在体女性盆腔动脉血管网数字化三维模型构建方法及意义

目的探讨构建在体女性盆腔动脉血管网数字化三维模型的方法及意义。方法基于双源CT血管成像(CTA)技术,获取1例子宫腺肌病患者的D icom 3.0原始二维断层图像数据集。利用M im ics10.01软件分别对骨盆、盆腔动脉血管网进行三维重建并配准融合。结果构建的在体女性盆腔动脉血管网数字化三维模型可以清楚地显示髂总动脉、髂外动脉、髂内动脉及其多级分支,甚至子宫动脉上行支等。与重建的骨盆配准融合后,各支动脉血管的解剖走行及供血范围变得更加清晰明确。结论基于CTA数据集,应用适当的计算机软件可构建出理想的在体女性盆腔动脉血管网数字化三维模型,为术前手术模拟真人化以及数字模型物理化提供了平台。     

基于CT血管成像在体宫颈癌动脉血管网数字化三维模型的构建及意义

目的探讨利用CT血管成像(CTA)原始数据集构建在体宫颈癌动脉血管网数字化三维模型的方法及意义。方法 2010年5月在南方医科大学南方医院基于双源CTA技术,获取1例宫颈癌患者的CT-Dicom 3.0原始二维断层图像数据集。利用Mimics软件分别构建其骨盆、宫颈癌动脉血管网数字化三维模型并配准融合。结果构建的宫颈癌动脉血管网数字化三维模型不仅可以清楚地显示盆腔动脉血管网的各级分支,而且可多方位、多角度地观察各级动脉的管径、长度及分叉角度。此外,其还可进一步了解癌灶供血动脉及计算癌灶血容量。结论基于CTA数据集,应用计算机三维重建技术可构建出理想的宫颈癌动脉血管网数字化三维模型,为临床实现宫颈癌患者的个性化评估及治疗提供了平台。     

数字化三维影像学与子宫肌瘤子宫动脉栓塞治疗

子宫肌瘤子宫动脉栓塞（UAE）治疗是通过栓塞肌瘤的动脉血管网而达到治疗的目的,因疗效确切、微创,深受要求保留子宫的肌瘤患者欢迎。但该术式仍有10%的患者效果不佳以及一定的并发症发生率。在术前筛选合适的病例、评估手术可行性及判断预后是进一步提高疗效、降低并发症发生的关键。传统的影像学手段不能达到上述目的,但应用数字化三维重建技术对患者的影像学原始数据集进行重建,可再现患者子宫及肌瘤的个体化血管解剖,为UAE的操作提供可视化动脉血管网模型,是解决上述关键问题的新兴手段。     

基于CT血管成像在体子宫肌瘤动脉血管网数字化三维模型构建的方法及意义

目的 探讨利用CT血管成像原始数据集构建在体子宫肌瘤动脉血管网数字化三维模型的方法及意义. 方法 采用双源CTA技术获取1例子宫肌瘤患者的CT-Dicom 3.0原始二维断层图像数据集.利用Mimics软件分别构建其骨盆、子宫肌瘤动脉血管网数字化三维模型并配准融合. 结果 构建的子宫肌瘤动脉血管网数字化三维模型可以...     

宫颈癌子宫动脉血管网三维模型的构建

目的 研究宫颈癌子宫动脉血管网的解剖学形态及血供分布情况.方法 2008年9月南方医科大学南方医院妇产科获取经病理证实的宫颈癌子宫、双附件及阴道标本一套,用15%的过氯乙烯填充剂经子宫动脉和卵巢动脉行分色灌注并铸型,观察宫颈癌子宫动脉血管网的解剖学形态及血供分配.结果 构建宫颈癌子宫动脉血管网模型具有子宫动脉血管网的基本形态特征,可清楚显示子宫动脉各主要分支、次级分支和细小血管网结构.宫颈癌癌灶部位血供丰富,血管形态紊乱,由双侧子宫动脉下行支供应,以患侧为主,但与对侧存在丰富的交通支,供血范围超过正常宫颈范围并包括部分阴道上段及左侧宫颈旁转移病灶;子宫动脉上行支近宫颈内口处的螺旋动脉通过交通支也参加部分供血.结论 应用血管铸型技术可成功构建宫颈癌子宫动脉血管网三维模型,通过模型可了解子宫动脉血管网及宫颈癌病灶的血供特点.     

