不同方法治疗剖宫产宫缩乏力性产后出血17例疗效分析

目的分析宫腔填塞纱布条术及B-Lynch缝合术对剖宫产宫缩乏力性产后出血的止血效果。方法回顾性分析17例剖宫产宫缩乏力性产后出血病例的临床资料,其中10例用宫腔填塞纱布条术止血,7例用B-Lynch缝合术止血。结果两者术后均无副作用,宫腔填塞纱布条术止血成功率为80%,B-Lynch缝合术止血成功率为100%。结论宫腔填塞纱条术及B-Lynch缝合术治疗剖宫产子宫收缩乏力性产后出血,方法简单、安全、有效,B-Lynch缝合术止血效果优于宫腔填塞纱布条术,值得临床推广运用,特别是基层医院。     

宫腔填塞纱条、低位B-Lynch缝合术、Bakri球囊填塞在前置胎盘剖宫产术中的临床应用

目的探讨宫腔填塞纱布、低位B-Lynch缝合术、Bakri球囊填塞在前置胎盘剖宫产术中的临床应用效果。方法将前置胎盘患者剖宫产术中采用宫腔填纱23例(A组)、低位B-Lynch缝合绑扎子宫止血57例(B组)、Bakri球囊填塞30例（C组）进行对比,观察手术时间、术中出血量、24小时总出血量、产褥病率。结果三组患者手术时间、术中出血量、24h总出血量比较差异有统计学意义(P<0.01)。低位B-Lynch缝合术比宫腔填纱及Bakri球囊填塞手术时间短,术中出血及术后至24小时出血量少。结论前置胎盘剖宫产术中控制出血量非常重要,与宫腔填纱止血及Bakri球囊填塞比较,低位B-Lynch缝合术有明显的优势。     

宫腔纱条填塞术和B-Lynch缝合法对术中子宫收缩乏力性出血的止血效果对比

目的:对比宫腔纱条填塞术和B-Lynch缝合法对子宫收缩乏力性出血的止血效果。方法:随机抽取子宫在手术过程中收缩乏力性出血的患者100例分为对照组50例和试验组50例,试验组患者采取B-Lynch缝合法进行治疗,对照组患者用宫腔纱条填塞术进行治疗,分别对两组患者的止血效率和手术进行情况进行对比。结果:B-Lynch缝合法出血量少于宫腔纱条填塞术,止血效果高于对照组,差异具有统计学意义(P<0.05)。结论:B-Lynch缝合法对手术过程中子宫乏力性出血的止血效果很好,能够明显减少患者的术中出血量,值得在临床过程中推广使用。     

宫腔纱条填塞法在前置胎盘剖腹产术中大出血的应用

目的:探讨宫腔纱条填塞法在前置胎盘剖腹产术中大出血时的止血效果.方法:对20例前置胎盘剖腹产术中大出血患者经用宫缩剂、手法按摩子宫、肠线"8"字缝合出血点无效,出血量＞500mL者,用宫腔纱条填塞术止血,观察其止血效果.结果:20例止血效果均满意,保留了子宫,有效率100%.结论:宫腔纱条填塞术是治疗前置胎盘剖腹产术中大出血的有效方法,其简单易行,效果明显,避免了子宫切除.     

3种手术方法在剖宫产术中出血的临床应用

目的探讨改良B-Lynch缝合、宫腔纱条填塞和子宫动脉栓塞在剖宫产宫缩乏力性出血的治疗效果。方法回顾性分析67例剖宫产术中宫缩乏力性出血患者,其中改良B-Lynch缝合法24例,宫腔纱条填塞治疗25例,子宫动脉栓塞18例,对比观察3种止血方法的效果。结果 3组均能有效控制出血,但改良B-Lynch缝合组手术时间、术中出血量、术后24 h出血量、术后发热天数、抗生素使用时间、术后住院时间及住院费用均少于宫腔纱条填塞组和子宫动脉栓塞组(<0.05)。结论改良B-Lynch缝合法治疗剖宫产术中宫缩乏力性出血效果佳,止血迅速可靠,是避免再次出血的有效手段,无并发症,操作简单,安全性高,适用于基层医院,值得推广。     

前置胎盘剖宫产术中宫腔纱条填塞止血效果观察43例

目的:探讨前置胎盘剖宫产术中出现大出血行宫腔纱条填塞止血的效果.方法:回顾2年内43例前置胎盘剖宫产术中大出血患者,分析术中出血原因,宫腔纱条填塞指征、方法.观察术后恢复情况,并与同期前置胎盘剖宫产术中出现出血未进行宫腔纱条填塞的40例进行比较,做回顾性分析.结果:宫腔纱条填塞组止血效果好,全部保留子宫,术后无感染,无晚期产后出血的发生.结论:前置胎盘剖宫产术中大出血患者宫腔纱条填塞止血效果好.     

宫腔填塞用于前置胎盘剖宫产60例止血效果分析

目的：总结60例子宫填塞纱条治疗前置胎盘剖宫产术大血的临床经验。方法：对1999年1月—2008年12月,用宫腔填塞纱条治疗前置胎盘剖宫产术大出血60例进行分析。结果：60例前置胎盘剖宫产术中大出血用纱条填塞子宫腔后均成功止血。（24~36）小时后阴道顺利取出纱条,未发现阴道大出血,产后42天随访子宫复旧好。结论：子宫填塞纱条是治疗前置胎盘剖宫产术大血的有效方法。     

安列克加宫腔填塞纱条在前置胎盘产妇出血治疗中的应用

目的探讨治疗前置胎盘剖宫产术中出血的有效措施。方法对20例采用安列克加宫腔填塞纱条治疗前置胎盘剖宫产术中大出血患者的临床资料进行回顾性分析。结果前置胎盘剖宫产术中大出血采用安列克加宫腔填塞纱条治疗,20例止血均获成功,24h后均经阴道顺利将纱条取出,随访至产后42d,无一例感染及晚期产后出血。结论安列克加宫腔填塞纱条是治疗前置胎盘剖宫产术中大出血的一种有效方法,可减少急症子宫切除率。     

B-Lynch缝合术在剖宫产产后出血中的临床应用

目的探讨B-Lynch缝合术在剖宫产产后出血中的临床效果。方法对剖宫产术中发生子宫收缩乏力性出血而行B-Lynch缝合术的21例患者的临床资料进行回顾性分析。结果 B-Lynch缝合术成功控制了产后出血。其中2例前置胎盘引起的产后出血,对胎盘剥离面作＂8＂字缝合止血后,再行子宫B-Lynch缝合术。2例胎盘早剥继发宫缩乏力的患者,先行宫腔填纱,然后再行B-Lynch缝扎术有效,术后均未见明显并发症。结论 B-Lynch缝合术用于剖宫产手术中子宫收缩乏力所致的产后出血,止血迅速有效持久,操作简便易行,可避免子宫切除,是治疗剖宫产术中产后出血的较好方法。     

前置胎盘剖宫产宫腔纱条填塞止血临床分析

目的探讨前置胎盘患者剖宫产术中出现大出血行宫腔纱条填塞止血的效果。方法回顾5年里32例前置胎盘剖宫产术中大出血患者,分析术中出血原因,宫腔纱条填塞指征、方法,观察术后恢复情况。结果止血效果好,全部保留子宫,术后无感染、晚期产后出血的发生。结论前置胎盘剖宫产术中出现子宫出血用宫腔纱条填塞止血效果好,值得推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.