient stay in the neonatal intensive care unit for cases with this malformation is approximately four weeks, the rise has considerable cost implications. The increasing incidence may also offer opportunities to determine the cause of gastroschisis. 相似文献
Design A retrospective case review study.
Setting The South West Region of England.
Population All known cases of gastroschisis were identified from the regional fetal medicine, ultrasound, pathology and neonatal surgery databases. Datasets to be collected were agreed prospectively and included demographic, past medical, family and obstetric information for all pregnancies conceived between January 1987 and December 1995.
Results In the first eight years the incidence was 1.61 10,000 but in 1995 a highly statistically significant rise to 4.4/ 10,000 was found ( P = 0.0009 ). The increased incidence was not associated with changes in maternal age, proportion of primigravidae, use of tobacco or illicit drugs, conception while taking the oral contraceptive pill, or an increase in the number of teenage pregnancies. The median maternal age at last menstrual period for pregnancies with gastroschisis was 20.4 years which was much younger than the national average of 28 years. Thirty-seven percent of these conceptions occurred during the first quarter of the year compared with the expected 25%.
Conclusions The incidence of gastroschisis has risen to a higher level than previously reported which, despite a marked association with young maternal age at conception, is not due to an increase in the teenage pregnancy rate. As the average length of inpatient stay in the neonatal intensive care unit for cases with this malformation is approximately four weeks, the rise has considerable cost implications. The increasing incidence may also offer opportunities to determine the cause of gastroschisis. 相似文献
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《The journal of sexual medicine》2020,17(7):1225-1228
BackgroundIn March 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a pandemic. Currently, data on changes in sexual behavior during the COVID-19 outbreak are limited.AimThe present study aimed to obtain a preliminary understanding of the changes in people's sexual behavior, as a result of the pandemic, and explore the context in which they manifest.MethodsA convenience sample of 270 men and 189 women who completed an online survey consisting of 12 items plus an additional question were included in the study.OutcomesThe study outcomes were obtained using a study-specific questionnaire to assess the changes in people's sexual behavior.ResultsWhile there was a wide range of individual responses, our results showed that 44% of participants reported a decrease in the number of sexual partners and about 37% of participants reported a decrease in sexual frequency. Multiple regression analysis showed that age, partner relationship, and sexual desire were closely related to sexual frequency. In addition, we found that most individuals with risky sexual experiences had a rapid reduction in risky sexual behavior.Clinical ImplicationsThe current findings contribute to identifying another potential health implication associated with the COVID-19 pandemic and report preliminary evidence of the need to provide potential interventions for the population.Strength & LimitationsThis study is the first to perform a preliminary exploration of sexual behavior during the COVID-19 outbreak. The generalizability of the results is limited, given that only a small convenience sample was used.ConclusionDuring the height of the COVID-19 outbreak, overall sexual activity, frequency, and risky behaviors declined significantly among young men and women in China.Li W, Li G, Xin C, et al. Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in China. J Sex Med 2020;17:1225–1228. 相似文献
