共查询到20条相似文献，搜索用时 31 毫秒
1.
Objective
To evaluate the serum vitamin D level in patients with chronic rhinosinusitis with nasal polyps and its correlation with the disease severity.Setting
Hospital of Zhejiang University.Study design
Retrospective analysis of collected data.Subjects and methods
Patients with chronic rhinosinusitis with or without nasal polyps who underwent endoscopic sinus surgery were recruited. Demographic information including age, gender, body mass index, smoke history, atopic status and asthma was collected. Disease severity was measured by the Lund-Mackay CT score and Sino-Nasal Outcome Test-22 score. Serum 25-hydroxyvitamin D3 was measured by enzyme-linked immunosorbent assay preoperatively.Results
Serum 25-hydroxyvitamin D3 levels were significantly lower in patients with nasal polyps (CRSwNP, 38.2?±?9.1?nmol/L; CRSsNP, 48.94?±?12.1?nmol/L; control, 54.1?±?17.1?nmol/L. p?<?0.001), and the levels were significantly associated with the preoperative Sino-Nasal Outcome Test-22 score (p?=?0.013), but not with the Lund-Mackay score (p?=?0.126). Furthermore, serum 25-hydroxyvitamin D3 levels were associated with the subjective improvement six months postoperatively (p?<?0.001),Conclusion
Serum 25-hydroxyvitamin D3 levels are lower in Chinese CRSwNP patients. These 25-hydroxyvitamin D3 levels are associated with SNOT-22 score. Preoperative 25-hydroxyvitamin D3 level may impact on the symptom improvement after surgery. 相似文献2.
Juan Li Jianhua Jin Songli Xi Qian Zhu Yuqin Chen Min Huang Chunyan He 《American journal of otolaryngology》2019,40(2):253-256
Background
Although cognitive behavioral therapy (CBT) has been known with a theoretical basis for tinnitus patients, there still were lack of clinical evidence.Objective
To evaluate the clinical efficacy of cognitive behavioral therapy (CBT) for treatment of chronic subjective tinnitus.Methods
One hundred patients with chronic subjective tinnitus patients were randomly divided into control (50 cases) and intervention (50 cases) groups, which received the masking therapy and sound treatment and masking therapy and sound treatment plus CBT. The treatment efficacy was evaluated.Results
The total effective rate in intervention group was significantly higher than control group (P?<?0.01). After treatment, compared with control group, in intervention group the psychotic somatization, interpersonal sensitivity, depression, anxiety, hostility, terror, and phobic anxiety scores in Symptom Checklist-90 and Tinnitus Handicap Inventory score were significantly decreased (P?<?0.05), the serum cortisol level was significantly decreased (P?<?0.05), and the serum interleukin-2 level was significantly increased (P?<?0.05).Conclusion
Based on the elimination the mood disorders and reduce the stress, CBT can significantly relieve the symptoms of chronic subjective tinnitus. 相似文献3.
Shaghayegh Shahsavan Ashkan Pirayesh Omid Zargari Samani Hedayatollah Shirzad Mohamad Ali Zamani Soroush Amani Seyyedeh Maryam Kazemi Mandana Moghni Fatemeh Deris Nader Bageri Loghman Salimzadeh Ghadir Tavakoli Mostafa Gholami Arjenaki 《American journal of otolaryngology》2019,40(2):173-178
Purpose
Several reactions leading to numerous effects are regulated by IL-22. However, the relationship between IL-22 and immunopathogensis of allergic rhinitis (AR) has been rarely investigated. The aim of the present study was to investigate the levels of IL-22 and IL-17A in AR patients and their association with clinical severity of persistent allergic rhinitis (PAR).Materials and methods
Thirty mild persistent allergic rhinitis (M PAR) patients, thirty moderate/severe persistent allergic rhinitis (M/S PAR) patients, and thirty healthy controls were enrolled in this study. Local production of IL-22 and IL-17A in PAR patients and healthy controls' nasal mucosa was examined by immunohistochemistry (IHC) and real-time polymerase chain reaction (RT-PCR) techniques. Serum levels of IL-22, IL-17A, specific immunoglobulin E (sIgE), and total IgE (tIgE) in PAR patients and healthy controls were determined by ELISA. In addition, blood eosinophil, nasal eosinophils per field, and total nasal syndrome score (TNSS) were also assessed.Results
In comparison with healthy controls, production of IL-22 and IL-17A in M/S PAR patients increased significantly. Furthermore, serum levels as well as the mean number of IL-22+ and IL-17A+ cells in nasal mucosa correlated with sIgE, nasal eosinophil count, and TNSS.Conclusion
The results of the present study provide the first evidence that local production of IL-22 might be expressed in PAR patients. The expression of IL-22 and IL-17A, and their correlations with clinical parameters in PAR patients suggest the role of these cytokines in the events involved in the development of PAR. 相似文献4.
