低频脉冲电磁场治疗骨质疏松症骨痛症状疗效观察

目的:观察低频脉冲电磁场物理治疗对缓解原发性骨质疏松症患者骨痛的临床疗效.方法:对306例原发性骨质疏松症患者进行低频脉冲电磁场治疗,每次30 min,每天1次,每周5次,连续4周共20次.用WHO疼痛分级标准进行疼痛评估和治疗前后组间比较.结果:治疗后按照疗效评定标准,治疗总有效率达85.95%;骨痛程度、时间、年龄与疗效之间呈负相关关系,差异有统计学意义(P<0.05).治疗过程中及治疗后无不良反应出现.结论:低频脉冲电磁场能有效缓解骨质疏松症的骨痛症状,提高其生活质量,同时也提示我们在社区骨质疏松症早防早治的重要性     

脉冲电磁场治疗原发性骨质疏松症

骨质疏松症是以骨强度减低为特征的全身性骨病。作者于2003年9月至2005年12月,应用脉冲电磁场治疗61例原发性骨质疏松症,同时用综合疗法治疗60例原发性骨质疏松症作为对照,进行疗效及不良反应的观察,现报告如下:1资料方法1.1病例选择共观察121例均为按标准[1~3]确诊原发性骨质疏松症的患者,其中男性17例,女性104例。年龄45~83岁,平均67.3岁。绝经年限1~33年,平均14.6年。随机将其分成观察组61例,治疗组60例。组间差异无统计学意义,具有可比性(P>0·05)。1.2治疗方法观察组:每天用脉冲电磁场治疗仪(天津产XT-2000B型),选择强度为中高档,频…     

低频脉冲电磁场联合金天格治疗老年骨质疏松症的疗效

骨质疏松是老年人的常见疾病。随着年龄的增长，骨量丢失，骨质疏松引起骨折的发生率也逐年增加。这些由骨质疏松及其并发症对人类生命质量的影响已经超过了慢性阻塞性肺病、脑血管意外等疾病，威为当今全球仅次于心血管疾病的最具危害的慢性疾病。骨质疏松严重影响老年人的生活质量，甚至缩短寿命，是老年人不可忽视的健康问题。我科从2011年3月开始开展低频脉冲电磁场联合金天格治疗老年骨质疏松症，报告如下。     

低频脉冲电磁场联合鲑鱼降钙素治疗原发性骨质疏松症

目的观察低频脉冲电磁场联合鲑鱼降钙素治疗对原发性骨质疏松症的疗效。方法将119例患者分为两组,一组采用低频脉冲电磁场联合鲑鱼降钙素治疗,一组采用鲑鱼降钙素治疗。结果 4周后疼痛缓解出现差异,低频脉冲电磁场联合鲑鱼降钙素治疗优于鲑鱼降钙素治疗组,6个月后,有67例复查骨密度,治疗组平均骨密度增长10.29%,两组比较差异有统计学意义。结论低频脉冲电磁场联合鲑鱼降钙素治疗原发性骨质疏松症,二者有明显协同作用,对缓解骨痛,提高骨密度,优于单一治疗。     

阿仑膦酸钠联合脉冲电磁场治疗原发性骨质疏松症的临床观察

目的探究阿仑膦酸钠联合脉冲电磁场治疗原发性骨质疏松症的临床疗效。方法择取我院2013年1月至2014年6月收治的原发性骨质疏松症患者100例作为本次的观察对象,按照入院治疗的顺序进行分组,共分为常规组与实验组两组,每组患者均50例。对常规组患者单纯给予适量的阿仑膦酸钠进行治疗,而实验组患者在此基础上联用脉冲电磁场治疗,比较两组患者的临床治疗效果。结果经过临床治疗后可知,实验组与常规组患者的治疗总有效率分别为96.0%与50.0%,两组比较数据差异显著(P<0.05);此外,实验组患者治疗2周、4周、8周的VAS评分均明显优于常规组,比较两组数据差异显著(P<0.05)。结论对原发性骨折疏松症患者给予阿仑膦酸钠+脉冲电磁场治疗的临床效果显著,可有效缓解患者骨痛症状,值得推荐采纳。     

低频电磁场治疗老年女性腰椎骨质疏松症的疗效分析

低频电磁场治疗腰椎骨质疏松症的报道尚少。本研究采用低频电磁场治疗老年女性腰椎骨质疏松症30例,并与同期类似病患者疗效进行对比分析．以探讨其疗效问题。现报告如下：     

电磁场治疗老年骨质疏松症及相关骨折的临床观察

骨质疏松症（Osteoporosis，OP）是中老年人群的一种常见的慢性病，易引起腰背疼痛和驼背，极易导致骨折，严重影响老年人的生活质量，加重经济负担。目前，骨质疏松症在全球常见疾病中居第六位。随着我国人口不断老龄化，骨质疏松症的发病率和伤残率越来越高，我国已成为世界上拥有骨质疏松症患者最多的国家，患者总人数高达9600万。     

