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1.
David Donnermeyer Hendrik Wyrsch Sebastian Bürklein Edgar Schäfer 《Journal of endodontics》2019,45(3):322-326
Introduction
The aim of the present study was to compare sonic activation using EDDY (VDW, Munich, Germany), passive ultrasonic irrigation (PUI), and mechanical activation using the XPendo Finisher (FKG Dentaire, La Chaux-des-Fonds, Switzerland) for the removal of calcium hydroxide from artificial grooves in straight root canals.Methods
The root canals of 90 human maxillary incisors with straight root canals were prepared using Mtwo files (VDW) up to size 40/.04, and the teeth were split longitudinally. A lateral groove in the apical or coronal part was prepared in each root half and filled with calcium hydroxide, and the root halves were reassembled. Five groups were established according to the removal techniques: group A, the XPendo Finisher; group B, EDDY; group C, PUI; group D, manual irrigation with a syringe; and group E, no irrigation (the control group). The activation procedures were performed for 30 seconds with 3 mL sodium hypochlorite 3% as the irrigant. The cleanliness of the grooves was scored under 10× magnification. The median of scoring was analyzed using the Kruskal-Wallis test (P = .05).Results
All activation techniques were significantly more effective in the removal of calcium hydroxide than manual irrigation (P < .05). Regarding the apical groove, EDDY and PUI were significantly more effective in the removal of calcium hydroxide than the XPendo Finisher (P < .05). No difference was found for the coronal groove (P > .05).Conclusions
EDDY and PUI were significantly more effective in the removal of calcium hydroxide than the XPendo Finisher regarding the apical region. Manual irrigation was significantly less effective than all activation techniques. 相似文献2.
Peerapohn Taweewattanapaisan Jeeraphat Jantarat Puey Ounjai Kajohnkiart Janebodin 《Journal of endodontics》2019,45(3):281-286
Introduction
In regenerative endodontic procedures (REPs), a blood clot acts as a natural scaffold for regenerating dental pulp tissue. In current protocols, 17% EDTA is recommended for liberating growth factors from root dentin. Although EDTA affects clot formation in periodontal studies, the anticoagulant effect of EDTA has not been shown in REPs. Therefore, this study aimed to evaluate the effects of 17% EDTA on the characteristics and fiber density of blood clots using in vitro dentin blocks.Methods
The roots of 35 human mandibular premolars were prepared to simulate open apices and irrigated with the following protocols:(1) normal saline solution (NSS),(2) EDTA (1 minute) + NSS (E1N),(3) EDTA (5 minutes) + NSS (E5N),(4) EDTA (1 minute) (E1), and(5) EDTA (5 minutes) (E5). The roots were split, and human blood was placed. The characteristics and fibrin density of clots were observed using a scanning electron microscope. Fibrin densities in all irrigation groups were evaluated using ImageJ software (National Institutes of Health, Bethesda, MD) and statistically analyzed using the Friedman test and the Kruskal-Wallis test with Bonferroni adjustment.Results
Samples in the NSS, E1N, and E5N groups revealed denser fibers with an abundance of erythrocytes when compared with those in the E1 and E5 groups. Fiber densities in the E1 and E5 groups showed significantly lower values than those in the NSS, E1N, and E5N groups in all regions of roots (P < .05). No statistically significant difference at all levels was observed in all irrigation groups.Conclusions
A decrease in clot formation was affected by EDTA irrigation for 1 and 5 minutes. Final flushing with NSS could improve fibrin formation. 相似文献3.
