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Objective

To review current non-pharmacologic and pharmacologic options for ovulation induction in women with polycystic ovary syndrome (PCOS).

Options

This guideline reviews the evidence for the various options for ovulation induction in PCOS.

Outcomes

Ovulation, pregnancy and live birth rates, risks, and side effects are the outcomes of interest.

Evidence

Published literature was retrieved through searches of Medline using appropriate controlled vocabulary and key words. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. Grey (unpublished) literature was identified through searching the websites of health technology assessment and of health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies.

Values

The evidence gathered was reviewed and evaluated by the Reproductive Endocrinology and Infertility Committee of the Society of Obstetricians and Gynaecologists of Canada. The quality of evidence was quantified using the Canadian Task Force on Preventive Health Care.

Benefits, Harms, and Costs

Benefits include weight reduction and improvements in ovulation, pregnancy, and live birth rates. Potential harms include medication side effects and multiple pregnancies.

Validation

These guidelines have been reviewed and approved by the Reproductive Endocrinology and Infertility Committee of the SOGC.

Sponsor

The Society of Obstetricians and Gynaecologists of Canada.  相似文献   

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Objectives

To review the etiology and incidence of and associative factors in the formation of adhesions following gynaecological surgery. To review evidence for the use of available means of adhesion prevention following gynaecological surgery.

Options

Women undergoing pelvic surgery are at risk of developing abdominal and/or pelvic adhesive disease postoperatively.Surgical technique and commercial adhesion prevention systems may decrease the risk of postoperative adhesion formation.

Outcomes

The outcomes measured are the incidence of postoperative adhesions, complications related to the formation of adhesions, and further intervention relative to adhesive disease.

Evidence

Medline, EMBASE, and The Cochrane Library were searched for articles published in English from 1990 to March 2009, using appropriate controlled vocabulary and key words. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, cohort studies, and meta-analyses specifically addressing postoperative adhesions, adhesion prevention, and adhesive barriers. Searches were updated on a regular basis and incorporated in the guideline to March 2009. Grey (unpublished) literature was identified through searching the websites of health technology assessment and health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies.

Values

The quality of evidence was rated using the criteria described in the Report of the Canadian Task Force on Preventive Health Care.  相似文献   

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