一氧化氮及相关物质在卵巢肿瘤患者外周血中的检测

目的：探讨一氧化氮（NitricOxideNO）及其相关物质谷胱甘肽（GlutathioneGSH）的含量及超氧化物歧化酶（Superoxide dismutaseSOD）活性的变化意义。方法：应用改良的镀铜镉还原法测定NO2^-/NO3^-的含量，二硫双苯甲酸（DTNB）法测定GSH的含量，黄嘌呤氧化酶法测定SOD的活性。取卵巢肿瘤患者的外周血共74例，其中良性肿瘤40例，恶性肿瘤34例。另外取经体检健康女性的外周血共70例。将以上三组标本所测的数据用方差分析作比较。每组标本中三项指标进行相关分析。结果：在正常人与卵巢良性肿瘤患者外周血的比较中，NO、GSH、SOD均无显著差异；在正常人与卵巢恶性肿瘤者的外周血的比较，NO及GSH的含量和SOD的活性均有显著差异（P＜0．05），正常人显著高于恶性肿瘤患者。在卵巢良性肿瘤患者与恶性肿瘤患者的比较中，NO及GSH珠含量均有显著差异（P＜0．05），良性肿瘤患者显著高于恶性肿瘤患者。二者之间SOD的活性有显著差异（P＜0．05），良性肿瘤患者显著高于恶性肿瘤患者、正常人的外周血中NO与GSH显著正相关，r＝0．672（P＜0．01）；NO与SOD，GSH与SOD均无相关关系，在卵巢良、恶性肿瘤患者的外周血中NO、GSH与SOD三者之间无相关关系。结论：NO本身及其相关物质GSH，SOD含量降低可能与卵巢恶性肿瘤有一定关系。     

肺癌患者血清SOD活力及LPO水平测定及意义

本文用亚硝酸盐形成法和硫代巴比分酸法测定了肺癌患者、肺部良性疾患者及健康人血清超氧化物歧化酶（SOD）活性及脂质过氧化物（LPO）水平。结果表明：随癌变发生，宿主血清SOD活力逐渐下降，健康组与肺部良性疾患组相比，后者呈下降趋势，二者无显著差异（P＞0．05）；与肺癌组相比，均有显著性差异（P＜0.05）．血清LPO水平测定结果表明：随病变进展，血清LPO水平明显升高，尤以癌症组为甚，组间有极显著性差异（P＜0．01）。LPO/SOD比值随病变进展呈显著升高趋势，健康组和良性疾患组与肺癌组间均有极显著差异（P＜0．01）。各组人群血清SOD活性与LPO含量间均呈负相关：回归方程，正常组为：Y＝16．97-0．28x；良性组为：Y＝16．68-0．20x；肺癌组为：Y＝17．87-0．34x。随SOD活力下降，LPO水平升高。肺癌组呈显著负相关（P＜0．05）。提示：SOD活性及LPO水平与疾病发生和发展可能存在量的关系。检测人血清SOD活性和LPO水平将有助于肺癌的诊断及治疗。     

恶性血液病患者血一氧化氮、内皮素及超氧化物歧化酶的变化

目的：探讨恶性血液病患者血一氧化氮（NO）、内皮素（ET）及超氧化物歧化酶（SOD）的变化。方法：采用RIA法、硝酸还原法对26例恶性血液病患者和20例正常对照进行NO、ET、SOD测定。结果：26例初治恶性血液病患者NO、ET水平明显高于正常对照（P＜0．05），SDO低于正常水平（P＜0．05）。26例恶性血液病患者治疗后，10例完全缓解，8例部分缓解，8例未缓解，其中完全缓解组NO、ET、SOD与正常对照组差异无显著性（P＞0．05）；而部分缓解与未缓解组三者水平仍与正常对照差异有显著性（P＜0．05）。结论：NO、ET、SOD可能与恶性血液病发病有关，对三者动态监测有利于判断疗效。     

红细胞SOD活力、血浆LPO含量对恶性肿瘤诊断价值及预后探讨

 检测了肺癌、肝癌、乳腺癌、鼻咽癌、肠癌、胃癌等12种恶性肿瘤共142例患者红细胞超氧化物歧化酶（SOD）活力和血浆脂质过氧化物（LPO）含量，结果显示12种恶性肿瘤患者红细胞SOD活力明显低于良性肿瘤组（P＜0.05）及正常对照组（P＜0.01），LPO含量明显高于良性肿瘤组及正常对照组（P＜0.01），但值得注意的是41例晚期肿瘤患者SOD明显高于中期组（P＜O.05）而与正常组无显著差别（P＞0.05），LPO明显高于正常组（P＜0.05）与中期组无显著差别（P＞0.05），尤其是在3周以内死亡的6例晚期患者SOD活力明显高于肿瘤组平均水平（P＜O.05），提示患恶性肿瘤时体内SOD防御系统受到严重破坏，由氧自由基引发的脂质过氧化反应与临床肿瘤发展过程一致，肿瘤后期SOD急剧上升可作为判断预后的重要指标。     

