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1.
紫外线照射自血回输对肺心病患者血液抗氧化能力的影响 总被引:6,自引:0,他引:6
为进一步探讨紫外线照射自血回输(AUVIB)对肺心病急性加重期患者辅助治疗的机理,对48例肺心病患者AUVIB治疗前后血液中超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)活性进行了检测,并以正常人作对照。结果发现:肺心病患者SOD水平虽高于正常对照组,但无显著差异(P>005),MDA含量显著高于正常对照组(P<001),而GSH-Px与CAT活性明显低于正常对照组(P<005)。经AUVIB辅助治疗后,GSH-Px与CAT活性显著升高(P<005),MDA水平显著降低(P<005)。说明AUVIB能提高肺心病患者血液抗氧化能力 相似文献
2.
脾肾阴虚证血清氧自由基损伤初探 总被引:2,自引:0,他引:2
目的从氧自由基损伤及机体抗氧化能力方面探讨脾阴虚证、肾阴虚证患者的客观病理学改变.方法观察脾阴虚组30例,肾阴虚组16例和健康人对照组16例.取受检者清晨空腹静脉血分离血清后分别测定:总SOD,Cu,ZnSOD(黄嘌呤氧化酶法);MDA(TBA法);总抗氧化能力(比色法).VitC(2,4DNPH比色法);VitE(高效液相色谱法);Cu,Zn(原子吸收法);数据以均数±标准差表示.用单因素方差分析,Schefe法作两两比较,P<005为显著性检验界值.结果总SOD及Cu,ZnSOD肾阴虚组低于脾阴虚与健康人组(F=1769和3032,P<005).脾阴虚组和肾阴虚组MDA高于健康人组(F=491,P<005),而总抗氧化能力却低于健康人组(F=5901,P<005).VitE肾阴虚组低于脾阴虚组和健康人(F=672,P<005).结论脾阴虚证、肾阴虚证患者都有一定程度的氧自由基损伤,但在形成的原因和机体防御消除的机制等方面是不同的 相似文献
3.
目的探讨导致糖尿病酮症(DK)及酮症酸中毒(DKA)患者肝损害的相关因素.方法DK或DKA患者99例,其中ALT及AST均异常升高11例(A组),单项ALT异常升高13例(B组),肝功能正常75例(C组),对以上各组患者的血二氧化碳结合力(CO2CP)、尿素氮(BUN)、血糖(BG)和血浆渗透压(OSM)进行了统计分析.结果A,B两组患者的CO2CP明显低于C组(P<001,t=633和t=643),而BUN则明显升高(P<001,t=361,AvsC;P<001,t=435,BvsC),A组的BG(P<005,t=284)和血浆OSM(P<005,t=310)水平也显著高于C组,而B组患者的BG及血浆OSM与C组比较无差异;与B组相比,A组患者的CO2CP明显降低(P<002,t=271),BG(P<005,t=289)和血浆OSM(P<005,t=236)明显升高.此外,Ⅰ型糖尿病患者血清转氨酶异常升高的发生率明显高于Ⅱ型糖尿病患者(P<005,χ2=438).结论酸中毒和脱水是导致糖尿病酮症及酮症酸中毒患者肝损害的重要因素,酸中毒及脱水程度与肝损害程度相关. 相似文献
4.
肝癌患者外周血树突状细胞免疫功能低下 总被引:4,自引:5,他引:4
目的研究肝癌患者外周血树突状细胞(DC)表面免疫分子HLADR及B7表达水平及其与DC免疫功能的相关性.方法以健康成人(n=10)作为对照,检测临床确诊中晚期肝癌(HCC)患者(n=10)外周血DC表面免疫分子HLADR及B7表达水平及DC免疫诱导T淋巴细胞增殖的能力.结果HCC患者DC表面HLADR及B7表达水平(VOF)为67±16及61±11,明显低于对照组(107±14及96±12,P<005).其DC体外诱导T细胞增殖能力(min-1)为3100±120,亦明显低于对照组(6200±90,P<001).结论.HCC患者DC表面HLADR及B7表达水平下降,并与DC免疫功能低下密切相关. 相似文献
5.
