Effect of curcumin on rats/mice with diabetic nephropathy: a systematic review and Meta-analysis of randomized controlled trials

ObjectiveTo assess the renal protective effects of curcumin administration on diabetic rats/mice.MethodsDatabases were searched electronically and conference papers searched manually for search terms to find relevant studies. Articles were assessed independently by two reviewers. Review Manager 5.1 was used for data analysis.ResultsFourteen randomized controlled experiments were included. Meta-analysis demonstrated that blood sugar levels and kidney weight to body weight ratios in the model group were higher than those in the normal group, and the curcumin group had significantly lower mesangial area to glomerular area ratios compared with the model group, and also lower levels of urinary protein, blood urea nitrogen and serum creatinine.ConclusionsCurcumin shows protective effects on the kidneys of rats/mice with diabetes.     

小儿推拿治疗多发性抽动症的Meta分析

目的:系统评价推拿或推拿联合其他疗法与药物治疗在治疗小儿多发性抽动症临床疗效的区别。方法:通过数据库[主要包括中国生物医学文献数据库(CBM)、中国维普全文数据库(VIP)、中国期刊全文数据库(CNKI)、万方数据库、Pubmed、Cochrane Library、Web of Science和EMbase等]检索,搜集有关推拿或推拿联合其他疗法治疗小儿多发性抽动症的随机对照试验(RCT)。由2名评价者独立提取资料并进行方法学的质量评估,质量评价参照Cochrane系统评价员手册5.0.1标准,数据分析采用Stata 15.1软件。结果:最终纳入25项RCTs,其Meta分析结果显示,治疗组小儿抽动症的临床总有效率、中医症候疗效、复发率、不良反应率均优于药物疗法对照组,差异具有统计学意义(P<0.05)。结论:推拿或推拿联合其他疗法治疗小儿多发性抽动症较药物治疗有一定优势,但确切的结论尚需要设计更为严谨的大样本临床试验进行验证。     

Sini decoction as an adjuvant therapy for angina pectoris: a systematic review of randomized controlled trials

OBJECTIVE

To systematically assess the effects and safety of Sini decoction as an adjuvant therapy for patients with angina pectoris.

穴位贴敷治疗腹泻型肠易激综合征的Meta分析*

目的: 比较穴位贴敷或穴位贴敷联合其他疗法与西药疗法在治疗腹泻型肠易激综合征的临床疗效。方法: 检索中国生物医学文献数据库(CBM)、中国维普全文数据库(VIP)、中国期刊全文数据库(CNKI)、万方数据库等,检索时间为建库起至2021年 5月;辅以手工检索漳州卫生职业学院图书馆过刊资料库。中文检索词为腹泻、泄泻、穴位贴敷法、贴敷、敷贴、穴位敷贴等,搜集有关穴位贴敷或穴位贴敷联合其他疗法治疗腹泻型肠易激综合征的随机对照试验(RCT)。由2名评价者独立提取资料并进行方法学质量评估,质量评价参照Cochrane系统评价员手册5.0.1标准,数据分析采用Stata 15.1软件。结果: 最终纳入23个RCT。Meta分析结果显示,治疗组腹泻型肠易激综合征的临床总有效率优于西药疗法对照组(P＜0.05)。结论: 穴位贴敷或穴位贴敷联合其他疗法治疗腹泻型肠易激综合征较西药治疗有一定优势。     

火针疗法干预神经性皮炎随机对照研究的Meta分析

目的 运用循证医学方法系统评价火针疗法干预神经性皮炎的临床疗效。方法 计算机检索PubMed、中国生物医学文献数据库、中国知网、重庆维普、万方数据库,检索所需的随机对照试验(RCT)文献进行Meta分析。结果 共纳入8篇文献,合计神经性皮炎病例共550例。火针疗法治疗神经性皮炎能有效提高治疗有效率(95%CI:1.89～6.20,P0.0001),不仅火针联合药物能够有效治疗神经性皮炎(P=0.0005),单纯火针治疗也能够提高治疗有效率(P=0.03);且火针疗法有效降低患者的瘙痒评分(95%CI:-0.87～-0.10,P=0.01);火针疗法与常规药物治疗在治疗神经性皮炎过程中的不良反应发生率比较,差异无统计学意义(95%CI:0.45～2.23,P=1.00);火针疗法不能降低治疗完成3个月后神经性皮炎的复发率(95%CI:0.08～1.15,P=0.08)。结论 火针疗法能有效治疗神经性皮炎,提高治疗有效率,但不能降低治疗过程中不良反应的发生率及3个月后的复发率。由于纳入文献数量过少,尤其缺少高质量、多中心的文献,因此还需要进一步深入研究。     

Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and Meta-analysis of randomized controlled trials

ObjectiveTo systematically evaluate the clinical efficacy and safety of puerarin injection in the treatment of diabetic peripheral neuropathy (DPN).MethodsRandomized controlled trials investigating the efficacy of puerarin injection on DPN were searched for in China National Knowledge Infrastructure Database, Chinese Scientific Journals Database, Wanfang Database, Chinese Biomedical Literature Database, PubMed, and Cochrane Library from establishment to April 30. Two reviewers independently retrieved and extracted the information. The included studies were assessed by the Cochrane risk of bias and analyzed by Review Manager 5.2 software.ResultsTwenty-two studies involving 1664 participants were included. The quality of the studies was found to be relatively low. Meta-analysis showed that puerarin injection combined with western medication was more effective than conventional therapy for DPN in terms of total effective rate, nerve conduction velocity (NCV), and hemorheology index. Six adverse drug reactions (ADRs) from puerarin injection were reported in two studies. Reactions included facial flushing, palpitations, and pain at infusion locations. However, no serious ADRs were reported.ConclusionsPuerarin injection was effective for the treatment of DPN. Puerarin can improve the total effective rate, correct NCV that was decreased by diabetes, and improve the hemorheology index. Puerarin was also relatively safe clinically. However, since the articles included in the study were not high-quality, more studies should be conducted to strengthen their findings.     

Heat-sensitive moxibustion for lumbar disc herniation:a meta-analysis of randomized controlled trials

OBJECTIVE:To assess the efficacy and safety of heat-sensitive moxibustion in the treatment of lumbar disc herniation(LDH).METHODS:Randomized controlled trials(RCTs) involving heat-sensitive moxibustion in the treatment of LDH were retrieved from the Chinese Biological Medical Literature database(1978-20011),Weipu database(1989-2011),Wanfang digital journal(1998-2011),China National Knowledge Internet(1979-2011),PubMed(1966-2011),EMBASE(1980-2011),and Cochrane Library(Issue 1,2011).Hand-search of the relevant journals from the Library of Jiangxi University of Traditional Chinese Medicine was also adopted for the collection of data.Data were extracted and evaluated by two reviewers independently with a specially designed extraction form.The Cochrane Collaboration’s RevMan 5.0.20 software was used for data analyses.RESULTS:A total of 6 trials involving 580 patients were included.Meta-analysis showed that the total effectiveness rate in the heat-sensitive moxibustion group was significantly different when compared with conventional moxibustion [RR=1.19,95% CI [1.06,1.33)] and diclofenac sodium [RR=1.47,95% CI [1.17,1.85)],but similar to that of acupuncture.The cure rate in the heat-sensitive moxibustion group was significantly different when compared with conventional moxibustion [RR=1.58,95% CI(1.04,2.40)] and diclofenac sodium [RR=1.91,95% CI(1.01,3.60)],but similar with that of acupuncture.In terms of the Japanese Orthopaedic Association scores,significant differences were noted in subjective indices,objective indices,and daily life subscales.Two trials reported that there were no adverse events over the duration of treatment.CONCLUSION:Compared with conventional moxibustion,acupuncture,and diclofenac sodium,heat-sensitive moxibustion in the treatment of LDH is superior in efficacy.Further large-scale trials are required to define the role of heat-sensitive moxibustion in the treatment of this disease.     

