影响胶囊内镜诊断不明原因消化道出血因素的分析

目的为提高胶囊内镜诊断不明原因消化道出血的诊断率,探讨影响胶囊内镜诊断不明原因消化道诊断率的因素。方法胶囊内镜检查172例,其中不明原因的消化道出血的患者61例,分为2组,A组为胶囊内镜检查明确出血病变者,B组为无明确出血病变者,根据年龄、性别、病史、病变程度、病变表现、排空时间、肠道清洁、检出率、诊断率等对比分析。结果消化道出血的检出率为88．52％,包括胃炎、肠炎、血管畸形、肠息肉、食管静脉曲张等。出血的诊断率为67．2％,包括小肠糜烂,克罗恩病、糜烂性胃炎、溃疡病、肿瘤等。两组病人年龄、性别比较无明显差异,A组病史活动性出血者多,病史长,合并症多,小肠转运时间较长,肠道清洁好,病变程度重,病变检出率高。结论注意病人的选择、合理的小肠转运时间、肠道清洁好、了解出血原因和排序、提高病变鉴别、图像解读及临床综合判断和随访等,可以提高胶囊内镜检查的诊断率,使不明原因消化道出血病变得到及时明确的处理。     

胶囊内镜对不明原因消化道出血的诊断分析

目的探讨胶囊内镜(CE)对不明原因的消化道出血(OGIB)中的诊断价值。方法对本院65例不明原因的消化道出血患者做胶囊内镜检查,详细观察统计分析其影像资料。结果 65例患者顺利完成检查,胶囊内镜摄片时间平均为507min(480～545min),检查过程中均无不适,65例患者均获得清晰图像,本组65例内镜检查结果阳性48例,一例可疑阳性,16例阴性。小肠多发溃疡并出血17例,空肠憩室并出血6例,空肠肿瘤6例,回肠出血3例,缺血性肠病2例,小肠血管瘤2例,小肠crohn疾病5例,血管畸形2例,Meckel憩室1例,空肠息肉3例,NSAID相关性小肠病1例,诊断阳性率73.85%(48/65)。结论胶囊内镜检查安全、无创,检出率较高,对不明原因的消化道出血患者的诊断具有较高的临床价值。     

胶囊内镜诊断不明原因消化道出血临床研究

胶囊内镜对小肠病变的诊断价值已得到肯定，尤其是对不明原因消化道出血的诊断，有其他传统方法不可替代的优势。我们在3年间进行该类检查56例，报道如下。     

胶囊内镜诊断不明原因消化道出血107例

目的:探讨胶囊内镜在不明原因消化道出血中的诊断价值及其与双气囊小肠镜在病因诊断中联合应用的意义。方法:采用M2A胶囊内镜对107例不明原因消化道出血患者进行检查,其中男61例,女46例,平均年龄(51.6±18.9)岁。其中36例患者依据胶囊内镜所观察到的结果,选择经口或经肛行双气囊小肠镜检查和(或)手术探查。结果:107例患者中106例(99.1%)完成胶囊内镜检查,75例(70.8%)胶囊内镜通过回盲瓣。107例中病变检出96例(89.7%)、确诊70例(65.4%)。36例中再经双气囊小肠镜检查和(或)手术后证实胶囊内镜诊断者为26例(72.2%)。2例(1.9%)发生胶囊滞留。结论:胶囊内镜对不明原因消化道出血具有较高的诊断价值,可作为病因诊断的首选筛查手段,与双气囊小肠镜联合应用可大大提高疾病的确诊率。     

