本刊对来搞的相关要求

正论著需附中、英文摘要。一般论著采用结构式摘要,即应包括研究目的、方法、结果和结论。结果中务必包含主要数据。病例报道类论著可用叙述式摘要。中文摘要一般采用第三人称撰写,不列图表,不引用文献,不加评论和解释。摘要中的缩略语、代号等,除公知公认者外,首次出现时需注明全称。中文摘要一般(300~500)个汉字;英文摘要应多于200个实词,一般与中文摘要内容相对应。关键词论著需标引(2~5)个关键词。关键词尽量从美国国立医学图书馆的Me SH数据库(http://     

本刊对来稿的相关要求

正摘要论著需附中、英文摘要。一般论著采用结构式摘要,即应包括研究目的、方法、结果和结论。结果中务必包含主要数据。病例报道类论著可用叙述式摘要。中文摘要一般采用第三人称撰写,不列图表,不引用文献,不加评论和解释。摘要中的缩略语、代号等,除公知公认者外,首次出现时需注明全称。中文摘要一般(300~500)个汉字;英文摘要应多于200个实词,一般与中文摘要内容相对应。关键词论著需标引(2~5)个关键词。关键词尽量从美国国立医学图书馆的Me SH数据库(http://www.ncbi.nlm.nih.gov)中选取,其中文译名可参照中国医学科学院信息研究所编译的《医学主题词注释字顺     

本刊对来稿的相关要求

关键词论著需标引2～5个关键词。关键词尽量从美国国立医学图书馆的MeSH数据库（http：／／www．nebi．nlm．nih．gov）中选取，其中文译名可参照中国医学科学院信息研究所编译的《医学主题词注释字顺表》。中医药关键词应从中国中医科学院中医药信息研究所编写的《中医药主题词表》中选取。     

本刊对来稿的相关要求

正关键词论著需标引2~5个关键词。关键词尽量从美国国立医学图书馆的Me SH数据库(http://www.ncbi.nlm.nih.gov)中选取,其中文译名可参照中国医学科学院信息研究所编译的《医学主题词注释字顺表》。中医药关键词应从中国中医科学院中医药信息研究所编写的《中医药主题词表》中选取。有英文摘要的文章,应标注与中文对应的英文关键词。关键词中的缩写词应按《医学主题词注释字顺表》还原为全称;每个英文关     

本刊1996年工作中的几点改进意见

本刊１９９６年工作中的几点改进意见：１．从１９９６年第一期始，本刊论著文章的中英文摘要改为结构式摘要。摘要一般以“为了……”开头，内容中包含目的、方法、结果、结论四大要素，字数在４００～５００字内为宜，并附关键词（主题词）ｌ～３个。中英文摘要内容要基本保持一致。请作者注意，从现在起，投稿的中英文摘要就要写成结构式摘要。２．从１９９６年第一期始，文章中的图题及表题中（包括图表中各横、竖栏文字）均用中文和英文两种文字（中文在上，英文在下）表达。从现在起，请作者投稿时注意正确运用两种文字。图题和表题都…     

干细胞治疗大疱性表皮松解症的文献计量学和可视化分析

目的 利用文献计量学对干细胞治疗大疱性表皮松解症的研究进行可视化分析，归纳研究热点和热门方向，为该领域的研究工作者的研究提供参考。方法 基于Web of Science核心数据库，通过结合Citespace6.1和VOSviewer 1.6.15对1993-2022年的年发文量、关键词、作者、机构、国家、期刊和被引情况等进行可视化分析。结果 筛选后共纳入535篇文献，目前干细胞治疗大疱性表皮松解症的相关研究的文献数量呈较高的增长趋势；美国是发文量最多的国家，文献数量（21），去除自引后总被引频次（8006）,H指数（51），中介中心度（0.41）均位居世界第一。中国学者的文献数量（219），去除自引后总被引频次（346）,H指数（8）虽然位居世界第十，但中心度（0.02）和篇均被引频次（16.48）较低，说明受关注程度及学术影响力不足，在发文质量上还有待提高。该领域的主要研究方向为皮肤科、细胞生物学、研究实验医学、生物技术应用微生物学。该领域的研究内容主要关注表皮干细胞、vii胶原蛋白、基因治疗、移植等方面的内容。通过对关键词进行聚类分析后得出前十关键词聚类分别为单纯性大疱性表皮松解、...     

