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1.
Van Breuseghem I 《European radiology》2004,14(2):184-192
The high incidence of cartilage lesions together with new surgical treatment techniques have necessitated the development of noninvasive cartilage evaluation techniques. Although arthroscopy has been the standard for cartilage evaluation, MR imaging has emerged as the imaging method of choice, allowing morphological evaluation of cartilage and cartilage repair tissue, as well as evaluation of its biochemical content. This article deals with current ultrastructural MR imaging techniques for cartilage evaluation, indicating the advantages as well as the drawbacks for routine clinical application. 相似文献
2.
Selective water excitation for faster MR imaging of articular cartilage defects: initial clinical results 总被引:4,自引:3,他引:1
Our objective was to compare a water-excitation (WE) 3D fast low-angle shot (FLASH) MR sequence for faster imaging of articular
cartilage defects of the knee to a conventional fat-saturated (FS) 3D FLASH MR sequence. This prospective study included 16
knees of 16 patients with suspected cartilage lesions. The MR imaging in transverse and sagittal planes included (a) FS 3D
FLASH (TR/TE: 45 ms/11 ms, scan time 8 min, flip angle 50°), and (b) WE 3D FLASH (TR/TE: 28 ms/11 ms, scan time 4 min 58 s,
flip angle 40°). For each sequence signal-to-noise ratios (SNR) and contrast-to-noise ratios (CNR) were quantified. The detected
cartilage lesions were evaluated using a semi-quantitative four-scale scoring system (grades 0–III). The data were compared
between the sequences using the paired Student's t-test. No statistically significant differences between the sequences were found for SNR, CNR, and cartilage defect grading
(p=0.14–0.8). The WE 3D FLASH MR imaging seems to be promising for fast imaging of articular cartilage lesions of the knee.
Electronic Publication 相似文献
3.
4.
MR microscopy of hyaline cartilage: current status 总被引:2,自引:0,他引:2
Cartilage degenerative diseases, such as osteoarthritis, affect million of people. Magnetic resonance imaging is presently the most accurate imaging modality in evaluating the state of hyaline cartilage; however, clinical MRI does not accurately reveal early degenerative alterations in cartilage, due mainly to low spatial resolution. Magnetic resonance microscopy (MRM, or microMRI) appears exceptionally well suited to the in vitro or ex vivo study of this heterogeneous tissue, due to its high spatial resolution; however, despite this, further studies are necessary to evaluate the potential of MRM in the detection of early cartilage damage. Herein we briefly review the current applications of MRM in the study of hyaline cartilage. In particular, we review the MR appearance of hyaline cartilage on high-resolution images, the different MRM techniques used to image normal and enzymatically or chemically degraded cartilage and the potential use of contrast agents. The future directions and the relevance of MRM findings for a better understanding of cartilage physiology in health and disease are also discussed. 相似文献
5.
Cartilage repair techniques and pharmacological therapies are currently areas of major clinical interest and research, in
particular to prevent and treat osteoarthritis. MR imaging-based techniques to visualize cartilage are prerequisites to guide
and monitor these therapies. In this review article, standard MR imaging sequences are described, including proton density-weighted
fast spin echo, spoiled gradient echo and dual echo steady state sequences. In addition, new sequences that have been developed
and are currently being investigated are presented, including driven equilibrium Fourier transform and steady-state free precession-based
imaging. Using high-field MR imaging at 3.0-T, visualization of cartilage and the related pathology has been improved. Volumetric
quantitative cartilage MR imaging was developed as a tool to monitor the progression of osteoarthritis and to evaluate new
pharmacological cartilage protective therapies. The most exciting developments, however, are in the field of cartilage matrix
assessment with quantitative dGEMRIC, T2 and T1rho mapping techniques. These techniques aim at detecting cartilage damage
at a stage when changes are potentially still reversible, before cartilage tissue is lost. There is currently substantial
interest in these techniques from rheumatologists and orthopedists; radiologists therefore need to keep up with these developments. 相似文献
6.