胃癌、大肠癌患者血清性激素水平测定的临床意义

目的：探讨胃肠癌患者血清性激素水平及其临床意义。方法：采用放射免疫法，测定116例胃肠癌患者血清黄体生成素（LH），卵泡刺激素（FSH），催乳素（PRL），睾酮（T）及雌二醇（E2）水平。结果：胃癌患者LH，FSH，PRL水平均高于对照组（P＞0．05），T，E2水平均低于对照组，男性胃癌患者T水平显著低于对照组（P＜0．05），年龄小于60岁的男性胃癌患者血清T水平随肿瘤恶性程度的增加而明显下降（P＜0．01），结直肠癌患者TH，FSH，PRL，T水平与正常人比较，无显著性差异（P＞0．05），男性患者血清E2水平在正常值范围，女性患者E2水平显著低于正常人（P＜0．05），并在绝经期前随肿瘤恶性程度的增加而明显下降（P＜0．01），结论：男性胃癌患者血清T水平和女性结直肠癌患者血清E2水平，可作为判断患者病情的指标之一。     

血清性激素的水平对男性肺癌患者诊断的意义

背景与目的研究表明内分泌激素失调在肿瘤的发生发展过程中有重要的作用。本研究拟探讨检测男性肺癌患者血清性激素水平的临床意义。方法采用放射免疫法和免疫放射法测定男性肺癌患者（62例）、肺良性疾病患者（30例）及正常健康人（30例）血清雌二醇（E2）、睾酮（T）、泌乳素（PRL）、生长激素（GH）、黄体生成素（LH）、卵泡刺激素（FSH）、促甲状腺激素（TSH）水平。结果男性肺癌组与正常对照组比较T水平显著降低（t=0．348，P〈0．01），E2、PRL、FSH水平显著升高（t=0．362，P〈0．01；t=2．913，P〈0．05；t=2．739，P〈0．01）；男性肺癌组与肺良性疾病组比较T水平显著降低（t=3．903，P〈0．05）；鳞癌组和腺癌组与小细胞肺癌组比较T水平显著降低（t=0．358，P〈0．01；t=3．902，P〈0．05），鳞癌组与腺癌组比较FSH及TSH显著升高（F3．918，P〈0．01；t=2．912，P〈0．05）。有淋巴结转移组与无淋巴结转移组比较T水平显著降低（t=3．914，P〈0．01），其它激素无明显差异。结论肺癌患者血清中性激素水平紊乱，检测血清中E2、T、PRL及FSH对肺癌的诊断有一定的价值，并可作为判断患者病情的指标。     

食管癌患者免疫功能的研究

目的：研究食管癌患者免疫功能的变化规律，探索食管癌的免疫发病机制。方法：应用形态学方法测定食管癌患者LBT、RBC－C3bRR、RBC－ICR及NTER；用ELISA法测定食管癌患者血清sIL-2R和TNF-α水平；用生化方法测定食管癌患者血清NO含量，并进行统计学分析。结果：食管癌患者血清NO含量、LBT、RBC－C3bRR和NTER均显著低于正常对照组（P均＜0．001）；而血清sIL-2R含量、血清TNF－α含量及RBC－ICR均显著高于正常对照组（P均＜0．001）。肿瘤根治术后患者血清NO含量、LBT、RBC－C3bRR和NTER较术前明显升高（P＜0．05；＜0．001；＜0．001；＜0．05），但仍低于正常对照组（P均＜0．001）；而血清sIL-2R含量、血清TNF－α含量及RBC－ICR较术前明显降低（P均＜0．001），但仍高于正常对照组（P均＜0．001）。本实验还发现食管癌患者RB－C3bRR与血清NO含量及LBT呈正相关，与血清sIL-2R含量呈负相关。结论：食管癌患者的多项免疫指标均发生了明显的改变，多项免疫指标的联合检测对食管癌发病机理探讨、疗效观察和预后判断均有重要的临床意义。     

