三种术式治疗子宫颈上皮内瘤样病变183例疗效观察

[目的]探讨宫颈冷刀锥切术（CKC）、子宫颈环形电切术（LEEP）和CO2激光切割术不同术式治疗子宫颈上皮内瘤样变（CIN）Ⅱ级的效果。[方法]对183例经细胞学检查、阴道镜检查及活体组织病检为CINⅡ级的患者分别采用三种手术方式治疗,切除组织全部行病理学检查,并比较治疗效果。[结果]CKC组（55例）取材满意率100%,治愈52例（治愈率94.5%）,术后复发3例（5.5%）;LEEP组（71例）取材满意率97.2%,治愈66例（治愈率93.0%）,术后复发5例（7.0%）;激光切割组（57例）治愈37例（治愈率64.9%）,术后复发20例（35.1%）。CKC组与LEEP组比较治愈率及取材满意率均无显著差异（P〉0.05）;激光切割组与CKC组及LEEP组之间比较治愈率和取材满意率均具显著差异（P〈0.05）。LEEP组和激光切割组在手术时间、术中出血量、住院费用及住院时间均优于CKC组（P〈0.05）,LEEP组与激光切割组相比,激光切割组术后再出血比例显著高于LEEP组（P〈0.05）。[结论]三种诊治方法中,LEEP效果可靠且具许多优点,为临床CINⅡ级患者的首选诊治方案。     

两种子宫颈锥形切除术式在临床中的应用分析

目的：探讨子宫颈电热圈环切术（LEEP）与冷刀子宫颈锥形切除术（CKC）两种术式的适应证、手术要点及并发症。方法：对LEEP130例．同期CKC108例手术资料进行分析比较。结果：LEEP主要适应于CIN1、CIN2及部分CIN3患者，CKC主要适应于CIN3及以上病变和子宫颈解剖异常患者；LEEP组在手术时间、术时出血、术后宫颈机能及手术费用等方面明显优于CKC组；两组病人均无宫颈狭窄发生；在术后出血、术后病变残留方面两组无明显差异。结论：（1）对LEEP与CKC要严格手术指征；（2）LEEP以其较明显的优势值得广泛推广。     

宫颈电环切除术和冷刀宫颈锥切术治疗宫颈上皮内瘤变的疗效比较

目的比较宫颈电环切除术（LEEP）和冷刀宫颈锥切术治疗宫颈上皮内瘤变（CIN）的临床疗效。方法将200例CINⅡ—Ⅲ级患者随机分为2组：A组102例和B组98例。A组行LEEP,B组行冷刀宫颈锥切术。并观察2组手术时间、术中出血量、脱痂期出血量及切口愈合时间情况。结果A组（CINⅡ级、CINⅢ级）手术时间均短于B组（CINⅡ级、CINⅢ级）,差异均有统计学意义（均P〈0．05）,A组（CINⅡ级、CINⅢ级）术中出血量均少于B组（CINⅡ级、CINⅢ级）,差异均有统计学意义（均P〈0．05）。A组（CINⅡ—Ⅲ级）和B组（CINⅡ-Ⅲ级）分别有7例（6．9％）和5例（5．1％）脱痂期出血量超过月经量,2组比较差异无统计学意义（P〉0．05）,A组（CINⅡ—Ⅲ级）切口愈合时间与B组（CINⅡ-Ⅲ级）比较差异无统计学意义（P〉0．05）。结论LEEP用于治疗CINⅡ-Ⅲ级患者较冷刀宫颈锥切术出血少、手术时间短,是一种有效的治疗方法。     