Osmo Tervonen Mark J. Dietz Stephen W. Carmichael Richard L. Ehman 《Journal of magnetic resonance imaging : JMRI》1993,3(4):663-668
Magnetic resonance (MR) imaging of cadaveric knees was performed to determine optimal sequences for visualization of hyaline cartilage. Full-thickness cartilage lesions ranging in diameter from 1 to 5 mm and a partial-thickness cartilage lesion 15 mm in diameter were created in the femoral articular surfaces of three cadaveric knees. The knees were then imaged with a 1.5-T imager with various two-dimensional and high-resolution three-dimensional (3D) techniques. After imaging, the knee specimens were sectioned for evaluation. Measurements of cartilage thickness in fast spin-echo images correlated best with those in the gross specimen. Diffuse areas of cartilage thinning were also most accurately identified with fast spinecho images. Small, focal cartilage defects were best delineated in 3D SPGR (spoiled GRASS [gradient-recalled acquisition in the steady state]) images. 相似文献
7.
关节软骨进行性退变是骨关节炎(OA)主要特点,而软骨基质中糖胺聚糖(GAG)的过度降解和丢失是软骨退变中最早出现的代谢变化。常规影像检查对其不敏感,发现时OA多已到晚期且不可逆。GAG化学交换饱和转移成像(MR gagCEST)作为一种最新软骨成分定量成像技术,能实现对软骨GAG成分无创、准确的定量,在OA早期诊断和治疗监测方面具有良好应用前景。对MR gagCEST技术的原理、优缺点及在OA中的临床应用进行综述。 相似文献
8.
G Adam C Nolte-Ernsting A Prescher M Bühne K Bruchmüller W Küpper R W Günther 《Journal of magnetic resonance imaging : JMRI》1991,1(6):665-672
The value of magnetic resonance (MR) imaging, with two-dimensional (2D) spin-echo and FISP (fast imaging with steady-state precession) and FLASH (fast low-angle shot) three-dimensional (3D) gradient-echo sequences, for the detection of hyaline cartilage defects of the femoral condyle and the tibial plateau, was investigated in an animal model. In eight dogs, the anterior cruciate ligament was transected in one knee joint, resulting in rapid development of osteoarthritis with degeneration of the hyaline cartilage. At autopsy, 24 cartilage lesions were found, which were classified into four grades. The overall detection of cartilage lesions with MR imaging was poor. Only five of the 24 lesions were visible on 2D spin-echo images, while 11 of 24 were visible on 3D FISP images and 15 of 24 were seen on 3D FLASH images. The best results were obtained in advanced stages of cartilage degeneration, involving ulceration and complete abrasion of the cartilage layer. Signal loss or signal intensity increase in the cartilage layer was seen inconsistently in grades 3 and 4 degeneration. In this animal model, 2D spin-echo imaging was inadequate for the diagnosis of hyaline cartilage lesions, while 3D gradient-echo imaging permitted satisfactory diagnosis in only grade 4 cartilage disease. 相似文献
9.
The aim of this study was to determine signal intensity patterns of cartilage defects at MR imaging. The MR imaging (3-mm-thick fat-suppressed intermediate-weighted fast spin-echo images) was obtained in 31 knees (21 male and 10 female patients; mean age 45.5 years) blindly selected from a series of 252 consecutive knees investigated by dual-detector spiral CT arthrography. Two radiologists determined in consensus the MR signal intensity of the cartilage areas where cartilage defects had been demonstrated on the corresponding reformatted CT arthrographic images. There were 83 cartilage defects at spiral CT arthrography. In 52 (63%) lesion areas, the MR signal intensity was higher than that of adjacent normal cartilage with signal intensity equivalent to (n=31) or lower than (n=21) that of articular fluid. The MR signal intensity was equivalent to that of adjacent normal cartilage in 17 (20%) lesion areas and lower than that of adjacent cartilage in 8 (10%) lesion areas. In 6 (7%) lesion areas, mixed low and high signal intensity was observed. The MR signal intensity of cartilage defects demonstrated on spiral CT arthrographic images varies from low to high on fat-suppressed intermediate-weighted fast spin-echo MR images obtained with our equipment and MR parameters. 相似文献
10.
MR imaging of articular cartilage 总被引:19,自引:0,他引:19
With the advent of new treatments for articular cartilage disorders, accurate noninvasive assessment of articular cartilage,
particularly with MR imaging, has become important. Understanding the MR imaging features of articular cartilage has led to
the development of two types of routinely available MR imaging techniques which have demonstrated clinical accuracy and interobserver
reliability.