Yunsong An Yanru Li Dan Kang S.K. Sharama-adhikari Wen Xu Yunchuan Li Demin Han 《American journal of otolaryngology》2019,40(1):52-56
Background
Many studies have indicated associations between impaired nasal breathing and sleep disorders. However, the precise nature of the relationship between nasal patency and sleep remains unclear.Purpose
We analysed the effects of nasal patency on sleep architecture and breath in nasal obstruction-predominant obstructive sleep apnoea (NO-OSA) patients by applying nasal decongestant.Material and methods
A randomized, placebo-controlled double-blind crossover study was performed in OSA patients with chronic nasal obstruction and without obvious pharyngeal narrowing. All OSA patients (confirmed by polysomnography) were recruited and completed 2 overnight studies (randomly applying oxymetazoline or placebo). Data collected after oxymetazoline or placebo treatments were compared. The ClinicalTrials.gov identifier is NCT03506178.Results
Compared with placebo, oxymetazoline resulted in significant increase in rapid eye movement sleep (p?=?0.027) and reduction of stage 1 sleep (p?=?0.004), as well as arousal index (p?=?0.002). Moreover, great improvements in apnoea/hypopnea index (AHI) were observed (p?<?0.001); AHI in the supine position was significantly reduced (p?=?0.001). Oxygen saturation during sleep was increased significantly [mean oxygen saturation (p?=?0.005) and lowest oxygen saturation (p?=?0.024)]. Oxygen desaturation index was significantly reduced (p?<?0.001).Conclusions
Improving nasal patency by decongestant could improve sleep quality, AHI, and oxygen saturation level during sleep. 相似文献5.
Importance
Repair of full-thickness nasal defects can often be associated with multi-stage operations that can result in significant physical and psychological morbidity for patients. We present a single-stage option for reconstruction of these defects.Objective
Demonstrate the utility of the pedicled levator labii superioris alaeque nasi flap and consistency of its vascular pedicle.Design
Anatomical study using fresh cadavers.Setting
Academic medical center.Main outcome and measures
Evaluation of vascular anatomy of pedicled flap and measurements of distances with relationship to facial anatomic landmarks.Results
With few noted anatomic variations, the vascular pedicle of the pedicled levator labii superioris alaeque nasi flap arises from the superior labial artery and is reliably located within 1?cm lateral and inferior of the nasal sill.Conclusions and relevance
As a robust single-stage option, the pedicled levator labii superioris alaeque nasi flap can serve as a powerful option in the arsenal of the reconstructive surgeon. The technique for harvest is simple with attention to a few anatomic variations as described herein, and excellent results can be obtained with proper application. 相似文献6.
Armita Kakavand Hamidi Nasrin Yazdani Kimia Haj Seyedjavadi Nakisa Zarrabi Ahrabi Ardavan Tajdini Keivan Aghazadeh Mahsa M. Amoli 《American journal of otolaryngology》2019,40(2):260-264
Hypothesis
Although the pathogenesis of sudden sensorineural hearing loss (SSNHL) is not clear, however several causes including genetic factors seems to be implicated. We hypothesized that common genetic variants might be involved in SSNHL.Background
SSNHL is known to be an idiopathic disease because the causative factors have not been identified. Several causes including genetic and viral infection besides immune system reaction, neurological disorders, medications, etc. have been previously reported. We examined the association between ApoE and MTHFR gene variants in SSNHL.Methods
This study includes case-control scheme encompassing a total of 177 individuals, include patients inflicted with SSNHL and healthy subjects as control group. Genotyping of MTHFR and ApoE variants was conducted by PCR – RFLP method.Result
Our study showed that MTHFR rs1801133 allele frequency is significantly different between cases and controls. Also genotype distribution of ApoE was significantly different between patients and healthy controls.Conclusions
MTHFR C677T and ApoE gene variant may be associated with sudden sensorineural hearing loss in an Iranian population. 相似文献7.