胶囊内镜诊断不明原因消化道出血的价值

背景：不明原因消化道出血（OGIB）的诊断是临床难题之一。随着内镜技术的革新,OGIB的诊治水平不断提高。目的：评价胶囊内镜诊断OGIB的价值。方法：回颐性分析南京鼓楼医院2003年5月～2008年4月行胶囊内镜检查的OGIB患者的资料。结果：胶囊内镜的OGIB总检出率为82．6％（228／276）。小肠病变检出率为77．5％（214／276）,其中以血管动静脉畸形（AVM）最为常见,其次为小肠占位和小肠克罗恩病（CD）。14例（5．1％）患者的出血部位位于小肠以外,其中5例位于胃内,9例为结肠病变。所有患者均未出现肠梗阻症状。与〈50岁的患者相比。≥50岁者的小肠AVM检出率显著增高（33．9％对19．6％,P=0．016）,小肠占位和寄生虫病检出率均无明显差异。男性患者的小肠CD检出率显著高于女性患者（17．1％对6．8％,P=0．018）。结论：胶囊内镜检查安全、无创伤,诊断OGIB的价值较高。OGIB以小肠AVM最为多见,其次为小肠占位和CD。     

应用胶囊内镜诊断不明原因消化道出血的临床价值探讨

[目的]探讨胶囊内镜(CE)对不明原因消化道出血(OGIB)的诊断价值。[方法]106例OGIB患者依据不同的临床表现分为隐性出血组和显性出血组,均采用CE检查,对诊断结果进行分析总结。[结果]106例OGIB患者中74例获阳性诊断(69.8%),显性出血组占50例(69.5%),隐性出血组占24例(70.6%),2组阳性诊断率比较,差异无统计学意义;阳性诊断结果中以血管病变居多,其次为小肠恶性肿瘤。[结论]CE检查诊断OGIB的价值较高,是一种安全、简便的诊断方法。     

胶囊内镜对不明原因消化道出血的诊断价值

目的 比较胶囊内镜与传统小肠俭查方法对不明原因消化道出血的诊断价值。方法 总结分析67例胃镜、肠镜检查阴性的消化道出血患者中消化道钡餐、肠系膜动脉造影、推进式小肠镜、胶囊内镜及剖腹探查包括手术中肠镜结果。结果 不明原因消化道出血上、中消化道钡餐检查检出率为17．6％，诊断率为13．8％；肠系膜动脉造影检查检出率和诊断率均为13．4％；推进式小肠镜检查检出率、诊断率为．32％；剖腹探查及术中肠镜检出率和诊断率均为83．3％；胶囊内镜检查检出率为80．6％，诊断率为67．7％结论 胶囊内镜检查对于不明原因消化道出血具有较高的检出率和诊断率．明显优于传统的检查方法。     

国产胶囊内镜对不明原因消化道出血的诊断价值

[目的]探讨国产OMOM型智能胶囊(OMOM)在不明原因消化道出血(OGIB)患者中的诊断价值。[方法]对36例OGIB患者进行OMOM检查,总结并分析其临床资料。[结果]36例均完成检查,其中25例发现病变,阳性检出率69.4%;≥60岁患者以小肠血管畸形为主。检查过程中无任何不适及并发症。[结论]OMOM对OGIB诊断具有较高的诊断率及准确性,临床安全性好。     

胶囊内镜在不明原因消化道出血诊断中的应用

背景：胶囊内镜是明确不明原因消化道出血（OGIB）的检查手段之一,其诊断率可能受到检查时机和出血自然病程的影响。目的：探讨胶囊内镜在OGIB诊断中的应用价值和最佳检查时机。方法：收集2010年10月～2012年6月厦门大学附属中山医院46例接受胶囊内镜检查的OGIB患者。回顾性分析胶囊内镜检查诊断OGIB的阳性率、疑诊率、敏感性、特异性、阳性预测值和阴性预测值,比较不同检查时机对OGIB检出率的影响。结果：胶囊内镜检查诊断OGIB的阳性率为71．7％,疑诊率为13．0％,阴性率为15．2％,诊断敏感性、特异性以及阳性预测值、阴性预测值分别为96．3％、75．0％、92．9％、85．7％。活动性出血组的检出率显著高于出血停止组（96．3％对68．4％,P=0．030）,显性出血者的检出率与隐性出血者相比差异无统计学意义（100％对75．0％,P=0．148）。出血停止≤2周者的检出率显著高于出血停止〉2周者（90．9％对37．5％,P=0．041）。结论：胶囊内镜是诊断OGIB的一种安全、有效的检查手段,出血后尽早行胶囊内镜检查可能提高阳性诊断率并为进一步干预创造条件。     