瘢痕妊娠动脉血管网数字化三维模型重建及意义

目的:探讨剖宫产瘢痕妊娠(CSP)数字化三维模型的构建方法及其在患者行子宫动脉栓塞术(UAE)中的应用和意义。方法:将10例CSP患者随机分为实验组和对照组,各5例。实验组:UAE术前行双源CTA扫描,获取CTA原始图像后利用Mimics10.01软件对盆腔动脉系统进行三维重建,将构建的CSP数字化三维模型用于指导UAE手术操作;对照组:常规行UAE手术。比较两组的手术时间、辐射时间、术后止血时间和副反应发生率。结果:5例CSP数字化三维模型重建特点:2例患者的病灶由双侧子宫动脉和卵巢动脉共同供血,3例仅由双侧子宫动脉供血;患者均双侧血供不均衡,其中3例以左侧为主,2例右侧为主。三维模型与DSA图形结果对比:DSA可显示病灶的血供来源,但1例有卵巢动脉供血的患者DSA图像未见卵巢动脉显影。三维重建可清晰显示动脉的开口角度和走行特点。10例患者UAE术后均无明显并发症发生。实验组的平均手术时间、辐射时间为(39.54±3.12)min和(9.41±0.83)min,显著小于对照组的(46.01±3.65)min和(11.75±1.63)min,差异均有统计学意义(P0.05)。两组的术后止血时间无统计学差异。结论:CSP的数字化三维模型可用于UAE的术前和术中指导,缩短CSP-UAE的手术时间和辐射剂量,并为模拟手术平台的建立提供基础。     

基于CT数据人离体胎盘血管网数字化三维模型重建研究

目的 探讨利用CT原始数据进行人离体胎盘血管网数字化三维模型重建的方法及应用。方法   选取2012年5月南方医科大学南方医院妇产科人正常妊娠足月离体胎盘20例,胎盘动脉灌注后进行增强CT扫描并获取DICOM原始数据集,随后行胎盘静脉灌注,胎盘标本再次行增强CT扫描,得到DICOM原始数据集。将两次数据导入Mimics 10.01软件分别重建得到胎盘动脉血管网及胎盘动静脉血管网的数字化三维模型。对CT扫描后的胎盘标本进行强酸腐蚀,得到胎盘血管铸型。对比同一胎盘标本的血管网数字化三维模型及血管铸型,明确数字化三维模型反映胎盘血管形态结构及走行的真实性和准确性。结果   基于CT原始数据,利用Mimics 10.01软件成功构建出胎盘血管网数字化三维模型。重建得到的模型立体感强,三维效果逼真,具有较佳的视觉效果,与胎盘血管铸型一致性高,可以清晰地再现胎盘动静脉各级血管分支的解剖形态结构,且可进行任意缩放、任意角度旋转观察。结论   基于CT原始数据构建的胎盘血管网数字化三维模型可全面、真实地展示胎盘血管,是一种胎盘血管研究的新方法;该模型的建立为后续研究提供了一定的三维重建的技术基础。     

子宫肌瘤肉瘤变特点及其相关问题

子宫肌瘤是女性生殖系统最常见的良性肿瘤,肌瘤肉瘤变属恶性变,其发生率虽低,但恶性度高、预后差,临床上具有术前诊断难度大,术中冰冻病检要求高,术后处理争议多的特点。文章对子宫肌瘤肉瘤变的临床特点、诊治现状及相关问题作一阐述,为临床医师规范化诊治本病提供参考。     

局部晚期宫颈癌癌灶动脉血管网特点及意义

宫颈癌的诊断是基于妇科各种检查,在诊断上存在主观性强,难以精确诊断宫旁组织受侵程度以及膀胱直肠浸润程度等问题,尤其是局部晚期宫颈癌（locally advanced cervical cancer,LACC）。LACC还有较多的高危因素,预后不良,对治疗方式的选择一直以来争议较大。通过对LACC数字化三维动脉血管网的定性定量分析,可以判断宫颈癌灶的局部大小、浸润深度,通过供血动脉来源及血流特点来精确诊断癌灶侵犯阴道、宫体、宫旁及邻近器官的情况及范围。通过LACC数字化三维动脉血管网的分析,为选择合适的手术方式并评估手术难度及预后提供依据。     

腹腔镜子宫肌瘤剔除术相关临床问题

腹腔镜子宫肌瘤剔除术已经成为治疗子宫肌瘤的重要术式,具有微创手术的优点。但由于腹腔镜手术本身的特点和技术局限,正确选择手术适应证和掌握良好的手术技巧,对保证手术效果,减少近期和远期的手术并发症尤其重要。     

子宫动脉血管网建模与子宫动脉栓塞术

子宫动脉栓塞术(UAE)是在子宫动脉血管内的手术.基于血管铸型技术构建的子宫动脉血管网模型成为我们研究子宫动脉血管网形态学的首个途径:它真实地显示了三维的子宫动脉及其血管网的解剖学特点,为UAE中如何正确操作避免部分并发症的发生并提高疗效提供了解剖学依据,也为进一步进行子宫动脉血管网的数字化研究奠定了基础.     