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《Hypertension in pregnancy》2013,32(3):339-348
The purpose of this open, prospective, randomized, comparative study was to examine the effectiveness of atenolol, a cardioselective beta1 blocker, alphamethyldopa, an alpha-adrenergic antagonist, and ketanserin, a serotonin receptor antagonist, in the treatment of 90 patients (N–30 each) with severe chronic hypertension (ChH) during pregnancy or severe pregnancy-induced hypertension, with or without proteinuria in either case.Arterial blood pressure (BP) for each drug group was analyzed at the onset of treatment, weekly for three weeks, and at the end of pregnancy. After one week of treatment a significant drop in BP was observed in the three groups of patients. Thereafter BP remained stable until the end of gestation, when a slight increase in BP was observed, especially in the group of patients treated with ketanserin.No significant difference was observed between the groups in mean birthweight and perinatal morbidity and mortality. No adverse effects from the drugs on the fetus or newborn were observed. No significant difference was observed among the three drugs in their antihypertensive effect. However, given the relatively small numbers of patients studied, definitive statements regarding the relative efficacy and safety of alphamethyldopa, ketanserin and atenolol cannot be made. Thus, additional, larger controlled trials of these agents are required. 相似文献
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《The journal of maternal-fetal & neonatal medicine》2013,26(2):280-283
During 2005–2009, a seroepidemiological study was carried out in Croatia to define the population susceptible to common TORCH agents among pregnant and non-pregnant women of childbearing age. The IgG seroprevalence was 29.1% forT. gondii, 94.6% for rubella, 75.3% for cytomegalovirus (CMV), 78.7% for herpes simplex virus type 1 (HSV-1), and 6.8% for HSV-2. Acute toxoplasmosis and CMV infection (positive IgM antibodies with low IgG avidity) were documented in 0.25% and 0.09% women, respectively. IgM prevalence was 1.2% for both HSV-1 and HSV-2. None of the participants showed acute rubella infection. Seropositivity to T. gondii and HSV-2 varied significantly between age groups (p?=?0.001 and p?=?0.036, respectively). Women residing in rural regions showed a significantly higher seroprevalence rate for T. gondii, CMV, and HSV-1 than urban women (T. gondii: 44.0% vs. 25.4%, p?<?0.001; CMV: 85.0% vs. 73.1%, p?=?0.018; HSV-1: 86.0% vs. 76.4%, p?=?0.041). 相似文献
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《国际妇产科学杂志》2020,(2):207-211
子宫腺肌病(adenomyosis)作为女性常见疾病之一,其常见症状如痛经、经量过多对患者生活质量造成严重影响,常并发贫血甚至休克,子宫腺肌病还可导致不良妊娠及不孕症。子宫腺肌病保守治疗效果较差、较易复发,部分患者需接受手术治疗。子宫腺肌病的发病机制目前尚不明确,近年也逐渐成为妇科领域的研究热点。细胞自噬(autophagy)作为调节细胞生长代谢的重要生理机制,其在包括肿瘤在内的众多疾病的发生、发展中发挥着重要作用。近年细胞自噬在子宫腺肌病发生、发展及转归方面的作用日益引起关注,针对两者之间关系的研究也越来越多。总结自噬在子宫腺肌病中作用的最新相关研究进展,并对自噬在子宫腺肌病治疗中的潜在作用进行探讨。 相似文献
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目的了解广州地区妇女生殖道人乳头状瘤病毒感染状况和基因亚型分布。方法 2006年10月至2010年2月,采用核酸分子快速导流杂交基因芯片分型技术(HybriMax)对广州地区6493例女性进行人乳头状瘤病毒检测,并对HPVDNA亚型、感染率和年龄分布进行分析。结果 6493例女性中检出HPV阳性1947例,阳性率为29.99%。阳性感染者中,单一型感染最多,为1436例,占73.75%,其中高危单一型感染者1143例,占58.71%,低危单一型感染者293例,占15.05%;混合型感染者511例,占26.25%,主要为双重感染,占19.41%。15个与宫颈癌密切相关的HPV高危亚型阳性率为25.24%,6个低危亚型HPV感染阳性率为7.98%。排在前十位的亚型分别是HPV52(25.22%)、HPV58(14.20%)、HPV16(13.56%)、HPV6(9.76%)、HPV11(8.32%)、HPV53(7.70%)、HPV33(6.73%)、CP8304(6.68)、HPV68(6.63)、HPV18(6.52%)。在各年龄组中,小于20岁女性感染率最高,为52.5%,各年龄组HPV感染差异有统计学意义... 相似文献