宫颈环形电切术治疗164例宫颈疾病的疗效分析

目的探讨宫颈环形电切术（LEEP）治疗宫颈疾病的疗效。方法回顾性分析新野县人民医院2008年5月至2011年4月门诊和住院患者经阴道镜活检初步诊断为宫颈病变者164例,所有患者均行LEEP术治疗,记录术中手术时间,术中出血量,术后病理结果,术后宫颈塑形情况。结果 164例患者中宫颈上皮内瘤变（CIN）68例,平均手术时间为7.2（3~16）min,术中出血量平均为10.2（5~34 ml）,治愈率为95.6%（65/68）,术后宫颈塑形满意率为89.4%（59/68）;宫颈良性疾病96例,其中宫颈尖锐湿疣17例,宫颈息肉22例,宫颈肌瘤8例,中重度宫颈糜烂49例。该组平均手术时间为6.8（2.0~14.0）min,术中出血量平均为9.4（3.0~22.0）ml,治愈率为94.9%（91/96）,术后宫颈塑形满意率为88.9%（85/96）;CIN组与宫颈良性疾病组在平均手术时间、术中出血量、宫颈塑形满意率及治愈率等方面比较差异均无统计学意义（P〉0.05）。结论 LEEP术治疗CIN和宫颈良性疾病简单、安全行之有效。     

252例宫颈上皮内瘤变LEEP术后随访分析

目的分析探讨高频电波刀电圈切除术（LEEP）治疗宫颈上皮内瘤变（CIN）Ⅰ~Ⅲ级患者的疗效。方法对因阴道镜下定位活检为CIN而行LEEP术的252例患者进行随访,CINⅠ级50例,CINⅡ级100例,CINⅢ级102例,分析术后的病变复发情况。结果随访时间6~30个月。LEEP术后6个月总治愈率为95.24%,病变持续存在率为4.76%,术后1年总复发率为2.38%。其中CINⅠ级6个月治愈率100.00%,病变持续存在率0.00%,1年复发率为2.00%;CINⅡ组6个月治愈率为94.00%,病变持续存在率6.00%,1年复发率2.00%;CINⅢ组6个月治愈率为94.12%,病变持续存在率5.88%,1年复发率为3.92%。CINⅠ与CINⅡ、CINⅢ级的治愈率、病变持续存在率比较差异有显著性（P〈0.05）,而复发率比较差异无显著性（P〉0.05）;CINⅡ级在治愈率、病变持续存在率、复发率与CINⅢ级比较差异无显著性（P〉0.05）。结论LEEP是治疗CIN的安全、有效方法,且术后保持随访能及时发现并治疗残留或复发的CIN。     

阴道镜下活检确诊为CIN2的患者在LEEP术后发生病理升级的高危因素分析

目的 探讨阴道镜下活组织检查（活检）确诊为宫颈上皮内瘤变2级（CIN2）的患者在宫颈环形电切术（LEEP）后病理升级至CIN2以上（CIN2+）的相关风险因素，为CIN2患者的分层管理提供依据。方法 回顾性分析阴道镜下活检病理诊断宫颈CIN2而进一步行LEEP术的210例患者临床资料，观察患者在LEEP手术前、后的病理诊断，采用单因素及多因素Logistic回归分析患者年龄、初次液基薄层细胞学检查（TCT）结果、高危型人乳头瘤病毒（HPV）分型、阴道镜下病变累及象限数目、可见病变面积占宫颈表面积的比例、可见病变的最长线性长度、转化区类型、病变是否累及腺体和阴道镜图像特征等相关因素与LEEP术后病理升级的关系。结果 210例阴道镜下活检病理诊断的宫颈CIN2中，37例（17.6%）LEEP术后病理诊断为CIN2+，其中1例为宫颈鳞癌IB1期。单因素分析显示LEEP术后病理升级与患者年龄、阴道镜下病变累及象限数目、可见病变面积占宫颈表面积的比例、可见病变的最长线性长度、转化区类型及阴道镜图像特征有关（P均<0.05）。多因素分析显示，阴道镜下病变累及>1个象限、可见病变面积占宫...     