《国外医学》皮肤性病学分册第二十五卷(1999年)主题索引

使用说明:①本索引按《医学主题词注释字顺表》标引主题。②主题词按首字汉语拼音字母顺序排列,以外文字母为首字的主题词排在最后。③同一主题词下的副主题词,     

关于本刊对文章关键词的标引要求

关键词是为了便于作文献索引、榆索和阅读而选取的能反映文章主题概念的词或词组，一般每篇论文选取2-5个关键词。关键词啦堪量从美同同直医学图书馆编印的，Medical Subject Headings（MeSH）中选取，其中文译名可参照中国医学科学院信息研究所编译的《医学卞题词汇注释字顺表》。未被问表收录的词（自由词）必要时也可以作为关键词使用。中医药关键词应从中国中医研究院中医药信息研究所编写的《中医药主题词表》中选取。有英文摘要的文章，腑标汴与中文对应的英文关键词。推荐将中、英文关键词川显著字体分别排在中、英文摘要下方。     

《国际皮肤性病学杂志》2013年第39卷主题词索引

使用说明：①本索引按《中文医学主题词表》标引。②主题词按首字汉语拼音字母顺序排列,以外文字母为首字的主题词排在最后。③作者后括号内数字为期号,最后为起页。④因篇幅所限,每篇文题仅以一个主题词条目出现,该文其他主题词以“见”表示。     

《中国医学文摘·皮肤科学》1996年全年主题索引

【说明】l·每篇屯献标引～一个或多个规范化的主题词二主题词后面暇列文摘顺序号 3为了加强主题词的专指性,采用规定的组配词加以组配。组配符号为“一～”.例如:皮肤病的诊断标皮肤病一诊断} 4主题词均按汉语拼音字母顺序排矽-。同音字按四声区剐;同声字按笔划多少排列;第一字相同时.昧次按第二、三字……拼音字母顺序排列;多音或多声字按使用习惯排列; Aa阿 5·主题词前冠有拉丁字母或希腊字母,均按汉字拼音排列·顺序排在同音主题词之看;常用的拉丁名缩写。按拉丁字母顺序排列; 6·标引主题词使用的:t肄书为《医学主题词波:释字顺表≯f…     

Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease

The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR complexes have been implicated in the development and progression of various skin diseases including melanoma, psoriasis, and acne vulgaris. Here, we review the role of both mTORC1 and mTORC2 as well as their upstream modulators, phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), and their downstream targets in various dermatologic diseases. Phytochemicals, plant-derived naturally occurring compounds, have been shown to regulate the mTOR pathway and may serve as novel therapeutic agents in dermatological disease. Here, we review phytochemicals in the context of the mTOR pathway and their potential use in cutaneous disease.     

Bullous Systemic Lupus Erythematosus: A Review and Update to Diagnosis and Treatment

Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous complication of systemic lupus erythematosus (SLE). It is a heterogeneous disease that is caused by autoantibodies to the dermoepidermal junction, mainly type VII collagen. Similarities in histology and immunopathology exist between BSLE and other primary bullous dermatoses, namely dermatitis herpetiformis (DH) and epidermolysis bullosa acquisita (EBA), respectively. EBA and BSLE commonly share the same autoantibody to type VII collagen and heterogeneous clinical presentations, creating a diagnostic challenge. However, clinical presentation combined with histology, immunological testing, and concomitant diagnosis of SLE distinguish this entity from other similar dermatoses. Diagnosis of this disease is important given its coexistence with SLE and its many complications. New developments in IgG subtyping have shown subtle variations in IgG subtypes between EBA and BSLE. In addition, rituximab was recently found to be efficacious in recalcitrant cases of BSLE that do not respond to dapsone and immunosuppressants. We review the topic of BSLE with emphasis on clinical, histologic, and immunopathologic features, as well as new methods of diagnosis and treatment.     

Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer

Actinic cheilitis exhibits a potential of malignant transformation in 10–20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases with a clinical and histopathological diagnosis of AC (n = 26) and SCC (n = 25) and specimens of labial semi-mucosa (n = 15) without clinical alterations or inflammation. The tissue samples were stained with hematoxylin-eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by the Kruskal–Wallis and Dunn’s tests (5 %). The median expression of MDM2 (kW = 36.8565; df = 3?1 = 2; p = 0.0001) and SUMO-1 (kW = 32.7080; df = 3?1 = 2; p = 0.0001) was similar in cases of AC and SCC of the lip, but differed significantly from that observed for normal labial semi-mucosa. Despite the limitations of the present study, immunohistochemistry demonstrated the overexpression of important proteins (MDM2 and SUMO-1) related to regulatory mechanisms of apoptosis in AC and SCC of the lip, but further studies are needed.     

Splicing mutation in MVK is a cause of porokeratosis of Mibelli

Porokeratosis is a chronic skin disorder characterized by the presence of patches with elevated, thick, keratotic borders, with histological cornoid lamella. Classic porokeratosis of Mibelli (PM) frequently appears in childhood with a risk of malignant transformation. Disseminated superficial actinic porokeratosis (DSAP) is the most common subtype of porokeratosis with genetic heterogeneities, and mevalonate kinase gene (MVK) mutations have been identified in minor portion of DSAP families of Chinese origin. To confirm the previous findings about MVK mutations in DSAP patients and test MVK’s role(s) in PM development, we performed genomic sequence analysis for 3 DSAP families and 1 PM family of Chinese origin. We identified a splicing mutation of MVK gene, designated as c.1039+1G>A, in the PM family. No MVK mutations were found in three DSAP families. Sequence analysis for complementary DNA templates from PM lesions of all patients revealed a mutation at splice donor site of intron 10, designated as c.1039+1G>A, leading to the splicing defect and termination codon 52 amino acids after exon 10. Although no MVK mutations in DSAP patients were found as reported previously, we identified MVK simultaneously responsible for PM development.     

A novel frameshift mutation in the cylindromatosis (CYLD) gene in a Chinese family with multiple familial trichoepithelioma

Multiple familial trichoepithelioma (MFT) (OMIM: 601606) is an autosomal dominantly inherited disorder characterized by numerous, skin-colored papules and nodules with pilar differentiation. Recently, several mutations in the cylindromatosis (CYLD) gene have been reported in MFT. In this study, a mutation analysis of the CYLD was conducted in a Chinese pedigree of typical MFT. Affected individuals were identified through probands from Shanxi Province, China. Lesional skin biopsy of the proband revealed the typical histopathological characteristics of trichoepithelioma. Individuals belonging to five consecutive generations were similarly affected, which indicated an autosomal dominant inheritance pattern. Genomic DNA was extracted from peripheral blood lymphocytes using standard phenol/chloroform extraction method. All the coding exons (4–20) and exon–intron boundaries of the CYLD gene were amplified by polymerase chain reaction (PCR). Direct sequencing of all PCR products amplified from the complete coding regions of the CYLD gene was performed to identify mutations. Sequencing of the CYLD gene was performed in a further 100 unrelated, unaffected control individuals to exclude the possibility of polymorphism. A novel heterozygous frameshift mutation c.1169_1170delCA (p.Thr390Argfs) was identified in exon 10 of the CYLD gene in the affected family members. This mutation was also detected in unaffected family members, but not in the unrelated, healthy individuals who were also analyzed. Our study expands the database on the CYLD gene mutations in MFT and should be useful in providing genetic counseling and prenatal diagnosis for families affected by MFT.     

Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers

Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treated keratinocytes cultured from those biopsies. We report for the first time the expression of some of these genes in healthy skin. Our results suggest that vitamin D may modulate the expression of some MMP gene family members in keratinocytes. Gene expression in DFU and in non-diabetic healthy skin (control) biopsies was evaluated by RT-qPCR for MMP-1, MMP-3, MMP-8, MMP-9, MMP-10, MMP-19, TIMP-1 and TIMP-2, and also by immunohistochemistry for MMP-1 and MMP-9. Primary keratinocytes cultured from DFU and healthy skin biopsies were used for gene expression analyses of selected MMPs and TIMPs by RT-qPCR, both in the presence and absence of calcitriol. The expression of MMP-1, MMP-8, MMP-9, MMP-10, and TIMP-2 in healthy skin is reported here for the first time. DFUs showed increased MMP-1, MMP-9 and TIMP-1 expression, compared to healthy skin. Calcitriol down-regulated MMP-1 and MMP-10 expression in DFU-derived keratinocytes but not in those derived from healthy skin. Our data demonstrate the expression of certain MMPs that had not been previously described in healthy skin, and further support previous reports of MMP and TIMP up-regulation in DFUs. Our results point to calcitriol as a potential modulator for the expression of certain MMP members in DFUs.     