Western印迹方法测定血清中胰岛素样生长因子结合蛋白-3水平 总被引:2,自引:0,他引:2
目的 研究正常人及生长激素分泌异常病人血清中胰岛素样生长因子结合蛋白3( I G F B P3) 的水平。方法 本文采用 Western 印迹方法测定20 例正常人,33 例活动性肢端肥大症病人和34 例特发性生长激素缺乏症( I G H D) 病人血清 I G F B P3 水平。结果 正常成人血清中存在五种分子量不同的 I G F B P, I G F B P3 含量为最高。本文测定了20 例正常成人和67 例生长激素分泌异常患者血清 I G F B P3 的相对光密度( R O D) ,正常人血清 I G F B P3 含量为(1 .1 ±0 .4) R O D,活动性肢端肥大病人为(2 .7 ±1 .2) R O D,明显高于正常成人( P< 0 .01) , I G H D 病人为(0 .4 ±0 .2) R O D,明显低于正常成人( P< 0 .01) 。血清生长激素与 I G F B P3 、胰岛素样生长因子 I与 I G F B P3 均呈正相关( P<0 .05) 。结论 Western 印迹测定血清 I G F B P3 正常值和病理值提示 I G F B P3 浓度的变化与生长激素功能状态密切相关,并依赖 G H。 相似文献
6.
老年高血压患者血压昼夜节律与胰岛素抵抗 总被引:4,自引:0,他引:4
目的为了探讨高血压病患者24h血压昼夜节律变化与糖、胰岛素(IS)代谢的关系。方法46例老年高血压病患者,按昼夜血压节律不同,分为杓型组(DG)与非杓型组(NDG),行葡萄糖耐量试验和IS释放试验。结果DG与NDG2组各时相血糖、血糖面积及空腹IS水平无显著性差异(P>005);而NDG在糖负荷后的60min、120minIS水平和IS释放指数(IRI)以及IS面积(IAUC)明显高于DG(P<001、005、001、0001、001);DG的IS敏感指数(ISSI)明显大于NDG(P<001);夜间平均血压下降率与IAUC、120minIRI及60minIS水平呈显著负相关(γ=-0598、-0511和-0486,P<001、001和005),与120minISSI呈显著正相关(γ=0462,P<001)。结论老年高血压节律异常者有更显著的胰岛素抵抗及高胰岛素血症。 相似文献
7.
消化系恶性肿瘤患者血清与腹水中细胞因子活性变化 总被引:6,自引:5,他引:1
目的研究消化系恶性肿瘤(DMT)患者血清与腹水中内源性IL2,IL6,IL8,TNFα和IFNγ的生物学活性.方法应用ELISA法检测了15例DMT患者(肝癌11例,胆总管癌1例,胰腺癌1例,胃癌1例,直肠癌1例)血清与腹水中5种细胞因子活性,并与6例肝硬变(LC)患者和8例正常成人进行了比较分析.结果DMT患者血清IL2,IL6的生物学活性显著低于LC(P<005);腹水中IL2,IL8活性显著低于LC组(P<001),而IL6和IFNγ活性则高于LC组(P<001,005).DMT患者血清中IL6,IL8活性明显高于正常成人组(P<005);IL2,IFNγ则低于正常成人组,但缺乏显著性.肝癌血清和腹水中IL2活性显著高于非肝癌组(P<005);而IL6活性则相对降低(P<005).结论恶性肿瘤患者血清中IL2和IFNγ活性低于正常人,是DMT患者抗肿瘤免疫功能缺陷的标志.IL6对于预测DMT患者的预后具有重要的意义 相似文献
8.