针灸治疗早泄疗效的Meta分析

目的系统评价针灸治疗早泄的疗效。方法计算机检索Cochrane图书馆临床对照试验注册中心CCTR（2011.4）、MEDLINE（1998～2011.4）、EMbase（1998～2011.4）、中国生物医学文献数据库CBM（1998～2011.4）、中国期刊全文数据库CNKI（1998～2010.4）、万方医学数据库（1998～2010.4）,并手工检索相关文献,纳入比较针灸与其它方法治疗早泄疗效的随机对照试验（RCT）。采用RevMan5.1软件进行统计分析。结果共纳入4个RCT进行分析,合计411例早泄患者。Meta分析显示：①针灸＋中药组治疗早泄的临床有效率稍高于单纯使用中药组[RR=1.50,95%CI（0.98～2.31）],但差异无统计学意义（P=0.06）。②一研究证实,针灸组治疗早泄的有效率明显高于帕罗西汀组[RR=1.29,95%CI（1.02～1.63）,P=0.03];而另两研究发现,针灸与帕罗西汀在改善患者性功能方面无统计学差异。③一研究证实,针灸治疗早泄疗效明显高于假针灸治疗（P〈0.05）。结论针灸治疗早泄疗效确切,且针灸操作简便,容易实行,创伤小,无明显毒副作用,值得临床推广运用。但因存在纳入研究数量较少,总体质量不高,各研究疗效评定标准不一致等易致偏倚的因素,影响论证真实性,期待更多高质量的多中心临床随机对照试验进一步验证。     

Efficacy of acupuncture on fibromyalgia syndrome: a Meta-analysis

ObjectiveTo comprehensively evaluate the effectiveness of acupuncture as a treatment for fibromyalgia syndrome.MethodsTwo review authors independently selected the trials for the Meta-analysis, assessed their methodological quality and extracted relevant data. A quality assessment was conducted according to the Cochrane Review Handbook 5.0. RevMan 5.0.20 software was used in the statistical analysis.ResultsA total of 523 trials were reviewed and 9 trials were selected for Meta-analysis. (a) Compared acupuncture with sham acupuncture, there was a significant difference in the visual analogue scale, but no difference in the pressure pain threshold. Additionally, and there was a difference in the fibromyalgia impact questionnaire and the multidisciplinary pain inventory after 4 weeks of treatment, but no difference after 7 weeks of therapy. There was no difference in the numerical rating scale in weeks 3, 8 and 13. (b) Acupuncture versus drugs. There were differences in the VAS after 20 days of acupuncture and moxibustion treatment comparing with the drug amitriptyline, and after 4 weeks of acupuncture and moxibustion treatment comparing with the drug fluoxetine and amitriptyline. There were also differences in the number of tender points when comparing acupuncture with amitriptyline or fluoxetine. There was no difference in total efficiency when comparing acupuncture with amitriptyline after 4 weeks of treatment, but there were differences between the two groups 45 days after treatment. There were also differences in total efficiency comparing acupuncture with fluoxetine, and when comparing 4 weeks post-treatment of acupuncture with a combination of amitriptyline, oryzanol and vitamin B. (c) A comparison of acupuncture, drugs and exercise with drugs and exercise showed PPT differences in months 3 and 6. There was no difference between the two comparison groups after follow-up visits in months 12 and 24.ConclusionsCompared with sham acupuncture, there was not enough evidence to prove the efficacy of acupuncture therapy for the treatment of fibromyalgia. Some evidence testified that the effectiveness of acupuncture therapy for fibromyalgia was superior to drugs; however, the included trials were not of high quality or had high bias risks. Acupuncture combined with drugs and exercise could increase pain thresholds in the short term, but there is a need for higher quality randomized controlled trials to further confirm this.     

针刺治疗青少年近视效果的系统评价

目的系统评价针刺治疗青少年近视的疗效。方法计算机检索维普数据库、中国知网、万方数据库,查找关于针刺治疗青少年近视的随机对照试验(RCT),检索时限均从1955年1月1日~2015年12月31日。主要由2位研究者先选择文献及其资料,再行Meta分析(RevMan 5.2软件)。结果共纳入6个研究,707例患者。Meta分析结果显示:针刺组治疗青少年近视的总有效率[RR=6.01,95%CI(1.29,28.07),P=0.02]优于对照组,与对照组间的差异有统计学意义。但发表偏倚较大,使该Meta分析过分夸大了治疗效应量。结论现有证据尚不能表明针刺治疗青少年近视有效,尚需开展更多研究予以验证。     

针灸治疗失眠症的随机对照试验评价

目的：对用针灸治疗失眠症的临床效果进行评价.方法：通过文献检索分析研究的方法,检索到2009年1月至2012年12月有关针灸治疗失眠症的临床对照试验相关文献共128篇,删除没有明确说明随机分配方法的RCT研究论文69篇,仅对剩余的59篇文献进行归类分析.结果：符合条件的7篇RCT共425例患者满足纳入标准,将针灸组和药物组进行对比,比值（OR）为3.25,95%的置信区间[2.50,5.05],P〈0.0001,差异显著,具有统计学意义.结论：针灸治疗失眠症可能有效,目前还不能明确针灸治疗失眠症的临床效果.     

