Use of a novel mechanical rinsing and aspiration thrombectomy device for treatment of deep venous and arteriovenous graft thrombosis

The KPS Rinspirator (Kerberos Proximal Solutions, Cupertino, Calif.) is a new thrombectomy device that operates by manually controlled, simultaneous, intravessel infusion and aspiration of fluid to cause localized clot dissolution. We evaluate the ability of the KPS Rinspirator to treat acute (<3 days) and subacute (3-7 days) deep venous and arteriovenous graft thrombosis in 4 patients and 13 vessels (2 arteriovenous grafts and 11 deep veins). Technical and clinical success was achieved in the two patients with acute arteriovenous graft thromboses. Therefore, in our experience, successful "rinspiration" was achieved in acute thrombosis of arteriovenous grafts.     

Iliocaval thrombosis: percutaneous treatment with hydrodynamic thrombectomy

Mechanical thrombectomy is of growing importance for the treatment of thrombus. Although there are numerous reports about dialysis fistulae and arterial thrombosis, venous applications are currently not well known. We report that an extensive venous thrombotic occlusion can be treated with mechanical thrombectomy, without additional local lysis. This report deals with the indication and technique of venous mechanical thrombectomy and discusses the possible applications. Received: 22 February 1999; Revised: 20 May 1999; Accepted: 29 July 1999     

Saline-jet aspiration thrombectomy catheter. Clinical results in patients with venous thrombosis

PURPOSE: To evaluate hydraulic thrombectomy using a saline-jet aspiration thrombectomy catheter in the treatment of venous thrombosis. MATERIAL AND METHODS: Ten patients underwent 12 hydraulic thrombectomy procedures using 2.7 or 4.0 mm catheters. The site of the thrombus was either central, peripheral or in portal veins. The age of the thrombi was between 2 and 60 days (mean 19.7 days). The efficacy of hydraulic thrombectomy was evaluated based on the aspirated thrombus ratio (ATR), i.e. the volume of the thrombus aspirated divided by the volume of the thrombus before thrombectomy. ATR was estimated by comparing the angiograms of the lesion before and after thrombectomy. RESULTS: Soft thrombi were usually rapidly removed. ATR was >2/3 in 3, 2/3-1/3 in 2, 1/3-0 in 4, and 0 in 1 patient. The activation time of the injector was 23-224 s (mean 102 s) and the volume of aspirated blood was 30-680 ml (mean 250 ml). Compensatory infusion of saline was performed for blood loss, and 400 ml of packed red blood cells was transfused in 1 patient. No complications of the hydraulic thrombectomy were observed. Thrombolysis or additional treatment were performed in 9 patients. CONCLUSION: Hydraulic thrombectomy using this catheter can contribute to the treatment of venous thrombosis.     

导管抽吸联合滤器保护治疗下腔静脉滤器血栓形成初步探讨

目的 评估导管抽吸联合滤器保护治疗下腔静脉滤器血栓形成(IVCFT)的安全性和有效性.方法 回顾性分析2017年6月至2019年11月东南大学附属中大医院收治的12例IVCFT患者临床资料.下肢静脉超声和肺动脉CTA明确下肢深静脉血栓形成(DVT)和肺栓塞(PE).健侧股静脉入路行下腔静脉滤器置入、导管抽吸清除血栓,并...     

Emergent right coronary artery thrombectomy with a jet aspiration thrombectomy catheter

A saline-jet aspiration thrombectomy (JAT) catheter was used in a patient with acute myocardial infarction. A right coronary arteriogram showed complete thrombotic occlusion at the proximal segment. With this catheter the thrombus was removed without complications in 5 sec. The patient underwent percutaneous transluminal coronary angioplasty and placement of a Palmaz-Schatz stent after successful thrombectomy. Thrombectomy with a JAT catheter was very useful in this patient.     

导管接触溶栓与手动经导管抽吸血栓清除术治疗急性肢体缺血临床效果对比

目的 比较导管接触溶栓(CDT)和手动经导管抽吸血栓清除术(mPAT)治疗急性肢体缺血(ALI)技术成功率和临床疗效.方法 回顾性分析2014年2月至2018年12月在两中心接受CDT或mPAT作为首选方法治疗的73例ALI患者临床资料,其中CDT组41例(41条患肢),mPAT组32例(33条患肢).观察两种治疗方法...     