Received: 25 January 2000 Revision requested: 21 March 2000 Revision received: 31 March 2000 Accepted: 3 April 2000 相似文献
11.
Magnetic resonance imaging of articular cartilage 总被引:3,自引:0,他引:3
Recent advances in treatments of the cartilage abnormalities require more information on the extent and shape of cartilage abnormalities and need for early detection of the lesions. In this article we review MR appearance of the cartilage correlated with histology, MR-related artifacts for cartilage imaging, conventional and dedicated MR techniques suitable for the cartilage, and their clinical utilization. 相似文献
12.
Pradip K. Paul M. Kris Jasani David Sebok Ashok Rakhit Alan W. Dunton Frank L. Douglas 《Journal of magnetic resonance imaging : JMRI》1993,3(4):569-574
Signal intensity(SI) of individual pixels on sagittal magnetic resonance (MR)images of normal human knee cartilage was quantified to investigate whether it was related to cartilage proteoglycan content. In five subjects, images were acquired with spin-echo sequences with a TR msec/TE msec ofl,OOO or 7OO/2O and a three-dimensional gradient-echo(GRE)sequence (60/15). In a sixth subject, the GRE sequence alone was used with 15°,30°,and 50° flip angles. In all subjects, SI was maximal in pixel layers of the medial zone and minimal at both cartilage edges, resulting in the presence of a bell-shaped curve of interpixel(zonal) SI variation across the cartilage thickness. The magnitude of SI was dependent on the pulse sequence and flip angle, but the bell shape of the SI variation curve was independent of them. For example, in the medial tibial cartilage, the peak SI was highest with the 1,000/20 spin-echo sequence, intermediate with the 7OO/2O sequence, and lowest with the GRE sequence. The differences were statistically significant. The bell-shaped SI variation curve resembled the curve for zonal variation in cartilage proteoglycan content but not the curves for collagen or free water content. The physiologic basis for this resemblance and the potential usefulness of the findings for early diagnosis of diseases such as osteoarthritis are discussed. 相似文献
13.
N L Monson V M Haughton J M Modl L A Sether K C Ho 《Journal of magnetic resonance imaging : JMRI》1992,2(1):41-45
Histologic correlation of the different magnetic resonance (MR) appearances of articular cartilage has not been studied extensively. Therefore, the authors correlated thin (high-resolution) MR sections of articular cartilage with histologic sections. Human cadaver lumbar facet joints were imaged with a 1-mm section thickness and a 4-cm field of view, then sectioned and stained for histologic comparison. MR imaging patterns were identified that correlated with normal cartilage and three histologically different patterns of degeneration. 相似文献
14.
MRI of the cartilage 总被引:1,自引:0,他引:1
Imhof H Nöbauer-Huhmann IM Krestan C Gahleitner A Sulzbacher I Marlovits S Trattnig S 《European radiology》2002,12(11):2781-2793
With the introduction of fat-suppressed gradient-echo and fast spin-echo (FSE) sequences in clinical routine MR visualization
of the hyaline articular cartilage is routinely possible in the larger joints. While 3D gradient-echo with fat suppression
allows exact depiction of the thickness and surface of cartilage, FSE outlines the normal and abnormal internal structures
of the hyaline cartilage; therefore, both sequences seem to be necessary in a standard MRI protocol for cartilage visualization.
In diagnostically ambiguous cases, in which important therapeutic decisions are required, direct MR arthrography is the established
imaging standard as an add-on procedure. Despite the social impact and prevalence, until recent years there was a paucity
of knowledge about the pathogenesis of cartilage damage. With the introduction of high-resolution MRI with powerful surface
coils and fat-suppression techniques, visualization of the articular cartilage is now routinely possible in many joints. After
a short summary of the anatomy and physiology of the hyaline cartilage, the different MR imaging methods are discussed and
recommended standards are suggested.
Electronic Publication 相似文献
15.
Evaluation of grades 3 and 4 chondromalacia of the knee using T2*-weighted 3D gradient-echo articular cartilage imaging 总被引:2,自引:0,他引:2
Murphy BJ 《Skeletal radiology》2001,30(6):305-311
Objective. To determine the accuracy of T2*-weighted three-dimensional (3D) gradient-echo articular cartilage imaging in the identification
of grades 3 and 4 chondromalacia of the knee.
