窄谱中波紫外线治疗白癜风

白癜风是一种常见的色素脱失性疾病,应用窄谱中波紫外线治疗有一定疗效.比较单独应用窄谱中波紫外线、窄谱中波紫外线联合其他药物的临床疗效及不良反应.窄谱中波紫外线是治疗成人或儿童泛发性白癜风以及严重影响患者生活质量的限局性白癜风安全有效的方法;尤其对于肤色较深患者及面颈部的皮损,疗效更佳.对于窄谱中波紫外线联合其他药物的利弊及长期应用的风险,需要进一步评估.     

Narrow-band ultraviolet B is a useful and well-tolerated treatment for vitiligo

BACKGROUND: The treatment of vitiligo remains a challenge. OBJECTIVE: The purpose of this article is to review our results and experience with narrow-band ultraviolet (UV) B phototherapy for vitiligo. METHODS: This is a retrospective analysis of our experience and results with patients with vitiligo who were treated with narrow-band UVB between November 1998 and November 1999. Narrow-band UVB phototherapy was given as monotherapy 3 times a week. The starting dose was 280 mJ/cm(2), with 15% dose increments at each subsequent treatment. RESULTS: Seven patients were able to be evaluated for the purposes of this analysis. Their ages ranged from 19 to 59 years (mean, 37.6 years). Three patients had Fitzpatrick skin phototype IV and V, and 4 had phototypes II and III. Five of the 7 patients achieved more than 75% repigmentation with a mean of 19 treatments; the mean duration of disease was 13 months. The remaining two patients had 50% and 40% repigmentation after 46 and 48 treatments, respectively. Their mean duration of disease was 132 months. Adverse effects were mild erythema and pruritus. CONCLUSION: This treatment protocol resulted in rapid repigmentation in many patients, including those with skin phototypes IV and V. In accordance with previous studies, this report indicates that narrow-band UVB is a useful and well-tolerated therapy for vitiligo.     

Narrow-band ultraviolet B phototherapy for early stage mycosis fungoides

Recently there have been some reports concerned the treatment of early stage mycosis fungoides (MF) with narrow-band ultraviolet B (NB-UVB) phototherapy. In most of the previous reports, NB-UVB phototherapy was given three times a week on non-consecutive days. Our aim was to evaluate the effect of a twice weekly regimen of NB-UVB phototherapy in the treatment of early-stage MF. Eight patients with early stage MF received NB-UVB phototherapy twice weekly. Six patients (75%) had a complete response in a mean of 23.4 treatments, two (25%) had a partial response. Upon discontinuation of treatment, four patients with complete response relapsed in a mean time to relapse of 5 months. The twice weekly regimen of NB-UVB phototherapy is effective and well-tolerated in the treatment of early stage MF.     

窄谱中波紫外线治疗白癜风疗效与相关因素的探讨

我科采用窄谱中波紫外线（NB-UVB）对2010年1月至2013年3月期间于本科就诊的135例白癜风患者进行治疗,现回顾性地分析总结临床因素与疗效的关系……     

Narrow-band ultraviolet B phototherapy in patients with recalcitrant nodular prurigo

Management of nodular prurigo has been less than satisfactory. Conventional therapies such as systemic antihistamines and topical steroids have not been particularly successful. The effects of narrow-band ultraviolet B (NB-UVB) phototherapy in the treatment of various inflammatory dermatoses have been proven, however, no data exist on the efficacy and the duration of remission in NB-UVB monotherapy for nodular prurigo. The aim of this study was to evaluate the effect of NB-UVB phototherapy on recalcitrant nodular prurigo. NB-UVB phototherapy was performed once a week on 10 patients with recalcitrant nodular prurigo. The initial dose was 0.4 J/cm(2), and the dose was increased by 0.1 J/cm(2) for each treatment. The treatment was performed until the eruption was almost clear. In each patient, a mean cumulative dose of 23.88 J/cm(2) was applied over a mean of 24.3 irradiations. The mean maximum daily dose of ultraviolet B was 1.2 +/- 0.4 J/cm(2). NB-UVB phototherapy notably improved the eruption of nodular prurigo in all patients. Follow up at 1 year revealed that only one patient had relapsed. The remaining nine patients continued to derive long-term benefits. NB-UVB phototherapy appears to be an effective treatment for recalcitrant nodular prurigo, offering long-term benefits in the majority of those treated.     