Thomas Connert Ralf Krug Florin Eggmann Isabel Emsermann Ashraf ElAyouti Roland Weiger Sebastian Kühl Gabriel Krastl 《Journal of endodontics》2019,45(3):327-331
Introduction
The aim of this in vitro study was to compare endodontic access cavities in teeth with calcified root canals prepared with the conventional technique and a guided endodontics approach regarding the detection of root canals, substance loss, and treatment duration.Methods
Six identical sets of upper and lower jaw models were produced with 3-dimensional–printed incisors that had simulated calcified root canals. Splints for guided access preparations were fabricated based on 3-dimensional surface scans and cone-beam computed tomographic data sets. Under simulated clinical conditions, 3 operators with different levels of experience prepared access cavities on each front tooth with the conventional technique and guided endodontics (8 teeth per technique and operator). Access cavities were volumetrically assessed on postoperative cone-beam computed tomographic scans. Statistical significance was tested by examining the overlap of 95% confidence intervals (CIs).Results
Canal location was successful in 10 of 24 cases (41.7%) using the conventional technique and 22 of 24 cases (91.7%) with the guided approach. The mean substance loss of the conventional access and the guided access was 49.9 mm3 (95% CI, 42.2–57.6 mm3) and 9.8 mm3 (95% CI, 6.8–12.9 mm3), respectively. The treatment lasted 21.8 minutes (95% CI, 15.9–27.7 minutes) for the conventional technique and 11.3 minutes (95% CI, 6.7–15.9 minutes) for guided endodontics. The success of the guided approach was not influenced by the experience of the operator.Conclusions
Guided endodontics allows a more predictable and expeditious location and negotiation of calcified root canals with significantly less substance loss. 相似文献4.
Wanaporn Nopnakeepongsa Jeeraphat Jantarat Rudee Surarit Apiwan Smutkeeree 《Pediatric Dental Journal》2019,29(1):23-29
Purpose
To evaluate root dentin pH changes using different calcium hydroxide medications in primary and permanent molar root canals.Methods
Sixty primary and 60 permanent molar roots were prepared with Twisted files and assigned in two subgroups: Group1, nonsetting calcium hydroxide (n = 30); group 2, viscous vehicle-based material (ApexCal®) (n = 30). The assigned materials were delivered in root canals and then stored for 24 h, 7 days and 14 days. All specimens were transversely cut in three sections and pH change was determined by Expandable Ion Analyzer cooperating with Flat Membrane pH Electrode and Reference Half-Cell Electrode at sample root surfaces. Two-way ANOVA was used for statistical analysis.Results
No significant difference was observed in primary teeth at all test periods. The mean pH values of the nonsetting calcium hydroxide group (pH10.39–10.90) were greater than those in viscous vehicle-based group (pH 9.84–10.12), but significant difference was observed only at 24 h. Among permanent teeth, the highest pH values of both materials were observed at 7 days. The pH values of the nonsetting calcium hydroxide group (pH 10.40–11.10) were greater than those in the viscous vehicle-based group (pH 9.80–10.41); however, no significant difference was observed at any test period.Conclusion
The peak pH of nonsetting calcium hydroxide group was at 24 h in primary teeth and 7 days in permanent teeth. The nonsetting calcium hydroxide group showed higher pH values than those in the viscous group in both primary and permanent teeth. 相似文献5.
Sevinç Kenan Özen Doğan Onur Seyhun Solakoğlu Tuğba Kotil Mustafa Ramazanoğlu Hakan Hamdi Çelik Mert Ocak Bora Uzuner Erhan Fıratlı 《Journal of cranio-maxillo-facial surgery》2019,47(3):473-483
Purpose
This study investigates the effects of semaphorin 3A on new bone formation in an experimental rat model.Materials and methods
Cortical bone defects, 5 mm, were created in the calvaria of 40 Wistar rats, which were then separated into three groups: empty defect (control) group, collagen group, collagen + semaphorin 3A group. The bone blocks were harvested after 4 and 8 weeks. New bone formation was assessed by micro-computed tomography (micro-CT), histology, histomorphometry, transmission electron microscope (TEM) and immunohistochemistry.Results
Increased bone formation was observed in collagen + semaphorin 3A groups both histologically and with micro-CT. In the histomorphometic analysis, the control group had significantly less bone formation compared to both the collagen and collagen + semaphorin 3A group at 4 weeks (p = 0.0001) and 8 weeks (p = 0.0001). The collagen group had significantly less bone formation compared to collagen + semaphorin 3A group both at 4 weeks (p = 0.002) and 8 weeks (p = 0.005). Immunohistochemical analysis revealed that semaphorin 3A inhibited receptor activator of nuclear factor-kB ligand (RANKL) expression and increased the expressions of osteoblastic bone markers at 4 weeks. In TEM analysis, the collagen + semaphorin 3A group had an increased proliferation and bone formation rate at 4 weeks, whereas bone quantity and maturation were enhanced at 8 weeks.Conclusion
Locally applied semaphorin 3A increases callus formation at 4 weeks and bone formation at 8 weeks. Semaphorin 3A prevents bone resorption by inhibiting osteoclasts and increases bone formation by inducing osteoblasts. 相似文献6.