宫颈电圈环切术中颈管黏膜环切预防宫颈柱状上皮外移效果分析

目的探讨宫颈电圈环切除术（LEEP）在治疗上皮内瘤样病变（CIN）时颈管黏膜环切对预防术后宫颈柱状上皮外移的作用。方法 156例CIN患者在行LEEP术前采用抽签方法分为两组,其中对照组78例选择Fisher电极行LEEP锥切;试验组78例在用Fisher电极切除宫颈病变后,再用小环形电极伸入颈管切除颈管黏膜0.5-0.8 cm。术后1、2、3及4周随访阴道流血、分泌物及创面恢复情况,术后3个月随访宫颈柱状上皮外移的发生率及宫颈粘连狭窄的发生率。比较两组手术时间、术中出血量、术后出血时间、术后宫颈柱状上皮外移的发生率及宫颈粘连狭窄的发生率。结果试验组术后4周及术后3个月宫颈柱状上皮外移的发生率分别为6.41%、2.56%,低于对照组24.36%、17.95%,差异有统计学意义（P〈0.05）;两组手术时间、术中出血量、术后出血时间和术后宫颈粘连狭窄发生率的差异均无统计学意义（P〉0.05）。结论 LEEP锥切术中颈管黏膜环切可有效预防术后宫颈柱状上皮外移的发生。     

宫颈电圈切除术及激光治疗重度宫颈糜烂的疗效分析

目的探讨宫颈电圈切除术（LEEP）治疗重度宫颈糜烂的疗效。方法将120例经妇科检查、宫颈脱落细胞学检查、宫颈活检初步诊断为重度宫颈糜烂的患者随机分为2组,电圈切除术组和CO2激光组,每组60例,分别采用LEEP手术和CO2激光治疗。治疗13周后对2组疗效进行比较。结果CO2激光组治愈率为56.67%,电圈切除术组的治愈率为91.67%,2组比较差异有统计学意义（P〈0.05）。结论LEEP治疗重度宫颈糜烂操作简单、安全,出血少,治疗效果显著,能提供完整的病例标本。     

宫颈环形电切术治疗宫颈病变266例临床疗效观察

目的探讨宫颈环形电切术（LEEP）治疗各种宫颈疾病的临床疗效。方法对妇科门诊常规检查初步诊断为各种宫颈疾病如慢性宫颈炎（宫颈糜烂、宫颈息肉、宫颈肥大、宫颈纳氏囊肿、宫颈湿疣等）、宫颈上皮内瘤样变（CINⅠ、CINⅡ、CINⅢ级）等的266例患者,采用环形电刀行宫颈环切术治疗,手术标本送病理检查,并观察手术时间、术中出血量、患者反应、病理检查及术后随访情况。结果 LEEP治疗宫颈疾病成功266例（100%）,手术时间（10±4）min,出血量（10.0±2.5）ml,仅12例（4.51%）患者出现下腹隐痛、阴道烧灼感;病理检查术前、术后符合率,慢性宫颈炎96.23%,宫颈上皮内瘤变CINⅠ～Ⅱ级100%,CINⅢ级90.00%,术后随访6个月均无复发情况,亦未出现术后感染、大出血及宫颈口粘连、宫颈口狭窄等并发症。结论 LEEP具有快速简便、并发症少、手术时间短、出血少、患者痛苦小等优点,在宫颈疾病治疗中安全有效,具有诊断及治疗双重疗效,是治疗宫颈病变较理想的方法,并且不需住院,大大减少了治疗费用,值得临床广泛推广应用。     