窄谱中波紫外线治疗白癜风临床研究

目的:评估窄谱中波紫外线(NB-UVB)治疗白癜风的临床疗效及安全性;探讨NB-UVB对稳定期白癜风患者治疗前、后免疫功能的影响.方法:对138例不同临床类型稳定期白癜风患者的652片皮损予NB-UVB照射治疗,在治疗前、后采用散射比浊速率法及流式细胞仪检测其中42例患者外周血IgA、IgM、IgC.C3、C4及T细胞亚群水平.结果:经NB-UVB照射治疗,138例患者有效率为64.72%.平均照射10.12次时皮损处出现色素沉着斑点,面颈部及躯干部疗效显著,局限型及泛发型白癜风患者疗效尤佳.主要不良反应为瘙痒与干燥.42例白癜风患者外周血IgA、IgM、IgG、C3、C4及T淋巴细胞亚群水平在治疗前、后差异无统计学意义.结论:NB-UVB治疗白癜风疗效显著、见效快、不良反应少.NB-UVB对稳定期白癜风患者治疗前、后免疫功能无影响.     

Narrow-band ultraviolet B treatment for vitiligo,pruritus, and inflammatory dermatoses

BACKGROUND: Narrow-band ultraviolet B (NB-UVB) therapy has been used successfully for the treatment of inflammatory and pigmentary skin disorders including atopic dermatitis, psoriasis, mycosis fungoides, polymorphous light eruption, and vitiligo. METHODS: This is a retrospective review of the treatment outcomes of 117 consecutive patients with vitiligo, pruritus, and other inflammatory dermatoses, excluding those with psoriasis and CTCL, who were treated with NB-UVB between 1998 and 2001 at our institution. RESULTS: Approximately 80% of all patients showed improvement in their condition. NB-UVB phototherapy was well tolerated, with no serious adverse effects. In patients with vitiligo, 6.4% had an abnormal thyroid-stimulating hormone level and 6.5% had anemia. CONCLUSION: NB-UVB may be considered as a viable therapeutic option in the treatment of vitiligo, pruritus, and other inflammatory dermatoses. Long-term adverse effects and cost-benefit analysis of NB-UVB therapy compared to other treatment modalities remain to be determined.     

窄谱中波紫外线联合外用药治疗炎性线状疣状表皮痣一例

【摘要】 目的 评价窄谱中波紫外线(NB-UVB)联合卡泊三醇和卤米松局部序贯疗法治疗炎性线状疣状表皮痣的疗效及不良反应。 方法 分析我科收治的1 例成年后发病炎性线状疣状表皮痣的临床、病理、实验室检查特点及诊疗经过, 并对文献进行复习,以治疗前后的皮损变化评价疗效。结果 患者2周后瘙痒减轻;6周后部分皮损消退、部分皮损变平,痒感消失。无不良反应发生。结论 NB-UVB联合局部序贯疗法（卡泊三醇联合卤米松）可能是治疗ILVEN的一个安全有效的方法。     

Treatment of adult diffuse pityriasis lichenoides chronica with narrowband ultraviolet B: experience and literature review

Pityriasis lichenoides chronica (PLC) is an infrequent dermatosis of unknown aetiology, wholse evolution and response to treatment differs between children and adults. When PLC is recalcitrant or unresponsive to topical treatment, phototherapy is one of the main treatments used. We carried out a prospective study of adult diffuse PLC treated with narrowband ultraviolet B (NB‐UVB). We treated eight patients whose disease showed no response to topical therapy, and obtained a complete response rate of 88% in a mean of 23 sessions (cumulative dose 16.99 J/cm²). However, the relapse rate was 43% in the first 6 months. Our results are similar to those of other published studies but there is much variability between them in the doses applied and the number of sessions needed. Further studies are necessary to devise a protocol for NB‐UVB treatment of PLC.