肝炎后肝硬变肝损害与细胞免疫功能(英文) 总被引:5,自引:0,他引:5
目的研究肝炎后肝硬变(PHC)患者的细胞免疫状态及其与肝功能损害的关系.方法51例PHC患者,包括ChildPuphA级20例、B例18例、C级13例和22例健康对照者,外周血经用FicolHypaque梯度离心分离单个核细胞后,采用3HTdR掺入技术测定了淋巴细胞转化,IL2和NK细胞活性.结果在PHC患者淋巴细胞转化指数(SI)、IL2活性(SI)和NK细胞活性(%)较对照组均明显降低(181±130VS349±217,P<001;81±60VS136±58,P<001;403±217VS613±205,P<001).免疫功能缺陷与ChildPuph分级有关,C级明显低于A、B级(P<001),B级低于A级(P<005).结论PHC患者存在细胞免疫功能缺陷,且与肝损害程度有关. 相似文献
9.
干扰素对人甲状腺细胞表面抗原表达的影响 总被引:5,自引:1,他引:4
目的研究干扰素(IFNα、IFNγ)及激素对人正常甲状腺细胞表面抗原表达的影响,以探讨IFNα导致自身免疫性甲状腺病(AITD)的可能机制。方法应用IFNα、IFNγ、促甲状腺激素(TSH)及催乳素(PRL),刺激体外培养的来自6名正常人的甲状腺细胞,通过免疫荧光染色及流式细胞仪测定其表面抗原—HLADR、细胞间粘附分子1(ICAM1)、B7.1和甲状腺过氧化物酶(TPO)的表达。结果(1)IFNα明显诱导甲状腺细胞表达ICAM1、B7.1和TPO(分别为P<0.01、P<0.01、P<0.05);(2)IFNγ明显诱导甲状腺细胞表达HLADR、ICAM1,但对B7.1的表达无促进作用(P<0.01、P<0.01、P>0.05);(3)PRL显著诱导甲状腺细胞表达ICAM1、B7.1和TPO(P<0.05、P<0.01、P<0.01)。结论协同刺激信号对AITD的发生起着关键作用。IFNα显著诱导甲状腺细胞表达协同刺激信号(B7.1)和自身抗原TPO,可能是临床应用IFNα诱致AITD的致病原因之一。PRL在产后甲状腺炎发病和发展中的作用应予以关注 相似文献
10.
目的探讨幽门螺杆菌(Hp)感染在功能性消化不良(FD)患者胃排空功能障碍中的作用.方法采用放射性同位素γ-照相法观测了56例FD患者胃固-液体排空情况,并用胃窦粘膜印片Giemsa染色及石蜡切片HE,W_S银染色镜检Hp.结果FD患者餐后30,60及90min时的胃排空率均显著低于正常对照组(P<005-001);FD患者Hp感染率无明显增高(P>005),Hp阳性组与阴性组在3个时相的胃排空率差异均无显著性(P>005)结论FD患者胃排空功能与Hp感染无关 相似文献
11.
Caleb R. Matthews Mackenzie Madison Chen Zhang Joshua Waters Jose P. Garcia Daniel Beckman 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2022,49(3)
We present a rare case of thrombosis associated with an occult colon malignancy (Trousseau syndrome) in a 25-year-old woman who also presented with previously unidentified Lynch syndrome and acute-on-chronic thromboembolic pulmonary hypertension. Staged treatment included bilateral pulmonary endarterectomy under deep hypothermic circulatory arrest, followed 11 days later by laparoscopic subtotal colectomy and creation of a primary anastomosis. The patient tolerated both procedures well and recovered normal functional status. Final pathologic analysis of the resected colon mass revealed a pT3N0, stage IIA adenocarcinoma; no adjuvant therapy was administered. At her one-year follow-up visit, the patient was cancer-free, remained on lifelong apixaban anticoagulation, and was undergoing routine monitoring and genetic counseling. This case highlights the need for multidisciplinary management of a patient with severe chronic thromboembolic pulmonary hypertension and a concomitant malignancy. 相似文献
12.