Design and patients. A retrospective evaluation of 80 patients who underwent both arthroscopic and MRI evaluation was performed. The 3D images
were interpreted by one observer without knowledge of the surgical results. The medial and lateral femoral condyles, the medial
and lateral tibial plateau, the patellar cartilage and trochlear groove were evaluated. MR cartilage images were considered
positive if focal reduction of cartilage thickness was present (grade 3 chondromalacia) or if complete loss of cartilage was
present (grade 4 chondromalacia). Comparison of the 3D MR results with the arthroscopic findings was performed.
Results. Eighty patients were included in the study group. A total of 480 articular cartilage sites were evaluated with MRI and arthroscopy.
Results of MR identification of grades 3 and 4 chondromalacia, all sites combined, were: sensitivity 83%, specificity 97%,
false negative rate 17%, false positive rate 3%, positive predictive value 87%, negative predictive value 95%, overall accuracy
93%.
Conclusion. The results demonstrate that T2*-weighted 3D gradient-echo articular cartilage imaging can identify grades 3 and 4 chondromalacia
of the knee.
Received: 18 April 2000 Revision requested: 18 July 2000 Revision received: 10 October 2000 Accepted: 27 November 2000 相似文献
16.
RATIONALE AND OBJECTIVES: The authors performed this study to (a) measure changes in T2 relaxation rates, signal-to-noise ratio (SNR), and contrast with sequential depletion of proteoglycan in cartilage; (b) determine whether there is a relationship between the T2 relaxation rate and proteoglycan in cartilage; and (c) compare the T2 mapping method with the spin-lattice relaxation time in the rotating frame (T1rho) mapping method in the quantification of proteoglycan-induced changes. MATERIALS AND METHODS: T2- and T1rho-weighted magnetic resonance (MR) images were obtained in five bovine patellae. All images were obtained with a 4-T whole-body MR unit and a 10-cm-diameter transmit-receive quadrature birdcage coil tuned to 170 MHz. T2 and T1rho maps were computed. RESULTS: The SNR and contrast on the T2-weighted images were, on average, about 43% lower than those on the corresponding T1rho-weighted images. The T2 relaxation rates varied randomly without any particular trend, which yielded a poor correlation with sequential depletion of proteoglycan (R2 = 0.008, P < .70). There was excellent linear correlation between the percentage of proteoglycan in the tissue and the T1rho relaxation rate (R2 = 0.85, P < .0001). CONCLUSION: T2-weighted imaging neither yields quantitative information about the changes in proteoglycan distribution in cartilage nor can be used for longitudinal studies to quantify proteoglycan-induced changes. T1rho-weighted imaging, however, is sensitive to sequential depletion of proteoglycan in bovine cartilage and can be used to quantify proteoglycan-induced changes. 相似文献
17.
Linda A. Jelicks Pradip K. Paul Elizabeth O'Byrne Raj K. Gupta 《Journal of magnetic resonance imaging : JMRI》1993,3(4):565-568
Viable bovine nasal cartilage was examined with magnetic resonance (MR) spectroscopy. Digestion of the proteoglycan matrix by papain or trypsin was accompanied by substantial changes in carbon-13, sodium-23, and hydrogen-1 MR spectra and relaxation parameters, with C-13 MR spectra showing the most pronounced changes. These results indicate the potential of MR spectroscopy (and imaging) for noninvasive evaluation of cartilage disease and monitoring of patients with degenerative joint diseases. 相似文献
18.