低频脉冲电磁场治疗骨关节炎的有效性及安全性观察

目的观察低频脉冲电磁场治疗骨关节炎的有效性及安全性。方法 80例骨关节炎患者运用低频脉冲电磁场方法进行治疗。以患者的疼痛程度视觉类比量表(VAS)评分、WOMAC骨关节炎指数评分在治疗开始前、治疗开始后1周、治疗开始后1个月、治疗开始后3个月的变化对患者进行疗效评估;以患者治疗前后重要生命体征和实验室检查结果进行安全性评估。结果治疗前,患者的疼痛程度VAS评分为(7.56±2.41),WOMAC骨关节炎指数评分为(57.21±10.68);治疗开始后1周、治疗开始后1个月、治疗开始后3个月患者的疼痛程度VAS评分分别为(6.16±1.84)、(3.58±1.79)、(3.43±1.92),WOMAC骨关节炎指数评分分别为(47.26±9.81)、(26.5±7.45)、(16.57±4.23);与治疗前相比,患者治疗开始后1周、治疗开始后1个月、治疗开始后3个月的疼痛程度VAS评分、WOMAC骨关节炎指数评分均有改善,各相应指标间的差异有统计学意义(P0.05)。治疗前后重要生命体征和实验室检查结果的差异无统计学意义(P0.05)。结论低频脉冲电磁场疗法是一种安全、有效的骨关节炎治疗手段。     

脉冲电磁场物理干预治疗Ⅱ型骨质疏松症疗效研究

目的观察脉冲电磁场治疗对Ⅱ型骨质疏松患者的疗效。方法对比分析70例Ⅱ型骨质疏松患者经脉冲电磁场治疗前后骨密度变化及腰背疼痛改善的情况。结果治疗3个疗程后,72.86%患者疼痛消失,22.86%疼痛改善,4.28%疼痛无改善,总有效率为95.72%;经脉冲电磁场治疗3个疗程完成后2～6个月复查骨密度,有31例患者骨密度值明显增加(P<0.05);39例患者骨密度值无升高。结论脉冲电磁场治疗Ⅱ型骨质疏松具有较好的疗效。     

脉冲电磁联合药物治疗老年性骨质疏松症研究

观察脉冲电磁场技术联合药物治疗老年性骨质疏松症的疗效。老年性骨质疏松症患者90例随机分为3组（观察组和对照1组、对照2组）,观察组试用脉冲电磁场治疗仪和口服碳酸钙D3片、骨化三醇胶丸进行治疗;对照组分别单纯使用脉冲电磁场治疗仪或口服碳酸钙D3片、骨化三醇胶丸进行治疗,临床观察骨密度改变及疼痛症状缓解程度。观察组疼痛缓解率82.76%,骨密度改善程度均优于对照1组和对照2组。初步研究表明,脉冲电磁场技术联合药物治疗能显著缓解老年性骨质疏松症患者疼痛、改善骨密度。     

碳酸钙维生素D3及鲑鱼降钙素联合脉冲电磁场治疗老年女性骨质疏松症的临床观察

目的 观察碳酸钙维生素D3及鲑鱼降钙素联合脉冲电磁场治疗老年女性骨质疏松症的疗效.方法 老年女性原发性骨质疏松症96例,随机分为对照组和观察组,每组48例.对照组给予口服碳酸钙维生素D3(每天1片)及降钙素鼻喷剂(每天喷两次,每次120 IU)治疗12个月,观察组在对照组治疗的基础上加用脉冲电磁场治疗8周.治疗前及治疗后第1、2、4、8周分别测定患者视觉模拟疼痛评分(VAS),治疗前及治疗后1年对患者进行腰椎骨密度(BMD)测量.结果 观察组和对照组在治疗前及治疗后1、2、4、8周,VAS评分分别为:(6.7±2.1),(2.6±0.9),(1.8±0.5),(1.4±0.3),(1.1±0.2)和(6.6±2.0),(4.5±1.3),(4.0±1.1),(3.2±1.0),(2.7±0.8).治疗后两组患者的疼痛均能获得减轻,而且治疗时间越长,疼痛减轻越明显,但观察组比对照组疼痛缓解得更快(P＜0.01).治疗前观察组和对照组的腰椎BMD分别为:(0.737±0.083)和(0.739±0.083),治疗后1年则分别为(0.793 ±0.082)和(0.791 ±0.081),观察组与对照组比较,BMD差别无统计学意义(P＞0.05),而各组治疗前后比较,BMD升高均具有统计学意义(P＜0.01).结论 碳酸钙维生素D3及鲑鱼降钙素治疗老年女性骨质疏松症疗效确切,联合短疗程脉冲电磁场治疗对缓解疼痛具有协同作用,但对治疗后1年的腰椎骨密度的增加似乎无影响.     