Joshua A. Manchester Kwok-Hung Chung James S. Brudvik Van Ramos Yen-Wei Chen 《The Journal of prosthetic dentistry》2019,121(5):828-835
Statement of problem
The prevalent use of computer-aided design and computer-aided manufacturing (CAD-CAM) for tooth-colored ceramic materials has led to several case reports and retrospective clinical studies of surveyed crowns used to support removable partial dentures. How the specific contour of a cingulum rest seat affects the fracture resistance of these CAD-CAM tooth-colored materials is unknown.Purpose
The purpose of this in vitro study was to compare the fracture resistance of monolithic CAD-CAM tooth-colored mandibular canine–surveyed ceramic crowns with cingulum rest seats of different designs.Material and methods
Five groups (n=24/group) of CAD-CAM tooth-colored crowns were milled from the same standard tessellation language (STL) file: group EM, lithium disilicate–based material (IPS e.max CAD CEREC blocks); group SM, zirconia-based material (NexxZr T); group LP, zirconia-based material (Lava Plus High Translucency); group ZC, zirconia-based material (ZirCAD LT); and group MZ, composite resin (MZ100 CEREC blocks), used as a control. Crowns from each group were divided into 2 subgroups representing 2 shapes of cingulum rest seat design: round design subgroup (n=12) with 0.5-mm radius of curvature and sharp design subgroup (n=12) with 0.25-mm radius of curvature for the rest seat preparation. The crowns were cemented with resin cement to a composite resin die on a steel nut. After 24 hours of storage in water at 37°C, the specimens were statically loaded to fracture with a custom metal retainer on top of the cingulum rest seat by using a universal testing machine at a crosshead speed of 1.5 mm/min. Two-way ANOVA and the Tukey honestly significant difference tests were used to control the familywise error rate (α=.05). Representative specimens were examined using an optical stereomicroscope at ×10 magnification and a scanning electron microscope to determine the failure patterns and fracture mechanism.Results
The results of the ANOVA test indicated statistically significant differences by materials and rest seat designs (P<.001). The mean ±standard deviation maximal load capacity was 773.5 ±255.0 N for group MZ, 1124.9 ±283.9 N for group EM, 2784.1 ±400.5 N for group SM, 2526.9 ±547.1 N for group LP, and 3200.8 ±416.8 N for group ZC. The round design subgroups had an approximately 30% higher mean failure load than the sharp design subgroups for all surveyed crowns.Conclusions
The present in vitro study demonstrated that zirconia-based groups fractured at twice the load as the lithium disilicate group. Of the 3 zirconia-based groups, group ZirCAD had a statistically greater fracture resistance than the other groups. Designing the cingulum rest seat to have a broad round shape provides a statistically significant higher fracture resistance than a sharp-shape design (P<.05). 相似文献7.
Ahmed Jamleh Amjad Alghaihab Abdulmohsen Alfadley Hussam Alfawaz Abdullah Alqedairi Khalid Alfouzan 《Journal of endodontics》2019,45(5):611-614
Introduction
The aim of this in vitro study was to compare the cyclic fatigue resistance and torsional resistance of EdgeTaper Platinum (ETP) with those of ProTaper Gold (PTG) at simulated body temperature.Methods
ETP and PTG files with #25 tip size were selected. Cyclic fatigue tests were performed in a stainless steel artificial canal until file fracture occurred. The time to fracture was recorded. For the torsional resistance testing, the apical 5 mm of the file was firmly secured with acrylic resin, and the assembly was fixed over torque gauge device. A uniform torsional stress was applied with continuous rotation motion until fracture occurred. The torque at failure was recorded. Both experiments were conducted at 35 ± 1°C. Fractured surfaces were tested via scanning electron microscopy. Statistical analysis was performed using independent Student t test at 5% significance level.Results
The ETP had superior cyclic fatigue resistance than PTG (P < .01). However, it exhibited lower torsional resistance (P < .05). The ETP and PTG showed typical features of cyclic and torsional fatigue behavior under scanning electron microscopy.Conclusions
The ETP exhibited superior resistance to cyclic fatigue but failed to show any improvement in the torsional resistance compared with PTG. 相似文献8.