化疗对晚期肺癌患者T淋巴细胞亚群和红细胞免疫功能的影响

目的：分析42例晚期肺癌者化疗前后T淋巴细胞亚群和红细胞免疫功能的变化,并探讨其与病情的关系。方法：对42例晚期肺癌化疗前后的血标本采用流式细胞术检测T淋巴细胞亚群和采用交体粘附法检测红细胞免疫功能,并与体检健康者作比较,结果：本组晚期肺癌患者治疗前后T淋巴细胞亚群和红细胞免疫功能均低于对照组（P＜0．05,P＜0．01）。治疗后,化疗有效率总T细胞（CD3^ ）、辅助／诱导T淋巴（CD4^ ）、CD4^ 与CD8^ 比值均显著升高（P＜0．01）,细胞毒／抑制性T淋巴细胞（CD8^ ）降低（P＜0．05）;化疗无效者CD3^ 、CD4^ 、CD4^ ／CD8^ 显著降低（P＜0．05,P＜0．01）,而CD8^ 升高（P＜0．01）,直向肿瘤红细胞花环（direct tumor erythrocyte rosette,DTER）,红细胞C3b受体花环（red blood cell C3b receptor rosette,RBC-C3bRR)和红细胞免疫复合物花环（red blood cell immunity complex rosette,RBC-ICR),化疗前后变化不明显（P＞0．05）。结论：晚期肺癌患者免疫功能低下,有铲化疗能提高患者的T淋巴细胞亚群免疫功能,临床上对免疫功能的观察对肺癌患者的治疗和预后有一定的监测作用。     

维吾尔族宫颈癌患者 Th1／Th2型细胞因子表达水平及临床意义

目的：评估宫颈癌及癌前病变患者免疫水平，进一步探讨维吾尔族宫颈癌患者血浆中Th1／Th2型细胞因子表达水平及临床意义。方法本研究收集宫颈癌、癌前病变（ CIN Ⅲ）患者及对照组外周血标本，使用ELISA法检测血浆中Th1型细胞因子IL－2、IFN－γ及Th2型细胞因子IL－4、IL－10的表达水平，绘制ROC曲线分析四种细胞因子在宫颈癌辅助诊断中的价值。结果与对照组相比，宫颈癌和癌前病变组Th1型细胞因子IL－2、IFN－γ表达量显著降低（P＜0．05），Th2型细胞因子IL－4、IL－10表达量显著升高（P＜0．05）；在宫颈癌组中，IL－10表达量随肿瘤分期逐渐升高（P＜0．05）；维吾尔族宫颈癌患者血浆IL－2表达量较汉族患者显著降低（ P＜0．05）；在区分宫颈癌组与对照组中，IL－2、IFN－γ、IL－4和IL－10的AUC分别为0．979、0．766、0．736和0．903。结论宫颈癌患者细胞免疫水平低下，体内发生Th1／Th2漂移，提示这可能是肿瘤细胞发生免疫逃逸的机制之一，Th1／Th2型细胞因子的检测对宫颈癌的辅助诊断具有一定参考价值，此外IL－2表达量的下调可能在维吾尔族宫颈癌发生发展过程中起到重要作用。     

恶性淋巴瘤患者血清瘦素及一氧化氮水平变化

目的 探讨恶性淋巴瘤患者血清瘦素及一氧化氮（NO）的水平变化。方法 采用RIA法，硝酸还原法对30例恶性淋巴瘤患者和30例正常对照进行瘦素及NO测定。结果 30例初治恶性淋巴瘤患者瘦素低于正常水平（P＜0．05），早晚期有明显差异（P＜0．05），缓解后瘦素水平上升，但仍低于正常对照（P＜0．05）；NO水平明显高于正常对照（P＜0．05），早晚期无明显差异（P＞0．05）。治疗缓解后NO与正常对照组无明显差异（P＞0．05）。结论 瘦素及NO可能与恶性淋巴瘤发病有关，并可能作为其临床分期及疗效判断的有效指标。     