脉冲电磁场对大鼠坐骨神经损伤的作用研究

目的探讨脉冲电磁场对坐骨神经损伤的作用。方法采用大鼠坐骨神经损伤动物模型,将48只SD大鼠随机分成治疗组、夹伤组、对照组,每组16只,根据实验动物的手术时间和处死取材时间的不同,组内再随机分为术后1,3,7,14d共4个时相观察点,各4只大鼠。夹伤组夹伤右侧坐骨神经,予以空白电磁场治疗(磁场强度为0);治疗组夹伤右侧坐骨神经,予以脉冲电磁场治疗;对照组不给予任何干预,保持同样饲养条件至实验结束。以坐骨神经功能指数(SFI)评定功能状况,HE染色观察组织学改变。结果治疗组SFI值与损伤组相比差异无统计学意义(P>0.05)。HE染色光镜下观察,治疗组神经变性程度较损伤组严重。结论脉冲电磁场对神经损伤早期功能的恢复无明显作用,能加速损伤早期远侧神经段的Wallerian变性进程。     

异黄酮对高频电磁场致雌性性腺毒性的保护作用

目的探讨异黄酮(IF)对亚慢性暴露高频电磁场(HF-EMF)雌性性腺毒性的保护效应。方法大鼠每天ig给予IF150mg·kg-1后分别全身暴露HF-EMF0(IF对照组),25,100,400和1600V·m-18h,每周5d,连续8周。第48天开始观察大鼠动情周期的变化,56d后取血清和卵巢,血清采用放免法测定黄体生成素(LH),卵泡刺激素(FSH),雌激素(E2)和孕激素(P4),卵巢采用HE染色法计算各级卵泡数目构成比和电镜观察卵巢细胞超微结构。结果与IF对照组比较,EMF1600V·m-1组动情间期时间由68±7延长至(104±8)h(P<0.01);黄体数目构成比由13.50%上升至19.25%(P<0.01),而初/次级卵泡由26.4%下降至22.7%,成熟卵泡构成比由2.8%下降至1.3%(P<0.01),HF-EMF400V·m-1和HF-EMF1600V·m-1组闭锁卵泡构成比均显著上升(P<0.01);HF-EMF1600V·m-1组的LH水平从8.2±0.7增加至(12.8±1.2)μmol·L-1·min-1(P<0.01),FSH,E2和P4有变化,但无统计学差异;电镜观察HF-EMF1600V·m-1组卵巢细胞核异染色质增多,线粒体出现水肿,线粒体嵴变短而少等。结论 IF对暴露HF-EMF25～400V·m-1的雌性性腺毒性有较好的保护效应。     