Julius Moratin Stefan Hartmann Roman C. Brands Dominik Horn Andreas Fuchs Grit Mutzbauer Axel Seher Claus Scholz Urs D.A. Müller-Richter Christian Linz 《Journal of cranio-maxillo-facial surgery》2019,47(3):523-529
Objectives
Locoregional disease recurrence and metastatic events are the leading causes of death and the most important prognostic factors in patients with head and neck squamous cell carcinoma (HNSCC). A major goal of oncology is the identification of clinical and molecular parameters to evaluate the individual risk of recurrence. MicroRNAs (miRNAs) have been shown to correlate well with tumor size and differentiation. Therefore, they are candidate biomarkers for estimating clinical outcomes.Materials and methods
In this study, the expression levels of distinct miRNAs extracted from formalin-fixed, paraffin-embedded (FFPE) samples of oral squamous cell carcinoma were compared.Results
Statistical analysis revealed significant correlations between distinct miRNAs and disease recurrence (miR-99*, miR-194*; p < 0.05) and overall survival (miR-99*; p < 0.05). The results were then validated via data from The Cancer Genome Atlas (TCGA).Conclusions
Our data show that miR-99* and miR-194* can possibly serve as biomarkers for clinical outcome in HNSCC. These findings may help to identify high-risk patients, who could profit from a more individualized treatment and follow-up. 相似文献9.
Jinxin Zheng Zhou Wu Kaijun Niu Yanan Xie Xiaoli Hu Jieni Fu Dongtao Tian Kaiyu Fu Bo Zhao Weiyang Kong Cuicui Sun Ligeng Wu 《Journal of endodontics》2019,45(3):302-309.e1
Introduction
This study examined the identity of the microbiome of deep dentinal caries and its correlation with the inflammation status of caries-induced pulpitis.Methods
Seventy-five cases were diagnosed based on the American Association of Endodontics's diagnostic criteria and divided into 4 groups: normal pulp with deep caries (NP; n = 13), reversible pulpitis with only cold-evoked pain (CRP; n = 17), reversible pulpitis with both cold/heat-evoked pain (CHRP; n = 24), and symptomatic irreversible pulpitis (SIP; n = 21). Samples were sequenced by 16S rDNA. Alpha and beta diversity were determined. Linear discriminant analysis effect size (LEfSe) analysis was used to detect intergroup differences, and receiver operating characteristic (ROC) curves were generated to assess the role of the caries microbiome in caries-induced pulpitis.Results
The 16S rDNA sequencing yielded 9100 operational taxonomic units. Lactobacillus had the highest relative abundance at the genus level among the 4 groups. There were significant differences in the distribution of the microbiome among the groups. In an alpha diversity analysis, species richness differed between the CRP group and the other groups. In a beta diversity analysis, the distribution of microorganisms in the SIP group was significantly different from those in the other 3 groups. LEfSe analysis indicated substantial differences in the microbiome among the groups, and the areas under the ROC curves (AUC) were all high (AUC: 0.734–0.952).Conclusions
Characterization of the caries microbiome has the potential to become an auxiliary method for the diagnosis of pulpitis. This finding may prompt new research on diagnostic strategies for caries-induced pulpitis. 相似文献10.