Koray Ak Selim Isbir Alper Kepez Kemal Turkoz Emre Elci Sinan Arsan 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2014,41(2):231-233
We present the case of a 58-year-old woman who had large lipomatous hypertrophy of the interventricular septum, a condition that is reported very infrequently. Preoperative cardiac magnetic resonance images revealed an inhomogeneous, infiltrating mass that was suppressed in fat-suppression mode. The extensive mass was causing right ventricular dysfunction, so we excised it through a right ventricular approach. The findings on histologic analysis of the mass were consistent with lipomatous hypertrophy. The patient died of septic shock on the 28th postoperative day. In addition to the patient''s case, we discuss the characteristics and diagnosis of this rare entity. 相似文献
13.
Rym Gribaa Mehdi Slim Elyes Neffati Essia Boughzela 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2015,42(5):450-453
Cardiac hemangiomas are benign tumors with an unpredictable natural history. Surgical resection is the treatment of choice; however, conservative management can be an alternative in some patients.We report a case of a left-sided cardiac hemangioma that we managed conservatively for 11 years without obvious major complications in the patient, an adult woman. 相似文献
14.
肝硬变腹水患者钾钠氯及酸碱失衡 总被引:2,自引:1,他引:2
目的研究肝硬变腹水患者的钾、钠、氯及酸碱失衡。方法肝硬变腹水患者154例,血K+、Na+、Cl-测定采用EEL公司自动分析仪及火焰光度计。血气及酸碱度测定采用IL1302型自动微机分析仪。结果低血钾者57例,高血钾者6例,低血钠者81例,高血钠者12例,低血氯者34例,高血氯者8例。24例血气及酸碱度测定结果显示,以碱中毒者为主。依次为呼碱、呼碱+代酸、代酸、代碱、呼酸。本组高血钾、低血钠与Child分级、BUN、Cr值相关。从本组资料表明,重症肝硬变腹水患者水盐代谢失衡多为医源性所致,且加重原有失衡。高钾血症、急性低钠血症及高钠血症大多如此,多为住院后发生,常可危及生命。结论肝硬变腹水患者的高钾血症、低钠血症和高钠血症大多在肝肾功能低下,不适当的治疗所致,是影响预后的重要因素 相似文献
15.
Todd Goldman Kathi Adamson Eugene Yang 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2014,41(5):533-536
Carcinoid tumors are rare neuroendocrine malignancies that typically originate from the gastrointestinal tract. Patients who are diagnosed with carcinoid heart disease generally have poor prognoses because of advanced metastases during staging and few therapeutic options. We present the case of a 61-year-old woman with right-sided heart failure, secondary to carcinoid heart disease caused by a primary ovarian carcinoid tumor. After undergoing surgical resection of the left ovary and fallopian tube, the patient experienced complete resolution of her heart failure symptoms. In addition to the patient''s case, we discuss the diagnosis, nature, and treatment of this rare condition. 相似文献
16.
Toshimasa Okabe Howard M. Julien Antony G. Kaliyadan Henry Siu Gregary D. Marhefka 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2015,42(5):474-478
In the modern period of reperfusion, left ventricular free-wall rupture occurs in less than 1% of myocardial infarctions. Typically, acute left ventricular free-wall rupture leads to sudden death from immediate cardiac tamponade. We present the case of a 59-year-old woman who sustained a posterior-wall myocardial infarction and subsequent cardiac arrest with pulseless electrical activity. A bedside transthoracic echocardiogram showed pericardial effusion with cardiac tamponade. Emergency pericardiocentesis yielded 500 mL of blood, and spontaneous circulation returned. Contrast-enhanced echocardiograms revealed inferolateral akinesis and a new, small myocardial slit with systolic extrusion of contrast medium, consistent with left ventricular free-wall rupture. During immediate open-heart surgery, a small hole in an area of necrotic tissue was discovered and repaired. This case highlights the usefulness of bedside contrast-enhanced echocardiography in confirming acute left ventricular free-wall rupture and enabling rapid surgical treatment. 相似文献
17.