血府逐瘀方治疗冠心病心绞痛随机对照试验的Meta分析

[目的] 对血府逐瘀方治疗冠心病心绞痛的有效性及安全性进行定量分析,以期为其临床应用提供理论依据,并在一定程度上指导辨证。[方法] 检索Web of science, Pubmed, Cochrane library,Elsevier,中国知网,万方数据知识服务平台,维普期刊资源整合服务平台及中国生物医学文献数据库(CBM)截至2015年12月已经发表的中英文文献,纳入单独使用血府逐瘀方或者合并西医常规用药,与西医常规用药治疗冠心病心绞痛进行疗效评价的临床随机对照试验。所有符合纳入标准的文章,将用Revman 5.3软件进行统计分析,结局的效应指标以相对危险度(RR)及95%可信区间(CI)来表示。[结果] 共有10篇文献745例冠心病心绞痛患者符合纳入标准,合并效应检验结果显示治疗组疗效好于对照组,P<0.000 01,RR=1.27,95%CI=[1.19, 1.37],且尚未见有关血府逐瘀方的严重不良反应报道。[结论] 血府逐瘀方在冠心病心绞痛的治疗方面,具有疗效显著且不良反应少的特点,但由于纳入研究的样本质量较低,可能存在发表偏倚等因素影响,需要更加严谨的大样本多中心随机对照试验对血府逐瘀方的有效性及安全性进行验证。     

补益强心片联合西药常规治疗慢性心力衰竭随机对照试验的Meta分析

[目的] 系统评价补益强心片联合西药常规治疗慢性心力衰竭的临床疗效与安全性。[方法] 计算机检索中国期刊全文数据库（CNKI）、维普中文期刊数据库（VIP）、万方期刊数据库（WanFang Data）、中国生物医学文献服务系统（SinoMed）、PubMed、Embase、Web of Science和The Cochrane Library（2018年3期）,检索时间均从数据库建库至2018年3月,纳入补益强心片联合西药常规与西药常规对照治疗慢性心力衰竭的临床随机对照研究。采用Cochrane协作网的偏倚风险评估工具对纳入研究进行方法学质量评价。采用RevMan 5.3.5对疗效指标进行Meta分析。[结果] 共纳入7个随机对照试验,573例患者。Meta分析显示,补益强心片联合西药常规治疗慢性心力衰竭可以进一步增加患者左室射血分数（LVEF）[MD=4.31,95%CI（3.73,4.90）,P<0.000 01],降低N末端B型利钠肽原（NT-proBNP）水平[SMD=-2.02,95%CI（-3.02,-1.02）,P<0.0001],改善心功能（NYHA）[RR=1.25,95%CI（1.09,1.43）,P=0.001],降低Lee氏心衰积分[MD=-1.09,95%CI（-1.36,-0.83）,P<0.000 01]和明尼苏达心衰生活质量评分（MLHFQ）[MD=-10.90,95%CI（-13.12,-8.68）,P<0.000 01]。[结论] 纳入研究评价提示,补益强心片联合西药常规治疗慢性心力衰竭可进一步改善患者心功能、临床症状和生活质量且安全。由于纳入文献质量普遍较低,证据强度不足,上述结论仍需更多大样本、高质量试验研究证实。     

Systematic review on randomized controlled clinical trials of acupuncture therapy for neurovascular headache

Objective:To evaluate the effectiveness of acupuncture as a treatment for neurovascular headache and to analyze the current situation related to acupuncture treatment.Methods:PubMed database (1966-2010),EMBASE database(1986-2010),Cochrane Library(Issue 1,2010),Chinese Biomedical Literature Database(1979-2010),China HowNet Knowledge Database(1979-2010),VIP Journals Database(1989-2010), and Wanfang database(1998-2010) were retrieved.Randomized or quasi-randomized controlled studies were included.The priority was given to high-quality randomized,controlled trials.Statistical outcome indicators were measured using RevMan 5.0.20 software.Results:A total of 16 articles and 1 535 cases were included. Meta-analysis showed a significant difference between the acupuncture therapy and Western medicine therapy [combined RR(random efficacy model)=1.46,95%CI(1.21,1.75),Z=3.96,P<0.0001],indicating an obvious superior effect of the acupuncture therapy;significant difference also existed between the comprehensive acupuncture therapy and acupuncture therapy alone[combined RR(fixed efficacy model)=3.35,95%CI (1.92,5.82),Z=4.28,P<0.0001],indicating that acupuncture combined with other therapies,such as points injection,scalp acupuncture,auricular acupuncture,etc.,were superior to the conventional body acupuncture therapy alone.Conclusions:The inclusion of limited clinical studies had verified the efficacy of acupuncture in the treatment of neurovascular headache.Although acupuncture or its combined therapies provides certain advantages,most clinical studies are of small sample sizes.Large sample size,randomized,controlled trials are needed in the future for more definitive results.     