Michael Chang Alanna Coughran Yu-Jin Lee Jeremy Collins Davud Sirjani 《American journal of otolaryngology》2019,40(2):152-155
Objective
To report the patient selection, surgical technique, and outcomes of parotidectomy using local anesthesia under monitored anesthesia care (MAC).Methods
A retrospective chart review was performed for patients undergoing parotidectomy under local anesthesia at an academic head and neck surgery center.Results
Six patients deemed high risk for general anesthesia (GA) due to medical comorbidities or with a strong preference to avoid GA underwent parotidectomy using local anesthesia and MAC. Parotidectomy was performed for several indications, including benign tumors, malignant tumors, and chronic sialadenitis. Mean age of patients was 78.0?±?7.9?years, and all had an American Society of Anesthesia score?≥?2 and Charlson comorbidity index ≥4. Mean operative time was 102.8?±?38.3?min, comparable to that of parotidectomy under general anesthesia. No major complications occurred. Minor complications included three cases of temporary postoperative facial nerve weakness limited to 1–2 lower division branches. At most recent follow up (10 to 48?months), all patients were medically stable and disease free.Conclusion
In carefully selected patients, parotidectomy under local anesthesia is a viable treatment alternative that can be offered to patients. Successful outcomes require preoperative counseling, meticulous technique, and close collaboration with anesthesia colleagues. 相似文献8.
Yasser Mohammad Hassan Mandour Samira Mohammed M.o.Abdel Menem 《American journal of otolaryngology》2019,40(2):168-172
Object
To compare between results of bacterial cellulose graft myringoplasty and fat graft myingoplasty in patients had mild or moderate size safe perforation.Methods
120 patients undergoing myringoplasty due to mild or moderate size perforation were divided into 3 groups: group I: 40 patients undergoing myringoplasty with use of bacterial cellulose graft, group II: 40 patients undergoing myringoplasty with use of fat graft, group III: 40 patients undergoing usual myringoplasty with use of temporalis fascia graft (control group).Results
Healing in 20 patients with small perforation and 17 patients with moderate perforation in Group I, Healing in 15 patients with small perforation and 10 patients with moderate perforation in Group II, Healing in 18 patients with small perforation and 12 patients with moderate perforation in Group III.Conclusion
Bacterial cellulose graft myringoplasty would be a good, simple, rapid and safe surgery that could be done under local anesthesia in outpatient clinic with shorter time of surgery than fat graft myringoplasty and temporalis fascia graft myringoplasty, with better hearing and healing.Summary at glance
120 patients undergoing myringoplasty were divided into 3 groups to compare between results of bacterial cellulose graft myringoplasty, fat graft myringoplasty and temporalis fascia graft myringoplasty. 相似文献9.
Purpose
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent inflammatory disease of yet unknown etiology. The purpose of this study was to uncover key genes and pathways related to the pathogenesis of CRSwNP via bioinformatics approaches.Materials and methods
The gene expression profile of GSE36830 extracted from Gene Expression Omnibus database was used to screen differentially expressed genes (DEGs) between nasal polyp samples and control samples. Furthermore, functional and pathway enrichment analysis was performed using the clusterProfiler package in R language. In addition, protein-protein interaction (PPI) network was constructed by STRING database and functional modules were detected using Molecular Complex Detection algorithm.Results
A total of 538 DEGs (326 up-regulated and 212 down-regulated) were identified. The most significantly enriched pathways for up-regulated and down-regulated genes were hematopoietic cell lineage and salivary secretion, respectively. Moreover, twenty hub genes with high connectivity degrees were selected from the PPI network, such as TYRO protein tyrosine kinase binding protein (TYROBP), G protein subunit gamma 2 (GNG2), CCR7, and CCR3. Besides, six important modules were obtained, which were highly associated with chemokine signaling pathway, Th1 and Th2 cell differentiation, complement and coagulation cascades, cell cycle, systemic lupus erythematosus, and Staphylococcus aureus infection.Conclusions
The results of this study may provide new insights into potential molecular mechanisms of CRSwNP. Nevertheless, further experiments are needed to confirm these findings. 相似文献10.