Akina Hisada Koichi Nakamura Yuki Toyota Ayako Maeda Toshihiro Yoshihara Yasutaka Yawaka 《Pediatric Dental Journal》2019,29(1):17-22
Objective
The objective of the present in vitro study was to evaluate the influence of endodontic irrigation systems on the removal of smear layer and ion diffusion of calcium hydroxide through dentinal tubules in root external resorption models.Materials and methods
Forty single-rooted teeth were divided into four groups (G1, G2, G3, and G4) according to the irrigation regimens: G1, saline solution; G2, 10% sodium hypochlorite with ultrasonic irrigation; G3, 14% EDTA with ultrasonic irrigation; G4, 14% EDTA with ultrasonic irrigation → 10% sodium hypochlorite with ultrasonic irrigation. Ultrasonic irrigation lasted 45 seconds and all the roots were irrigated with 2 mL of saline solution. In experiment 1, the samples were observed on the root canal wall using scanning electron microscope and the percentage of opened dentinal tubules (POD) was calculated. Experiment 2 evaluated the diffusion of calcium ions through dentinal tubules.Results
In the middle region of root canals, the mean POD values were 0.11, 5.02, 82.17 and 96.72 in G1, G2, G3, and G4, respectively. In the apical region of root canals, the mean POD values were 0.06, 0.43, 4.41, and 12.70 in G1, G2, G3, and G4, respectively. The diffusion of calcium ions in G4 was significantly high in all groups.Conclusion
This study demonstrated that a combination of EDTA and sodium hypochlorite with ultrasonic irrigation was most effective in removing the smear layer and ion diffusion from the root canal to the surrounding media. 相似文献11.
Çağman Aksoy Elif Yıldızer Keriş Sis Darendeliler Yaman Mert Ocak Ferhat Geneci Hakan Hamdi Çelik 《Journal of endodontics》2019,45(3):338-342
Introduction
The purpose of the present study was to evaluate the frequency of dentinal microcracks observed after root canal preparation with XP-endo Shaper (XP), Reciproc Blue (RB), and ProTaper Universal (PTU) instruments using micro-computed tomographic (μCT) analysis.Methods
Thirty extracted mandibular first and second molars with mesial roots having 2 separate canals with an angle between 10°and 20° were randomly assigned to 3 experimental groups (n = 10) according to the different nickel-titanium systems used for root canal preparation: XP, RB, and PTU. The specimens were scanned using μCT imaging before and after root canal preparation. Then, preoperative and postoperative cross-sectional images of the teeth were evaluated to identify the presence of dentinal defects. For each group, the number of microcracks was determined as a percentage rate. The McNemar test was used to determine significant differences before and after instrumentation. The level of significance was set at P ≤ .05.Results
No new dentinal microcracks were observed in the XP and RB groups. The PTU system significantly increased the percentage rate of microcracks compared with preoperative specimens (P < .05).Conclusions
Root canal preparations with XP and RB systems might not induce the formation of new dentinal microcracks on the mesial roots of mandibular molars. Further assessments are suggested for the examination of the morphology of microcracks after the use of these instruments. 相似文献12.
Edilmar Moura Santos Felipe Rodrigues de Matos Everton Freitas de Morais Hébel Cavalcanti Galvão Roseana de Almeida Freitas 《Journal of cranio-maxillo-facial surgery》2019,47(4):676-681
Purpose
The aim of this study was to evaluate the population of CD8+ and natural killer (NK) cells in samples of oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma.Patients and methods
Fifty-four cases squamous cell carcinoma (42 OSCC and 12 OPSCC) were immunohistochemically treated by CD8 and CD57 monoclonal antibodies. It was evaluated the relationship of CD8+ and NK cells with tumor size, lymph node metastasis (LNM), clinical staging (CS), overall survival (OS) and disease-free survival (DFS).Results
Only CD8 was higher expressed in both tumors T1 and T2 than T3 and T4, as well as in tumours without LNM and with CS II or III (P < 0.05). There was no association with OS and DFS of both biomarkers.Conclusions
These findings suggest that the differential CD8+ cells infiltration in OSCC and OPSCC might reflect a distinctive tumor microenvironment with a favorable local cytotoxic immune response against neoplastic cells. 相似文献13.