头穴透刺法治疗失眠症的随机对照研究

背景：失眠已成为威胁公众身体健康的突出问题,针灸在治疗失眠方面具有疗效高和副作用小的优势。 目的：观察头穴透刺法治疗失眠症的临床疗效。 设计、场所、对象和干预措施：将符合纳入标准、源于解放军总医院针灸科门诊的70例失眠患者随机分为头穴透刺组和常规针刺组,其中脱落4例,最终头穴透刺组纳入32例,常规针刺组纳入34例。头穴透刺组给予头穴透刺法,而常规针刺组则给予一般针刺疗法。两组患者均治疗4周。 主要结局指标：比较两组临床疗效、治疗前后匹兹堡睡眠质量指数量表积分和睡眠结构各成分的变化。 结果：头穴透刺组总有效率为90.6%,优于常规针刺组的73.5%（P＜0.05）。头穴透刺法对睡眠质量、睡眠时间及睡眠效率的改善均优于常规针刺法（P＜0.05,P＜0.01）。头穴透刺法能明显增加睡眠总时间和深睡期时间,与常规针刺组相比,差异有统计学意义（P＜0.01）。 结论：头穴透刺法治疗失眠症的临床疗效优于常规针刺法,主要体现在改善睡眠质量、睡眠时间及睡眠效率等方面。     

Influence of clinical pathways used the hospitals of Traditional Chinese Medicine on patients hospitalized with stroke: a systematic review and Meta-analysis

Objective

To evaluate the influence of clinical pathways in the hospitals using the Traditional Chinese Medicine in treatment of stroke in terms of postoperative complications, length of stay (LOS), costs incurred during hospitalization, compared with standard medical care.

单孔与传统腹腔镜阑尾切除术治疗成人急性阑尾炎的比较：随机对照试验的Meta 分析

目的：评价单孔腹腔镜阑尾切除术( single-incision laparoscopic appendectomy,SILA)与传统腹 腔镜阑尾切除术(conventional laparoscopic appendectomy,CLA)的安全性和有效性。方法：计算机检索各数 据库中有关SILA与CLA的前瞻性随机对照试验。检索时限均为建库至2014年5月。按Cochrane系统评价员手册 对纳入文献的方法学质量进行评价后提取数据,采用RevMan5.1统计软件行Meta分析。结果：筛选后最终纳入 10项研究,共1 183例患者,其中SILA组582例,CLA组601例。Meta分析结果显示,手术中转率SILA组高于CLA 组(RR=4.38,95% CI 1.96~9.79,Z=3.59,P=0.0003),手术时间SILA组长于CLA组(RR=4.83,95% CI 1.57~8.09, Z=2.90,P=0.004),住院时间SILA组短于CLA组(WMD=−0.11,95% CI −0.21~−0.01,Z=2.02,P=0.04),术后切口外 观评分SILA组优于CLA组(WMD=0.94,95% CI 0.49~1.40,Z=4.06,P<0.001);术后并发症和术后疼痛评分两组间差 异无统计学意义(RR=1.03,95% CI 0.74~1.45,Z=0.18,P=0.86;WMD=−0.19,95% CI −0.59~0.20,Z=0.95,P=0.34)。 结论：在有条件的医院经严格选择病例,SILA是一项安全有效的手术方式,尤其适用于对切口外观有强烈要求的 病人。     

Safety and effectiveness of Traditional Chinese Medicinal herbs for diabetic foot: a systematic review and Meta-analysis

Objective

To evaluate the safety and effectiveness of traditional Chinese medicinal herbs (TCMHs) as an adjunctive treatment for diabetic foot (DF).