Osman Kayapinar Adnan Kaya Cem Ozde Derya Cebeci Ilhan Unlu 《American journal of otolaryngology》2019,40(2):179-182
Background
Recent studies have demonstrated that right ventricular (RV) dysfunction and increased pulmonary artery pressure may be frequent in patients with upper airway obstruction. In this study, we evaluated atrial conduction delays in patients with upper airway obstruction secondary to nasal septum deviation (NSD).Methods
A total of 32 patients with upper airway obstruction secondary to NSD undergoing a septoplasty procedure were enrolled in this study. Preoperative electrocardiography and transthoracic echocardiography were performed in all patients who underwent surgery. The mean pulmonary artery pressure (mPAP) and atrial conduction time (ACT) were recorded before and 6?months after the surgical procedures.Results
The PAP was significantly lower postoperatively than preoperatively (20.75?±?4.83 vs. 24.68?±?5.26; P?<?0.001). The postoperative Electromechanical Delay of Mitral septal wall (EMD-MS) value was significantly lower than that preoperatively (46.20?±?8.5 vs. 40.5?±?9.9; P?<?0.001). The postoperative Electromechanical Delay of Mitral lateral wall (EMD-ML) value decreased significantly compared to the preoperative period (46.3?±?7.4 vs. 40.6?±?9.3; P?<?0.001). The postoperative Electromechanical Delay of Tricuspit lateral wall (EMD-TL) value was significantly lower than that preoperatively (43.8?±?7.0 vs. 38.1?±?9.1; P?<?0.001). There was no significant change in pre- or postoperative measurements of inter- and intra-atrial conduction delays.Conclusions
We demonstrated that upper airway obstruction secondary to NSD causes a significant increase in mPAP and a significant delay in ACT, which improved after nasal septoplasty. According to these results, we conclude that upper airway obstruction may be an important risk factor for pulmonary arterial hypertension, RV dysfunction, and atrial arrhythmias, especially in unoperated cases. 相似文献11.
Lizhi Wang Lai Wei Weili Lu Ziye Liu Meiyi Wang Zhiqiang Wang 《American journal of otolaryngology》2019,40(2):257-259
Purpose
To introduce a feasible approach for excising a preauricular sinus with abscess in children.Materials and methods
Patients under 14?years old with a preauricular sinus abscess and volunteering for surgery were involved in this study.Results
Neither recurrence nor local deformity was found in these patients with a follow-up of 3 to 72?months.Conclusions
Excising the preauricular sinus with abscess in children is a feasible approach to treatment. 相似文献12.
Alia Saberi Seyed Hashem Pourshafie Ehsan Kazemnejad-Leili Shadman Nemati Sara Sutohian Sara Sayad-Fathi 《American journal of otolaryngology》2019,40(1):10-15
Background
Vertigo is a common annoying complaint needing emergent treatment. There are various treatment options for this condition with different outcomes and side effects.Objectives
Assessment and comparison of the effectiveness of Ondansetron and Promethazine in the treatment of acute peripheral vertigo.Materials and methods
This clinical trial was conducted in an academic hospital in the north of Iran in 2017. A total of 170 eligible patients were randomly allocated to groups A: received intramuscular (IM) promethazine; and B: received intravenous (IV) Ondansetron, using quadripartite blocks. The severity of vertigo, nausea, blood pressure, heart rate, side-effects, need for re-administration, and the time to become asymptomatic were assessed before the injections, 30?min after and 2?h after the injections.Results
Excellent improvement in vertigo occurred in both groups (P?<?0.001), with a more significant reduction in the promethazine-treated group (P?<?0.001). Nausea was reduced more significantly in the ondansetron-treated group (P?<?0.05). There were more side-effects seen in the promethazine-treated when compared to the group with ondansetron treatment (P?<?0.001). No significant differences were seen in the blood pressures between groups (P?>?0.05). Heart rates were reduced in both groups but the changes were insignificant (P?>?0.05). The ondansetron-treated group showed a greater need for re-administration of the medication (50.6% vs. 27.1%). The relief score was significantly higher in the ondansetron-treated group compared with the group received promethazine (P?<?0.001). The time to become asymptomatic showed no statistically significant difference between groups (p?=?0.28).Conclusion
Our results indicated that while promethazine cures peripheral vertigo more efficiently, ondansetron is more beneficial for the improvement of nausea and vomiting. 相似文献13.