胞核雄激素受体测定对评价前列腺癌、肝癌受体状态的意义

背景与目的:雄激素受体(androgenreceptor,AR)与前列腺癌(prostatecarcinoma,PC)、原发性肝癌(hepatocellularcacinoma,HCC)的发生、发展有关,对临床治疗方案选择及预后的评估等有一定影响,准确判断肿瘤组织的AR状态有重要的临床意义。本研究旨在通过对胞核雄激素受体(nuclearAR,AnR)进行分析,探讨AnR对评估前列腺癌、原发性肝癌雄激素受体状态的意义。方法:取94例PC和192例HCC患者的肿瘤组织及癌周组织,采用受体放射配基结合分析法(radioligandbindingassay,RBA)对组织中胞浆雄激素受体(cytosolAR,AcR)、胞核雄激素受体的亲和力(affinity,KD)、最大结合容量(maximumconcentrationofreceptor,Bmax)进行分析。结果:PC患者中肿瘤组织AcR、AnR的Bmax值(58.82±34.73)、(543.70±249.44)fmol/mgprotein明显高于癌周组织的(21.63±14.89)、(89.20±47.32)fmol/mgprotein(P<0.001);其KD值(0.84±0.52)、(2.15±0.79)nmol/L与癌周组织的(0.78±0.49)、(2.24±0.84)nmol/L之间的差异无统计学意义(P>0.50)。HCC患者中,肿瘤组织AcR、AnR的Bmax值(18.09±16.87)、(59.93±34.12)fmol/mgprotein亦明显高于癌周组织的(10.87±7.60)、(25.54±20.10)fmol/mgprotein(P<0.001);其KD值(0.76±0.57)、(1.89±0.74)nmol/L与     

三阴性乳腺癌与基底细胞样乳腺癌临床病理分析

目的研究CK5／6、CK14在三阴性乳腺癌（triple negativebreast carcinoma,TNBC）中的表达情况,并探讨基底细胞样乳腺癌（basal—like breast carcinoma,BLBC）与TNBC的关系。方法利用免疫组化方法从浸润性乳腺癌中筛选TNBC病例,然后利用CK5／6和CK14从TNBC中筛选出BLBC的病例,分析两者的临床与病理资料及免疫组化表达情况并复习有关文献。结果TNBC的发病率占浸润性乳腺癌的16．1％。TNBC中的CK5／6和CK14表达有正相关性（γ=0．463）。应用CK5／6、CK14从TNBC中筛选出的BLBC的百分率为54％。结论BLBC与TNBC有大部分交叉。CK5／6和CK14可以用来从TNBC中筛选出大部分的BLBC的病例。BLBC相对其他类型乳腺癌,预后不良,有必要将其从TNBC中鉴别出来。     

Clinical role of tissue and serum levels of SCCA antigen in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer in the world and a common occurrence in patients with liver cirrhosis in western and North American countries. Ultrasound screening is a powerful technique for HCC diagnosis, whereas the only available serologic test, alpha-fetoprotein, has poor reliability. It has been reported that the squamous cell carcinoma antigen (SCCA) is overexpressed in HCC tissue. In our study, the expression of SCCA was investigated in tumoral and peritumoral tissues and in the serum of 52 HCC patients, as well as in the serum of 48 cirrhotic patients. The results show that SCCA expression is much stronger in the tumoral than in the peritumoral tissue of HCC. Moreover, it is also evident in metastatic nodules present in the peritumoral tissue. SCCA serum levels were significantly higher in HCC samples than in cirrhotic samples. However, no correlation was found between SCCA expression and the HCC histologic degree, nor did SCCA expression correlate with tumor size, presence of metastasis or clinical outcome. In conclusion, in HCC patients, the SCCA antigen could represent a useful marker for the detection of micro-metastasis in the tissues and for large-scale screening of serum in patients at risk.     

Association between the frequency of tooth brushing and esophageal carcinoma risk: an update systematic review and meta-analysis

BackgroundLower frequency of tooth brushing was thought to be associated with esophageal carcinoma (EC). However, some researchers suggested that this association did not exist or had not yet reached statistical significance. The purpose of this study was to calculate a more precise estimation of the relationship between the frequency of tooth brushing and the risk of EC by combining the results between different studies using the meta-analysis.MethodsWe searched the PubMed, Embase, Web of Science, and Scopus electronic databases up to July 2021. According to PECO approach (Population, Exposure, Comparator and Outcomes), we assessed the association between tooth brushing frequency and EC risk which reported the adjusted risk ratios (adjRR), hazard ratios (adjHR), or odds ratios (adjOR) with 95% confidence interval (CI). The random effects model was used to quantitatively evaluate the combined results. Two researchers independently evaluated the risk bias of the included studies using the Newcastle-Ottawa Scale (NOS). The robustness of results was evaluated by subgroup analysis, sensitivity analysis, and publication bias.ResultsIn total, we identified 13 articles with 14 case-control studies which included 16,773 participants and 5,673 patients. Pooled results showed the lowest frequency of brushing was significantly associated with an increased risk of EC in comparison to the highest (adjOR: 2.00, 95% CI: 1.61–2.48). There was moderate heterogeneity among included studies (P=0.001, I²=61.4%). The original studies included in this meta-analysis were all case-control studies. Study quality was all moderate or above based on NOS score ranges of 6 stars or more.ConclusionsAvailable evidence suggests a low frequency of tooth brushing may be an important risk factor for EC. However, higher quality studies should continue to be conducted to investigate the optimal threshold of brushing frequency for the prevention of EC.     