影响环形电切术治疗宫颈上皮内瘤变转归的因素

目的探讨影响环形电切术（LEEP）治疗宫颈上皮内瘤变（CIN）转归的相关因素。方法选取行LEEP治疗的CIN患者240例,通过跟踪随访,收集患者是否吸烟、术前病理组织学检查情况、有无HPV感染、病变是否累及腺体、手术切缘、病变范围等情况,比较复发患者及未复发患者的相关资料。结果 240例患者中,218例患者治愈（治愈组）,22例患者复发（复发组）,CIN复发率为9.17%;治愈组的年龄、术前HPV感染、手术切缘情况、病变范围、是否累及腺体等方面与复发组比较差异有统计学意义（P〈0.05）;对于术前病理结果而言,与CINⅠ级的患者相比,CINⅡ级、CINⅢ级的患者复发率显著升高（均P〈0.05）;而2组患者的初次性生活年龄、是否吸烟间差异无统计学意义（P〉0.05）。结论 LEEP术对于CIN的治疗具有较好的疗效,年龄、术前HPV感染、病例分级、手术切缘、病变范围等均会影响CIN的复发。应加强对于高龄、切缘阳性、术前HPV感染、病例分级较高等患者的筛查,制定相应的预防措施,以降低CIN复发率。     

根据阴道镜下病变范围选择宫颈上皮内瘤样变的治疗方法

目的探讨治疗宫颈上皮内瘤样病变(CIN)的一种新策略——根据阴道镜下的病变特点选择“个体化”的治疗方法。方法应用这个策略治疗CIN48例,23例病变未延伸至宫颈管内的满意阴道镜选择激光气化治疗(其中CINⅠ期15例,CINⅡ期5例,CINⅢ期3例),25例病变延伸至宫颈管内的不满意阴道镜选择LEEP或冷刀锥切(其中CINⅠ期9例,CINⅡ期10例,CINⅢ期6例)。同期50例对照组根据传统策略选择治疗方法,即根据病变程度选择,32例CINⅠ期采用激光气化,18例CINⅡ或Ⅲ期采用LEEP或冷刀锥切(CKC)。比较两种策略的治疗结局。结果实验组激光治疗无1例复发(0%),而对照组激光治疗6例复发(19%),差异有统计学意义(P=0.035);实验组LEEP或CKC治疗4例复发(16%),而对照组2例复发(11%),差异无统计学意义(P=1.000);实验组总复发率8%,对照组总复发率16%(P=0.357)。结论根据阴道镜下的病变范围选择治疗方法是一种有效的宫颈CIN治疗策略,优于传统的根据病变程度选择治疗方法。     

Pregnancy after laser therapy for the treatment of uterine cervical neoplasia

Three hundred and twenty-four patients with cervical intraepithelial neoplasia (33 mild dysplasia, 109 moderate dysplasia, 118 severe dysplasia, 64 carcinoma in situ) underwent laser vaporization with the CO 2 laser. Eighty-two patients with CIN (mild dysplasia 7, moderate dysplasia 10, severe dysplasia 16, carcinoma in situ 46) and microinvasive cancer (3) underwent laser excisional conization with the YAG laser. Their first cure rates showed 93.5% and 98.8%, respectively, for the follow-up period 6 months to 7 years. During the same period, 36 pregnancies in 34 patients occurred. Of these patients, 14 underwent dilatation and curettage, 6 terminated by spontaneous abortion in the first trimester and 1 in the second trimester (previous MacDonald's suture), and 1 had fetal death at 13 weeks of gestational age. There were 13 deliveries, 2 by cesarean section (either postenucleation of uterine myoma or premature rupture of the membranes and fetal distress), 3 by vacuum extraction, 1 by breech delivery, and 7 by normal vaginal delivery. One patient is currently in her 22nd week of pregnancy. Our laser therapies are good conservative methods for the treatment of CIN because of favorable cure rates and no effect on succeeding pregnancy and delivery.     