Renhui Chen Qian Cai Faya Liang Peiliang Lin Ling Chen 《American journal of otolaryngology》2019,40(2):233-235
Objective
To confirm the pre-treatment diagnosis of parapharyngeal space malignancy could aid the treatment plan.Methods
For patients with suspected malignant parapharyngeal space tumors following preoperative imaging, oral biopsy was conducted for pathological diagnosis with the use of 22-G biopsy needles.Results
A total of 11 patients were enrolled. There were three previously diagnosed cases of head and neck malignancy, and eight cases were newly diagnosed. The tumor diameters were in the range of 3 to 5.5?cm. Ten cases (90.9%) achieved positive results, of which eight cases (72.7%) obtained positive results with one puncture and two cases obtained positive pathological results with two punctures. One case did not obtain positive results with two punctures; open surgical resection was performed for this patient. There were no complications such as needle track implantation, heavy bleeding or neurological damage symptoms during the puncture process.Conclusions
Oral biopsy is a minimally invasive, safe and effective technique for the diagnosis of parapharyngeal space tumors. It is easy to operate and could facilitate a comprehensive treatment plan for parapharyngeal space malignancies. 相似文献14.
Brent A. Chang S. Ryan Hall Brittany E. Howard Gregory S. Neel Carrlene Donald Devyani Lal Thomas H. Nagel Richard E. Hayden 《American journal of otolaryngology》2019,40(2):218-223
Purpose
Large anterior skull base, orbital, and high facial defects can present a challenging reconstructive problem. Limited data exists in the literature on the use of a submental flap for reconstructing such defects. We aimed to describe the feasibility, success, and advantages of using variations of the submental flap for reconstruction of anterior skull base, orbital, and high facial defects.Materials & methods
Outcomes measured included flap method, flap survival, flap size, reconstructive site complications, donor site complications, and length of hospital stay.Results
Nine patients were identified that underwent submental flap reconstruction of anterior skull base, orbital, or high facial soft tissue defects. There were 5 pedicled, 2 hybridized, and 2 free submental flap reconstructions. Flap survival was 100%. One flap required leech therapy for early post-operative venous congestion. Average flap skin paddle size was 63.7?cm2. Average length of hospital stay was 7.3?days. No complications from the donor site were reported.Conclusions
Different variations on the submental flap are viable options for reconstruction of high defects in the head and neck. Such flaps have a number of unique qualities that are suitable for reconstruction of anterior skull base, orbital, and high facial defects. 相似文献15.
Shirley Hu Samuel Helman Peter Filip Jonathan Cabin Patrick Colley 《American journal of otolaryngology》2019,40(1):115-120
Background
Headaches are commonly evaluated in otolaryngology and often represent a diagnostic dilemma. This review addresses rhinogenic headache as well as trigeminal neuralgia and migraine, both of which can masquerade as sinus headache and whose management increasingly involves otolaryngology intervention. Discussion considers diagnostic criteria and novel therapies and derives an algorithm for clinical decision-making.Data sources
OVID MEDLINE, Cochrane Library, and Google Scholar databases.Methods
A literature search was performed to identify relevant articles published in the past 10?years addressing the diagnosis and management of rhinogenic headache, trigeminal neuralgia and/or migraine.Findings
Rhinogenic headache: Identification of the specific cause must be achieved before treatment. No studies have mentioned the effect of certain therapies on the amelioration of headache. New techniques of balloon dilation for sinusitis are controversial, and their use remains contingent on surgeon preference. Removal of mucosal contact points has been shown to benefit quality of life in patients with contact point headache. Trigeminal neuralgia: Microvascular decompression is considered the gold standard for treatment, but percutaneous therapies can be effective for achieving pain control. Migraine: Patients who report amelioration of symptoms after targeted botulinum toxin injection may benefit from definitive decompression or nerve avulsion. Patients with mucosal contact points may have less favorable outcomes with migraine surgery if they are not simultaneously addressed.Conclusions
A comprehensive understanding of the diagnostic workup and therapeutic options available for common headache etiologies is key to the management of a patient presenting with headache attributed to a rhinogenic cause. 相似文献16.
Yasser Mohammad Hassan Mandour Shaimaa Magdy Abo Youssef Hany Hussein Moussa 《American journal of otolaryngology》2019,40(2):187-190
Object
To compare Polysomnography and Pulmonary function tests before and after Septoplasty with Turbinectomy in patients complaining of nasal obstruction and sleep problems due to deviated septum with hypertrophic inferior turbinate.Methods
90 patients underwent Septoplasty with Turbinectomy due to nasal obstruction and sleep problems involved in this study, their sleep quality evaluated by polysomnography before and after the surgery, their pulmonary functions assessed by spirometry before and after the operation.Results
The postoperative pulmonary function values; FVC, FEV1, PEFR and postoperative polysomonographic values; AHI, Snoring index/hour, SpaO2 were higher than the preoperative values, and the results were statistically significant (p-values <0.001).Conclusion
Septoplasty with partial inferior turbinectomy might be a useful operation in the management of nasal obstruction and sleep problems that caused by a deviated nasal septum and hypertrophied inferior turbinate. 相似文献17.