手动机械性血栓碎吸治疗急性下肢深静脉血栓疗效

目的 分析急性下肢深静脉血栓形成(lower extremity deep venous thrombosis,LEDVT)的解剖部位,评价手动机械性血栓碎吸治疗的中、长期疗效.方法 回顾分析1998年4月至2011年3月745例急性LEDVT机械性血栓碎吸治疗的临床资料.根据静脉造影显示的血栓解剖部位,分为中央型258例(A组),混合型487例(B组),经健侧股静脉安置下腔静脉滤器,患侧股静脉插入8～14F鞘管手动机械性碎吸血栓.287例合并髂总静脉狭窄或闭塞,采取经皮血管腔内成形术和支架植入处理.随访16～147个月,平均(46±39)个月,根据临床症状及造影复查,评价两组患者的治疗效果.结果 出院时健、患肢膝上、下15 cm处周径差A组分别为(1.34±1.07)和(0.93±0.52)cm,B组分别为(2.89±1.53)和(1.72±0.89)cm,与术前比较差异均有统计学意义(t=19.46、24.13,P=0.000、0.000和t=16.14、17.79,P=0.000、0.000).随访发现患肢膝下15 cm处周径差A组下降为(0.53±0.42)cm,B组为(1.42±1.35)cm,组间差异有统计学意义(t=13.38,P=0.000).水肿、色素沉着、溃疡等后遗症发生率A组分别为27.91％(72/258)、13.18％(34/258)、0％;B组分别为35.12％(171/487)、22.59％(110/487)、2.46％(12/487),组间差异有统计学意义(x2=3.98,9.58,5.00,P=0.046,0.002,0.025).A组静脉通畅率为96.51％,瓣膜功能正常率为78.68％,B组分别为78.03％和56.47％,组间差异均有统计学意义(x2=52.70、40.57,P=0.000、0.000).随访疗效A组优占92.64％,B组占65.09％,组间差异均有统计学意义(x2=67.58,P=0.000).结论 急性LEDVT机械性血栓碎吸治疗,应根据血栓解剖分布类型指导治疗方案的选择;中央型单纯机械性血栓碎吸治疗效果最好,而混合型应配合系统溶栓可提高疗效.     

AngioJet血栓抽吸联合置管溶栓与单纯置管溶栓治疗门静脉血栓形成对比研究

【摘要】 目的 比较AngioJet血栓抽吸联合置管溶栓与单纯置管溶栓治疗门静脉血栓形成（PVT）的有效性和安全性。方法 回顾性分析2016年1月至2018年6月徐州医科大学附属医院收治的35例PVT患者临床资料。根据介入术式不同,分为AngioJet血栓抽吸联合置管溶栓治疗组（联合治疗组,n=16）和单纯置管溶栓组（n=19,置管溶栓组）。观察比较门静脉血栓清除率分级、导管溶栓时间、住院时间、尿激酶用量和手术相关并发症。术后随访比较门静脉通畅状态。结果 联合治疗组、置管溶栓组拔管后血栓清除率分级Ⅲ级患者分别有11例、2例,Ⅱ级分别有5例、14例,Ⅰ级分别有0例、3例,差异均有统计学意义（P＜0.05）;溶栓时间分别为（4.06±0.35） d、（5.26±0.40） d,住院时间分别为（10.56±0.76） d、（13.89±0.48） d,尿激酶用量分别为（161.25±12.58）万U、（208.42±18.00）万U,差异均有统计学意义（P＜0.05）。两组手术相关并发症差异无统计学意义,未出现致命性并发症。术后随访12个月,联合治疗组门静脉再通率显著高于置管溶栓组（P＜0.01）。两组患者住院期间均未出现严重肝肾功能损伤,均无致命溶栓并发症出现。 结论 AngioJet血栓抽吸联合置管溶栓治疗PVT安全有效,与单纯置管溶栓相比可提高血栓清除率,降低溶栓时间、住院时间及尿激酶用量,提高门静脉再通率。     