Venkateshbabu Nagendrababu Shaju Jacob Pulikkotil Peerawat Jinatongthai Sajesh K. Veettil Nattawat Teerawattanapong James L. Gutmann 《Journal of endodontics》2019,45(4):364-371
Introduction
This review aimed to find the most effective oral premedication in reducing pain in adults after nonsurgical root canal therapy (NSRCT) using network meta-analysis.Methods
The review protocol was registered in the PROSPERO database (CRD42017071899). A literature search was performed in the MEDLINE and EBSCOhost databases until June 2017 with no language restriction. Randomized controlled trials evaluating the efficacy of oral premedications, whether given alone or in combination, compared with other agents, placebo, or no treatment in adult patients before NSRCT for postoperative pain were included. Nonintervention studies, nonendodontic studies, animal studies, and reviews were excluded. The quality of the studies was assessed using the revised Cochrane risk of bias tool. Pair-wise meta-analysis, network meta-analysis, and quality of evidence assessment using the Grading of Recommendations Assessment, Development and Evaluation criteria was performed.Results
Eleven studies comparing pharmacologic groups of medications were included in the primary analysis. Compared with placebo, corticosteroids (prednisolone 30–40 mg) was ranked best for reducing postoperative pain (median difference [MD] = ?18.14 [95% confidence interval (CI), ?32.90 to ?3.37] for the pain score at 6 hours; MD = ?22.17 [95% CI, ?36.03 to ?8.32] for the pain score at 12 hours; and MD = ?21.50 [95% CI, ?37.95 to ?5.06] for the pain score at 24 hours). However, the evidence was very low (6 and 24 hours) to moderate quality (12 hours). Nonsteroidal anti-inflammatory drugs were ranked least among the medications, and the quality of this evidence was very low. Additional analysis based on the chemical name showed that sulindac, ketorolac, and ibuprofen significantly reduced pain at 6 hours, whereas piroxicam and prednisolone significantly reduced the pain at 12 and 24 hours. Etodolac was found to be least effective in reducing pain. Overall, the evidence was of moderate to very low quality.Conclusions
Based on the limited and low-quality evidence, oral premedication with piroxicam or prednisolone could be recommended for controlling postoperative pain after NSRCT. However, more trials are warranted to confirm the results with a higher quality of evidence. 相似文献14.
Krista A. Strange Peter Z. Tawil Ceib Phillips Harmeet D. Walia Ashraf F. Fouad 《Journal of endodontics》2019,45(5):507-512
Introduction
Resilon (Resilon Research LLC, Madison, CT) with Epiphany Sealer (Pentron Clinical Technologies, Wallingford, CT) was introduced into the market in 2004 as a new method of root canal obturation. This material as well as the traditionally used gutta-percha with AH Plus sealer (Dentsply Maillefer, Tulsa, OK) were in use over a 9-year span in the University of North Carolina endodontic clinics. Although Resilon was initially thought to create a “monoblock” seal between the material and the canal, in vitro studies later suggested this concept not to be true. The long-term outcome of Resilon using a validated radiographic index and a systematic approach has not been reported. The purpose of this retrospective cohort study was to radiographically evaluate the outcome of Resilon/Epiphany-treated root canals compared with traditional gutta-percha/AH Plus.Methods
One hundred twenty-five teeth were radiographically evaluated using the periapical index; 80 were treated with Resilon and 45 with gutta-percha. Age, sex, tooth position, and number of months to follow-up were documented, and a multivariate analysis with odds ratio was performed.Results
Resilon-treated teeth were 5.3 times more likely to have a periapical index of 3 to 5 at follow-up compared with gutta-percha (P = .009). Teeth presenting with preoperative lesions, regardless of the material used, were also more likely to present with a lesion at follow-up (P = .04).Conclusions
Teeth obturated with Resilon were more likely to present with a lesion at follow-up compared with gutta-percha obturated teeth after controlling for the presence of a preoperative lesion and the length to follow-up. 相似文献15.