Ameya Jategaonkar Jaclyn Klimczak Jay Agarwal Arvind Badhey William M. Portnoy Angela Damiano Raymond L. Chai 《American journal of otolaryngology》2019,40(2):143-146
Objective
Syphilis is a sexually transmitted infection with various presentations. Although, oropharyngeal manifestations are known to occur, the purpose of this study is to present the first case series in which the lesions were initially mistaken for human-papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC).Methods
A multi-institutional retrospective review.Results
Six cases of oropharyngeal syphilis were initially thought to be secondary to OPSCC due to presentation. Symptoms were vague and exam findings consisted of either a tonsillar or base of tongue mass, or lymphadenopathy. Biopsies were negative for OPSCC. Further workup diagnosed syphilis, with resolution of symptoms and lesions after antibiotic treatment.Conclusions
Head and neck manifestations of syphilis have been reported in the literature. However, this is the first series reporting on oropharyngeal syphilis masquerading as HPV-related OPSCC. Ultimately, otolaryngologists must maintain a high suspicion for syphilis in order to ensure prompt diagnosis and treatment. 相似文献18.
Eda Şimşek Cemile Koca Bicer Muhammed Recai Mazlumoğlu Soner Sertan Kara Ozcan Erel Ayşe Çarlıoğlu 《American journal of otolaryngology》2019,40(2):164-167
Background
We evaluated the relationship between otitis media with effusion and thiol/disulfide homeostasis using a novel marker of oxidative stress.Methods
The study group consisted of 30 patients (mean age 8.33?±?3.30?years) with bilateral otitis media with effusion admitted to our hospital. The control group consisted of 35 (mean age 7.40?±?3.97?years) age-, sex-, and body mass index-matched healthy subjects. Thiol/disulfide homeostasis was measured using a newly developed method.Results
Native and total thiol levels were lower in the study than the control group (native thiols 421.37?±?72?μmol/L vs. 464.46?±?46.42?μmol/L, p?<?0.05; total thiols 468.42?±?77.89?μmol/L vs. 501.32?±?50.30?μmol/L, respectively). Disulfide levels and the disulfide/native thiol and disulfide/total thiol ratios were higher in the study group (disulfides 23.56?±?4.68?μmol/L vs. 18.43?±?4.94?μmol/L; disulfide/native thiol ratio 5.65?±?1.05 vs. 3.97?±?1.03%; disulfide/total thiol ratio 5.06?±?0.83 vs. 3.66?±?0.88%, respectively).Conclusion
Oxidative stress may be the major cause of the increase in oxidized thiols in patients with bilateral otitis media with effusion, however, this relationship requires further investigation. 相似文献19.
Objective
To compare the effects of epidermal growth factor (EGF) and observation only on human subacute tympanic membrane perforation (TMP).Methods
A total of 44 patients with traumatic TMPs >2?months after trauma were divided into an observation group (n?=?18) and EGF group (n?=?26). Patients in the EGF group underwent direct application of EGF without stripping of the perforation edge. All patients were followed up for at least 6?months. The TMP closure rate, closure time, and hearing gain were evaluated.Results
At 6?months, 25 of 26 (96.2%) perforations achieved complete closure with a mean closure time of 9.1?±?3.9?days (range, 3–14?days) in the EGF group. However, only 11 of 18 (61.1%) perforations achieved complete closure in the observation group, with a mean closure time of 20.6?±?10.7?days (range?=?9–71?days). The patients in the EGF-treated group had significantly improved closure rates (P?=?0.026) and a reduced closure time (P?<?0.01) compared to those in the observation group. The difference in mean hearing improvement between the two groups was not statistically significant (P?=?0.86).Conclusions
Topical application of EGF improved the closure rate and shortened the closure time of human subacute TMPs compared with spontaneous healing, the stripping of the perforation edge was unnecessary. This treatment is simple and convenient and should be recommended pre-myringoplasty. 相似文献20.