胶囊内镜在不明原因消化道出血中的临床应用

目的探讨胶囊内镜在不明原因消化道出血中的诊断价值、耐受性、并发症。方法对20例不明原因消化道出血患者行OMOM胶囊内镜检查。结果15例胶囊内镜下发现异常,12例明确为出血病灶,诊断率为60%（12/20）,包括克罗恩病5例,间质瘤4例,晚期肿瘤1例,新鲜出血1例,血管瘤1例。20例受检者均耐受良好,2例出现了胶囊滞留。结论胶囊内镜对不明原因消化道出血有较高的诊断率,易耐受,胶囊滞留是其主要并发症,易发生于克罗恩病患者。     

Outcome in obscure gastrointestinal bleeding after capsule endoscopy

AIM: To investigate the clinical impact of capsule endoscopy (CE) after an obscure gastrointestinal bleeding (OGIB) episode, focusing on diagnostic work-up, follow-up and predictive factors of rebleeding.METHODS: Patients who were referred to Hospital del Mar (Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid anti-inflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings (significant or non-significant), work-up and patient outcomes were analyzed from electronic charts. Variables were compared by χ² analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model.RESULTS: There were 105 patients [45.7% women, median age of 72 years old (interquartile range 56-79)] and a median follow-up of 326 d (interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1% (55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients (69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios (HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above (HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE (HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding.CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions.     

胶囊内镜对不明原因消化道出血诊断的相关影响因素探讨

目的 分析在不同情况下胶囊内镜(CE)对于不明原因消化道出血(OGIB)患者的小肠疾病检出率,以探讨CE检查时机、OGIB出血类型、出血量等因素对于OGIB诊断率的影响.方法 收集北京军区总医院2005年7月-2012年5月209例因OGIB行CE检查患者的临床资料进行分析,将全部入选者分为显性出血组与隐性出血组及轻、中、重出血组;根据患者出血时间与胶囊内镜检查间隔时间将各组患者分别分为3组(A组:72 h内检查组;B组:2周内检查组;C组:2周后检查组).对各组小肠疾病检出情况进行记录并对各组间小肠疾病检出率进行比较.结果 显性出血组中小肠病变检出率58.0％,隐性出血组中小肠病变检出率37.9％,两组比较差异有统计学意义.轻、中、重出血3组小肠疾病检出率分别为30.6％、57.4％、61.3％.显性出血组中A组患者与B组患者小肠疾病检出率差异无统计学意义,A组及B组患者小肠疾病检出率明显高于C组患者.隐性出血组中B组小肠疾病检出率高于A组及C组患者.结论 CE对于OGIB的小肠疾病检出率与显性出血、出血量及CE检查时间等因素相关.对于显性出血患者来说,出血2周内行CE检查小肠疾病检出率明显高于出血2周后进行CE检查;选择显性出血时及中、重度出血患者可获得较高CE小肠疾病检出率.OGIB最常见病因为小肠血管发育异常.     

Small bowel parasitosis as cause of obscure gastrointestinal bleeding diagnosed by capsule endoscopy

Hookworm infection is a relatively common cause of anemia in endemic areas. However, it is rarely encountered in Europe. In this report we describe the case of a 24-year old patient originating from an endemic area who was admitted due to severe anemia, with an Hct of 15.6% and eosinophilia (Eosinophils: 22.4%). While both esophagogastroduodenoscopy and colonoscopy were non-diagnostic, capsule endoscopy revealed a large number of hookworms infesting his small bowel and withdrawing blood. The patient was successfully treated with Albendazole. Capsule endoscopy was proven an important tool in diagnosing intestinal parasitosis.     