Kathrin J. Grochau Ali-Farid Safi Uta Drebber Andrea Grandoch Joachim E. Zöller Matthias Kreppel 《Journal of cranio-maxillo-facial surgery》2019,47(3):505-509
Purpose
The aim of this prospective work was to examine oral leukoplakia for their podoplanin expression to determine whether podoplanin expression is associated with the degree of dysplasia.Materials and methods
We took biopsy samples from 50 patients with oral leukoplakia in 2013. The preparations studied by immunohistochemistry were analyzed in correlation with the degree of dysplasia and other clinicopathological variables.Results
The Chi-square test showed a significant correlation between podoplanin expression and the degree of dysplasia according to the squamous intraepithelial neoplasia (SIN) classification (p = 0.033). Also, a significant association between age grouping and podoplanin expression was found. We were able to show that the distribution is the same for both age groups in relation to the score of podoplanin expression (p = 0.003).Conclusion
In a comparable retrospective work of our working group, it could be shown that podoplanin is a reliable predictive marker for the assessment of the risk of malignant transformation. The present work was able to substantiate the assumption that podoplanin not only plays an important role in the context of malignant degeneration but also exerts a major influence in advance. 相似文献16.
Bing Guo Yu-an Cao Xingjun Qin Chunyue Ma 《Journal of cranio-maxillo-facial surgery》2019,47(5):826-831
Purpose
Cystadenocarcinoma (CAC) is an extremely rare disease in parotid gland. This study aimed to identify the clinical characteristics of CAC, and the therapeutic options for its treatment. An attempt was also made to identify postoperative recurrence-related risk factors.Material and methods
A retrospective study was conducted of CAC patients treated between 2008 and 2018. Predictive factors for postoperative recurrence (5-year RFS rate) were preliminarily filtered by Kaplan–Meier analysis and then further confirmed by a Cox regression model. Postoperative recurrence was defined as the primary outcome variable and was measured using both univariate and multivariate analysis.Results
A total of 27 patients were analyzed, and the total incidence of postoperative recurrence was 33.3% (9/27). In the Cox regression analysis, patients who received a superficial parotidectomy were 0.046 times more likely to develop tumor relapse than those who only underwent enucleation (p = 0.032; 95% CI: 0.003–0.070). The chances of tumor recurrence in patients with the cribriform subtype were 9.701 times that for cases with a papillary pattern (p = 0.016; 95% CI: 1.517–62.030). The risk of postoperative recurrence increased abruptly, with an OR of 6.373 (p = 0.042; 95% CI: 1.070–37.965), when LN metastasis was found in patients.Conclusion
Preoperative diagnosis of CAC in parotid gland is extremely important for allowing surgeons to apply appropriate therapeutic strategies (enucleation or superficial parotidectomy). Patients with LN metastasis, cribriform pattern, and Ki-67 positivity should be treated further to avoid tumor relapse. 相似文献17.
Kaidiliya Yalikun Manabu Kanazawa Mariko Tanoue Shunsuke Minakuchi 《The Journal of prosthetic dentistry》2019,121(3):492-497
Statement of problem
Single-implant–retained mandibular overdentures (1-IODs) may be an alternative to 2-IOD for maladaptive denture patients giving comparable satisfaction, lower cost, and shorter treatment times. However, studies evaluating the effect of the number of implants on the strain exerted around the implants of IODs using strain-gauge analysis are lacking.Purpose
The purpose of this in vitro study was to evaluate the effect of the number of implants on the strain in an IOD under various loading and dislodging conditions.Material and methods
A mandibular IOD with the Locator attachment system (pink nylon inserts) was fabricated on artificial mucosa. Three implant positions recorded the loading: 1-IOD (mid-anterior), 2-IOD (bilateral lateral incisor), and 3-IOD (mid-anterior and bilateral canine) were prepared. Strain gauges attached to the mid-anterior implant replica for the 1-IOD, the left lateral incisor replica for the 2-IOD, and the anterior and left canine replicas for the 3-IOD. Vertical loads of 50 N were applied to the experimental overdenture in the mid-anterior and right molar and left molar regions. Three dislodging tests were performed in 3 different areas: mid-anterior, posterior, and mid-anterior and bilateral molar. Six measurements were made under each loading and dislodging condition for each IOD (N=6). During the calibration test, the resultant strain measured by strain gauge was converted into a lateral force (F) value by using linear regression: Fanterior-posterior(N)=1.08×strain (με), Fposterior-anterior(N)=0.192×strain (με), Fleft-right(N)=0.590×strain (με), Fright-left(N)=0.560×strain (με). Statistical analysis was performed by using 1-way ANOVA and the Tukey honestly significant difference test (α=.05).Results
The 3-IOD demonstrated the significantly highest strain under loading and dislodging conditions (P<.05). The 1-IOD demonstrated the significantly highest strain during right-side loading (P<.05). Upon anterior and left-side loading, no significant difference was noted in strain between the 1-IOD and 2-IOD (P=.413, P=.272). Under dislodging conditions, the 1-IOD exhibited the significantly lowest strain (P<.05).Conclusions
Within the limitations of this study, the 3-IOD demonstrated the highest lateral resistance force during load and dislodge testing, whereas the 1-IOD exhibited the lowest. 相似文献18.