经皮血栓碎吸联合血管成形治疗髂静脉压迫综合征并深静脉血栓形成

目的探讨经皮血栓碎吸联合血管成形治疗髂静脉压迫综合征并下肢深静脉血栓形成的临床效果。资料与方法回顾性分析184例髂静脉压迫综合征并下肢深静脉血栓形成的病例资料。经皮穿刺患侧股静脉,在导丝引导下采用12～14 F鞘管抽吸髂、股静脉内血栓;对于股、腘静脉血栓,利用Fogarty球囊导管将血栓碎解、拖拉至髂静脉内,再行机械性血栓抽吸术。对髂静脉严重狭窄或闭塞者,行经皮腔内血管成形术或支架置入治疗。结果本组血栓清除率Ⅲ级80.98%,Ⅱ级19.02%;出院时患肢膝上、下15 cm 周径为（43.9±4.7） cm、（31.5±4.1） cm,与入院时相比其间差异有统计学意义（t=6.43,t=5.79,均P=0.000）。随访6～24个月,治疗有效率为97.75%;178例支架置入病人术后6、12、24个月彩色多普勒超声或 DSA 复查,支架通畅率为97.19%、94.94%、92.13%。结论血栓碎吸联合血管成形治疗髂静脉压迫综合征并下肢深静脉血栓形成,其近、中期疗效显著,住院时间短,是一种安全有效的介入治疗方法。     

Mechanical thrombectomy in patients with deep venous thrombosis

Purpose: To report our experience with mechanical thrombectomy in proximal deep vein thrombosis (DVT). Methods: Eighteen patients with a mean (± SD) age of 37.6 ± 16.1 years who presented with DVT in the iliac and femoral vein (n = 3), inferior vena cava (n = 5), or inferior vena cava and iliac vein (n = 10), were treated with the Amplatz Thrombectomy Device after insertion of a temporary caval filter. Results: Successful recanalization was achieved in 15 of 18 patients (83%). Overall, the percentage of thrombus removed was 66 ± 29%: 73 ± 30% at caval level and 55 ± 36% at iliofemoral level. Complementary interventions (seven patients) were balloon angioplasty (n = 2), angioplasty and stenting (n = 2), thrombo-aspiration alone (n = 1), thrombo-aspiration, balloon angioplasty, and permanent filter (n = 1), and permanent filter alone (n = 1). There was one in-hospital death. Follow-up was obtained at a mean of 29.6 months; three patients had died (two cancers, one myocardial infarction); 10 had no or minimal sequelae; one had post-phlebitic limb. Conclusion: Mechanical thrombectomy is a potential therapeutic option in patients presenting with proximal DVT.     

Mechanical thrombectomy for the treatment of lower extremity deep vein thrombosis

Deep venous thrombosis (DVT) has potentially debilitating long-term sequelae if left untreated. Conventional treatment (systemic anticoagulation with heparin followed by coumadin or low molecular weight heparin) often does not adequately relieves clot burden or symptoms, and patients may be left with post-thrombotic syndrome. Although the advent of catheter-directed thrombolysis has markedly improved the treatment of DVT and long-term outcomes of patients treated for DVT, it remains only partially effective on subacute or chronic clot. Mechanical thrombolysis may work synergistically with catheter-directed thrombolysis to decrease clot burden, treatment time, and complication rates, thereby improving outcomes.     

机械性血栓抽吸治疗中央型下肢深静脉血栓的临床疗效

目的探讨机械性血栓抽吸治疗中央型下肢深静脉血栓形成(lower extremity deep venous thrombosis,LED-VT)的临床疗效。方法回顾分析我院2005年4月～2009年1月236例急性中央型LEDVT病例的临床资料。经健侧股静脉置入下腔静脉滤器,患侧股静脉插入12～14F鞘管手动抽吸髂股段静脉血栓。112例合并髂静脉狭窄或闭塞患者,行PTA和支架置入术;术后辅以肝素抗凝治疗。结果出院时健、患肢膝上、下15cm处周径差降为(1.34±0.57)cm和(0.93±0.42)cm,与入院比较差异有统计学意义(t=19.37和23.99,P=0.00);随访16～48个月,中位随访35个月,随访率97.88%。术后36个月,水肿、色素沉着、溃疡等后遗症发生率:12.99%(30/231)、8.23%(19/231)、0%;静脉通畅率98.27%;随访疗效:优92.21%。支架置入术后12、24、36个月通畅率均100%。结论机械性血栓抽吸治疗中央型下肢深静脉血栓疗效显著,并发症少,住院周期短,能够明显降低后遗症的发生率。     

AngioJet机械性血栓抽吸联合导管接触溶栓治疗急性下肢深静脉血栓形成效果观察

目的 探讨经皮机械性血栓清除术(PMT)联合导管接触溶栓(CDT)治疗下肢深静脉血栓形成(DVT)的安全性和近期效果.方法 回顾性分析2017年1月至2018年12月徐州医科大学附属医院收治的56例急性中央型、混合型下肢DVT患者临床资料.其中28例接受AngioJet机械性血栓抽吸联合CDT治疗(A组),28例接受单...     

