药物化学网络教材的研制

网络的出现使现代教育获得了又一个先进工具,用于网络的网络教材比通常认为的多媒体教材具有更多的优点。我们在药物化学课程建设的过程中,研究制作了一套药物化学网络教材,现正在我校使用,并受到其它兄弟院校的欢迎。     

药物化学教学中的分层教学

根据中等职业学校所用药物化学教材的特点，在讲授药物化学之前，与基础课教师及各班班主任进行交流，了解每一位学生的相关化学知识的掌握情况。讲授药物化学之初，通过课堂提问、观察、课后作业、交流等方式了解学生，将学生划分为基础较好的学生、中等水平的学生、基础较差的学生。根据既定教材和大纲，针对不同层次的学生，设置不同的教学目标，采用不同的教学手段和方法，组织课堂教学。     

药物化学的教学思考

药物化学是药学专业的专业课程之一,它是在无机化学、有机化学等化学基础知识上开设的,是设计、合成和研究应用于预防、诊断和治疗疾病药物的学科［1］。随着科学技术的进步和发展,不断改革教学模式,探寻新的教学方式和方法,提高教学质量,是药物化学教学改革的重点。本文尝试利用先进的科学技术,多样的教学方法渗透到教学中,培养学生求知的兴趣,帮助理论知识的理解,达到教学的目标。     

教学互动在天然药物化学课程教学中的应用

天然药物化学是药学专业的基础课程.随着中医药事业的快速发展,培养具有较强专业技能的人才是我们药学领域教育工作者不容忽视的职责,所以在教学过程中有必要适当的调整教学方法,以达到教学目的.就近年的教学实践,对教学体会进行总结.     

药物化学教学研究

药物化学是一门综合性很强的药学专业必修课,涉及到药理学、生理学、药剂学、药物分析、有机化学等专业,特别是与有机化学、药理学联系更加紧密。而对于药学专业的学生而言,有机化学是其学习药物化学的软肋,因为药学专业用的有机化     

药物化学实验教学改革的思路与实践

药物化学是临床药学专业的一门专业基础课程,它是一门实验性很强的学科.在以往的药化实验教学中,学生习惯按照实验指导书上的步骤循序渐进,按部就班,这种照方抓药的形式,枯燥乏味,没有新意,因此学生的积极性和主动性不高,实验效果不佳.     

药物化学的理论课教学

<药物化学>是药剂专业教学中一门重要的专业课,学好这门应用课程关系到学生能否依据基础理论、基础知识和基本技能独立完成药物的调剂、制剂的关键.特别是在药学事业飞速发展的今天,在学生必学的知识量不断增加的情况下,教师如何使学生在有限的学习时间里达到培养目标所要求的知识水平,如何认识药物化学的规律,使得这门在理论上较为抽象的课程通过深入浅出的讲解,便于学生的理解和记忆,这是药化教师认真研讨的课题.笔者在多年的教学实践中采用了以下几个步骤,收到了较好的效果.     

中职药剂专业天然药物化学课堂教学体会

天然药物化学是药剂专业的一门重要专业课程,本文从本专业的教学特点、建立学生学习兴趣、提高学生学习积极性、教学方式的转变以及注意因材施教等6个方面,阐述了中职药剂专业天然药物化学课堂的教学体会。     

天然药物化学课程教学改革初探

为提高天然药物化学课程教学质量,采用PBL教学法实施课堂教学,增加谱图解析内容,将讲解文献和观看小视频相结合,补充课堂小测验,丰富课程考试内容,以此改革课堂教学,提高教学效果。     

初探分析化学与药物分析实验合并的教学改革与实践

分析化学和药物分析都是药学专业非常重要的课程,根据两者的关系和特点,我们从实验教学方面进行合并教学研究改革,以期达到优化教学资源,增强教学效果,培养实用型人才的目的     

Bioconjugation in pharmaceutical chemistry.

Polymer conjugation is of increasing interest in pharmaceutical chemistry for delivering drugs of simple structure or complex compounds such peptides, enzymes and oligonucleotides. For long time drugs, mainly with antitumoral activity, have been coupled to natural or synthetic polymers with the purpose of increasing their blood permanence time, taking advantage of the increased mass that reduces kidney ultrafiltration. However only recently complex constructs were devised that exploit the 'enhanced permeability and retention' (EPR) effect for an efficient tumor targeting, the high molecular weight for adsorption or receptor mediated endocytosis and finally a lysosomotropic targeting, taking advantage of acid labile bonds or cathepsin susceptible polypeptide spacers between polymer and drug. New original, very active conjugates of this type, as those based on poly(hydroxyacrylate) polymers, are already in advanced state of development. Labile oligonucleotides, including antisense drugs, were also successfully coupled to polymers in view of an increased cell penetration and stabilization towards nucleases. However, the most active research activity resides in the field of polypeptides and proteins delivery, mainly for the two following reasons: first of all because a great number of therapeutically interesting compounds are now being produced by genetic engineering in large quantity and, secondly, because these products are difficult to administer to patients for several inherent drawbacks. Proteins are in fact easily digested by many endo- and exo-peptidases present in blood or in other body districts; most of them are immunogenic to some extent and, finally, they are rapidly excreted by kidney ultrafiltration. Covalent polymer conjugation at protein surface was demonstrated to reduce or eliminate these problems, since the bound polymer behaves like a shield hindering the approach of proteolytic enzymes, antibodies, or antigen processing cell. Furthermore, the increase of the molecular weight of the conjugate allows to overcome the kidney elimination threshold. Many successful results were already obtained in peptides and proteins, conjugated mainly to water soluble or amphiphilic polymers like poly(ethylene glycol) (PEG), dextrans, or styrenemaleic acid anhydride. Among the most successful are the conjugates of asparaginase, interleukin-2 or -6 and neocarcinostatin, to remind some antitumor agents, adenosine deaminase employed in a genetic desease treatment, superoxide dismutase as scavenger of toxic radicals, hemoglobin as oxygen carrier and urokinase and streptokinase as proteins with antithrombotic activity. In pharmaceutical chemistry the conjugation with polymers is also of great importance for synthetic applications since many enzymes without loss of catalytic activity become soluble in organic solvents where many drug precursors are. The various and often difficult chemical problems encountered in conjugation of so many different products prompted the development of many synthetic procedures, all characterized by high specificity and mild condition of reaction, now known as 'bioconjugation chemistry'. Bioconjugation developed also the design of new tailor-made polymers with the wanted molecular weight, shape, structure and with the functional groups needed for coupling at the wanted positions in the chain.     

流动化学在药物合成中的应用进展

在过去二十多年的时间里,流动化学作为一项过程强化技术,已经应用于复杂化合物的制备过程中(如天然产品或活性药物成分)。当前流动化学不论是在工业化药物合成中还是实验室学术研究方面都取得了令人瞩目的进展。现阶段制药工业仍然依赖于间歇式或半间歇式反应器,但药物化学工作者们对连续流动化学技术产生了极大的兴趣。本文在简单介绍流动化学技术特点的同时,通过大量实例介绍流动化学在药物活性成分或中间体合成中的应用,综述了流动化学技术在药物合成中的最新研究进展。