The role of chemotherapy and/or octreotide in patients with metastatic gastroenteropancreatic and hepatobiliary neuroendocrine carcinoma

Background

Neuroendocrine carcinomas (NECs) of the gastro-entero-pancreatic (GEP) and hepatobiliary (HB) tract are rare and a heterogenous group of malignancies. Octreotide showed the anti-tumor activity in functional and nonfunctional well differentiated metastatic midgut neuroendocrine tumors (NETs). However, the effect of octreotide on survival has not been evaluated.

Patients and methods

We analyzed 17 patients (6 HB- and 11 GEP- tract) with metastatic NEC diagnosed between January 2009 and June 2012. All patients had one or more cytotoxic chemotherapy and nine patients had received octreotide as single agent (n=3) or combination of cytotoxic chemotherapy (n=6).

Results

The median age was 68 years (range, 23-79 years) and median Eastern Cooperative Oncology Group performance status (ECOG PS) was 1. Sixteen of all patients (n=17) received cytotoxic chemotherapy with or without octreotide as the first line therapy and 10 of 16 patients who experienced disease progression to the first line therapy received the second line therapy. Overall response rates (RR) and disease control rates (DCR) to the 1^st line therapy were 41.2% and 76.5%, respectively. The median overall survival (OS) was 16 months [95% confidence interval (CI), 12.8-19.2] and the median OS in patients receiving octreotide during treatment was 40.2 months. In univariate analysis, any clinico-pathologic features including sex, the location of primary tumor, the number of metastatic sites, the debulking operation and the liver metastasis did not have prognostic value regarding OS. However, the use of octreotide offered favorable trend for OS (P=0.091).

Conclusions

The use of octreotide may benefit for patients with GEP- and HB- NECs as a single agent or a combination therapy.     

子宫内膜癌组织雌、孕激素受体测定及其临床意义

目的:探讨子宫内膜癌组织雌激素受体(ER)和孕激素受体(PR)与临床病理特征的关系。方法:采用葡聚糖-活性炭吸附法(DCC法)对68例子宫内膜癌组织进行ER、PR测定,同时采用免疫组化法对其中30例进行ER、PR检测。结果:DCC法检测ER、PR的阳性率分别为79·4%和77·9%,免疫组化法均为86·7%。两种测定方法比较,ER与PR的总符合率分别为82·4%和85·7%。免疫组化法可在DCC法基础上进一步明确组织来源。ER、PR水平与组织学分级呈负相关。组织类型中腺癌(包括乳头状腺癌)与腺棘癌的ER、PR水平高于其他癌。ER水平与肥胖呈正相关。结论:ER、PR水平与组织学分级、组织学类型均反映了子宫内膜癌的生物学行为,ER、PR的测定对估计预后和临床选择激素治疗具有重要意义。     

Detection of High-Risk Human Papillomavirus Genotypes 16 and 18 in Head and Neck Squamous Cell Carcinomas in Jordan

Background: Recently, associations of the human papillomavirus (HPV) with head and neck cancer have become well established. Of particular concern, the severity and pathological outcomes of squamous cell carcinomas are remarkably affected by the genotypes of HPV present in such lesions. This study was conducted to investigate the occurrence of HPV genotypes, particularly high risk 16 and 18, among oral and laryngeal squamous cell carcinomas in Jordan. Methods: During the period of May 2015 to March 2016, we evaluated a total of 108 paraffin-embedded tissue samples, histologically confirmed as SCC, of both oral and laryngeal tumors for the presence of HPV DNA. DNA was extracted using a Zymogen commercial kit. HPV genotypes were detected by nested PCR using consensus primers followed by primer-specific PCR for HPV-16 and HPV-18 genotypes. The genotypes were confirmed by DNA sequencing methods. Results: Sixteen samples were positive for HPV DNA (14.8%) with higher rates in oral tumors compared to their laryngeal counterparts (20% and 6% respectively). The HPV-16 genotype predominated, being detected in 81.3% of the cases as a single infection and in 18.7% in combination with HPV-18. A significant association between the anatomical location and the HPV-16 genotype was observed (p < 0.05). In contrast, no significant associations could be established with tumor grade and gender or age. Conclusions: A relatively high rate of high-risk HPV genotypes, especially HPV 16, is evident in head and neck cancers SCCs in Jordan. Genotyping of HPV might be of considerable value for evaluation of progression.     