Saba Darda Marcel E. Zughaib Patrick B. Alexander Christian E. Machado Shukri W. David Souheil Saba 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2014,41(3):319-323
In patients with cardiac sarcoidosis, the sarcoid granulomas usually involve the myocardium or endocardium. The disease typically presents as heart failure with ventricular arrhythmias, conduction disturbances, or both. Constrictive pericarditis has rarely been described in patients with sarcoidosis: we found only 2 reports of this association.We report the case of a 57-year-old man who presented with clinical and hemodynamic features of constrictive pericarditis, of unclear cause. He was admitted for treatment of recurrent pleural effusion. After a complicated hospital course, he underwent pericardiectomy. His clinical and hemodynamic conditions improved substantially, and he was discharged from the hospital in good condition. The pathologic findings, the patient''s clinical course, and his response to pericardiectomy led to our diagnosis of cardiac sarcoidosis presenting as constrictive pericarditis. In addition to the patient''s case, we discuss the nature and diagnostic challenges of cardiac sarcoidosis. Increased awareness of this disease is necessary for its early detection, appropriate management, and potential cure. 相似文献
18.
19.
Prabhjot Singh Nijjar Sofia Carolina Masri Ashenafi Tamene Helina Kassahun Kenneth Liao Uma Valeti 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2014,41(6):657-659
Primary cardiac tumors are far rarer than tumors metastatic to the heart. Angiosarcoma is the primary cardiac neoplasm most frequently detected; lymphomas constitute only 1% of primary cardiac tumors.We present the case of a 55-year-old woman with a recently diagnosed intracardiac mass who was referred to our institution for consideration of urgent orthotopic heart transplantation. Initial images suggested an angiosarcoma; however, a biopsy specimen of the mass was diagnostic for diffuse large B-cell lymphoma. The patient underwent chemotherapy rather than surgery, and she was asymptomatic 34 months later.We use our patient''s case to discuss the benefits and limitations of multiple imaging methods in the evaluation of cardiac masses. Certain features revealed by computed tomography, cardiac magnetic resonance, and positron emission tomography can suggest a diagnosis of angiosarcoma rather than lymphoma. Cardiac magnetic resonance and positron emission tomography enable reliable distinction between benign and malignant tumors; however, the characteristics of different malignant tumors can overlap. Despite the great usefulness of multiple imaging methods for timely diagnosis, defining the extent of spread and the hemodynamic impact, and monitoring responses to treatment, we think that biopsy analysis is still warranted in order to obtain a correct histologic diagnosis in cases of suspected malignant cardiac tumors. 相似文献
20.
Manoj Thangam Sriram Nathan Biswajit Kar Marija Petrovic Manish Patel Pranav Loyalka L. Maximilian Buja Igor D. Gregoric 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2016,43(3):236-240
We discuss the case of a 38-year-old black man who presented at our hospital with his first episode of syncope, recently developed atrial arrhythmias refractory to pharmacologic therapy, and a left atrial thrombus. He was diagnosed with primary cardiac sarcoidosis characterized by predominant involvement of the epicardium that caused atrial fibrillation and atrial flutter. Histologic analysis of his epicardial lesions yielded a diagnosis of sarcoidosis. This patient''s atrial arrhythmia was successfully treated with a hybrid operation that involved resection of his atrial appendage, an Epicor maze procedure, and radiofrequency ablation during a catheter-based electrophysiologic study. The cardiac sarcoidosis was successfully managed with corticosteroid therapy.Our case report shows that sarcoidosis can initially manifest itself as syncope with new-onset atrial arrhythmia. Sarcoidosis is important in the differential diagnosis because of its progressive nature and its potential for treatment with pharmacologic, surgical, and catheter-based interventions. 相似文献