子宫颈环形电切术治疗宫颈上皮内瘤样病变的疗效

目的：观察宫颈电环切除术（LEEP）治疗不同级别宫颈上皮内瘤变（CIN）的疗效。方法：对宫颈薄层液基细胞学（TCT）检查结果为不典型鳞状上皮（ASC）以上,阴道镜下活检诊断为宫颈CINⅠ级75例、宫颈CIN II级21例、CIN III级2例患者行LEEP治疗,组织标记后行病理检查。LEEP术后每3个月以液基细胞学和阴道镜检查方法随访所有的患者。结果：术后3个月随访,宫颈糜烂100%愈合,宫颈细胞检查阴性96例,核异质2例,Leep治愈率可达97.9%。术后9个月复查均阴性,无复发病例。结论：LEEP是目前临床上诊治CIN的有效方法。     

宫颈上皮内瘤变的环形电切术和阴道镜活检病理分析

目的探讨宫颈环形电切术(LEEP)和阴道镜活检在诊断宫颈上皮内瘤变(CIN)中的价值。方法对门诊阴道镜活检诊断为CIN的患者123例行LEEP,比较其病理诊断结果的差异。结果123例患者LEEP后病检结果:慢性宫颈炎16例,CINⅠ级21例,Ⅱ级40例,Ⅲ级40例,早期浸润癌4例,浸润癌2例。阴道镜下活检结果为CINⅠ、Ⅱ级和Ⅲ级的与LEEP后病检结果的符合率分别为43.9%、73.8%、85.0%,总符合率为67.5%。其中诊断过度者19例(15.5%),诊断不足者21例(17.1%),宫颈癌漏诊率为4.9%。阴道镜下活检对诊断CINⅡ、Ⅲ级的准确率要高于CINⅠ级,两者相比较有差异(P<0.01)。阴道镜下活检诊断CINⅢ级的患者,其漏诊癌的比例较CINⅠ级和Ⅱ级高(P<0.05)。结论阴道镜活检是诊断CIN的一种简单而有效的方法,但存在一定的局限性,LEEP可以弥补阴道镜活检的缺陷,提高诊断的准确率。     

Conization of the cervix using harmonic scalpel

Conization, as a surgical treatment for cervical intraepithelial neoplasm (CIN), is a good method that preserves reproductive functions. Technological developments have introduced a wide variety of energy sources for surgical procedures. Traditional cold knife conization has been replaced by laser conization and by the loop electrosurgical excisional procedure (LEEP). However, laser conization and LEEP have some disadvantages. Laser conization requires expensive equipment. LEEP induces electrocautery artifacts and cannot excise the cervical tissue as a single-piece, because of the various extensions and depths of lesion, so that evaluation of the margins is sometimes not possible. Laser conization and LEEP both generate smoke. The presence of smoke is not only inconvenient, but also dangerous. Harmonic Scalpel (HS), ultrasonic cutting and coagulation system, is a new surgical tool that cuts and coagulates using ultrasonic mechanical vibrations. Eleven women with CIN III underwent conization using HS. HS eliminated the major disadvantages of electrosurgery and laser surgery. No complications during conization were observed. Postoperative hemorrhage was noted in only one patient. Histological diagnosis was not affected by heat or ultrasound. This surgical method using HS is characterized by negligible bleeding, a good visual field not obscured by smoke and resection of an ideal shape that fits the size of the lesion. It is concluded that this method overcomes most problems associated with conization using conventional methods.     

Four categories of LEEP for CIN of various areas: a retrospective cohort study

Purpose: To compare the effectiveness and safety of loop electrosurgical excision procedures (LEEP) with four different excisions in treating cervical intraepithelial neoplasia (CIN) of different areas.

Methods: Four hundred and sixty-six cases of CIN were treated with different types of LEEP. Following visual inspection with acetic acid and Lugol’s iodine, LEEP were performed to excise the transformation zone to a 20–25?mm depth with a 2–3?mm margin. Four categories of procedures are described below: (i) LEEP-A for lesion ≥2/3 of cervical area: conization of ≥2/3 of cervical tissue. (ii) LEEP-B for?≥1/3 but <2/3: conization of 1/3 to?<2/3. (iii) LEEP-C for?<1/3: conization of <1/3. (iv) LEEP-D: endocervical canal resection.