Reproductive and teratologic effects of electromagnetic fields

The reproductive risks of electromagnetic fields (EMF) were evaluated based on an extensive review of the scientific literature pertaining to human epidemiologic studies, secular trend data, in vivo animal studies and in vitro studies, and biologic plausibility. The epidemiologic studies involving the reproductive effects of EMF exposures to human populations have included populations exposed to: (1) video display terminals (VDTs), and (2) power lines and household appliances. The clinical use of diagnostic MRI (magnetic resonance imaging) has been increasing, but there are few reports or studies of pregnant women or individuals of reproductive age who have been exposed to MRI, and whose reproductive performance has been evaluated. The population that has been studied most frequently are women exposed to VDTs, but their EMF exposures are extremely low and frequently are at the level of the ambient EMF in a house or office. The results of epidemiologic studies involving VDTs are generally negataive for the reproductive effects that have been studied. Based on the number of studies, the exposure levels, and the fairly consistent results, it can be argued that VDT epidemiologic studies should no longer be given priority. There have been fewer studies concerned with the reproductive risks of power lines, electric substations, and home appliances. In some publications, positive findings for reproductive risks were reported, but the more consistent findings indicate that EMF, even at these higher exposures, do not generate a measurable increase in reproductive failures in the human population. When compared to other fields of human epidemiology, it is obvious that these studies have many difficulties. Exposures are rarely determined. Studies frequently involve small sample sizes and the investigators rarely have a combined expertise in EMF physics, engineering, and reproductive biology. Because of the allegation that there may be particular windows of frequency, wave shape, and intensity that may be deleterious, it is impossible to disregard low frequency EMF exposures as having no deleterious reproductive effects. Yet the epidemiologic data that are available would point in that direction. Secular trend data analysis of birth defect incidence data indicate that increasing generation of electric power during this century is not associated with a concomitant rise in the incidence of birth defects. There are over 70 EMF research projects dealing with animal and in vitro studies that are concerned with some aspect of reproduction and growth. Unfortunately, a large proportion of the embryology studies utilized the chick embryo and evaluated the presence or absence of teratogenesis after 48 to 52 hours of development. The chick embryo studies were of little assistance to the epidemiologist or clinician in determining whether EMF exposure represents a hazard to the human embryo, and the results were, in any case, inconsistent. Embryo culture or cell culture studies are also of little assistance in determining the human risk of EMF. In vitro or in vivo studies in nonhuman species can be used to study mechanisms and the effects that have been suggested by human investigations. Only well designed whole-animal teratology studies are appropriate when the epidemiologists and clinical teratologists are uncertain about the environmental risks. Other aspects of reproductive failure such as abortion, infertility, stillbirth, and prematurity cannot be addressed by in vitro or culture experiments. In fact, it is very difficult to design and interpret nonprimate in vivo studies. Biologic plausability for teratogenesis can be supported if an agent such as EMF can be demonstrated to be cytotoxic or mutagenic. The studies dealing with mutagenesis, cell death, and cell proliferation using in vitro systems do not indicate that EMF have the potential for deleteriously affecting proliferating and differentiating embryonic cells at the exposures to which populations are usually exposed. Of course, there is no environmental agent that has no effect, deleterious or not, at very high exposures. While there does not appear to be measurable risk of reproductive failure and birth defects from EMF exposures in humans, a modest program of investigation is warranted epidemiologically and in the laboratory to answer some of the issues that have been raised that need clarification. It does not appear that the risk of EMF exposure is significant and, therefore, although preparing conducted research in the area of EMF risks is appropriate, it does not necessitate a massive expenditure of resources.     

Evaluation of testicular degeneration induced by low-frequency electromagnetic fields

The population exposure to electromagnetic fields (EMF) has been growing in recent decades. The generation, distribution and use of electric energy can generate low-frequency electromagnetic fields. The present study investigates the effects of EMF (60 Hz and 1 mT) on spermatogenesis of rats during different periods of maturation. Wistar rats were exposed to EMF from day 13 of gestation to postnatal day 21 or 90 in three daily applications of 30 min. Plasma testosterone concentration was not changed by EMF exposure; however, histopathological and histomorphometrical analyses of the testes showed testicular degeneration in a subset of animals exposed to EMF. The magnitude of the degenerative process varied between those individuals affected, indicating different individual sensitivity to EMF. The main alterations observed through transmission electron microscopy were highly electron-dense mitochondria with loss of their organization and cristae. Exposure to 60 Hz and 1 mT EMF can disturb spermatogenesis and may produce subfertility or infertility.     

The influences of extremely low frequency magnetic fields on drug-induced convulsion in mouse

This study investigated the effects of extremely low frequency magnetic fields (ELF-MFs) on the sensitivity of seizure response to bicuculline, picrotoxin and NMDA in mice. The mice were exposed to either a sham or 20 G ELF-MFs for 24 hours. Convulsants were then administered i.p. at various doses. The seizure induction time and duration were measured and lethal dose (LD50) and convulsant dose (CD50) of the clonic and tonic convulsion were calculated. The analysis of glutamate, glycine, taurine and GABA of mouse brain was accomplished by HPLC. The mice exposed to ELF-MFs showed moderately higher CD50, LD50 and onset time on the bicuculline-induced seizure. However, the ELF-MFs did not influence them in the NMDA and picrotoxin-induced seizures. After the exposure to MFs exposure, the glutamate level was increased and GABA was decreased significantly in NMDA and picrotoxin-induced seizure. The level of glutamate and GABA were not changed by MFs in bicuculline-induced seizure. These results suggest that ELF-MFs may alter the convulsion susceptibility through GABAergic mechanism with the involvement of the level of glutamate and GABA.     