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孕产妇在妊娠期、分娩期和产褥期具有独特的解剖生理特点,容易发生生殖道细菌感染,病情进展可导致早产、流产、胎膜早破、羊膜腔感染、胎儿窘迫、死胎、产褥感染及脓毒血症等不良妊娠结局。目前,抗生素作为预防和治疗细菌感染最有效的药物,广泛应用于产科临床。值得注意的是,孕产妇的合理用药既要考虑到病情本身,同时也要兼顾到妊娠期、哺乳期的母婴双重安全,因此抗生素在产科的实际临床应用中仍存在许多问题,应得到更多的关注。就如何合理使用抗生素,结合不同时期、常见病种进行综述,有助于为妊娠期和哺乳期用药指导提供更多的理论依据。 相似文献
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孙琳琳 《中国中西医结合儿科学》2022,(1)
目的了解营口市婴幼儿贫血情况,为预防和干预贫血提供科学依据。方法选取2019年1~12月进行定期健康体检的1199例婴幼儿作为研究对象,检测血常规,分析不同年龄段婴幼儿的贫血患病率,通过调查问卷对贫血的相关影响因素进行分析。结果1199例受检婴幼儿贫血患病率为20.5%(246/1199),以轻度贫血为主,占96.7%(238/246)。6个月至1岁患儿贫血患病率最高,为29.2%(136/465),高于>1~2岁及>2~3岁婴幼儿的患病率,随年龄增长贫血患病率逐渐降低(P<0.05)。研究分析表明,母亲孕期是否贫血、是否及时合理添加辅食、是否经常接受育儿指导、出生半年内喂养方式、近两周有无反复腹泻等方面因素与婴幼儿贫血的发生有关,差异有统计学意义(P<0.05)。结论加强孕期保健,防治孕期贫血,防治孕期并发症,减少早产率,定期对婴幼儿进行健康体检,加强宣教,普及喂养知识,提倡科学喂养,及时合理添加辅食,是预防贫血发生的关键。 相似文献
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钙是人体必需的矿物质之一,是机体骨骼系统的重要组成元素,尤其胎儿时期需要从母体摄入大量的钙以供其骨骼生长。近年来随着医学的不断发展,人们对于钙在妊娠期作用的认识不再局限于其仅仅为胎儿骨骼生长提供矿物质的单一层面,而是发现钙与胎儿生长发育、早产、妊娠期高血压疾病、产后出血和妊娠期糖尿病等产科情况存在关联,具有较好的应用价值。查阅国内外相关文献报道和最新研究资料,综述钙在产科中的应用进展,以期提高产科医师对钙在产科中的作用有更好的认识,为临床处理相关疾病提供参考。 相似文献
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Shunji Suzuki 《The journal of maternal-fetal & neonatal medicine》2019,32(11):1864-1868
Objective: We examined the clinical characteristics and obstetric outcomes in adolescent pregnancies in Japanese women.Methods: The present study was a retrospective investigation of all primiparous Japanese women with singleton pregnancies who gave birth at ≥22 weeks’ gestation aged ≤18 years old (adolescent pregnancy, n?=?325) and aged 28–30 years old (n?=?2029) at Japanese Red Cross, Katsushika Maternity Hospital between 2002 and 2016.Results: The frequencies of smoking, economic problems, an unmarried single status at delivery and the start of prenatal care in the first trimester in the adolescent pregnancy group were significantly higher than in the control group (p?.01). The incidences of Chlamydia trachomatis, Condyloma acuminatum, and mental disorders in the adolescent pregnancy group were significantly higher than in the control group (p?.01). Pregnancy in adolescence was not related to adverse obstetric outcomes except preterm delivery (p?=?.02).Conclusions: Adolescent pregnancy was not associated with adverse obstetric outcomes; however, adequate social, economic, and mental support is needed for adolescent pregnant women. 相似文献
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Mordechai Goldenberg David Bider Zion Ben-Rafael Joshua Dor David Levran Gabriel Oelsner Shlomo Mashiach 《Journal of assisted reproduction and genetics》1991,8(6):336-338
Two hundred twenty-four women underwent hysteroscopic evaluation without anesthesia after at least two failed attempts of in vitro fertilization and embryo transfer. One hundred fifty-three (68%) women were diagnosed as having mechanical infertility, and abnormal hysteroscopic findings were observed in 32 (21%). Forty-one women were diagnosed as having unexplained infer-tility (18%) and six (15%) had abnormal findings with hysteroscopy. Of the 30 couples who entered the in vitro fertilization regimen program because of male infertility, 4 (13%) had abnormal findings. The overall rate of abnormal findings was 19%; cervical canal and intrauterine abnormalities were found in 10 and 32 patients, respectively. Ten patients were treated during hysteroscopic evaluation procedure, and four patients subsequently underwent operative hysteroscopy under general anesthesia. We suggest that diagnostic hysteroscopy should be a routine procedure before in vitro fertilization and embryo transfer therapy. 相似文献
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M Giannoni 《Minerva ginecologica》1986,38(12):1011-1012
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