Mona H. El-Zekrid Salah H. Mahmoud Fawzy A. Ali Mohamed E. Helal Mohammed E. Grawish 《Journal of endodontics》2019,45(3):287-294
Introduction
Partial pulpotomy is a vital treatment for carious and traumatic exposure, especially in young permanent teeth. Cell-based therapy for partially pulpotomized teeth can be considered a promising approach for dentin-pulp complex regeneration. This study evaluated the healing capacity of autologous bone marrow–derived stem cells (BMSCs) on partially pulpotomized teeth in a dog model.Methods
Twelve mongrel dogs were selected, and a total number of 192 posterior mandibular and maxillary teeth were involved in the study (16 teeth per dog). Partial pulpotomies were performed, and the dogs were assigned into 2 equal groups (groups 1 and 2), 6 dogs in each group. The coronal pulp cavities (n = 96) of group 1 were filled with calcium silicate–based capping material. Group 2 coronal pulp cavities (n = 96) were seeded with 1 × 105 cell/mL BMSCs, and then the cavities were filled with calcium silicate–based capping material. After placing the capping materials, the cavities of both groups (1 and 2) were filled with resin-modified glass ionomer restorative material. From each group, 48 teeth from 3 dogs were evaluated histologically after 1 week, and the other 48 teeth from the remaining 3 dogs were evaluated after 9 weeks. Scoring was done for the amount of inflammatory cell infiltrates, tissue necrosis, and thickness of hard tissue bridge formation.Results
The Mann-Whitney U statistical test performed for hard tissue bridge formation revealed significant differences between the 2 groups at the 1- (P < .05) and 9-week (P < .05) examination periods.Conclusions
Autologous BMSCs have significant therapeutic potential because they enhance the healing capacity of partially pulpotomized dogs' teeth. 相似文献19.
Zhien Feng Chong Wang Bo Li Kyojin Kim Jinzhong Li Minghui Mao Lizheng Qin Hua Li Zhengxue Han 《Journal of cranio-maxillo-facial surgery》2019,47(3):516-522
Objective
To explore the application of modified resection compared with traditional segmental resection of the mandible for patients with anterior floor of the mouth and tongue squamous cell carcinoma (SCC) without infiltration of the mandible.Subjects and Methods
This is a retrospective study including 36 eligible patients with anterior floor of the mouth SCC(9 patients received modified mandibulectomy, and 27 patients received segmental mandibulectomy).Results
No patients in the modified mandibulectomy group developed recurrence in the floor of the mouth, and all of the patients survived. Only one patient developed osteoradionecrosis. When the modified mandibulectomy group was compared with the segmental mandibulectomy group, the former exhibited a lower recurrence rate in the floor of the mouth (0.0% vs. 14.8%), less blood loss (516.7 ± 70.7 ml vs. 533.3 ± 93.0 ml), shorter durations of gastric tube placement (11.4 ± 4.5 days vs. 20.7 ± 11.9 days) and tracheostomy (6.9 ± 0.6 days vs. 8.5 ± 1.6 days), a lower postoperative infection rate (11.1% vs. 18.5%), and a shorter postoperative hospital stay (13.7 ± 3.8 days vs. 15.9 ± 5.1 days).Conclusion
This modified mandibulectomy method is safe and feasible and is recommended for further prospective study in a clinical setting. 相似文献20.