Results: The cases included 108 of CIN I, 232 of CIN II, and 106 of CIN III (not including carcinoma in situ) patients. No positive margin was found in any specimens. The cure rates for LEEP-A, B, C, and D were 99.1%, 98.5%, 100.0%, and 93.2%, respectively (p?>?.05). The pregnancy rate at two years after LEEP was significantly higher in groups C and D compared to group A (p?Conclusions: Four categories of LEEP are highly effective in the treatment of CIN when appropriately applied. However, large loop excision may lead to adverse obstetric outcomes in pregnancy.     

阴道镜下LEEP治疗宫颈上皮内瘤变临床观察

目的探讨宫颈高频电波刀电圈切除术（LEEP）治疗宫颈上皮内瘤变（CIN）的效果。方法采用阴道镜辅助下的宫颈环形电切术：对53例CIN患者进行治疗并对其疗效进行回顾性分析。结果根据宫颈细胞学涂片检查结果,诊断为低度鳞状上皮内瘤变（LSIL）和高度鳞状上皮内瘤变（HSIL）,经活检病理诊为CINⅠ～Ⅲ,行LEEP锥切,术后病理检查结果尖锐湿疣2例（3。77％）;CINⅠ级25例（47．2％）;CIN Ⅱ级20例（37．7％）,CINⅢ级6例（11．3％）。术后6个月复查TCT,均未见不典型细胞。结论LEEP是治疗CIN的一种安全有效的方法。     

环形电切术治疗宫颈上皮内瘤病变的临床分析

目的:探讨高频电波刀环形电切术(LEEP)治疗宫颈上皮内瘤变(CIN)的有效性与可行性。方法:选取电子阴道镜下活检病理诊断为CIN的病人108例,经阴道镜辅助高频电波刀治疗,治疗方法分别采用LEEP锥切术(42例)、活检术(66例),观察术后组织病理变化以及术后随访情况,并对其疗效进行分析。结果:LEEP术前术后病理诊断CIN相符合者83例(76．85%)。CIN病理诊断级别降低32例(29．63%),CIN病理诊断级别升高15例(13．89%)。半年总治愈率99．05%,CIN病变持续存在率为0．95%,复发率1．9%。4例(3．81%)出现宫颈管狭窄。结论:高频电波刀环形电切术是治疗CIN安全、有效的方法,能得到完整的病理标本,治疗的同时有诊断的作用。术后的定期随访十分重要。     

子宫颈病变电环切(LEEP)术的护理

子宫颈癌是女性中最常见的恶性肿瘤之一,严重威胁着妇女的健康。其发生率仅次于乳腺癌,死亡率仅次于卵巢癌。医学科学的发展对其病因的研究已取得巨大的突破,证实高危型人乳头瘤病毒(hum an pap illom avirus,HPV)病毒感染是引起宫颈癌及其癌前病变的最主要的原因,几乎所有的宫     

Clinical investigation with KTP/YAG laser for lower genital tract disease

The KTP/YAG laser (Laserscope) was clinically investigated in treatment of 54 patients, 28 of whom had cervical intraepithelial neoplasia (CIN), 11 who had cervical polyp, 4 with cervical myoma, 9 with condyloma acuminata, and 2 with vulvar tumors. All patients were treated on an outpatient basis with local anesthesia. The procedure was performed in contact and noncontact irradiation modes with the tissue by using a bare fiber held in a handpiece with a power setting of 10-15 watts. Laser excisional conization was carried out for the treatment of CIN, laser excision was used for the treatment of condyloma of the cervix, cervical polyp, cervical myoma, and benign tumor of the vulva, and laser vaporization was used for condyloma of the vulva. The first cure rates were all satisfactory for the follow-up periods of 4-10 months. Complications during and post operation were minimal. The KTP laser provided good vaporizing ability compared with CO 2 and YAG lasers. When massive bleeding occurred which could not be stopped with the KTP laser, the YAG laser was used.