A novel classification in predicting prognosis and guiding postoperative management after R0 liver resection for patients with hepatocellular carcinoma and microvascular invasion

BackgroundMicrovascular invasion (MVI) is a significant risk factor affecting survival outcomes of patients after R0 liver resection (LR) for hepatocellular carcinoma (HCC). The current classification of MVI is not refined enough to prognosticate long-term survival of these patients, and a new MVI classification is needed.MethodsPatients with HCC who underwent R0 LR at the Eastern Hepatobiliary Surgery Hospital from January 2013 to December 2013 and with resected specimens showing MVI were included in this study with an aim to establish a novel MVI classification. The classification which was developed using multivariate cox regression analysis was externally validated.ResultsThere were 180 patients in the derivation cohort and 131 patients in the external validation cohort. The following factors were used for scoring: α-fetoprotein level (AFP), liver cirrhosis, tumor number, tumor diameter, MVI number, and distance between MVI and HCC. Three classes of patients could be distinguished by using the total score: class A, ≤3 points; class B, 3.5–5 points and class C, >5 points with distinct long-term survival outcomes (median recurrence free survival (mRFS), 22.6, 10.2, and 1.9 months, P < 0.001). The predictive accuracy of this classification was more accurate than the other commonly used classifications for HCC patients with MVI. In addition, the mRFS of class C patients was significantly prolonged (1.9 months vs. 6.2 months, P < 0.001) after adjuvant transcatheter arterial chemoembolization (TACE).ConclusionsA novel MVI classification was established in predicting prognosis of HCC patients with MVI after R0 LR. Adjuvant TACE was useful for class C patients.     

鼻咽癌患者放射性骨坏死引起的正电子显像假阳性结果1例及文献复习

目的:探讨鼻咽癌(NPC)患者放射性骨坏死(osteoradionecrosis,ORN)引起正电子假阳性结果的原因及避免因此引发诊断错误的方法。方法:回顾性分析1例放疗后的鼻咽癌患者,行鼻咽部MRI及正电子显像后,再行组织病理学检查,对三种结果进行分析、比较。结果:MRI及正电子显像均诊断患者颅底区域肿瘤复发,组织病理学结果则显示鼻咽部病灶为放射性骨坏死。因此正电子扫描结果为假阳性结果。结论:鼻咽癌患者放疗后所致的放射性骨坏死容易引起正电子显像假阳性结果并可能引发不必要的治疗,因此NPC患者的正电子图像,对于可能的局限性肿瘤复发诊断,应该非常慎重。     

Magnetic resonance elastography can predict the development of hepatocellular carcinoma: a meta-analysis and systematic review

BackgroundHepatocellular carcinoma (HCC) has become the third leading cause of cancer-related death worldwide, and its incidence rate is increasing. Magnetic resonance elastography (MRE) can indirectly realize the accurate non-invasive evaluation of liver reserve function in HCC patients. In this study, we aimed to evaluate the effectiveness of MRE in the diagnosis of HCC patients.MethodsWe searched globally-recognized electronic databases, such as PubMed, EMBASE, China National Knowledge Infrastructure, and Cochrane Central, for relevant literature on MRE prediction of HCC. The diagnostic performance of all studies was quantitatively summarized using a bivariate random effects model including heterogeneity analysis, receiver operating characteristic (ROC) curve, and bias determination.ResultsThe diagnostic accuracy of MRE for HCC was based on 1,735 patients. The sensitivity (31–100%) was lower than the specificity (81–94%). The overall sensitivity was 64% [95% confidence interval (CI): 46–79%; I²=92.44%], and the overall specificity was 85% (95% CI: 82–88%; I²=67.86%). Limited publication bias was observed in this study, and the sensitivity analysis showed that the study was robust.DiscussionThe results of our meta-analysis show that MRE has moderate sensitivity and excellent specificity in the detection of HCC. MRE can be an effective diagnostic tool for HCC and can provide strong support for the selection of clinical treatment methods and prognostic judgment.