Terence C. F. Tan Dennis M. Wilcox Lawrence Frank Chunhsi Shih Deborah J. Trudell David J. Sartoris D. Resnick 《Skeletal radiology》1996,25(8):749-755
Objective. To assess hyaline cartilage of cadaveric ankles using different magnetic resonance (MR) imaging techniques and various methods
of measurement. Design and patients. Cartilage thicknesses of the talus and tibia were measured in ten cadaveric ankles by naked eye and by digitized image analysis
from MR images of fat-suppressed T1-weighted gradient recalled (FS-SPGR), sequences and pulsed transfer saturation sequences
with (FS-STS) and without fat-suppression (STS); these measurements were compared with those derived from direct inspection
of cadaveric sections. The accuracy and precision errors were evaluated statistically for each imaging technique as well as
measuring method. Contrast-to-noise ratios of cartilage versus joint fluid and marrow were compared for each of the imaging
sequences. Results. Statistically, measurements from FS-SPGR images were associated with the smallest estimation error. Precision error of measurements
derived from digitized image analysis was found to be smaller than that derived from naked eye measurements. Cartilage thickness
measurements in images from STS and FS-STS sequences revealed larger errors in both accuracy and precision. Interobserver
variance was larger in naked eye assessment of the cartilage. Contrast-to-noise ratio of cartilage versus joint fluid and
marrow was higher with FS-SPGR than with FS-STS or STS sequences. Conclusion. Of the sequences and measurement techniques studied, the FS-SPGR sequence combined with the use of digitized image analysis
provides the most accurate method for the assessment of ankle hyaline cartilage. 相似文献
19.
Non-invasive MRI assessment of the articular cartilage in clinical studies and experimental settings
Attrition and eventual loss of articular cartilage are important elements in the pathophysiology of osteoarthritis (OA). Preventing the breakdown of cartilage is believed to be critical to preserve the functional integrity of a joint. Chondral injuries are also common in the knee joint, and many patients benefit from cartilage repair. Magnetic resonance imaging (MRI) and advanced digital post-processing techniques have opened possibilities for in vivo analysis of cartilage morphology, structure, and function in healthy and diseased knee joints. Techniques of semi-quantitative scoring of human knee cartilage pathology and quantitative assessment of human cartilage have been developed. Cartilage thickness and volume have been quantified in humans as well as in small animals. MRI detected cartilage loss has been shown to be more sensitive than radiographs detecting joint space narrowing. It is possible to longitudinally study knee cartilage morphology with enough accuracy to follow the disease-caused changes and also evaluate the therapeutic effects of chondro-protective drugs. There are also several MRI methods that may allow evaluation of the glycosaminoglycan matrix or collagen network of articular cartilage, and may be more sensitive for the detection of early changes. The clinical relevance of these methods is being validated. With the development of new therapies for OA and cartilage injury, MR images will play an important role in the diagnosis, staging, and evaluation of the effectiveness of these therapies. 相似文献
20.
Autogenous osteochondral ”plug” transfer for the treatment of focal chondral defects: postoperative MR appearance with clinical correlation 总被引:7,自引:0,他引:7
Timothy G. Sanders Kurt D. Mentzer Mark D. Miller William B. Morrison Scot E. Campbell Brian J. Penrod 《Skeletal radiology》2001,30(10):570-578
Objective: To describe the MR appearance following autogenous osteochondral ”plug” transfer for the treatment of focal chondral defects
of the knee.
Design and patients: Twenty-nine 1.5-T MR knee studies including dynamic gadolinium enhancement were performed on 21 patients following autogenous
osteochondral ”plug” transfer. Three musculoskeletal radiologists retrospectively reviewed images to evaluate graft and donor
site appearance and MR findings were correlated with clinical outcomes.
Results: MR images demonstrated graft protuberance (n=12/21; range 1–2 mm), depression (n=2/21; range 1 mm), and surface incongruity: mild (n=17/21), moderate (n=2/21), marked (n=1/21). The T2 signal of graft cartilage was similar to that of adjacent cartilage in 25 of 29 examinations, and increased
in four. Graft cartilage thickness relative to adjacent cartilage was <50% in six patients, 50–100% in 15. Graft enhancement
in bone was absent at 2 weeks, but present at between 4 and 6 weeks following surgery. All patients had clinical follow-up
examinations and knee outcome survey scores were obtained in 15 patients with follow-up greater than 3 months after surgery.
All patients demonstrated the expected short-term progressive clinical improvement.
Conclusion: MR images reveal a wide range of appearances following osteochondral ”plug” transfer. Minor variations in graft orientation
and surface congruity do not result in adverse clinical outcome in the short term.
Received: 8 January 2001 Revision requested: 21 February 2001 Revision received: 6 March 2001 Accepted: 6 March 2001 相似文献