Potential synergism between ulipristal acetate and vitamin D3 in uterine fibroid pharmacotherapy – 2 case studies

Abstract

This is a preliminary report of the first cases of successful simultaneous use of ulipristal acetate (UPA) and vitamin D3 in uterine fibroid (UF) oral treatment in humans. We present two cases of 37- and 49-year-old females with clinically symptomatic UFs and vitamin D deficiency. Both patients were treated with a standard 3?months of UPA scheme (5?mg daily) with the additional use of vitamin D3 (7000?IU daily orally). In the 37-year-old female all the symptoms (pain, pressure, frequent urination) decreased, total tumor volume after the treatment changed by 47.8%. In the 49-year-old female most symptoms perished, total tumor volume was reduced by 63.3%. UPA and vitamin D share synergistic anti-fibroid properties. Further studies are necessary to show the exact effect of UPA and vitamin D as co-drugs.     

Hysteroscopy after uterine fibroid embolization in women of fertile age

AIM: Uterine artery embolization for fibroids is a controversial issue for women with incomplete reproductive plans. Ovarian failure and uterine infection are the most dreaded complications of this procedure. The purpose of the present study was to assess the types and the frequency of intrauterine abnormalities and the histological features of the endometrium after embolization. METHODS: Uterine artery embolization was performed on 51 women (average age 34.5 years) with intramural fibroid/s larger than 4 cm. Hysteroscopy and endometrial biopsy was performed from 3 to 9 months later in the luteal phase of the cycle. RESULTS: Despite all women having no major symptoms prior to hysteroscopy, only 19 (37%) had completely normal hysteroscopic findings. There was intrauterine protrusion of fibroid/s in 19 cases (37%), yellowish coloration of the endometrium in 14 (28%), intrauterine or cervical adhesions in seven (14%), and communication between the myoma and the uterine cavity in five cases (10%). A normal, functional endometrium was histologically verified in 44 women of 49 (90%) who could be evaluated. Regressive changes (necrosis or hyalinization) of leiomyoma or of indefinite origin were found in 17 patients and embolization particles in five, including one patient with microspheres inside the endometrial vessel. No case of Asherman syndrome or endometrial atrophy was observed. CONCLUSION: The frequency of abnormal hysteroscopic findings after embolization is surprisingly high. The clinical significance, reversibility, and impact on fertility of abnormal hysteroscopic findings after embolization remain unclear. Regardless, hysteroscopy should be strongly recommended to all patients after uterine fibroid embolization, prior to conception.     

Non-puerperal incomplete uterine inversion due to large sub-mucous fundal fibroid found at hysterectomy: a report of two cases

Two cases of non-puerperal incomplete uterine inversion due to large sub-mucous fundal fibroid are presented. This is rare and the diagnosis is often difficult. In both the cases diagnosis was made only during surgery.     

Treatment of uterine fibroids for abnormal uterine bleeding: myomectomy and uterine artery embolization

Uterine myoma is a common benign tumour in women and most cases do not require treatment. Excessive uterine bleeding is usually due to a submucous myoma or an intramural myoma that is encroaching into the uterine cavity. After eliminating endometrial malignancy, perimenopausal women could be managed expectantly or with gonadotrophin-releasing hormone agonist until menopause. Hysteroscopic myomectomy is highly effective in controlling menorrhagia that is related to submucous myoma. Concomitant endometrial ablation improves menorrhagia; however, the subsequent hysterectomy rate remains the same. For those with an intramural myoma, abdominal myomectomy results in good bleeding control. It could also be done by laparoscopic approach; however, the surgeon should have expertise in laparoscopic suturing and the uterine incision should be properly sutured. In women who have completed their family, hysterectomy remains the most effective treatment for excessive uterine bleeding. Compared with uterine artery embolization (UAE), it is associated with better improvement in pelvic pain. Nevertheless, UAE is a good alternative to hysterectomy.