单气囊小肠镜对不明原因消化道出血的诊治价值

目的评价单气囊小肠镜对不明原因消化道出血的诊治价值及安全性。方法 2009年6月-2011年12月共有60例不明原因消化道出血患者进行单气囊小肠镜检查。结果 60例接受单气囊小肠镜检查患者中53例有阳性发现,发现阳性病变55处,阳性诊断率为88.33%。所有患者均顺利完成检查,未发生出血、穿孔等严重并发症,也未出现麻醉并发症或麻醉意外。结论单气囊电子小肠镜对不明原因消化道出血具有较高病变检出率和病因诊断准确率,是一种安全、可靠的检查手段。     

Capsule endoscopy： Current status in obscure gastrointestinal bleeding

Capsule endoscopy (CE) is a safe, non invasive diagnostic modality for the evaluation of small bowel lesions. Obscure gastrointestinal bleeding (OGIB) is one of the most important indications of capsule endoscopy. Capsule endoscopy has a very high diagnostic yield especially if the bleeding is ongoing. This technique appears to be superior to other techniques for the detection of suspected lesions and the source of bleeding. Capsule endoscopy has been shown to change the outcome in patients with obscure gastrointestinal (GI) bleed.     

Yield of capsule endoscopy in obscure gastrointestinal bleeding: A comparative study between premenopausal and menopausal women

AIM To evaluate differences in capsule endoscopy(CE) performed in the setting of obscure gastrointestinal bleeding(OGIB) among premenopausal women(PMW) and menopausal women(MW).METHODS Retrospective, single-center study, including female patients submitted to CE in the setting of OGIB between May 2011 and December 2016. Patients were divided into 2 groups according to age, considering fertile age as ≤ 55 years and postmenopausal age as 55 years. The diagnostic yield(DY), the rebleeding rate and the time to rebleed were evaluated and compared between groups. Rebleeding was defined as a drop of Hb 2 g/dL or need for transfusional support or presence of melena/hematochezia.RESULTS A hundred and eighty three female patients underwent CE for OGIB, of whom 30.6%(n = 56) were PMW and 69.4%(n = 127) were MW. The DY was 30.4% in PMW and 63.8% in MW. The most common findings were angiodysplasias in both groups(PMW: 21.4%, MW: 44.9%)(P = 0.003). In PMW, only 1.8% required therapeutic endoscopy. In 17.3% of MW, CE findingsled to additional endoscopic treatment. Rebleeding at 1, 3 and 5 years in PMW was 3.6%, 10.2%, 10.2% and 22.0%, 32.3% and 34.2% in MW. Postmenopausal status was significantly associated with higher DY(P 0.001), TY(P = 0.003), rebleeding(P = 0.031) and lower time to rebleed(P = 0.001).CONCLUSION PMW with suspected OGIB are less likely to have significant findings in CE. In MW DY, need for endoscopic treatment and rebleeding were significantly higher while time to rebleed was lower.     

胶囊内镜检查不明原因消化道出血临床转归115例

目的:探讨胶囊内镜诊断不明原因消化道出血(OGIB)的可靠性及根据其诊断结果指导疾病,临床转归的有效性.方法:收集2002-05/2005-06间因不明原因消化道出血连续至本院行胶囊内镜检查的患者99例,通过就诊记录、电话追踪和门急诊随访等分析胶囊内镜诊断结果的临床符合情况、根据该诊断指导干预措施的结果、患者再出血及再检查等情况.结果:胶囊内镜对OGIB的病变检出率为89.9%,平均随访时间为18.4(6-41)mo,63例(63.6%)胶囊内镜检查结果得以验证,病变检出率在验证前后无显著差异(P=0.36),最终确诊率达90.5%(57/63).根据胶囊内镜诊断结果指导的特异性治疗率为50.5%(50/99),总成功率为82%(41/50),且经胶囊内镜诊断结果指导的对小肠阳性病变的有效干预率显著高于可疑阳性病变(P=0.01).结论:胶囊内镜诊断不明原因消化道出血的准确性高,能有效指导对疾病的进一步治疗,并能较大程度地影响这些疾病,特别是溃疡、肿瘤及血管发育不良所致的不明原因消化道出血的临床转归.