Manual aspiration thrombectomy with a standard PTCA guiding catheter for treatment of acute massive pulmonary thromboembolism

PURPOSE: To evaluate the efficacy and safety of percutaneous manual aspiration thrombectomy for the treatment of acute massive pulmonary thromboembolism with hemodynamic impairment. MATERIALS AND METHODS: Over a period of 6 years and 9 months, 15 patients with hemodynamic impairment (4 men, 11 women; aged 27-79 years) were treated by manual clot aspiration with a standard, large-lumen percutaneous transluminal coronary angioplasty (PTCA) guiding catheter. RESULTS: After treatment, angiography demonstrated improvement of pulmonary perfusion in all patients (mean Miller score: before treatment 18.9, after treatment 12.1; P < 0.01). Mean pulmonary arterial pressure decreased from 29.6 to 22.5 mmHg (P < 0.01). The mean treatment time was 114.2 min. All of the patients survived and their clinical status improved. No patient had any significant complication. CONCLUSION: Percutaneous manual aspiration thrombectomy with a standard 8 Fr PTCA guiding catheter achieved rapid, safe improvement of the hemodynamic situation in cases of acute massive pulmonary thromboembolism, with low cost both in terms of time and money.     

Mechanical thrombectomy of acute iliofemoral deep vein thrombosis with use of an Arrow-Trerotola percutaneous thrombectomy device

PURPOSE: To evaluate the immediate and 1-year clinical outcomes of mechanical thrombectomy with use of the Arrow-Trerotola percutaneous thrombectomy device (PTD) with or without low-dose urokinase in the treatment of acute iliofemoral deep vein thrombosis (DVT). MATERIALS AND METHODS: Mechanical thrombectomy with the PTD was performed in 25 patients with acute iliofemoral DVT. Thrombolytic therapy with low-dose urokinase was used in all patients without contraindications (n = 20). Other therapies used in combination included inferior vena cava filter insertion (n = 5), sheath aspiration thrombectomy (n = 25), and angioplasty and stent placement (n = 20). RESULTS: Initial technical and clinical success was achieved in all cases. In the 20 patients who had no contraindications to the use of urokinase, the dosage of urokinase did not exceed 1 million IU (range, 360,000-1,000,000 IU; mean, 640,000 IU). The mean time of urokinase infusion was 16 hours (range, 12-20). In five patients who had a contraindication to the use of urokinase, mechanical thrombectomy with the PTD was successful without the use of urokinase. There were no major complications. Primary patency of the stent-implanted common iliac vein segment was achieved at 1 year in 17 of 20 patients (85%). The overall 1-year clinical success rate was 92% (23 of 25 patients). Valvular insufficiency occurred in two patients (8%). CONCLUSION: The PTD is an effective mechanical thrombectomy device in the treatment of acute iliofemoral DVT with or without adjunctive urokinase thrombolysis.     

机械性血栓清除装置治疗深静脉血栓的临床研究现状

相对于传统溶栓治疗,机械性血栓清除术具有即刻恢复血流、缩短溶栓时间、减少溶栓剂剂量等优势,是治疗深静脉血栓最有前景的方案。本文就目前临床常用于深静脉血栓治疗的机械性血栓清除装置进行综述如下。     

Combined aspiration thrombectomy and continuous intrasinus thrombolysis for cerebral venous sinus thrombosis: technical note and case series

Cerebral venous sinus thrombosis is an uncommon cause of stroke with high morbidity and mortality rates from venous infarction, intracranial hemorrhage, and extensive cerebral edema. Endovascular treatment with various devices has been proposed as a salvage treatment when standard medical treatment with systemic anticoagulation is ineffective, especially in long segment dural sinus thrombosis. We describe our technique of transvenous endovascular aspiration thrombectomy with large bore thrombectomy catheters, followed by placement of microcatheter for local thrombolytic infusion at the site of thrombosis. We report a retrospective study of angiographic and clinical outcome of six consecutive patients treated with this approach. Endovascular aspiration thrombectomy with large bore catheters followed by continuous local thrombolytic infusion appeared to be a safe and effective salvage treatment for selected patients with cerebral dural venous sinus thrombosis refractory to medical treatment.