An association study on the CHRNA5/A3/B4 gene cluster,smoking and psoriasis vulgaris

Genome-wide association and large cohort studies have consistently linked several single nucleotide polymorphisms (SNPs) located in the CHRNA5/A3/B4 gene cluster to smoking behaviors and nicotine dependence. Smoking is one of the well-established environmental risk factors for psoriasis and also associated with severity of the disease. Then we conduct the study to examine whether the genetic variations related to smoking behavior located in the CHRNA5/A3/B4 gene cluster also predict the risk of psoriasis vulgaris (PV). The investigations may help explain the mechanisms of the smoking-PV relationship. This is a hospital base case–control study including 634 subjects (329 PV patients and 305 controls), all Chinese Han population. 8 SNPs were selected based on findings from recent studies on smoking and nicotine dependence, all located in the nicotinic acetylcholine receptor subunits CHRNA5/A3/B4 gene cluster. The variants were typed by SNaPshot Multiplex Kit (Applied Biosystems Co., USA). We confirmed that smoking, alcohol consumption and higher body mass index (BMI ≥25) were risk factors for PV. However, none of the selected SNPs was associated with PV risk in the overall analysis and stratification analysis. And we found no association between the selected SNPs in CHRNA5/A3/B4 gene cluster and the clinical features of PV in case-only analysis. This exploratory study does not provide a relationship between these smoking-related SNPs in the CHRNA5/A3/B4 gene cluster and PV in Chinese Han population.     

Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris

In acne vulgaris, antimicrobial peptides (AMPs) could play a dual role; i.e., protective by acting against Propionibacterium acnes, pro-inflammatory by acting as signalling molecules. The cutaneous expression of 15 different AMPs was investigated in acne patients; furthermore, the impact of isotretinoin therapy on AMP expression was analysed in skin biopsies from 13 patients with acne vulgaris taken before, during and after a 6-month treatment cycle with isotretinoin using quantitative real-time polymerase chain reaction. Cutaneous expression of the AMPs cathelicidin, human β-defensin-2 (HBD-2), lactoferrin, lysozyme, psoriasin (S100A7), koebnerisin (S100A15), and RNase 7 was upregulated in untreated acne vulgaris, whereas α-defensin-1 (HNP-1) was downregulated compared to controls. While relative expression levels of cathelicidin, HBD-2, lactoferrin, psoriasin (S100A7), and koebnerisin (S100A15) decreased during isotretinoin treatment, only those of cathelicidin and koebnerisin returned to normal after 6 months of isotretinoin therapy. The increased expression of lysozyme and RNase 7 remained unaffected by isotretinoin treatment. The levels of granulysin, RANTES (CCL5), perforin, CXCL9, substance P, chromogranin B, and dermcidin were not regulated in untreated acne patients and isotretinoin had no effect on these AMPs. In conclusion, the expression of various AMPs is altered in acne vulgaris. Isotretinoin therapy normalizes the cutaneous production of distinct AMPs while the expression of others is still increased in healing acne. Considering the antimicrobial and pro-inflammatory role of AMPs, these molecules could serve as specific targets for acne therapy and maintenance of clinical remission.     

Analysis of acne‐related judicial precedents from 1997 to 2018 in South Korea

Medicolegal disputes are increasing in practical medicine. Medications or procedures related to acne could lead to medical malpractice. This study analyzed medical litigation associated with acne in South Korea. Acne‐related judgments were searched using the Supreme Court of Korea’s Written Judgment Management System based on the keyword “acne”. Eleven cases were selected; eight cases were related to acne scar and three cases were related to acne. Treatment modalities such as peeling, laser treatment, photodynamic therapy and antibiotics resulted in lawsuits. Claimed sequelae of the treatments were hyperpigmentation, scar worsening, erythema, skin bumps and liver transplant. Eight cases were awarded to the plaintiff, and the others were dismissed. This study shows that various treatments for acne can cause medical disputes.