柚皮素对去卵巢所致大鼠骨质疏松症的影响

目的：观察柚皮素对去卵巢所致大鼠骨质疏松症的治疗作用。方法50只雌性SD大鼠随机分为假手术组、模型组、柚皮素低、中、高剂量组,每组10只。假手术组施行假手术,其余4组均行卵巢摘除术,术后4周开始灌胃给予35、70、140 mg/kg柚皮素。12周后分别检测5组大鼠血清雌二醇(E2)、孕激素(P)、抗酒石酸酸性磷酸酶( TRACP)、碱性磷酸酶( ALP)、骨钙素( BGP),尿液钙( Ca)、磷( P)及脱氧吡啶啉( DPD)、骨密度( GMD)、股骨三点弯曲应力、L5腰椎抗压缩载荷及骨小梁形态变化。结果与假手术组比较,模型组大鼠体重明显增加,子宫脏器系数明显降低,差异有统计学意义( P <0.05);柚皮素低、中、高剂量组大鼠体重较模型组明显降低,子宫脏器系数较模型组明显增加,差异有统计学意义( P <0.05),并呈剂量依赖性。与假手术组比较,模型组大鼠血清E2、P明显降低,差异有统计学意义( P <0.05);柚皮素低、中、高剂量组大鼠血清E2、P较模型组明显增加,差异有统计学意义( P <0.05),呈剂量依赖性。与假手术组比较,模型组大鼠血清TRACP及尿液Ca、P、DPD明显增加,差异有统计学意义(P<0.05);柚皮素低、中、高剂量组血清 TRACP及尿液 Ca、P、DPD较模型组明显降低,差异有统计学意义( P <0.05),且呈剂量依赖性。与假手术组比较,模型组大鼠血清ALP明显增加,BGP明显降低,差异有统计学意义( P <0.05);柚皮素低、中、高剂量组大鼠血清ALP较模型组明显降低,BGP较模型组明显增加,差异有统计学意义( P <0.05),呈剂量依赖性。与假手术组比较,模型组大鼠BMD明显降低,差异有统计学意义( P <0.05);柚皮素低、中、高剂量组大鼠BMD较模型组明显增加,差异有统计学意义( P <0.05),呈剂量依赖性。与假手术组比较,模型组大鼠股骨三点弯曲应力、L5腰椎抗压缩载荷明显降低,差异有统计学意义( P <0.05);柚皮素低、中、高剂量组大鼠股骨三点弯曲应力、L5腰椎抗压缩载荷较模型组明显增加,差异有统计学意义( P <0.05),呈剂量依赖性。与假手术组比较,模型组大鼠骨小梁面积百分数、骨小梁数、骨小梁厚度明显降低,骨小梁分离度明显增加,差异有统计学意义( P <0.05);柚皮素低、中、高剂量组大鼠骨小梁面积百分数、骨小梁数、骨小梁厚度较模型组明显增加,骨小梁分离度较模型组明显降低,差异有统计学意义( P <0.05),呈剂量依赖性。结论柚皮素对去卵巢所致大鼠骨质疏松症具有良好的治疗作用。     

Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils

The present study describes the effect of low frequency, low energy, pulsing electromagnetic fields (PEMFs) on A2A adenosine receptors in human neutrophils. Saturation experiments performed using a high affinity adenosine antagonist [3H]-ZM 241385 revealed a single class of binding sites in control and in PEMF-treated human neutrophils with similar affinity (KD=1.05+/-0.10 and 1.08+/-0.12 nM, respectively). Furthermore, after 1 h of exposure to PEMFs the receptor density was statistically increased (P<0.01) (Bmax =126+/-10 and 215+/-15 fmol mg-1 protein, respectively). The effect of PEMFs was specific to the A2A adenosine receptors. This effect was also intensity, time and temperature dependent. In the adenylyl cyclase assays the A2A receptor agonists, HE-NECA and NECA, increased cyclic AMP accumulation in untreated human neutrophils with an EC50 value of 43 (40 - 47) and 255 (228 - 284) nM, respectively. The capability of HE-NECA and NECA to stimulate cyclic AMP levels in human neutrophils was increased (P<0.01) after exposure to PEMFs with an EC50 value of 10(8 - 13) and 61(52 - 71) nM, respectively. In the superoxide anion (O2-) production assays HE-NECA and NECA inhibited the generation of O2- in untreated human neutrophils, with an EC50 value of 3.6(3.1 - 4.2) and of 23(20 - 27) nM, respectively. Moreover, in PEMF-treated human neutrophils, the same compounds show an EC50 value of 1.6(1.2 - 2.1) and of 6.0(4.7 - 7.5) nM respectively. These results indicate the presence of significant alterations in the expression and in the functionality of adenosine A2A receptors in human neutrophils treated with PEMFs.